Aliases for CYP2C19 Gene
- Cytochrome P450 Family 2 Subfamily C Member 19 2 3 5
- Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19 2 3
- Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 2 3
- Fenbendazole Monooxygenase (4'-Hydroxylating) 3 4
- (R)-Limonene 6-Monooxygenase 3 4
- (S)-Limonene 6-Monooxygenase 3 4
- (S)-Limonene 7-Monooxygenase 3 4
- Mephenytoin 4-Hydroxylase 3 4
- Cytochrome P450 2C19 3 4
- Cytochrome P450-254C 3 4
- Cytochrome P450-11A 3 4
- EC 188.8.131.52 4 51
- P450IIC19 2 3
- CYPIIC17 3 4
External Ids for CYP2C19 Gene
Previous HGNC Symbols for CYP2C19 Gene
Previous GeneCards Identifiers for CYP2C19 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP2C19 Gene
CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) is a Protein Coding gene. Diseases associated with CYP2C19 include Drug Metabolism, Poor, Cyp2c19-Related and Peptic Ulcer Disease. Among its related pathways are Cytochrome P450 - arranged by substrate type and Imipramine/Desipramine Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C9.
UniProtKB/Swiss-Prot Summary for CYP2C19 Gene
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).
Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.