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Aliases for CYP2S1 Gene

Aliases for CYP2S1 Gene

  • Cytochrome P450 Family 2 Subfamily S Member 1 2 3 5
  • Cytochrome P450, Family 2, Subfamily S, Polypeptide 1 2 3
  • EC 4 56
  • CYPIIS1 3 4
  • Cytochrome P450, Subfamily IIS, Polypeptide 1 2
  • Cytochrome P540, Subfamily IIS, Polypeptide 1 3
  • Cytochrome P450 2S1 3

External Ids for CYP2S1 Gene

Previous GeneCards Identifiers for CYP2S1 Gene

  • GC19P042338
  • GC19P042090
  • GC19P046375
  • GC19P046390
  • GC19P046391
  • GC19P041699
  • GC19P038131

Summaries for CYP2S1 Gene

Entrez Gene Summary for CYP2S1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2S1 Gene

CYP2S1 (Cytochrome P450 Family 2 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are superpathway of tryptophan utilization and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP1B1.

UniProtKB/Swiss-Prot for CYP2S1 Gene

  • Has a potential importance for extrahepatic xenobiotic metabolism.

Gene Wiki entry for CYP2S1 Gene

Additional gene information for CYP2S1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2S1 Gene

Genomics for CYP2S1 Gene

GeneHancer (GH) Regulatory Elements for CYP2S1 Gene

Promoters and enhancers for CYP2S1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I041192 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 554.9 +0.4 430 2.6 ZFP64 KLF17 SIN3A NFXL1 ZNF335 GLIS2 ZNF213 ZNF366 KLF7 SP3 CYP2S1 GC19P041185 AXL
GH19I041172 Enhancer 1.2 Ensembl ENCODE dbSUPER 13.4 -18.3 -18302 5.5 ELF3 KLF17 SIN3A SLC30A9 SCRT2 FOS CREM THAP11 SP5 USF2 CYP2S1 AXL CYP2F1 NUMBL DMAC2 PCAT19 RPL36P16 GC19P041185
GH19I041188 Enhancer 0.9 ENCODE dbSUPER 10.1 -3.1 -3097 2 MZF1 SIN3A ZIC2 ZNF335 POLR2A PRDM10 ZBTB20 EGR2 MAZ ZNF189 RN7SL718P CYP2S1 GC19P041185
GH19I041186 Enhancer 0.5 ENCODE dbSUPER 11.4 -5.9 -5873 2 USF1 GC19P041185 CYP2S1 RN7SL718P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYP2S1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP2S1 gene promoter:

Genomic Locations for CYP2S1 Gene

Genomic Locations for CYP2S1 Gene
14,491 bases
Plus strand

Genomic View for CYP2S1 Gene

Genes around CYP2S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2S1 Gene

Proteins for CYP2S1 Gene

  • Protein details for CYP2S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 2S1
    Protein Accession:
    Secondary Accessions:
    • Q9BZ66

    Protein attributes for CYP2S1 Gene

    504 amino acids
    Molecular mass:
    55817 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP2S1 Gene


neXtProt entry for CYP2S1 Gene

Selected DME Specific Peptides for CYP2S1 Gene


Post-translational modifications for CYP2S1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2S1 Gene

Domains & Families for CYP2S1 Gene

Gene Families for CYP2S1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CYP2S1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2S1: view

Function for CYP2S1 Gene

Molecular function for CYP2S1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Has a potential importance for extrahepatic xenobiotic metabolism.

Enzyme Numbers (IUBMB) for CYP2S1 Gene

Gene Ontology (GO) - Molecular Function for CYP2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0008401 retinoic acid 4-hydroxylase activity TAS --
genes like me logo Genes that share ontologies with CYP2S1: view
genes like me logo Genes that share phenotypes with CYP2S1: view

Animal Models for CYP2S1 Gene

MGI Knock Outs for CYP2S1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP2S1

miRNA for CYP2S1 Gene

miRTarBase miRNAs that target CYP2S1

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP2S1 Gene

Localization for CYP2S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2S1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2S1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYP2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA,IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP2S1: view

