This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arach... See more...

Aliases for CYP2J2 Gene

Aliases for CYP2J2 Gene

  • Cytochrome P450 Family 2 Subfamily J Member 2 2 3 5
  • Cytochrome P450, Subfamily IIJ (Arachidonic Acid Epoxygenase) Polypeptide 2 2 3
  • Cytochrome P450, Family 2, Subfamily J, Polypeptide 2 2 3
  • Albendazole Monooxygenase (Sulfoxide-Forming) 3 4
  • Albendazole Monooxygenase (Hydroxylating) 3 4
  • Hydroperoxy Icosatetraenoate Isomerase 3 4
  • Arachidonic Acid Epoxygenase 3 4
  • Cytochrome P450 2J2 3 4
  • CYPIIJ2 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • EC 1.14.14.74 4
  • EC 1.14.14.73 4
  • EC 1.14.14.1 52
  • EC 1.14.14.- 4
  • EC 5.4.4.7 4
  • CPJ2 3

External Ids for CYP2J2 Gene

Previous GeneCards Identifiers for CYP2J2 Gene

  • GC01M060284
  • GC01M059282
  • GC01M059716
  • GC01M059728
  • GC01M060071
  • GC01M058469

Summaries for CYP2J2 Gene

Entrez Gene Summary for CYP2J2 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP2J2 Gene

CYP2J2 (Cytochrome P450 Family 2 Subfamily J Member 2) is a Protein Coding gene. Diseases associated with CYP2J2 include Clopidogrel Resistance and Cardiovascular System Disease. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2D6.

UniProtKB/Swiss-Prot Summary for CYP2J2 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256).

Gene Wiki entry for CYP2J2 Gene

PharmGKB "VIP" Summary for CYP2J2 Gene

Additional gene information for CYP2J2 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP2J2 Gene

Genomics for CYP2J2 Gene

GeneHancer (GH) Regulatory Elements for CYP2J2 Gene

Promoters and enhancers for CYP2J2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J059926 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 506.2 +0.4 372 2 POLR2G ZNF10 ZIC2 ZBTB26 MXI1 ZNF341 KMT2B SIN3A POLR2A KLF9 CYP2J2 piR-30350-005
GH01J059891 Enhancer 0.7 Ensembl ENCODE 12.1 +33.7 33678 3 GATA3 FOXA1 RXRA HNF4A EGR2 FOXA2 SP1 YY1 CYP2J2 lnc-HOOK1-4 piR-30350-005
GH01J059966 Enhancer 1 Ensembl ENCODE 5.3 -40.5 -40539 1.1 NRF1 MYC CTBP1 HDAC3 NCOR1 TRIM25 ZNF316 NFIC ARNT TARDBP lnc-C1orf87-1 piR-33422-006 C1orf87 CYP2J2 HOOK1
GH01J059920 Enhancer 0.7 Ensembl ENCODE 6.7 +5.0 5043 3.1 ZNF217 CUX1 CTBP1 DPF2 GATA3 SMARCE1 SCRT2 CYP2J2 piR-30350-005 lnc-HOOK1-4
GH01J059541 Enhancer 1 FANTOM5 Ensembl ENCODE 2.4 +383.1 383118 4.6 NR2F2 ZBTB33 JUND ZGPAT RAD21 RXRA CEBPB THAP11 MAX HNF4A lnc-HOOK1-5 FGGY CYP2J2 piR-57176-029
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP2J2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP2J2

Top Transcription factor binding sites by QIAGEN in the CYP2J2 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • RelA
  • Sp1
  • YY1

Genomic Locations for CYP2J2 Gene

Genomic Locations for CYP2J2 Gene
chr1:59,893,308-59,926,773
(GRCh38/hg38)
Size:
33,466 bases
Orientation:
Minus strand
chr1:60,358,980-60,392,462
(GRCh37/hg19)
Size:
33,483 bases
Orientation:
Minus strand

