This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; howev... See more...

Aliases for CYP2S1 Gene

Aliases for CYP2S1 Gene

  • Cytochrome P450 Family 2 Subfamily S Member 1 2 3 5
  • Cytochrome P450, Family 2, Subfamily S, Polypeptide 1 2 3
  • Hydroperoxy Icosatetraenoate Dehydratase 3 4
  • Thromboxane-A Synthase 3 4
  • Cytochrome P450 2S1 3 4
  • CYPIIS1 3 4
  • Cytochrome P540, Subfamily IIS, Polypeptide 1 3
  • Cytochrome P450, Subfamily IIS, Polypeptide 1 2
  • EC 1.14.14.1 54
  • EC 1.14.14.- 4
  • EC 4.2.1.152 4
  • EC 5.3.99.5 4

External Ids for CYP2S1 Gene

Previous GeneCards Identifiers for CYP2S1 Gene

  • GC19P042338
  • GC19P042090
  • GC19P046375
  • GC19P046390
  • GC19P046391
  • GC19P041699
  • GC19P038131

Summaries for CYP2S1 Gene

Entrez Gene Summary for CYP2S1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2S1 Gene

CYP2S1 (Cytochrome P450 Family 2 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and superpathway of tryptophan utilization. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A13.

UniProtKB/Swiss-Prot Summary for CYP2S1 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195).

Gene Wiki entry for CYP2S1 Gene

Additional gene information for CYP2S1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP2S1 Gene

Genomics for CYP2S1 Gene

GeneHancer (GH) Regulatory Elements for CYP2S1 Gene

Promoters and enhancers for CYP2S1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041192 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 754.8 +0.4 392 2.8 ZNF785 POLR2A SREBF1 ZBTB33 ELF1 SP5 GLIS2 ZIC2 ZBTB8A PRDM10 CYP2S1 AXL
GH19J041172 Enhancer 1 ENCODE dbSUPER 13.4 -18.5 -18460 5.5 TCF7L2 USF2 ZNF217 HLF SP1 ZBTB33 ELF3 TFE3 SP7 ELF1 CYP2S1 AXL CYP2F1 NUMBL DMAC2 PCAT19 RF00017-2985 RPL36P16 lnc-CYP2S1-2
GH19J041188 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 -3.6 -3606 2.8 ZNF785 POU5F1 SP1 ZIC2 PRDM10 ZBTB20 OSR2 ZBTB17 PRDM4 NFIC RN7SL718P lnc-TGFB1-5 CYP2S1 piR-38580-147
GH19J041186 Enhancer 0.6 Ensembl ENCODE dbSUPER 11.4 -6.0 -6031 2 USF1 piR-38580-147 CYP2S1 piR-56759-280
GH19J041184 Enhancer 0.3 Ensembl 5 -8.2 -8206 0.4 SCRT1 CYP2S1 piR-38580-147 piR-56759-280
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP2S1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP2S1 gene promoter:
  • AhR
  • AP-2alpha
  • AP-4
  • AREB6
  • ATF-2
  • c-Jun
  • HEN1
  • HOXA5

Genomic Locations for CYP2S1 Gene

Genomic Locations for CYP2S1 Gene
chr19:41,193,207-41,207,539
(GRCh38/hg38)
Size:
14,333 bases
Orientation:
Plus strand
chr19:41,698,954-41,713,444
(GRCh37/hg19)
Size:
14,491 bases
Orientation:
Plus strand

Genomic View for CYP2S1 Gene

Genes around CYP2S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2S1 Gene

Proteins for CYP2S1 Gene

  • Protein details for CYP2S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SQ9-CP2S1_HUMAN
    Recommended name:
    Cytochrome P450 2S1
    Protein Accession:
    Q96SQ9
    Secondary Accessions:
    • Q9BZ66

    Protein attributes for CYP2S1 Gene

    Size:
    504 amino acids
    Molecular mass:
    55817 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP2S1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2S1 Gene

Selected DME Specific Peptides for CYP2S1 Gene

Q96SQ9:
  • EAFLPFS
  • EEFSGRG
  • PGPTPLP
  • ELFLFFTTILQ

Post-translational modifications for CYP2S1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2S1 Gene

Domains & Families for CYP2S1 Gene

Gene Families for CYP2S1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CYP2S1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52866, highly similar to Cytochrome P450 2S1 (EC 1.14.14.1) (B4DJI0_HUMAN)
  • CYPIIS1 (CP2S1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96SQ9

UniProtKB/Swiss-Prot:

CP2S1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2S1: view

Function for CYP2S1 Gene

Molecular function for CYP2S1 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:139183; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55861; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51985; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48633; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37948; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prostaglandin H2 = thromboxane A2; Xref=Rhea:RHEA:17137, ChEBI:CHEBI:57405, ChEBI:CHEBI:57445; EC=5.3.99.5; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17138; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde; Xref=Rhea:RHEA:48644, ChEBI:CHEBI:57405, ChEBI:CHEBI:90694, ChEBI:CHEBI:566274; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48645; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48717; Evidence=. ;.
UniProtKB/Swiss-Prot Induction:
Up-regulated in skin upon exposure to ultraviolet radiation or treatment with all-trans retinoic acid (substrate-inducible).

