This gene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is a segregating pseudogene, where some individuals may have an allele that encodes a functional enzyme, while other individuals have an allele ...
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Aliases for CYP2D7 Gene
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Cytochrome P450 Family 2 Subfamily D Member 7 (Gene/Pseudogene)
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5
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Putative Cytochrome P450 2D7
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Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc., -Metabolizing) Cluster
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Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 Pseudogene 1
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Cytochrome P450, Subfamily II (Debrisoquine, Sparteine, Etc., -Metabolising), Polypeptide 7 Pseudogene 1
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Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 (Gene/Pseudogene)
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Nonfunctional Cytochrome P450 Family 2 Subfamily D Polypeptide 6
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Cytochrome P4502D6
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EC 1.14.14.1
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CYP2D7AP
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CYP2D7P1
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RNA40057
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CYP2D7P
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P450C2D
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P450DB1
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CYP2D6
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CYP2D@
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CYP2D7
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CYP2D
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External Ids for CYP2D7 Gene
Previous HGNC Symbols for CYP2D7 Gene
- CYP2D
- CYP2D@
- CYP2D7P1
- CYP2D7P
Previous GeneCards Identifiers for CYP2D7 Gene
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This gene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is a segregating pseudogene, where some individuals may have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. In this case, the functional allele is thought to be rare. This locus is part of a cluster of cytochrome P450 genes on chromosome 22. [provided by RefSeq, Jan 2017]
CYP2D7 (Cytochrome P450 Family 2 Subfamily D Member 7 (Gene/Pseudogene)) is a Protein Coding gene.
Among its related pathways are Serotonergic synapse and Drug metabolism - cytochrome P450.
Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
An important paralog of this gene is CYP2D6.
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May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503).
No data available for
CIViC Summary ,
Tocris Summary ,
Gene Wiki entry ,
PharmGKB "VIP" Summary ,
Rfam classification and
piRNA Summary
for CYP2D7 Gene