Genomic View for CYP2J2 Gene

Genes around CYP2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2J2 Gene

Proteins for CYP2J2 Gene

  • Protein details for CYP2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51589-CP2J2_HUMAN
    Recommended name:
    Cytochrome P450 2J2
    Protein Accession:
    P51589
    Secondary Accessions:
    • B2RD33
    • Q8TF13

    Protein attributes for CYP2J2 Gene

    Size:
    502 amino acids
    Molecular mass:
    57611 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2J2 Gene

Selected DME Specific Peptides for CYP2J2 Gene

P51589:
  • EIDRVIG
  • LFFAGTET
  • VSNIICS
  • PFSIGKR
  • ELFIFFT
  • EERIQEE
  • AGTETTS

Post-translational modifications for CYP2J2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2J2 Gene

Domains & Families for CYP2J2 Gene

Gene Families for CYP2J2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CYP2J2 Gene

Blocks:
  • E-class P450 group I signature
  • CYP2J P450 family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP2J2 Gene

GenScript: Design optimal peptide antigens:
  • CYPIIJ2 (CP2J2_HUMAN)
  • Cytochrome P450 2J2 (Q8TF13_HUMAN)
  • Cytochrome P450 (Q96RX4_HUMAN)
  • Cytochrome P450 epoxygenase (Q9UN91_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51589

UniProtKB/Swiss-Prot:

CP2J2_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2J2: view

Function for CYP2J2 Gene

Molecular function for CYP2J2 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49936, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131992; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49937; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49884, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131975; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49885; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49928, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131974; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49929; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49881; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49876, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131969; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49877; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence={ECO:0000269 PubMed:19965576, ECO:0000269 PubMed:8631948}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49861; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence={ECO:0000269 PubMed:19965576, ECO:0000269 PubMed:8631948}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49857; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:53400, ChEBI:CHEBI:57446, ChEBI:CHEBI:137320; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53401; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:37959, ChEBI:CHEBI:57446, ChEBI:CHEBI:75235; EC=5.4.4.7; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37960; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39780; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39783, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76635; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39784; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52121; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136411; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52125; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:56288, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16664, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:140182; EC=1.14.14.74; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56289; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55924, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16664, ChEBI:CHEBI:16959, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.73; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55925; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55928, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35812, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77092; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55929; Evidence=. ;.
GENATLAS Biochemistry:
cytochrome p450,subfamily 2J catalyzing the NADPH-dependent oxidation of arachidonic acid to form eicosanoids,highly expressed in heart,airway,pancreatic islet cells,intestinal vascular endothelium,involved in the bioactivation of fatty acids

Enzyme Numbers (IUBMB) for CYP2J2 Gene

Phenotypes From GWAS Catalog for CYP2J2 Gene

Gene Ontology (GO) - Molecular Function for CYP2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IDA 8631948
GO:0008395 steroid hydroxylase activity IBA 21873635
GO:0008404 arachidonic acid 14,15-epoxygenase activity IDA 11901223
GO:0008405 arachidonic acid 11,12-epoxygenase activity IDA 11901223
genes like me logo Genes that share ontologies with CYP2J2: view
genes like me logo Genes that share phenotypes with CYP2J2: view

Animal Model Products

CRISPR Products

miRNA for CYP2J2 Gene

miRTarBase miRNAs that target CYP2J2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2J2 Gene

Localization for CYP2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2J2 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2J2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
cytoskeleton 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP2J2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2J2 Gene

Pathways & Interactions for CYP2J2 Gene

genes like me logo Genes that share pathways with CYP2J2: view

Pathways by source for CYP2J2 Gene

UniProtKB/Swiss-Prot P51589-CP2J2_HUMAN

  • Pathway: Lipid metabolism; arachidonate metabolism.

