This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin,... See more...

Aliases for CYP2C19 Gene

Aliases for CYP2C19 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 19 2 3 5
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19 2 3
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 2 3
  • Fenbendazole Monooxygenase (4'-Hydroxylating) 3 4
  • (R)-Limonene 6-Monooxygenase 3 4
  • (S)-Limonene 6-Monooxygenase 3 4
  • (S)-Limonene 7-Monooxygenase 3 4
  • Mephenytoin 4-Hydroxylase 3 4
  • Cytochrome P450 2C19 3 4
  • Cytochrome P450-254C 3 4
  • Cytochrome P450-11A 3 4
  • EC 1.14.14.1 4 51
  • P450IIC19 2 3
  • CYPIIC17 3 4
  • CYPIIC19 3 4
  • CPCJ 2 3
  • Flavoprotein-Linked Monooxygenase 3
  • S-Mephenytoin 4-Hydroxylase 3
  • Mephenytoin 4'-Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P-450 II C 3
  • EC 1.14.14.53 4
  • EC 1.14.14.51 4
  • EC 1.14.14.52 4
  • EC 1.14.14.75 4
  • P450C2C 3
  • CYP2C19 5
  • CYP2C 3

External Ids for CYP2C19 Gene

Previous HGNC Symbols for CYP2C19 Gene

  • CYP2C

Previous GeneCards Identifiers for CYP2C19 Gene

  • GC10P095415
  • GC10P095677
  • GC10P096574
  • GC10P096188
  • GC10P096189
  • GC10P096512
  • GC10P090150
  • GC10P096447

Summaries for CYP2C19 Gene

Entrez Gene Summary for CYP2C19 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C19 Gene

CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) is a Protein Coding gene. Diseases associated with CYP2C19 include Drug Metabolism, Poor, Cyp2c19-Related and Peptic Ulcer Disease. Among its related pathways are Cytochrome P450 - arranged by substrate type and Imipramine/Desipramine Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C9.

UniProtKB/Swiss-Prot Summary for CYP2C19 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).

Tocris Summary for CYP2C19 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

Gene Wiki entry for CYP2C19 Gene

PharmGKB "VIP" Summary for CYP2C19 Gene

No data available for CIViC Summary , Rfam classification and piRNA Summary for CYP2C19 Gene

Genomics for CYP2C19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYP2C19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J094762 Promoter 0.6 EPDnew 600.7 0.0 -19 0.1 YY1 HNF4A SP1 CYP2C19 piR-59928-025 MN309174-059 ENSG00000276490
GH10J094775 Promoter 0.4 EPDnew 600.4 +12.8 12789 0.1 RXRA MTND4P19 lnc-CYP2C8-5 piR-40348-009 piR-59928-026 CYP2C19 MN309174-059 piR-33605-062 ENSG00000276490 CYP2C9
GH10J094842 Promoter 0.3 EPDnew 600.2 +80.2 80226 0.1 CYP2C19 piR-33142-004 lnc-CYP2C8-4 CYP2C58P MN309174-059 CYP2C9 ENSG00000276490
GH10J094761 Enhancer 0.2 FANTOM5 600.7 -0.8 -808 0 CYP2C19 MN309174-059 ENSG00000276490
GH10J094679 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 15 -80.3 -80250 5.9 GATAD2A ATF7 ZNF629 REST SP1 CEBPA SCRT2 SOX13 CEBPB ZBTB20 CYP2C18 ACSM6 CYP2C19 MTND4P19 NOC3L CYP2C9 piR-33605-061 HELLS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP2C19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP2C19

Top Transcription factor binding sites by QIAGEN in the CYP2C19 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • p53

Genomic Locations for CYP2C19 Gene

Genomic Locations for CYP2C19 Gene
chr10:94,762,681-94,855,547
(GRCh38/hg38)
Size:
92,867 bases
Orientation:
Plus strand
chr10:96,447,911-96,613,017
(GRCh37/hg19)
Size:
165,107 bases
Orientation:
Plus strand

