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Aliases for CYP2C9 Gene

Aliases for CYP2C9 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 9 2 3 5
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 2 3
  • Cytochrome P450 PB-1 3 4
  • Cytochrome P450 2C9 3 4
  • Cytochrome P-450MP 3 4
  • CYP2C10 3 4
  • CYPIIC9 3 4
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9 2
  • Cytochrome P-450 S-Mephenytoin 4-Hydroxylase 3
  • Flavoprotein-Linked Monooxygenase 3
  • (R)-Limonene 6-Monooxygenase 4
  • (S)-Limonene 6-Monooxygenase 4
  • (S)-Limonene 7-Monooxygenase 4
  • S-Mephenytoin 4-Hydroxylase 4
  • Cholesterol 25-Hydroxylase 4
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 MP-4 4
  • Cytochrome P450 MP-8 4
  • EC 1.14.14.53 4
  • EC 1.14.14.51 4
  • EC 1.14.14.52 4
  • EC 1.14.14.1 56
  • EC 1.14.14.- 4
  • P450IIC9 3
  • CYP2C 3
  • CPC9 3

External Ids for CYP2C9 Gene

Previous HGNC Symbols for CYP2C9 Gene

  • CYP2C10

Previous GeneCards Identifiers for CYP2C9 Gene

  • GC10P095591
  • GC10P095932
  • GC10P096829
  • GC10P096363
  • GC10P096688
  • GC10P090325

Summaries for CYP2C9 Gene

Entrez Gene Summary for CYP2C9 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C9 Gene

CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) is a Protein Coding gene. Diseases associated with CYP2C9 include Coumarin Resistance and Oral Antidiabetic Drugs Toxicity Or Dose Selection. Among its related pathways are Drug metabolism - cytochrome P450 and Arachidonate Epoxygenase / Epoxide Hydrolase. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2C9 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).

Gene Wiki entry for CYP2C9 Gene

PharmGKB "VIP" Summary for CYP2C9 Gene

Additional gene information for CYP2C9 Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C9 Gene

Genomics for CYP2C9 Gene

GeneHancer (GH) Regulatory Elements for CYP2C9 Gene

Promoters and enhancers for CYP2C9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J094901 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 600.3 -35.0 -34969 4.7 ELF3 CEBPG RERE MAFK SP1 PPARG HNF1A SP5 ZNF644 KAT8 CYP2C9 ACSM6 CYP2C19 CYP2C115P GC10M094889
GH10J094938 Promoter 0.9 EPDnew 600.7 0.0 -19 0.1 SP1 JUND YY1 HNF4A RXRA MAX REST HNF4G TAF1 FOXA1 CYP2C9 CYP2C115P
GH10J094679 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.7 -256.0 -256027 6.3 CEBPG SP7 SP1 HNF1A SP5 ZNF644 KAT8 RXRA CEBPA GATAD2A CYP2C18 ACSM6 CYP2C19 FRA10AC1 MTND4P19 NOC3L CYP2C9 CTBP2P2
GH10J095220 Enhancer 1 Ensembl ENCODE dbSUPER 4.6 +282.7 282743 2.8 SP1 FOXA2 TEAD1 FOSL2 FOXA1 HOMEZ RARA TEAD3 ACSM6 PDLIM1 CYP2C8 CYP2C9 ENSG00000234026
GH10J094212 Enhancer 0.9 Ensembl ENCODE 4 -724.8 -724796 2.7 SP1 RXRA CEBPA POLR2A FOXA2 CEBPB JUND ATF3 YY1 ZBTB33 NOC3L MTND4P19 HELLS CYP2C9 ENSG00000228553 GC10M094156 RNU6-657P PLCE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP2C9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP2C9 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • GATA-1
  • HNF-4alpha1
  • HNF-4alpha2
  • HOXA5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CYP2C9 Gene

Genomic Locations for CYP2C9 Gene
chr10:94,938,658-94,990,091
(GRCh38/hg38)
Size:
51,434 bases
Orientation:
Plus strand
chr10:96,698,415-96,749,148
(GRCh37/hg19)
Size:
50,734 bases
Orientation:
Plus strand

Genomic View for CYP2C9 Gene

Genes around CYP2C9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C9 Gene

Proteins for CYP2C9 Gene

  • Protein details for CYP2C9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11712-CP2C9_HUMAN
    Recommended name:
    Cytochrome P450 2C9
    Protein Accession:
    P11712
    Secondary Accessions:
    • P11713
    • Q16756
    • Q16872
    • Q5VX92
    • Q6IRV8
    • Q8WW80

    Protein attributes for CYP2C9 Gene

    Size:
    490 amino acids
    Molecular mass:
    55628 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C9 Gene

