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CYP2C9 Gene(Protein Coding)

Cytochrome P450 Family 2 Subfamily C Member 9

GCID:
GC10P094938
GIFtS:
60
Genes Participants
UDN Logo

Aliases for CYP2C9 Gene

Aliases for CYP2C9 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 9 2 3 5
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 2 3
  • Cytochrome P450 PB-1 3 4
  • Cytochrome P-450MP 3 4
  • CYP2C10 3 4
  • CYPIIC9 3 4
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9 2
  • Cytochrome P-450 S-Mephenytoin 4-Hydroxylase 3
  • Flavoprotein-Linked Monooxygenase 3
  • (R)-Limonene 6-Monooxygenase 4
  • (S)-Limonene 6-Monooxygenase 4
  • (S)-Limonene 7-Monooxygenase 4
  • S-Mephenytoin 4-Hydroxylase 4
  • Cholesterol 25-Hydroxylase 4
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 MP-4 4
  • Cytochrome P450 MP-8 4
  • Cytochrome P450 2C9 3
  • EC 1.14.14.53 4
  • EC 1.14.14.51 4
  • EC 1.14.14.52 4
  • EC 1.14.99.38 4
  • EC 1.14.14.1 56
  • EC 1.14.13.- 4
  • P450IIC9 3
  • CYP2C 3
  • CPC9 3

External Ids for CYP2C9 Gene

Previous HGNC Symbols for CYP2C9 Gene

  • CYP2C10

Previous GeneCards Identifiers for CYP2C9 Gene

  • GC10P095591
  • GC10P095932
  • GC10P096829
  • GC10P096363
  • GC10P096688
  • GC10P090325

Summaries for CYP2C9 Gene

Entrez Gene Summary for CYP2C9 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C9 Gene

CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9) is a Protein Coding gene. Diseases associated with CYP2C9 include Coumarin Resistance and Oral Antidiabetic Drugs Toxicity Or Dose Selection. Among its related pathways are Gefitinib Pathway, Pharmacokinetics and Statin Pathway - Generalized, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2C9 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).

Gene Wiki entry for CYP2C9 Gene

PharmGKB "VIP" Summary for CYP2C9 Gene

Additional gene information for CYP2C9 Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C9 Gene

Genomics for CYP2C9 Gene

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  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CYP2C9 Gene

Promoters and enhancers for CYP2C9 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10I094938 Promoter 0.9 EPDnew 550.8 0.0 -19 0.1 TAF1 MAX REST RAD21 FOXA1 YY1 JUND HNF4G HNF4A CYP2C9 CYP2C115P
GH10I094679 Promoter/Enhancer 1.4 EPDnew ENCODE 4.7 -256.5 -256478 5.4 FOXA2 KLF17 RAD21 RARA YY1 ZNF335 SCRT2 ATF7 CREM THAP11 CYP2C18 ACSM6 CYP2C19 MTND4P19 NOC3L CYP2C9 CTBP2P2
GH10I094212 Enhancer 0.9 Ensembl ENCODE 4 -725.0 -724975 2.3 FOXA2 MAX RAD21 YY1 POLR2A HNF4G RXRA CEBPB USF2 REST NOC3L MTND4P19 HELLS CYP2C9 ENSG00000228553 RNU6-657P GC10M094156 PLCE1
GH10I095331 Enhancer 0.8 FANTOM5 dbSUPER 1.6 +391.6 391648 0.4 CTBP1 PKNOX1 GATA3 FOXA2 CREB1 DPF2 FOXA1 SORBS1 CYP2C8 CYP2C9 PDLIM1 GC10M095392
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYP2C9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP2C9 gene promoter:

Genomic Locations for CYP2C9 Gene

Genomic Locations for CYP2C9 Gene
chr10:94,938,658-94,989,391
(GRCh38/hg38)
Size:
50,734 bases
Orientation:
Plus strand
chr10:96,698,415-96,749,148
(GRCh37/hg19)

Genomic View for CYP2C9 Gene

Genes around CYP2C9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP2C9 Gene

Proteins for CYP2C9 Gene

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  • Protein details for CYP2C9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11712-CP2C9_HUMAN
    Recommended name:
    Cytochrome P450 2C9
    Protein Accession:
    P11712
    Secondary Accessions:
    • P11713
    • Q16756
    • Q16872
    • Q5VX92
    • Q6IRV8
    • Q8WW80

    Protein attributes for CYP2C9 Gene

    Size:
    490 amino acids
    Molecular mass:
    55628 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C9 Gene

    Alternative splice isoforms for CYP2C9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C9 Gene

Protein Expression for CYP2C9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CYP2C9 Gene

P11712:
  • CLVEELRK
  • LTSVLHD
  • FGMGKRS
  • YGPVFTLY
  • EEFSGRG
  • EKVKEHQ
  • GMGKRSIE
  • PFSAGKR
  • PGPTPLP
  • GKRICVGE
  • LLLLLKHP
  • IEDRVQEEA
  • LPHAVTCD
  • RRFSLMTL
  • KEFPNPE
  • GYEAVKEAL
  • CDPTFIL
  • EEIERVIG
  • GKLPPGP
  • VVLVLCLS
  • TTSTTLRY
  • DIKFRNY
  • AGTETTS
  • KFRNYLIPKGT
  • TAKVQEEI
  • PCNVICS

Post-translational modifications for CYP2C9 Gene

No Post-translational modifications

Other Protein References for CYP2C9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP2C9 Gene

Gene Families for CYP2C9 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for CYP2C9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP2C9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11712

UniProtKB/Swiss-Prot:

CP2C9_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C9: view

Function for CYP2C9 Gene

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Molecular function for CYP2C9 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 9
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.25 mM for S-mephenytoin {ECO:0000269 PubMed:3079764}; KM=46.24 uM for tolbutamide {ECO:0000269 PubMed:25994031}; KM=4.73 uM for diclofenac {ECO:0000269 PubMed:25994031}; KM=1.58 uM for losartan {ECO:0000269 PubMed:25994031}; Vmax=9.22 pmol/min/pmol enzyme with tolbutamide as substrate {ECO:0000269 PubMed:25994031}; Vmax=17.16 pmol/min/pmol enzyme with diclofenac as substrate {ECO:0000269 PubMed:25994031}; Vmax=210.30 pmol/min/pmol enzyme with losartan as substrate {ECO:0000269 PubMed:25994031};
UniProtKB/Swiss-Prot CatalyticActivity:
(+)-(R)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (+)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (-)-trans-carveol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
(S)-limonene + [reduced NADPH--hemoprotein reductase] + O(2) = (-)-perillyl alcohol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
Cholesterol + AH(2) + O(2) = 25-hydroxycholesterol + A + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).
UniProtKB/Swiss-Prot Induction:
By rifampicin.

Enzyme Numbers (IUBMB) for CYP2C9 Gene

Phenotypes From GWAS Catalog for CYP2C9 Gene

Gene Ontology (GO) - Molecular Function for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001567 cholesterol 25-hydroxylase activity IEA --
GO:0004497 monooxygenase activity TAS,IDA --
GO:0005506 iron ion binding IEA --
GO:0008144 drug binding IDA 19448135
GO:0008392 arachidonic acid epoxygenase activity IBA --
genes like me logo Genes that share ontologies with CYP2C9: view
genes like me logo Genes that share phenotypes with CYP2C9: view

Human Phenotype Ontology for CYP2C9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for CYP2C9 Gene

miRTarBase miRNAs that target CYP2C9

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No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2C9 Gene

Localization for CYP2C9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C9 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2C9 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle TAS 2827463
genes like me logo Genes that share ontologies with CYP2C9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2C9 Gene

Pathways & Interactions for CYP2C9 Gene

SuperPathways for CYP2C9 Gene

PathCards logo More details on SuperPathways for CYP2C9
SuperPathway Contained pathways
1 Drug metabolism - cytochrome P450
Drug metabolism - cytochrome P450
.71
Metabolism of xenobiotics by cytochrome P450
.71
Chemical carcinogenesis
.70
Retinol metabolism
.34
Retinol metabolism
.32
Celecoxib Pathway, Pharmacokinetics
.01
Haloperidol Pathway, Pharmacokinetics
.01
Ifosfamide Pathway, Pharmacokinetics
.01
Naproxen Pathway, Pharmacokinetics
.01
Voriconazole Pathway, Pharmacokinetics
.01
Benzo[a]pyrene metabolism
.01
2 Cytochrome P450 - arranged by substrate type
Cytochrome P450 - arranged by substrate type
.64
Oxidation by Cytochrome P450
.64
Phase 1 - Functionalization of compounds
.63
Biological oxidations
.49
Xenobiotics
.39
Metapathway biotransformation
.36
Clobazam Pathway, Pharmacokinetics
.01
CYP2E1 reactions
.01
Estradiol metabolism
.01
Vitamin D2 (ergocalciferol) metabolism
.01
3 Gefitinib Pathway, Pharmacokinetics
Gefitinib Pathway, Pharmacokinetics
.58
Imatinib Pathway, Pharmacokinetics/Pharmacodynamics
.58
Warfarin Pathway, Pharmacokinetics
.45
Nevirapine Pathway, Pharmacokinetics
.40
Pazopanib Pathway, Pharmacokinetics
.36
Doxepin Pathway, Pharmacokinetics
.01
Fluoxetine Pathway, Pharmacokinetics
.01
4 Statin Pathway - Generalized, Pharmacokinetics
Ibuprofen Pathway, Pharmacokinetics
.42
Statin Pathway - Generalized, Pharmacokinetics
.42
Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
.01
Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
.01
Fluvastatin Pathway, Pharmacokinetics
.01
Rosiglitazone Pathway, Pharmacokinetics
.01
5 Metabolism
Metabolism
.37
Metabolism of lipids and lipoproteins
.37
Metabolic pathways
.36
genes like me logo Genes that share pathways with CYP2C9: view

Gene Ontology (GO) - Biological Process for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0016098 monoterpenoid metabolic process IDA 16401082
GO:0017144 drug metabolic process IMP 21127708
genes like me logo Genes that share ontologies with CYP2C9: view

No data available for SIGNOR curated interactions for CYP2C9 Gene

Drugs & Compounds for CYP2C9 Gene

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(495) Drugs for CYP2C9 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acenocoumarol Approved, Investigational Pharma Enzyme, substrate, inhibitor 35
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor, Enzyme, substrate Selective cyclooxygenase-2 (COX-2) inhibitor 459
Flurbiprofen Approved, Investigational Pharma Channel blocker, Enzyme, substrate 56
Fluvoxamine Approved, Investigational Pharma Enzyme, inhibitor 53
Tolbutamide Approved, Investigational Pharma Inhibitor, Enzyme, substrate, inhibitor CAMP inhibitor 22

(111) Additional Compounds for CYP2C9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
Paraxanthine
  • 1,7-Dimethyl-Xanthine
  • 1,7-Dimethylxanthine
 611-59-6
(-)-trans-Carveol
  • Carveol
 1197-07-5
(+)-Limonene
  • (+)-(4R)-Limonene
  • (+)-(R)-Limonene
 5989-27-5
(+)-trans-Carveol

(3) ApexBio Compounds for CYP2C9 Gene

Compound Action Cas Number
Amiodarone HCl Anti-arrhythmic drug 19774-82-4
Benzbromarone 3562-84-3
Gemfibrozil 25812-30-0
genes like me logo Genes that share compounds with CYP2C9: view

Drug Products

Transcripts for CYP2C9 Gene

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mRNA/cDNA for CYP2C9 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(175) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2C9 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CYP2C9 Gene

GeneLoc Exon Structure for
CYP2C9
ECgene alternative splicing isoforms for
CYP2C9

Expression for CYP2C9 Gene

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  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP2C9 Gene

mRNA expression in normal human tissues for CYP2C9 Gene
mRNA expression by BioGPS for CYP2C9 GenemRNA expression by GTEx for CYP2C9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C9 Gene

This gene is overexpressed in Liver (x49.5).

Protein differential expression in normal tissues from HIPED for CYP2C9 Gene

This gene is overexpressed in Gallbladder (43.7) and Liver (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2C9 Gene



Protein tissue co-expression partners for CYP2C9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP2C9 Gene:

CYP2C9

SOURCE GeneReport for Unigene cluster for CYP2C9 Gene:

Hs.282624

Evidence on tissue expression from TISSUES for CYP2C9 Gene

  • Heart(5)
  • Liver(5)
  • Blood(3)
  • Intestine(2.6)
  • Urine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2C9 Gene

Germ Layers:
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • lymphatic
Regions:
Thorax:
  • thymus
Abdomen:
  • liver
  • spleen
General:
  • blood
  • bone marrow
  • coagulation system
  • red blood cell
  • white blood cell
genes like me logo Genes that share expression patterns with CYP2C9: view

No data available for mRNA Expression by UniProt/SwissProt for CYP2C9 Gene

Orthologs for CYP2C9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC100616515 33
  • 99.46 (n)
CYP2C9 34
  • 99 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia LOC505468 33
  • 83.79 (n)
-- 34
  • 79 (a)
 ManyToMany
CYP2C18 34
  • 78 (a)
 ManyToMany
CYP2C87 34
  • 78 (a)
 ManyToMany
-- 34
  • 77 (a)
 ManyToMany
rat
(Rattus norvegicus)
 Mammalia Cyp2c11 33
  • 80.75 (n)
mouse
(Mus musculus)
 Mammalia Cyp2c66 33 16 34
  • 80.54 (n)
Cyp2c29 34
  • 76 (a)
 ManyToMany
Cyp2c65 34
  • 76 (a)
 ManyToMany
Cyp2c37 34
  • 73 (a)
 ManyToMany
Cyp2c39 34
  • 73 (a)
 ManyToMany
Cyp2c50 34
  • 73 (a)
 ManyToMany
Cyp2c38 34
  • 72 (a)
 ManyToMany
Cyp2c54 34
  • 71 (a)
 ManyToMany
Cyp2c67 34
  • 67 (a)
 ManyToMany
Cyp2c69 34
  • 67 (a)
 ManyToMany
Cyp2c68 34
  • 66 (a)
 ManyToMany
Cyp2c40 34
  • 63 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 68 (a)
 ManyToMany
-- 34
  • 67 (a)
 ManyToMany
-- 34
  • 67 (a)
 ManyToMany
-- 34
  • 65 (a)
 ManyToMany
-- 34
  • 64 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta Cyp18a1 35
  • 32 (a)
Cyp303a1 35
  • 26 (a)
worm
(Caenorhabditis elegans)
 Secernentea F42A9.5 35
  • 34 (a)
B0213.12 35
  • 33 (a)
B0213.14 35
  • 33 (a)
C12D5.7 35
  • 33 (a)
F41B5.3 35
  • 33 (a)
B0213.10 35
  • 32 (a)
C49C8.4 35
  • 32 (a)
F41B5.7 35
  • 32 (a)
F44C8.1 35
  • 32 (a)
K09A11.3 35
  • 32 (a)
T10H4.11 35
  • 32 (a)
Y49C4A.9 35
  • 32 (a)
B0304.3 35
  • 31 (a)
C34B7.3 35
  • 31 (a)
C41G6.1 35
  • 31 (a)
C45H4.17 35
  • 31 (a)
C45H4.2 35
  • 31 (a)
F41B5.2 35
  • 31 (a)
F41B5.4 35
  • 31 (a)
T09H2.1 35
  • 31 (a)
T10H4.10 35
  • 31 (a)
B0213.15 35
  • 30 (a)
F14H3.10 35
  • 30 (a)
K09D9.2 35
  • 30 (a)
B0213.16 35
  • 29 (a)
C03G6.15 35
  • 29 (a)
C49G7.8 35
  • 29 (a)
K07C6.2 35
  • 29 (a)
K07C6.3 35
  • 29 (a)
K07C6.5 35
  • 29 (a)
R08F11.3 35
  • 29 (a)
C25E10.2 35
  • 28 (a)
Y5H2B.6 35
  • 28 (a)
Species where no ortholog for CYP2C9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2C9 Gene