Gene Ontology (GO) - Biological Process for CYP2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IBA 21873635
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006690 icosanoid metabolic process TAS,IDA 19737933
GO:0006805 xenobiotic metabolic process TAS 11901223
genes like me logo Genes that share ontologies with CYP2J2: view

No data available for SIGNOR curated interactions for CYP2J2 Gene

Drugs & Compounds for CYP2J2 Gene

(35) Drugs for CYP2J2 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Astemizole Approved, Withdrawn Pharma Pore Blocker, Inhibitor, Enzyme, substrate 0
Terfenadine Approved, Withdrawn Pharma Pore Blocker, Inhibitor, Enzyme, inhibitor Histamine H1-receptor antagonist 52
Vitamin D3 Approved Nutra Enzyme, substrate Fat-soluble secosteroids 1053,1044
Amiodarone Approved, Investigational Pharma Pore Blocker, Enzyme, inhibitor 130
Apixaban Approved Pharma Enzyme, substrate Factor Xa inhibitor 252

(24) Additional Compounds for CYP2J2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
81276-02-0
11,14,15-THETA
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid
genes like me logo Genes that share compounds with CYP2J2: view

Transcripts for CYP2J2 Gene

mRNA/cDNA for CYP2J2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2J2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - -
SP3:
SP4: - - - - - -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for CYP2J2 Gene

GeneLoc Exon Structure for
CYP2J2

Expression for CYP2J2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP2J2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2J2 Gene

This gene is overexpressed in Heart - Left Ventricle (x8.3), Heart - Atrial Appendage (x6.9), and Liver (x6.2).

Protein differential expression in normal tissues from HIPED for CYP2J2 Gene

This gene is overexpressed in Fetal Liver (18.7), Liver (13.6), Gallbladder (9.3), Fetal heart (7.2), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP2J2 Gene



Protein tissue co-expression partners for CYP2J2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP2J2

SOURCE GeneReport for Unigene cluster for CYP2J2 Gene:

Hs.152096

mRNA Expression by UniProt/SwissProt for CYP2J2 Gene:

P51589-CP2J2_HUMAN
Tissue specificity: Highly expressed in heart, present at lower levels in liver, kidney and skeletal muscle (at protein level).

Evidence on tissue expression from TISSUES for CYP2J2 Gene

  • Liver(4.6)
  • Nervous system(4.5)
  • Skin(4.2)
  • Heart(3)
  • Muscle(2.8)
genes like me logo Genes that share expression patterns with CYP2J2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2J2 Gene

Orthologs for CYP2J2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC456896 30
  • 99.4 (n)
CYP2J2 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP2J2 31 30
  • 84.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC530929 30
  • 82.41 (n)
-- 31
  • 78 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cyp2j4 30
  • 79.93 (n)
mouse
(Mus musculus)
Mammalia Cyp2j6 17 31 30
  • 78.4 (n)
Cyp2j9 31
  • 73 (a)
OneToMany
Cyp2j13 31
  • 72 (a)
OneToMany
Cyp2j12 31
  • 71 (a)
OneToMany
Cyp2j7-ps 31
  • 70 (a)
OneToMany
Cyp2j5 31
  • 70 (a)
OneToMany
Cyp2j8 31
  • 70 (a)
OneToMany
Cyp2j11 31
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 66 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
-- 31
  • 64 (a)
OneToMany
-- 31
  • 63 (a)
OneToMany
-- 31
  • 63 (a)
OneToMany
-- 31
  • 63 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CYP2J2 31
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC424729 30
  • 61.08 (n)
-- 31
  • 58 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CYP2J2 31
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496620 30
  • 52.06 (n)
zebrafish
(Danio rerio)
Actinopterygii cyp2p10 31 30
  • 55.62 (n)
OneToMany
cyp2p8 31
  • 51 (a)
OneToMany
cyp2p7 31
  • 50 (a)
OneToMany
cyp2j20 31
  • 50 (a)
OneToMany
cyp2p9 31
  • 50 (a)
OneToMany
cyp2v1 31
  • 48 (a)
OneToMany
cyp2n13 31
  • 48 (a)
OneToMany
cyp2ad2 31
  • 48 (a)
OneToMany
cyp2ad3 31
  • 47 (a)
OneToMany
cyp2p6 31
  • 46 (a)
OneToMany
cyp2ae1 31
  • 46 (a)
OneToMany
cyp2ad6 31
  • 46 (a)
OneToMany
Dr.25426 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1599 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012937 30
  • 47.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cyp305a1 32 30
  • 45.06 (n)
Cyp18a1 32
  • 33 (a)
Cyp303a1 32
  • 29 (a)
Cyp304a1 32
  • 28 (a)
Cyp307a1 32
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea cyp-14A3 30
  • 46.7 (n)
R08F11.3 32
  • 36 (a)
B0304.3 32
  • 35 (a)
K09A11.4 32
  • 34 (a)
B0213.11 32
  • 34 (a)
K05D4.4 32
  • 33 (a)
K09A11.2 32
  • 33 (a)
F41B5.2 32
  • 33 (a)
F41B5.7 32
  • 33 (a)
C41G6.1 32
  • 33 (a)
F41B5.4 32
  • 33 (a)
C49C8.4 32
  • 33 (a)
Y49C4A.9 32
  • 33 (a)
C12D5.7 32
  • 32 (a)
C50H11.15 32
  • 32 (a)
C45H4.17 32
  • 32 (a)
B0213.15 32
  • 32 (a)
C45H4.2 32
  • 32 (a)
B0213.12 32
  • 32 (a)
F44C8.1 32
  • 32 (a)
F41B5.3 32
  • 32 (a)
F42A9.5 32
  • 32 (a)
C34B7.3 32
  • 31 (a)
T09H2.1 32
  • 31 (a)
Y5H2B.6 32
  • 31 (a)
K07C6.3 32
  • 31 (a)
B0213.14 32
  • 30 (a)
K07C6.2 32
  • 30 (a)
F14H3.10 32
  • 29 (a)
B0213.10 32
  • 29 (a)
Species where no ortholog for CYP2J2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP2J2 Gene