    Alternative splice isoforms for CYP2C9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C9 Gene

Selected DME Specific Peptides for CYP2C9 Gene

P11712:
  • CLVEELRK
  • LTSVLHD
  • FGMGKRS
  • YGPVFTLY
  • EEFSGRG
  • EKVKEHQ
  • GMGKRSIE
  • PFSAGKR
  • PGPTPLP
  • GKRICVGE
  • LLLLLKHP
  • IEDRVQEEA
  • LPHAVTCD
  • RRFSLMTL
  • KEFPNPE
  • GYEAVKEAL
  • CDPTFIL
  • EEIERVIG
  • GKLPPGP
  • VVLVLCLS
  • TTSTTLRY
  • DIKFRNY
  • AGTETTS
  • KFRNYLIPKGT
  • TAKVQEEI
  • PCNVICS

Post-translational modifications for CYP2C9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP2C9 Gene

Gene Families for CYP2C9 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CYP2C9 Gene

GenScript: Design optimal peptide antigens:
  • S-mephenytoin 4-hydroxylase (CP2C9_HUMAN)
  • Cytochrome p4502C9 (Q5EDC5_HUMAN)
  • cDNA FLJ75561, highly similar to Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9), mRNA (Q5VX92_HUMAN)
  • CYP2C9 protein (Q6IRV8_HUMAN)
  • Cytochrome P450, family 2, subfamily C, polypeptide 9, isoform CRA_a (Q8WW80_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11712

UniProtKB/Swiss-Prot:

CP2C9_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C9: view

Function for CYP2C9 Gene

Molecular function for CYP2C9 Gene

UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:18957, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15382, ChEBI:CHEBI:15388, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.53; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17945, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15383, ChEBI:CHEBI:15389, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.51; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:23432, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:10782, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15383, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.52; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50256, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:42977, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.25 mM for S-mephenytoin {ECO:0000269 PubMed:3079764}; KM=46.24 uM for tolbutamide {ECO:0000269 PubMed:25994031}; KM=4.73 uM for diclofenac {ECO:0000269 PubMed:25994031}; KM=1.58 uM for losartan {ECO:0000269 PubMed:25994031}; Vmax=9.22 pmol/min/pmol enzyme with tolbutamide as substrate {ECO:0000269 PubMed:25994031}; Vmax=17.16 pmol/min/pmol enzyme with diclofenac as substrate {ECO:0000269 PubMed:25994031}; Vmax=210.30 pmol/min/pmol enzyme with losartan as substrate {ECO:0000269 PubMed:25994031};
UniProtKB/Swiss-Prot Induction:
By rifampicin.
GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 9

Enzyme Numbers (IUBMB) for CYP2C9 Gene

Phenotypes From GWAS Catalog for CYP2C9 Gene

Gene Ontology (GO) - Molecular Function for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity NAS 2827463
GO:0005506 iron ion binding IEA --
GO:0008144 drug binding IDA 19448135
GO:0008392 arachidonic acid epoxygenase activity IBA 21873635
GO:0008395 steroid hydroxylase activity IMP 18356043
genes like me logo Genes that share ontologies with CYP2C9: view
genes like me logo Genes that share phenotypes with CYP2C9: view

Human Phenotype Ontology for CYP2C9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for CYP2C9 Gene

miRTarBase miRNAs that target CYP2C9

Clone Products

  • Applied Biological Materials (abm): Clones for CYP2C9 - Now 50% OFF >
  • * CYP2C9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CYP2C9 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2C9 Gene

Localization for CYP2C9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C9 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2C9 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP2C9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2C9 Gene

Pathways & Interactions for CYP2C9 Gene

PathCards logo

SuperPathways for CYP2C9 Gene

SuperPathway Contained pathways
1 Drug metabolism - cytochrome P450
2 Paroxetine Pathway, Pharmacokinetics
3 Cytochrome P450 - arranged by substrate type
4 Statin Pathway - Generalized, Pharmacokinetics
5 Metabolism
genes like me logo Genes that share pathways with CYP2C9: view

Gene Ontology (GO) - Biological Process for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IBA 21873635
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0008210 estrogen metabolic process IDA 12865317
genes like me logo Genes that share ontologies with CYP2C9: view

No data available for SIGNOR curated interactions for CYP2C9 Gene

Drugs & Compounds for CYP2C9 Gene

(568) Drugs for CYP2C9 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acenocoumarol Approved, Investigational Pharma Enzyme, substrate 38
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor, Enzyme, substrate Selective cyclooxygenase-2 (COX-2) inhibitor 512
Flurbiprofen Approved, Investigational Pharma Channel blocker, Enzyme, substrate 61
Fluvoxamine Approved, Investigational Pharma Enzyme, inhibitor 59
Meloxicam Approved, Vet_approved Pharma Enzyme, substrate 94

