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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; howev... See more...
Aliases for CYP2S1 Gene
Aliases for CYP2S1 Gene
External Ids for CYP2S1 Gene
- HGNC: 15654
- Entrez Gene: 29785
- Ensembl: ENSG00000167600
- OMIM: 611529
- UniProtKB: Q96SQ9
Previous GeneCards Identifiers for CYP2S1 Gene
- GC19P042338
- GC19P042090
- GC19P046375
- GC19P046390
- GC19P046391
- GC19P041699
- GC19P038131
Summaries for CYP2S1 Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP2S1 Gene
CYP2S1 (Cytochrome P450 Family 2 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and acetone degradation I (to methylglyoxal). Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A13.
UniProtKB/Swiss-Prot Summary for CYP2S1 Gene
-
A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195).
Additional gene information for CYP2S1 Gene
- HGNC(15654)
- Entrez Gene(29785)
- Ensembl(ENSG00000167600)
- OMIM(611529)
- UniProtKB(Q96SQ9)
- Open Targets Platform(ENSG00000167600)
- Search for CYP2S1 at DataMed
- Search for CYP2S1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP2S1 Gene
Genomics for CYP2S1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CYP2S1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J041192 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE dbSUPER | 604.8 | +0.4 | 389 | 2.8 | PRDM10 ZNF629 ZNF7 ZIC2 ZNF24 PATZ1 REST POLR2A ZNF561 CEBPB | CYP2S1 AXL | |
| GH19J041172 | Enhancer | 1 | ENCODE dbSUPER | 13.4 | -18.5 | -18463 | 5.5 | GATAD2A CTCF TFE3 KDM1A RCOR2 PRDM1 REST CEBPA SCRT2 SOX13 | CYP2S1 AXL CYP2F1 NUMBL DMAC2 PCAT19 RF00017-2987 RPL36P16 lnc-CYP2S1-2 | |
| GH19J041188 | Enhancer | 1.2 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 10 | -3.6 | -3609 | 2.8 | TEAD4 PRDM10 RFX5 KDM1A ZIC2 ZBTB20 SP1 OSR2 ZBTB17 NFIC | RN7SL718P lnc-TGFB1-5 CYP2S1 piR-38580-147 CYP2F1 | |
| GH19J041186 | Enhancer | 0.7 | Ensembl ENCODE dbSUPER | 11.4 | -6.0 | -6034 | 2 | CEBPB USF1 | piR-38580-147 CYP2S1 piR-56759-280 CYP2F1 | |
| GH19J041184 | Enhancer | 0.3 | Ensembl | 5 | -8.2 | -8209 | 0.4 | SCRT1 | CYP2S1 piR-38580-147 piR-56759-280 CYP2F1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CYP2S1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP2S1
- Top Transcription factor binding sites by QIAGEN in the CYP2S1 gene promoter:
-
- AhR
- AP-2alpha
- AP-4
- AREB6
- ATF-2
- c-Jun
- HEN1
- HOXA5
Genomic Locations for CYP2S1 Gene
Genomic Locations for CYP2S1 Gene
- chr19:41,193,210-41,207,539
- (GRCh38/hg38)
- Size:
- 14,330 bases
- Orientation:
- Plus strand
- chr19:41,698,954-41,713,444
- (GRCh37/hg19)
- Size:
- 14,491 bases
- Orientation:
- Plus strand
Genomic View for CYP2S1 Gene
Genes around CYP2S1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by HGNC
- 19q13.2 by Entrez Gene
- 19q13.2 by Ensembl
CYP2S1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP2S1 Gene
Proteins for CYP2S1 Gene
-
Protein details for CYP2S1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96SQ9-CP2S1_HUMAN
- Recommended name:
- Cytochrome P450 2S1
- Protein Accession:
- Q96SQ9
- Q9BZ66
Protein attributes for CYP2S1 Gene
- Size:
- 504 amino acids
- Molecular mass:
- 55817 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP2S1 Gene
Selected DME Specific Peptides for CYP2S1 Gene
- Q96SQ9:
-
- EAFLPFS
- EEFSGRG
- PGPTPLP
- ELFLFFTTILQ
Post-translational modifications for CYP2S1 Gene
Other Protein References for CYP2S1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Cytochrome P450 2S1 Antibody
- Novus Biologicals Antibodies for CYP2S1
-
Abcam antibodies for CYP2S1
- Invitrogen Antibodies for CYP2S1 (AFLGC-CYP2S1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP2S1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP2S1
- Origene Custom Protein Services for CYP2S1
- antibodies-online: Show 3 available CYP2S1 Proteins ranked by validation data
- Compare Top CYP2S1 Proteins
-
Quality Products:
Assay Products
- antibodies-online: Show 2 available CYP2S1 Elisa Kits ranked by validation data
- Compare Top CYP2S1 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CYP2S1
-
Signalway ELISA kits for CYP2S1
Domains & Families for CYP2S1 Gene
Gene Families for CYP2S1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CYP2S1 Gene
- InterPro:
- Blocks:
-
- E-class P450 group I signature
- CYP2A P450 family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP2S1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ52866, highly similar to Cytochrome P450 2S1 (EC 1.14.14.1) (B4DJI0_HUMAN)
- CYPIIS1 (CP2S1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96SQ9- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP2S1 Gene
Molecular function for CYP2S1 Gene
- UniProtKB/Swiss-Prot Function:
- A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:139183; Evidence={ECO:0000269|PubMed:12711469};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence={ECO:0000269|PubMed:12711469};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=prostaglandin H2 = thromboxane A2; Xref=Rhea:RHEA:17137, ChEBI:CHEBI:57405, ChEBI:CHEBI:57445; EC=5.3.99.5; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644, ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in skin upon exposure to ultraviolet radiation or treatment with all-trans retinoic acid (substrate-inducible).
