Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]
CYP2S1 (Cytochrome P450 Family 2 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and acetone degradation I (to methylglyoxal). Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A13.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J041192 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE dbSUPER | 604.8 | +0.4 | 389 | 2.8 | PRDM10 ZNF629 ZNF7 ZIC2 ZNF24 PATZ1 REST POLR2A ZNF561 CEBPB | CYP2S1 AXL | |
GH19J041172 | Enhancer | 1 | ENCODE dbSUPER | 13.4 | -18.5 | -18463 | 5.5 | GATAD2A CTCF TFE3 KDM1A RCOR2 PRDM1 REST CEBPA SCRT2 SOX13 | CYP2S1 AXL CYP2F1 NUMBL DMAC2 PCAT19 RF00017-2987 RPL36P16 lnc-CYP2S1-2 | |
GH19J041188 | Enhancer | 1.2 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 10 | -3.6 | -3609 | 2.8 | TEAD4 PRDM10 RFX5 KDM1A ZIC2 ZBTB20 SP1 OSR2 ZBTB17 NFIC | RN7SL718P lnc-TGFB1-5 CYP2S1 piR-38580-147 CYP2F1 | |
GH19J041186 | Enhancer | 0.7 | Ensembl ENCODE dbSUPER | 11.4 | -6.0 | -6034 | 2 | CEBPB USF1 | piR-38580-147 CYP2S1 piR-56759-280 CYP2F1 | |
GH19J041184 | Enhancer | 0.3 | Ensembl | 5 | -8.2 | -8209 | 0.4 | SCRT1 | CYP2S1 piR-38580-147 piR-56759-280 CYP2F1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004497 | monooxygenase activity | IEA,IDA | 12711469 |
GO:0004796 | thromboxane-A synthase activity | IEA,IDA | 21068195 |
GO:0005506 | iron ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008392 | arachidonic acid epoxygenase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005783 | endoplasmic reticulum | IEA,IDA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
.39
|
.01
|
2 | superpathway of tryptophan utilization | ||
3 | Metabolism |
.40
|
|
4 | Drug metabolism - cytochrome P450 | ||
5 | nicotine degradation IV |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006082 | organic acid metabolic process | IBA | 21873635 |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006690 | icosanoid metabolic process | IDA | 21068195 |
GO:0006693 | prostaglandin metabolic process | IDA | 21068195 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Caffeine | Approved | Pharma | Antagonist, Activator | 603 | ||
Citalopram | Approved | Pharma | 597 | |||
Codeine | Approved, Illicit | Pharma | Agonist, Full agonist | 94 | ||
Estradiol | Approved, Investigational, Vet_approved | Pharma | Sex hormone | 1113 | ||
Estrone | Approved | Pharma | Agonist | Estrogenic hormone | 22 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
11,12,15-THETA |
|
|
||||
11,12-EpETrE |
|
81276-02-0 |
|
|||
11,14,15-THETA |
|
|
||||
11H-14,15-EETA |
|
219535-29-2 |
|
|||
12,13-EpOME |
|
|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||
SP4: | - | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC739649 30 |
|
||
CYP2S1 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | CYP2S1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CYP2S1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cyp2s1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cyp2s1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CYP2S1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CYP2S1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Cyp304a1 32 |
|
|
|
Worm (Caenorhabditis elegans) |
Secernentea | T10H4.10 32 |
|
|
|
B0213.15 32 |
|
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
715745 | Benign: not provided | 41,203,532(+) | C/T | SYNONYMOUS_VARIANT | |
788469 | Benign: not provided | 41,197,858(+) | G/A | SYNONYMOUS_VARIANT | |
rs34971233 | - | p.Pro466Leu |
No disorders were found for CYP2S1 Gene.