(102) Additional Compounds for CYP2C9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-dichloro-4-hydroxyanilino)Phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • (O-(2,6-dichloro-4-hydroxyanilino)Phenyl)acetate
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Paraxanthine
  • 3,7-dihydro-1,7-Dimethyl-1H-purine-2,6-dione
  • P-Xanthine
  • 1,7-Dimethyl-xanthine
  • 1,7-Dimethylxanthine
611-59-6
(-)-trans-Carveol
  • (-)-(4R,6S)-trans-Carveol
  • (1S,5R)-Carveol
  • Carveol
1197-07-5
(R)-p-Mentha-1,8-dien-7-ol
  • (+)-Perillyl alcohol
  • (R)-(+)-Perillyl alcohol
  • (R)-4-(1-Methylethenyl)-1-cyclohexene-1-methanol
  • (R)-Perillyl alcohol
  • 4-(1-Methylethenyl)-(4R)-1-cyclohexene-1-methanol
57717-97-2, 18457-55-1

(3) ApexBio Compounds for CYP2C9 Gene

Compound Action Cas Number
Amiodarone HCl Anti-arrhythmic drug 19774-82-4
Benzbromarone 3562-84-3
Gemfibrozil 25812-30-0
genes like me logo Genes that share compounds with CYP2C9: view

Drug Products

Transcripts for CYP2C9 Gene

mRNA/cDNA for CYP2C9 Gene

Unigene Clusters for CYP2C9 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 9:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CYP2C9 - Now 50% OFF >
  • * CYP2C9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CYP2C9 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CYP2C9 Gene

GeneLoc Exon Structure for
CYP2C9
ECgene alternative splicing isoforms for
CYP2C9

Expression for CYP2C9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP2C9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C9 Gene

This gene is overexpressed in Liver (x49.5).

Protein differential expression in normal tissues from HIPED for CYP2C9 Gene

This gene is overexpressed in Gallbladder (43.7) and Liver (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP2C9 Gene



Protein tissue co-expression partners for CYP2C9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP2C9 Gene:

CYP2C9

SOURCE GeneReport for Unigene cluster for CYP2C9 Gene:

Hs.282624

Evidence on tissue expression from TISSUES for CYP2C9 Gene

  • Heart(5)
  • Liver(5)
  • Blood(3)
  • Intestine(2.6)
  • Urine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2C9 Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • lymphatic
Regions:
Thorax:
  • thymus
Abdomen:
  • liver
  • spleen
General:
  • blood
  • bone marrow
  • coagulation system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with CYP2C9: view

No data available for mRNA Expression by UniProt/SwissProt for CYP2C9 Gene

Orthologs for CYP2C9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100616515 34
  • 99.46 (n)
CYP2C9 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC505468 34
  • 83.79 (n)
-- 35
  • 79 (a)
ManyToMany
CYP2C87 35
  • 78 (a)
ManyToMany
CYP2C18 35
  • 78 (a)
ManyToMany
-- 35
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2c11 34
  • 80.75 (n)
mouse
(Mus musculus)
Mammalia Cyp2c66 17 35 34
  • 80.54 (n)
Cyp2c29 35
  • 76 (a)
ManyToMany
Cyp2c65 35
  • 76 (a)
ManyToMany
Cyp2c39 35
  • 73 (a)
ManyToMany
Cyp2c50 35
  • 73 (a)
ManyToMany
Cyp2c37 35
  • 73 (a)
ManyToMany
Cyp2c38 35
  • 72 (a)
ManyToMany
Cyp2c54 35
  • 71 (a)
ManyToMany
Cyp2c69 35
  • 67 (a)
ManyToMany
Cyp2c67 35
  • 67 (a)
ManyToMany
Cyp2c68 35
  • 66 (a)
ManyToMany
Cyp2c40 35
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 36
  • 32 (a)
Cyp303a1 36
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea F42A9.5 36
  • 34 (a)
F41B5.3 36
  • 33 (a)
C12D5.7 36
  • 33 (a)
B0213.12 36
  • 33 (a)
B0213.14 36
  • 33 (a)
Y49C4A.9 36
  • 32 (a)
K09A11.3 36
  • 32 (a)
F41B5.7 36
  • 32 (a)
C49C8.4 36
  • 32 (a)
T10H4.11 36
  • 32 (a)
B0213.10 36
  • 32 (a)
F44C8.1 36
  • 32 (a)
T10H4.10 36
  • 31 (a)
F41B5.4 36
  • 31 (a)
F41B5.2 36
  • 31 (a)
C45H4.17 36
  • 31 (a)
B0304.3 36
  • 31 (a)
C41G6.1 36
  • 31 (a)
T09H2.1 36
  • 31 (a)
C45H4.2 36
  • 31 (a)
C34B7.3 36
  • 31 (a)
B0213.15 36
  • 30 (a)
F14H3.10 36
  • 30 (a)
K09D9.2 36
  • 30 (a)
B0213.16 36
  • 29 (a)
K07C6.3 36
  • 29 (a)
K07C6.5 36
  • 29 (a)
C03G6.15 36
  • 29 (a)
C49G7.8 36
  • 29 (a)
K07C6.2 36
  • 29 (a)
R08F11.3 36
  • 29 (a)
Y5H2B.6 36
  • 28 (a)
C25E10.2 36
  • 28 (a)
Species where no ortholog for CYP2C9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2C9 Gene