Enzyme Numbers (IUBMB) for CYP2S1 Gene
Phenotypes From GWAS Catalog for CYP2S1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004497 | monooxygenase activity | IEA,IDA | 12711469 |
| GO:0004796 | thromboxane-A synthase activity | IEA,IDA | 21068195 |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008392 | arachidonic acid epoxygenase activity | IBA | 21873635 |
Phenotypes for CYP2S1 Gene
- MGI mutant phenotypes for CYP2S1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CYP2S1:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability of wild-type and TP53 knockout cells
- Increased gamma-H2AX phosphorylation
- Reduced mammosphere formation
- Strongly decreased NFAT1-GFP nuclear translocation
- Increased hepcidin::fluc mRNA expression
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
Animal Models for CYP2S1 Gene
- MGI Knock Outs for CYP2S1:
-
- Cyp2s1 Cyp2s1<tm1Ding>
Animal Model Products
-
Taconic Biosciences Mouse Models for CYP2S1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYP2S1 - Select products 50% OFF >
- * CYP2S1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CYP2S1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP2S1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2S1
miRNA for CYP2S1 Gene
- miRTarBase miRNAs that target CYP2S1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP2S1
- Browse OriGene Inhibitory RNA Products For CYP2S1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2S1
Clone Products
- Applied Biological Materials (abm): Clones for CYP2S1 - Select products 50% OFF >
- * CYP2S1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CYP2S1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP2S1
Cell Line Products
-
Horizon Cell Lines for CYP2S1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP2S1 Gene
Localization for CYP2S1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP2S1 Gene
- Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| extracellular | 3 |
| nucleus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Endoplasmic reticulum (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005783 | endoplasmic reticulum | IEA,IDA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CYP2S1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
.01
|
| 2 | superpathway of tryptophan utilization | ||
| 3 | Metabolism |
.40
|
|
| 4 | Drug metabolism - cytochrome P450 | ||
| 5 | nicotine degradation IV | ||
Pathways by source for CYP2S1 Gene
9 BioSystems pathways for CYP2S1 Gene
7 Reactome pathways for CYP2S1 Gene
3 KEGG pathways for CYP2S1 Gene
1 GeneGo (Thomson Reuters) pathway for CYP2S1 Gene
- Naphthalene metabolism
UniProtKB/Swiss-Prot Q96SQ9-CP2S1_HUMAN
- Pathway: Lipid metabolism; fatty acid metabolism.
Interacting Proteins for CYP2S1 Gene
Selected Interacting proteins:
Q96SQ9-CP2S1_HUMAN
ENSP00000308032
for CYP2S1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CYP2S1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | IBA | 21873635 |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006690 | icosanoid metabolic process | IDA | 21068195 |
| GO:0006693 | prostaglandin metabolic process | IDA | 21068195 |
No data available for SIGNOR curated interactions for CYP2S1 Gene
Drugs & Compounds for CYP2S1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Caffeine | Approved | Pharma | Antagonist, Activator | 603 | ||
| Citalopram | Approved | Pharma | 597 | |||
| Codeine | Approved, Illicit | Pharma | Agonist, Full agonist | 94 | ||
| Estradiol | Approved, Investigational, Vet_approved | Pharma | Sex hormone | 1113 | ||
| Estrone | Approved | Pharma | Agonist | Estrogenic hormone | 22 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 11,12,15-THETA |
|
|
||||
| 11,12-EpETrE |
|
81276-02-0 |
|
|||
| 11,14,15-THETA |
|
|
||||
| 11H-14,15-EETA |
|
219535-29-2 |
|
|||
| 12,13-EpOME |
|
|
Transcripts for CYP2S1 Gene
mRNA/cDNA for CYP2S1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000310054 2612 nts (view in UCSC)
- ENST00000597754 580 nts (view in UCSC)
- ENST00000593545 1479 nts (view in UCSC)
- ENST00000600561 580 nts (view in UCSC)
- ENST00000595590 759 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYP2S1 - Select products 50% OFF >
- * CYP2S1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CYP2S1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP2S1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2S1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP2S1
- Browse OriGene Inhibitory RNA Products For CYP2S1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2S1
Clone Products
- Applied Biological Materials (abm): Clones for CYP2S1 - Select products 50% OFF >
- * CYP2S1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CYP2S1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP2S1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | - | - | - | - | - |
Relevant External Links for CYP2S1 Gene
- GeneLoc Exon Structure for
- CYP2S1
Expression for CYP2S1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CYP2S1 Gene
This gene is overexpressed in Stomach (x13.9), Small Intestine - Terminal Ileum (x5.8), Esophagus - Mucosa (x4.5), and Colon - Transverse (x4.5).