Pathways & Interactions for CYP2S1 Gene

genes like me logo Genes that share pathways with CYP2S1: view

Gene Ontology (GO) - Biological Process for CYP2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019373 epoxygenase P450 pathway IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP2S1: view

No data available for SIGNOR curated interactions for CYP2S1 Gene

Drugs & Compounds for CYP2S1 Gene

(18) Drugs for CYP2S1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 526
Codeine Approved, Illicit Pharma Full agonist, Agonist 83
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1400
Estrone Approved Pharma Agonist Estrogenic hormone 22
Formaldehyde Approved, Vet_approved Pharma 102

(25) Additional Compounds for CYP2S1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP2S1: view

Transcripts for CYP2S1 Gene

Unigene Clusters for CYP2S1 Gene

Cytochrome P450, family 2, subfamily S, polypeptide 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2S1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP3: -
SP4: - - - - -

Relevant External Links for CYP2S1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP2S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP2S1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2S1 Gene

This gene is overexpressed in Stomach (x13.9), Small Intestine - Terminal Ileum (x5.8), Esophagus - Mucosa (x4.5), and Colon - Transverse (x4.5).

Protein differential expression in normal tissues from HIPED for CYP2S1 Gene

This gene is overexpressed in Nasal epithelium (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYP2S1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP2S1 Gene:


SOURCE GeneReport for Unigene cluster for CYP2S1 Gene:


mRNA Expression by UniProt/SwissProt for CYP2S1 Gene:

Tissue specificity: High level of expression in trachea, lung, stomach, small intestine, and spleen.

Evidence on tissue expression from TISSUES for CYP2S1 Gene

  • Blood(4.1)
  • Intestine(3)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with CYP2S1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2S1 Gene

Orthologs for CYP2S1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2S1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC739649 33
  • 99.57 (n)
CYP2S1 34
  • 83 (a)
(Canis familiaris)
Mammalia CYP2S1 33 34
  • 84.99 (n)
(Bos Taurus)
Mammalia CYP2S1 33 34
  • 84.11 (n)
(Mus musculus)
Mammalia Cyp2s1 33 16 34
  • 80.76 (n)
(Rattus norvegicus)
Mammalia Cyp2s1 33
  • 79.01 (n)
(Monodelphis domestica)
Mammalia CYP2S1 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia CYP2S1 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp304a1 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea T10H4.10 35
  • 32 (a)
B0213.15 35
  • 30 (a)
Species where no ortholog for CYP2S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2S1 Gene

Gene Tree for CYP2S1 (if available)
Gene Tree for CYP2S1 (if available)

Paralogs for CYP2S1 Gene

Variants for CYP2S1 Gene

Sequence variations from dbSNP and Humsavar for CYP2S1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000445594 -- 41,194,881(+) G/A intron_variant
rs1000457038 -- 41,195,060(+) G/A intron_variant
rs1000605392 -- 41,194,360(+) G/A intron_variant
rs1000780713 -- 41,200,090(+) C/T intron_variant
rs1000792142 -- 41,193,813(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2S1 Gene

Variant ID Type Subtype PubMed ID
nsv523521 CNV loss 19592680

Variation tolerance for CYP2S1 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2S1 Gene

The Human Cytochrome P450 Allele Nomenclature Database
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2S1 Gene

Disorders for CYP2S1 Gene

Additional Disease Information for CYP2S1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYP2S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2S1 Gene

Publications for CYP2S1 Gene

  1. Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). (PMID: 11181079) Rylander T … Oscarson M (Biochemical and biophysical research communications 2001) 2 3 4 22 58
  2. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
  3. Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. (PMID: 19713358) Bui PH … Hankinson O (Molecular pharmacology 2009) 3 22 58
  4. Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals. (PMID: 17495422) Hanzawa Y … Mizugaki M (Drug metabolism and pharmacokinetics 2007) 3 44 58
  5. CYP2S1 gene polymorphisms in a Korean population. (PMID: 17529885) Jang YJ … Shin JG (Therapeutic drug monitoring 2007) 3 22 58

Products for CYP2S1 Gene

Sources for CYP2S1 Gene

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