Enzyme Numbers (IUBMB) for CYP2S1 Gene

Phenotypes From GWAS Catalog for CYP2S1 Gene

Gene Ontology (GO) - Molecular Function for CYP2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 12711469
GO:0004796 thromboxane-A synthase activity IDA 21068195
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008392 arachidonic acid epoxygenase activity IBA 21873635
genes like me logo Genes that share ontologies with CYP2S1: view
genes like me logo Genes that share phenotypes with CYP2S1: view

Animal Models for CYP2S1 Gene

MGI Knock Outs for CYP2S1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CYP2S1

CRISPR Products

miRNA for CYP2S1 Gene

miRTarBase miRNAs that target CYP2S1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP2S1 Gene

Localization for CYP2S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2S1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2S1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
mitochondrion 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYP2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IDA,IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP2S1: view

Pathways & Interactions for CYP2S1 Gene

genes like me logo Genes that share pathways with CYP2S1: view

UniProtKB/Swiss-Prot Q96SQ9-CP2S1_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Gene Ontology (GO) - Biological Process for CYP2S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IBA 21873635
GO:0006690 icosanoid metabolic process IDA 21068195
GO:0006693 prostaglandin metabolic process IDA 21068195
GO:0006805 xenobiotic metabolic process IBA 21873635
GO:0019373 epoxygenase P450 pathway IBA 21873635
genes like me logo Genes that share ontologies with CYP2S1: view

No data available for SIGNOR curated interactions for CYP2S1 Gene

Drugs & Compounds for CYP2S1 Gene

(19) Drugs for CYP2S1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caffeine Approved Pharma Antagonist, Activator 541
Citalopram Approved Pharma 573
Codeine Approved, Illicit Pharma Full agonist, Agonist 91
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1379
Estrone Approved Pharma Agonist Estrogenic hormone 23

(24) Additional Compounds for CYP2S1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
81276-02-0
11,14,15-THETA
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid
genes like me logo Genes that share compounds with CYP2S1: view

Transcripts for CYP2S1 Gene

mRNA/cDNA for CYP2S1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2S1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP3: -
SP4: - - - - -

Relevant External Links for CYP2S1 Gene

GeneLoc Exon Structure for
CYP2S1
ECgene alternative splicing isoforms for
CYP2S1

Expression for CYP2S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP2S1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2S1 Gene

This gene is overexpressed in Stomach (x13.9), Small Intestine - Terminal Ileum (x5.8), Esophagus - Mucosa (x4.5), and Colon - Transverse (x4.5).

Protein differential expression in normal tissues from HIPED for CYP2S1 Gene

This gene is overexpressed in Nasal epithelium (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP2S1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CYP2S1 Gene:

CYP2S1

SOURCE GeneReport for Unigene cluster for CYP2S1 Gene:

Hs.98370

mRNA Expression by UniProt/SwissProt for CYP2S1 Gene:

Q96SQ9-CP2S1_HUMAN
Tissue specificity: Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469).

Evidence on tissue expression from TISSUES for CYP2S1 Gene

  • Blood(4.1)
  • Intestine(3)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with CYP2S1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2S1 Gene

Orthologs for CYP2S1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2S1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC739649 32
  • 99.57 (n)
CYP2S1 33
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP2S1 33 32
  • 84.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CYP2S1 33 32
  • 84.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp2s1 17 33 32
  • 80.76 (n)
rat
(Rattus norvegicus)
Mammalia Cyp2s1 32
  • 79.01 (n)
oppossum
(Monodelphis domestica)
Mammalia CYP2S1 33
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYP2S1 33
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp304a1 34
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea T10H4.10 34
  • 32 (a)
B0213.15 34
  • 30 (a)
Species where no ortholog for CYP2S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2S1 Gene

ENSEMBL:
Gene Tree for CYP2S1 (if available)
TreeFam:
Gene Tree for CYP2S1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP2S1: view image

Paralogs for CYP2S1 Gene

(29) SIMAP similar genes for CYP2S1 Gene using alignment to 7 proteins:

  • CP2S1_HUMAN
  • B4DJI0_HUMAN
  • M0QY51_HUMAN
  • M0QYI2_HUMAN
  • M0R057_HUMAN
  • M0R152_HUMAN
  • M0R2G8_HUMAN
genes like me logo Genes that share paralogs with CYP2S1: view

Variants for CYP2S1 Gene

Sequence variations from dbSNP and Humsavar for CYP2S1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000445594 -- 41,194,881(+) G/A intron_variant
rs1000457038 -- 41,195,060(+) G/A intron_variant
rs1000605392 -- 41,194,360(+) G/A intron_variant
rs1000780713 -- 41,200,090(+) C/T intron_variant
rs1000792142 -- 41,193,813(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2S1 Gene

Variant ID Type Subtype PubMed ID
nsv523521 CNV loss 19592680

Variation tolerance for CYP2S1 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2S1 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP2S1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2S1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2S1 Gene

Disorders for CYP2S1 Gene

Additional Disease Information for CYP2S1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYP2S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2S1 Gene

Publications for CYP2S1 Gene

  1. Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). (PMID: 11181079) Rylander T … Oscarson M (Biochemical and biophysical research communications 2001) 2 3 4 23 56
  2. Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. (PMID: 21068195) Bui P … Hankinson O (Drug metabolism and disposition: the biological fate of chemicals 2011) 3 4 56
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 43 56
  4. Functional characterization of human cytochrome P450 2S1 using a synthetic gene-expressed protein in Escherichia coli. (PMID: 19713358) Bui PH … Hankinson O (Molecular pharmacology 2009) 3 23 56
  5. Three novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals. (PMID: 17495422) Hanzawa Y … Mizugaki M (Drug metabolism and pharmacokinetics 2007) 3 43 56

Products for CYP2S1 Gene

Sources for CYP2S1 Gene