ENSEMBL:
Gene Tree for CYP2J2 (if available)
TreeFam:
Gene Tree for CYP2J2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP2J2: view image

Paralogs for CYP2J2 Gene

(28) SIMAP similar genes for CYP2J2 Gene using alignment to 3 proteins:

  • CP2J2_HUMAN
  • Q96RX4_HUMAN
  • Q9UN91_HUMAN
genes like me logo Genes that share paralogs with CYP2J2: view

Variants for CYP2J2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP2J2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
711960 Benign: not provided 59,893,663(-) A/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
791796 Benign: not provided 59,916,002(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs11572190 - p.Arg49Ser
rs11572242 - p.Val113Met
rs2228113 - p.Asn124Ser

Additional dbSNP identifiers (rs#s) for CYP2J2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP2J2 Gene

Variant ID Type Subtype PubMed ID
nsv1012703 CNV gain 25217958

Variation tolerance for CYP2J2 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2J2 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP2J2
Human Gene Mutation Database (HGMD)
CYP2J2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2J2 Gene

Disorders for CYP2J2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CYP2J2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
cardiovascular system disease
  • disease of subdivision of hemolymphoid system
hypertension, essential
  • eht
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP2J2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP2J2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2J2 Gene

Publications for CYP2J2 Gene

  1. Identification of novel substrates for human cytochrome P450 2J2. (PMID: 19923256) Lee CA … Totah RA (Drug metabolism and disposition: the biological fate of chemicals 2010) 3 4 23 54
  2. The common functional polymorphism -50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes. (PMID: 19851119) Fava C … Melander O (Journal of hypertension 2010) 3 23 41 54
  3. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. (PMID: 18769365) Smith HE … Totah RA (Pharmacogenetics and genomics 2008) 3 23 41 54
  4. The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile. (PMID: 19105833) Börgel J … Spiecker M (BMC cardiovascular disorders 2008) 3 23 41 54
  5. Cytochrome P450 2J2*7 polymorphisms in Japanese, Mongolians and Ovambos. (PMID: 18729130) Takeshita H … Fujihara J (Cell biochemistry and function 2008) 3 23 41 54

Products for CYP2J2 Gene

  • Boster Bio Antibodies for CYP2J2
  • Boster Bio ELISA Kits for CYP2J2

Sources for CYP2J2 Gene