This gene is overexpressed in Nasal epithelium (67.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP2S1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP2S1
SOURCE GeneReport for Unigene cluster for CYP2S1 Gene:
Hs.98370mRNA Expression by UniProt/SwissProt for CYP2S1 Gene:
Q96SQ9-CP2S1_HUMAN
Tissue specificity:
Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469).
Evidence on tissue expression from TISSUES for CYP2S1 Gene
- Blood(4.4)
- Intestine(3.4)
- Stomach(2.5)
- Liver(2.4)
- Kidney(2.2)
Primer Products
-
OriGene qPCR primer pairs for CYP2S1
-
OriGene qPCR primer pairs and template standards for CYP2S1
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2S1 Gene
Orthologs for CYP2S1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC739649 30 |
|
||
| CYP2S1 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | CYP2S1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CYP2S1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cyp2s1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cyp2s1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CYP2S1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CYP2S1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cyp304a1 32 |
|
|
|
| Worm (Caenorhabditis elegans) |
Secernentea | T10H4.10 32 |
|
|
|
| B0213.15 32 |
|
|
- Species where no ortholog for CYP2S1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for CYP2S1 Gene
- ENSEMBL:
- Gene Tree for CYP2S1 (if available)
- TreeFam:
- Gene Tree for CYP2S1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYP2S1: view image
Paralogs for CYP2S1 Gene
Paralogs for CYP2S1 Gene
(29) SIMAP similar genes for CYP2S1 Gene using alignment to 7 proteins:
- CP2S1_HUMAN
- B4DJI0_HUMAN
- M0QY51_HUMAN
- M0QYI2_HUMAN
- M0R057_HUMAN
- M0R152_HUMAN
- M0R2G8_HUMAN
Variants for CYP2S1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP2S1 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 715745 | Benign: not provided | 41,203,532(+) | C/T | SYNONYMOUS_VARIANT | |
| 788469 | Benign: not provided | 41,197,858(+) | G/A | SYNONYMOUS_VARIANT | |
| rs34971233 | - | p.Pro466Leu |
Residual Variation Intolerance Score:
69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.10;
51.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYP2S1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2S1 Gene
Disorders for CYP2S1 Gene
Additional Disease Information for CYP2S1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CYP2S1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2S1 Gene
Publications for CYP2S1 Gene
- Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). (PMID: 11181079) Rylander T … Oscarson M (Biochemical and biophysical research communications 2001) 2 3 4 23
- Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. (PMID: 21068195) Bui P … Hankinson O (Drug metabolism and disposition: the biological fate of chemicals 2011) 3 4
- Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. (PMID: 19713358) Bui PH … Hankinson O (Molecular pharmacology 2009) 3 23
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 41
- CYP2S1 gene polymorphisms in a Korean population. (PMID: 17529885) Jang YJ … Shin JG (Therapeutic drug monitoring 2007) 3 23
ExternalLinks
Products for CYP2S1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP2S1
- Origene Custom Protein Services for CYP2S1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP2S1
- Browse OriGene Inhibitory RNA Products For CYP2S1
- OriGene qPCR primer pairs for CYP2S1
- OriGene qPCR primer pairs and template standards for CYP2S1
- OriGene CRISPR knockouts for CYP2S1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CYP2S1
- Sino Biological Human cDNA Clone for CYP2S1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CYP2S1
- Novus Biologicals proteins and lysates for CYP2S1
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for CYP2S1
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Taconic Biosciences Mouse Models for CYP2S1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CYP2S1 (AFLGC-CYP2S1)
- VectorBuilder Custom and pre-made DNA vectors for CYP2S1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CYP2S1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CYP2S1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CYP2S1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CYP2S1
- antibodies-online: Show 17 available CYP2S1 Antibodies ranked by validation data
- Compare Top CYP2S1 Antibodies
- antibodies-online: Show 2 available CYP2S1 Elisa Kits ranked by validation data
- Compare Top CYP2S1 Elisa Kits
- Quality Products:
- antibodies-online: Show 3 available CYP2S1 Proteins ranked by validation data
- Compare Top CYP2S1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for CYP2S1
- Search Santa Cruz Biotechnology (SCBT) for CYP2S1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CYP2S1
- Horizon Cell Lines for CYP2S1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP2S1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP2S1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CYP2S1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2S1
- Signalway ELISA kits for CYP2S1
Sources for CYP2S1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB