This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xeno... See more...

Aliases for CYP2C8 Gene

Aliases for CYP2C8 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 8 2 3 5
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 8 2 3
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 2 3
  • S-Mephenytoin 4-Hydroxylase 3 4
  • Cytochrome P450 Form 1 3 4
  • Cytochrome P450 MP-12 3 4
  • Cytochrome P450 MP-20 3 4
  • Cytochrome P450 IIC2 3 4
  • Cytochrome P450 2C8 3 4
  • EC 1.14.14.1 4 50
  • CYPIIC8 3 4
  • CPC8 2 3
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • MP-12/MP-20 3
  • P450 Form 1 3
  • CYP2C8DM 3
  • CYP2C8 5

External Ids for CYP2C8 Gene

Previous GeneCards Identifiers for CYP2C8 Gene

  • GC10M095689
  • GC10M096030
  • GC10M096927
  • GC10M096461
  • GC10M096786
  • GC10M090423

Summaries for CYP2C8 Gene

Entrez Gene Summary for CYP2C8 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CYP2C8 Gene

CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8) is a Protein Coding gene. Diseases associated with CYP2C8 include Drug Metabolism, Altered, Cyp2c8-Related and Osteonecrosis Of The Jaw. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Naphthalene metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot Summary for CYP2C8 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:7574697, PubMed:15766564, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316).

Gene Wiki entry for CYP2C8 Gene

PharmGKB "VIP" Summary for CYP2C8 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP2C8 Gene

Genomics for CYP2C8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYP2C8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J095069 Promoter 0.8 EPDnew 250.7 0.0 -20 0.1 YY1 FOXA2 RXRA ZBTB33 JUND HNF4A FOXA1 RAD21 REST MAX CYP2C8 piR-44198-002 ACSM6
GH10J095259 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -195.2 -195210 10.6 NCOR1 ZNF600 IKZF1 JUND ZNF592 ZMYM3 ATF2 CEBPA ZNF10 ATF3 PDLIM1 CYP2C8 ACSM6 lnc-SORBS1-2
GH10J095227 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -160.7 -160712 5.4 JUND POLR2A YY1 CEBPB ETS1 EP300 ELF1 PRDM1 RFX5 STAT3 ENSG00000234026 HSALNG0079833 LOC107984257 piR-32559-054 ACSM6 PDLIM1 CYP2C8 TCTN3
GH10J095182 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas 8.2 -114.2 -114204 1.8 BCLAF1 ZNF654 ZNF207 MYC ZIC2 POLR2A ZBTB10 YY1 NONO CTCF PAWRP1 lnc-ACSM6-2 ZNF518A TCTN3 CCNJ PDLIM1 HELLS CYP2C8 ACSM6 SORBS1
GH10J095234 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.1 -167.1 -167147 3.5 BCLAF1 JUND POLR2A NFIC BCL11A CEBPB TRIM22 NR2C1 EP300 PRDM1 ACSM6 CYP2C8 PDLIM1 TCTN3 piR-32559-054 lnc-SORBS1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP2C8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP2C8

Top Transcription factor binding sites by QIAGEN in the CYP2C8 gene promoter:
  • AREB6
  • GR
  • GR-alpha
  • GR-beta
  • HNF-1
  • HNF-1A
  • HNF-4alpha1
  • p300

Genomic Locations for CYP2C8 Gene

Latest Assembly
chr10:95,036,772-95,069,497
(GRCh38/hg38)
Size:
32,726 bases
Orientation:
Minus strand

Previous Assembly
chr10:96,796,529-96,829,254
(GRCh37/hg19 by Entrez Gene)
Size:
32,726 bases
Orientation:
Minus strand

chr10:96,796,530-96,829,254
(GRCh37/hg19 by Ensembl)
Size:
32,725 bases
Orientation:
Minus strand

Genomic View for CYP2C8 Gene

Genes around CYP2C8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C8 Gene

Proteins for CYP2C8 Gene

  • Protein details for CYP2C8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10632-CP2C8_HUMAN
    Recommended name:
    Cytochrome P450 2C8
    Protein Accession:
    P10632
    Secondary Accessions:
    • A8K9N8
    • B0AZN2
    • B7Z1F6
    • Q5VX93
    • Q8WWB1
    • Q9UCZ9

    Protein attributes for CYP2C8 Gene

    Size:
    490 amino acids
    Molecular mass:
    55825 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C8 Gene

    Alternative splice isoforms for CYP2C8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C8 Gene

Selected DME Specific Peptides for CYP2C8 Gene

P10632:
  • CLVEELRK
  • LTSVLHD
  • QVCNNFP
  • KSDYFMPFS
  • FGMGKRS
  • VFTVYFG
  • EEFSGRG
  • EKVKEHQ
  • GMGKRSIE
  • PGPTPLP
  • PFSAGKR
  • LLLLLKHP
  • IEDRVQEEA
  • NPRDFID
  • QIDVKDI
  • GYEAVKEAL
  • GEGLARME
  • CDPTFIL
  • YGPVFTVY
  • SLPPSYQ
  • VIGRHRS
  • VVLVLCLS
  • FDPGHFL
  • TTILQNF
  • TTSTTLRY
  • FLFLTTILQ
  • LARMELFLFLT
  • AGTETTS
  • GNFKKSD
  • TAKVQEEI
  • KFRNYLIPKGT
  • PCNVICS

Post-translational modifications for CYP2C8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CYP2C8 Gene

Gene Families for CYP2C8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CYP2C8 Gene

InterPro:
Blocks:
  • E-class P450 group I signature

Suggested Antigen Peptide Sequences for CYP2C8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59468, highly similar to Cytochrome P450 2C8 (EC 1.14.14.1) (B7Z1F6_HUMAN)
  • S-mephenytoin 4-hydroxylase (CP2C8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10632

UniProtKB/Swiss-Prot:

CP2C8_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C8: view

Function for CYP2C8 Gene

Molecular function for CYP2C8 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:7574697, PubMed:15766564, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:14559847};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence={ECO:0000269|PubMed:7574697, ECO:0000305|PubMed:15766564};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49876, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131969; Evidence={ECO:0000269|PubMed:7574697, ECO:0000305|PubMed:15766564};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence={ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:7574697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence={ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:7574697};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52172, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:136441; Evidence={ECO:0000269|PubMed:15766564};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52176, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:136443; Evidence={ECO:0000269|PubMed:15766564};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39783, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76635; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136411; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51984, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134178; Evidence={ECO:0000269|PubMed:11093772};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47332, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:27974, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:14559847};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47204, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:14559847};.
UniProtKB/Swiss-Prot Induction:
By phenobarbital.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=50 uM for all-trans-retinoate (4-hydroxylation) {ECO:0000269|PubMed:11093772}; KM=5.4 uM for (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate (epoxygenation) {ECO:0000269|PubMed:15766564}; KM=6 uM for (5Z,8Z,11Z,14Z)-eicosatetraenoate (epoxygenation) {ECO:0000269|PubMed:15766564}; KM=7.18 uM for paclitaxel {ECO:0000269|PubMed:26427316}; KM=1.35 uM for amodiaquine {ECO:0000269|PubMed:26427316}; Vmax=1211 pmol/min/nmol enzyme toward all-trans-retinoate (4-hydroxylation) {ECO:0000269|PubMed:11093772}; Vmax=6.2 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate (epoxygenation) {ECO:0000269|PubMed:15766564}; Vmax=4.6 nmol/min/nmol enzyme toward (5Z,8Z,11Z,14Z)-eicosatetraenoate (epoxygenation) {ECO:0000269|PubMed:15766564}; Vmax=2.18 pmol/min/pmol enzyme toward paclitaxel {ECO:0000269|PubMed:26427316}; Vmax=11.30 pmol/min/pmol enzyme toward amodiaquine {ECO:0000269|PubMed:26427316};
GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 8

Enzyme Numbers (IUBMB) for CYP2C8 Gene

Phenotypes From GWAS Catalog for CYP2C8 Gene

Gene Ontology (GO) - Molecular Function for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA,IDA 15766564
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 32814053
GO:0008392 arachidonic acid epoxygenase activity IDA 7574697
GO:0008395 steroid hydroxylase activity IBA 21873635
genes like me logo Genes that share ontologies with CYP2C8: view
genes like me logo Genes that share phenotypes with CYP2C8: view

miRNA for CYP2C8 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2C8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2C8 Gene

Localization for CYP2C8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C8 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2C8 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP2C8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2C8 Gene

Pathways & Interactions for CYP2C8 Gene

PathCards logo

SuperPathways for CYP2C8 Gene

genes like me logo Genes that share pathways with CYP2C8: view

UniProtKB/Swiss-Prot P10632-CP2C8_HUMAN

  • Pathway: Steroid metabolism.
  • Pathway: Lipid metabolism; arachidonate metabolism.
  • Pathway: Cofactor metabolism; retinol metabolism.

Gene Ontology (GO) - Biological Process for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006082 organic acid metabolic process IDA 19651758
GO:0006629 lipid metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IDA 14559847
genes like me logo Genes that share ontologies with CYP2C8: view

No data available for SIGNOR curated interactions for CYP2C8 Gene

Drugs & Compounds for CYP2C8 Gene

(336) Drugs for CYP2C8 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved, Vet_approved Pharma Enzyme, substrate Tubulin and Bcl2 inhibitor, Taxanes 3989
Rosiglitazone Approved, Investigational Pharma Enzyme, substrate, inhibitor Potent PPARγ agonist, Potent and selective PPARgamma agonist; antidiabetic agent. 226
Amodiaquine Approved, Investigational Pharma Enzyme, substrate 119
Montelukast Approved Pharma Enzyme, substrate, inhibitor 321
Repaglinide Approved, Investigational Pharma Enzyme, substrate Kir6 (KATP) channel blocker 63

(46) Additional Compounds for CYP2C8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-Epoxyeicosatrienoic acid
  • (11S,12R)-EpETrE
  • (11S,12R)-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
  • (11S,12R)-Epoxy-(5Z,8Z,14Z)-icosatrienoic acid
  • 11(S),12(R)-EET
  • 11(S),12(R)-EpETrE
123931-40-8
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosatrienoic acid
  • 11,14,15-Trihydroxy-(5Z,8Z,12E)-eicosatrienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoic acid
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid

(1) ApexBio Compounds for CYP2C8 Gene

Compound Action Cas Number
Amiodarone HCl Anti-arrhythmic drug 19774-82-4
genes like me logo Genes that share compounds with CYP2C8: view

Drug products for research

Transcripts for CYP2C8 Gene

mRNA/cDNA for CYP2C8 Gene

5 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2C8

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - -
SP10:

Relevant External Links for CYP2C8 Gene

GeneLoc Exon Structure for
CYP2C8

Expression for CYP2C8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP2C8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C8 Gene

This gene is overexpressed in Liver (x49.4).

Protein differential expression in normal tissues from HIPED for CYP2C8 Gene

This gene is overexpressed in Gallbladder (48.7) and Liver (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP2C8 Gene



Protein tissue co-expression partners for CYP2C8 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP2C8

SOURCE GeneReport for Unigene cluster for CYP2C8 Gene:

Hs.709188

Evidence on tissue expression from TISSUES for CYP2C8 Gene

  • Liver(5)
  • Blood(4.5)
  • Kidney(4.4)
  • Urine(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CYP2C8: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2C8 Gene

Orthologs for CYP2C8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CYP2C8 29 30
  • 98.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cyp2c39 29 16 30
  • 77.44 (n)
ManyToMany
Cyp2c65 30
  • 73 (a)
ManyToMany
Cyp2c38 16 30
  • 72 (a)
ManyToMany
Cyp2c66 30
  • 72 (a)
ManyToMany
Cyp2c29 16 30
  • 71 (a)
ManyToMany
Cyp2c50 30
  • 69 (a)
ManyToMany
Cyp2c37 30
  • 68 (a)
ManyToMany
Cyp2c54 30
  • 68 (a)
ManyToMany
Cyp2c69 30
  • 66 (a)
ManyToMany
Cyp2c68 30
  • 66 (a)
ManyToMany
Cyp2c67 30
  • 65 (a)
ManyToMany
Cyp2c40 30
  • 62 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia CYP2C18 30
  • 77 (a)
ManyToMany
-- 30
  • 75 (a)
ManyToMany
-- 30
  • 75 (a)
ManyToMany
CYP2C87 30
  • 75 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Cyp2c7 29
  • 76.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 67 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 63 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia CYP2C21 30
  • 66 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.15643 29
Zebrafish
(Danio rerio)
Actinopterygii -- 29
Fruit Fly
(Drosophila melanogaster)
Insecta Cyp18a1 31
  • 33 (a)
Cyp307a1 31
  • 27 (a)
Cyp303a1 31
  • 27 (a)
Cyp304a1 31
  • 27 (a)
Worm
(Caenorhabditis elegans)
Secernentea B0213.11 31
  • 39 (a)
C12D5.7 31
  • 33 (a)
C49C8.4 31
  • 33 (a)
C50H11.15 31
  • 33 (a)
F41B5.4 31
  • 33 (a)
F44C8.1 31
  • 33 (a)
K09A11.2 31
  • 33 (a)
K09A11.4 31
  • 33 (a)
B0213.10 31
  • 32 (a)
C45H4.17 31
  • 32 (a)
F41B5.3 31
  • 32 (a)
K09A11.3 31
  • 32 (a)
Y49C4A.9 31
  • 32 (a)
C45H4.2 31
  • 32 (a)
C34B7.3 31
  • 31 (a)
C41G6.1 31
  • 31 (a)
F41B5.2 31
  • 31 (a)
F41B5.7 31
  • 31 (a)
K05D4.4 31
  • 31 (a)
R08F11.3 31
  • 31 (a)
T10H4.11 31
  • 31 (a)
B0213.16 31
  • 31 (a)
B0304.3 31
  • 30 (a)
C03G6.15 31
  • 30 (a)
C49G7.8 31
  • 30 (a)
F14H3.10 31
  • 30 (a)
K07C6.2 31
  • 30 (a)
K07C6.3 31
  • 30 (a)
K07C6.5 31
  • 30 (a)
K09D9.2 31
  • 30 (a)
T09H2.1 31
  • 30 (a)
T10H4.10 31
  • 29 (a)
Y5H2B.6 31
  • 29 (a)
C25E10.2 31
  • 28 (a)
Species where no ortholog for CYP2C8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CYP2C8 Gene