ENSEMBL:
Gene Tree for CYP2C9 (if available)
TreeFam:
Gene Tree for CYP2C9 (if available)

Paralogs for CYP2C9 Gene

Variants for CYP2C9 Gene

Sequence variations from dbSNP and Humsavar for CYP2C9 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1057910 drug-response, other, Warfarin response, Tolbutamide response, Phenytoin response, Glipizide response, diclofenac response - Toxicity/ADR, celecoxib response - Dosage, Antiinflammatory agents, non-steroids response - Toxicity/ADR, celecoxib response - Toxicity/ADR, warfarin response - Dosage, Toxicity/ADR, acenocoumarol response - Dosage, Toxicity/ADR, not provided 94,981,296(+) A/C/G coding_sequence_variant, missense_variant
rs1799853 drug-response, confers-sensitivity, benign, Warfarin response, warfarin response - Dosage, not specified 94,942,290(+) C/T coding_sequence_variant, missense_variant
rs28371686 drug-response, other, warfarin response - Dosage, not provided 94,981,301(+) C/A/G coding_sequence_variant, missense_variant
rs4917639 drug-response, warfarin response - Dosage 94,965,778(+) A/C intron_variant
rs56165452 drug-response, warfarin response - Dosage 94,981,297(+) T/A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2C9 Gene

Variant ID Type Subtype PubMed ID
esv2674280 CNV deletion 23128226
esv2739707 CNV deletion 23290073
esv2741937 CNV deletion 23290073
esv3624264 CNV gain 21293372
esv3624265 CNV gain 21293372
esv3891886 CNV loss 25118596
nsv1035409 CNV loss 25217958
nsv1047782 CNV gain 25217958
nsv551962 CNV loss 21841781
nsv551963 CNV loss 21841781
nsv7497 CNV insertion 18451855

Variation tolerance for CYP2C9 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2C9 Gene

Human Gene Mutation Database (HGMD)
CYP2C9
The Human Cytochrome P450 Allele Nomenclature Database
CYP2C9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2C9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C9 Gene

Disorders for CYP2C9 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CYP2C9 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP2C9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP2C9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C9 Gene

Publications for CYP2C9 Gene

  1. Pharmacogenetics of oral anticoagulants: a basis for dose individualization. (PMID: 18698879) Stehle S … Fuhr U (Clinical pharmacokinetics 2008) 3 22 25 44 58
  2. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. (PMID: 15606435) Zhang Y … Zhou H (British journal of clinical pharmacology 2005) 3 22 25 44 58
  3. The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients. (PMID: 20089352) Tan L … Yu Y (Clinical neurology and neurosurgery 2010) 3 22 44 58
  4. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. (PMID: 19794411) Pautas E … Siguret V (Clinical pharmacology and therapeutics 2010) 3 22 44 58
  5. Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin. (PMID: 19941044) Yuen E … Aarons L (Journal of pharmacokinetics and pharmacodynamics 2010) 3 22 44 58

Products for CYP2C9 Gene

Sources for CYP2C9 Gene

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