ENSEMBL:
Gene Tree for CYP2C9 (if available)
TreeFam:
Gene Tree for CYP2C9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP2C9: view image

Paralogs for CYP2C9 Gene

(38) SIMAP similar genes for CYP2C9 Gene using alignment to 12 proteins:

  • CP2C9_HUMAN
  • Q5EDC5_HUMAN
  • Q6IRV8_HUMAN
  • Q8WW80_HUMAN
  • Q9UEH3_HUMAN
  • Q9UQ59_HUMAN
  • S5R8G8_HUMAN
  • S5R8H1_HUMAN
  • S5RG22_HUMAN
  • S5RV20_HUMAN
  • S5RV29_HUMAN
  • S5RXA4_HUMAN
genes like me logo Genes that share paralogs with CYP2C9: view

Variants for CYP2C9 Gene

Sequence variations from dbSNP and Humsavar for CYP2C9 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1057910 drug-response, other, Warfarin response, Tolbutamide response, Phenytoin response, Glipizide response, diclofenac response - Toxicity/ADR, celecoxib response - Dosage, Antiinflammatory agents, non-steroids response - Toxicity/ADR, celecoxib response - Toxicity/ADR, warfarin response - Dosage, Toxicity/ADR, acenocoumarol response - Dosage, Toxicity/ADR, not provided, warfarin response - Dosage, acenocoumarol response - Toxicity/ADR, warfarin response - Toxicity/ADR, - 94,981,296(+) A/C/G coding_sequence_variant, missense_variant
rs1799853 drug-response, benign-likely-benign, Warfarin response, warfarin response - Dosage, not specified, warfarin response - Efficacy, Toxicity/ADR, - 94,942,290(+) C/T coding_sequence_variant, missense_variant
rs28371686 drug-response, other, warfarin response - Dosage, not provided, - 94,981,301(+) C/A/G coding_sequence_variant, missense_variant
rs4917639 drug-response, warfarin response - Dosage 94,965,778(+) A/C/T intron_variant
rs56165452 drug-response, warfarin response - Dosage, - 94,981,297(+) T/A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2C9 Gene

Variant ID Type Subtype PubMed ID
esv2674280 CNV deletion 23128226
esv2739707 CNV deletion 23290073
esv2741937 CNV deletion 23290073
esv3624264 CNV gain 21293372
esv3624265 CNV gain 21293372
esv3891886 CNV loss 25118596
nsv1035409 CNV loss 25217958
nsv1047782 CNV gain 25217958
nsv551962 CNV loss 21841781
nsv551963 CNV loss 21841781
nsv7497 CNV insertion 18451855

Variation tolerance for CYP2C9 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2C9 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP2C9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2C9
Human Gene Mutation Database (HGMD)
CYP2C9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C9 Gene

Disorders for CYP2C9 Gene

MalaCards: The human disease database

(20) MalaCards diseases for CYP2C9 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP2C9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP2C9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C9 Gene

Publications for CYP2C9 Gene

  1. Pharmacogenetics of oral anticoagulants: a basis for dose individualization. (PMID: 18698879) Stehle S … Fuhr U (Clinical pharmacokinetics 2008) 3 23 26 45 58
  2. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. (PMID: 15606435) Zhang Y … Zhou H (British journal of clinical pharmacology 2005) 3 23 26 45 58
  3. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. (PMID: 19794411) Pautas E … Siguret V (Clinical pharmacology and therapeutics 2010) 3 23 45 58
  4. Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin. (PMID: 19941044) Yuen E … Aarons L (Journal of pharmacokinetics and pharmacodynamics 2010) 3 23 45 58
  5. Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements. (PMID: 20020283) Cadamuro J … Oberkofler H (European journal of clinical pharmacology 2010) 3 23 45 58

Products for CYP2C9 Gene

Sources for CYP2C9 Gene

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