ENSEMBL:
Gene Tree for CYP2C8 (if available)
TreeFam:
Gene Tree for CYP2C8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP2C8: view image
Alliance of Genome Resources:
Additional Orthologs for CYP2C8

Paralogs for CYP2C8 Gene

(30) SIMAP similar genes for CYP2C8 Gene using alignment to 5 proteins:

  • CP2C8_HUMAN
  • E9PIW6_HUMAN
  • E9PLI9_HUMAN
  • F5H7Q9_HUMAN
  • G3V188_HUMAN

Pseudogenes.org Pseudogenes for CYP2C8 Gene

genes like me logo Genes that share paralogs with CYP2C8: view

Variants for CYP2C8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C8 Gene

CP2C8_HUMAN-P10632
Several alleles are found in the human population, contributing to interindividual variations in the therapeutic efficacy and toxicity of a myriad of drugs such as paclitaxel or amodiaquine. The allele shown here is CYP2C8*1 (PubMed:26427316). CYP2C8 genetic variations are associated with altered drug metabolism and adverse drug effects including acute rhabdomyolysis after cerivastatin use [MIM:618018].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP2C8 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs10509681 Drug Response: rosiglitazone response - Metabolism/PK 95,038,992(-) T/Cp.Lys399Arg
NM_000770.3(CYP2C8):c.1196A>G (p.Lys399Arg)
MISSENSE
rs1058930 Benign: CYP2C8 POLYMORPHISM 95,058,362(-) G/Cp.Ile264Met
CYP2C8*4
MISSENSE
rs11188150 Benign: not provided 95,042,980(-) G/A
NM_000770.3(CYP2C8):c.1059C>T (p.His353=)
SYNONYMOUS
rs11572103 Benign: CYP2C8 POLYMORPHISM 95,058,349(-) T/Ap.Ile269Phe
CYP2C8*2
MISSENSE
rs1385534979 Uncertain Significance: not provided 95,043,006(-) T/C
NM_000770.3(CYP2C8):c.1033A>G (p.Met345Val)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CYP2C8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CYP2C8 Gene

Variant ID Type Subtype PubMed ID
esv2761618 CNV gain 21179565
esv3624264 CNV gain 21293372
nsv1035409 CNV loss 25217958
nsv1044182 CNV gain 25217958
nsv1050544 CNV gain 25217958
nsv467436 CNV loss 19166990
nsv551964 CNV loss 21841781

Variation tolerance for CYP2C8 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2C8 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP2C8
Human Gene Mutation Database (HGMD)
CYP2C8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2C8
Leiden Open Variation Database (LOVD)
CYP2C8

SNP Genotyping and Copy Number Assays for research

Disorders for CYP2C8 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CYP2C8 Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
drug metabolism, altered, cyp2c8-related
  • enzalutamide toxicity
osteonecrosis of the jaw
sulfamethoxazole allergy
  • smx allergy
osteonecrosis
  • aseptic necrosis
hypertrophy of tongue papillae
  • tongue papillary hypertrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP2C8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CYP2C8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C8 Gene

Publications for CYP2C8 Gene

  1. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. (PMID: 18413310) Schoch GA … Johnson EF (The Journal of biological chemistry 2008) 3 4 22 25
  2. Pharmacogenetic studies of Paclitaxel in the treatment of ovarian cancer. (PMID: 19143748) Gréen H … Peterson C (Basic & clinical pharmacology & toxicology 2009) 3 22 40
  3. Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population. (PMID: 19954515) Kudzi W … Mills JJ (BMC medical genetics 2009) 3 22 40
  4. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. (PMID: 18769365) Smith HE … Totah RA (Pharmacogenetics and genomics 2008) 3 22 40
  5. Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers. (PMID: 19129086) Aquilante CL … Kosmiski LA (Human genomics 2008) 3 22 40

Products for CYP2C8 Gene

Sources for CYP2C8 Gene