Genomic View for CYP2C19 Gene

Genes around CYP2C19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C19 Gene

Proteins for CYP2C19 Gene

  • Protein details for CYP2C19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33261-CP2CJ_HUMAN
    Recommended name:
    Cytochrome P450 2C19
    Protein Accession:
    P33261
    Secondary Accessions:
    • P33259
    • Q8WZB1
    • Q8WZB2
    • Q9UCD4

    Protein attributes for CYP2C19 Gene

    Size:
    490 amino acids
    Molecular mass:
    55931 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C19 Gene

neXtProt entry for CYP2C19 Gene

Selected DME Specific Peptides for CYP2C19 Gene

P33261:
  • CLVEELRK
  • LTSVLHD
  • FGMGKRS
  • YGPVFTLY
  • EEFSGRG
  • EKVKEHQ
  • GMGKRSIE
  • PFSAGKR
  • PGPTPLP
  • GKRICVGE
  • LLLLLKHP
  • IEDRVQEEA
  • LPHAVTCD
  • RRFSLMTL
  • NPRDFID
  • KEFPNPE
  • TSLTSVLH
  • GEGLARME
  • CDPTFIL
  • GKLPPGP
  • VVLVLCLS
  • TTSTTLRY
  • LARMELFLFLT
  • AGTETTS
  • KFRNYLIPKGT
  • TAKVQEEI
  • PCNVICS

Post-translational modifications for CYP2C19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP2C19 Gene

Gene Families for CYP2C19 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CYP2C19 Gene

InterPro:
Blocks:
  • E-class P450 group I signature
ProtoNet:

Suggested Antigen Peptide Sequences for CYP2C19 Gene

GenScript: Design optimal peptide antigens:
  • Cytochrome P450 family 2 subfamily C polypeptide 19 (B0ZDM8_HUMAN)
  • Mephenytoin 4-hydroxylase (CP2CJ_HUMAN)
  • Unspecific monooxygenase (Q16750_HUMAN)
  • Cytochrome P450 (Q767A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P33261

UniProtKB/Swiss-Prot:

CP2CJ_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C19: view

Function for CYP2C19 Gene

Molecular function for CYP2C19 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18577768, PubMed:19965576, PubMed:20972997). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position (PubMed:18577768). Catalyzes the epoxidation of double bonds of PUFA (PubMed:20972997, PubMed:19965576). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position (PubMed:23959307).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50076, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78043, ChEBI:CHEBI:132024; Evidence={ECO:0000269|PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence={ECO:0000269|PubMed:10411572, ECO:0000269|PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence={ECO:0000269|PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:132025; Evidence={ECO:0000269|PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49884, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131975; Evidence={ECO:0000269|PubMed:20972997};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence={ECO:0000269|PubMed:20972997};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49876, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131969; Evidence={ECO:0000269|PubMed:20972997};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence={ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136411; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:18957, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15382, ChEBI:CHEBI:15388, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.53; Evidence={ECO:0000269|PubMed:11950794};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17945, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15383, ChEBI:CHEBI:15389, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.51; Evidence={ECO:0000269|PubMed:11950794};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:23432, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:10782, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15383, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.52; Evidence={ECO:0000269|PubMed:11950794};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:56292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77092, ChEBI:CHEBI:140184; EC=1.14.14.75; Evidence={ECO:0000269|PubMed:23959307};.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 19,with poor metabolizing phenotype mutant associated with CYP2C19,not predisposing to systemic lupus erythematosus

Enzyme Numbers (IUBMB) for CYP2C19 Gene

Phenotypes From GWAS Catalog for CYP2C19 Gene

Gene Ontology (GO) - Molecular Function for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS,IDA 19651758
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA 21873635
GO:0008395 steroid hydroxylase activity IMP 18356043
GO:0016491 oxidoreductase activity IDA 16401082
genes like me logo Genes that share ontologies with CYP2C19: view
genes like me logo Genes that share phenotypes with CYP2C19: view

Human Phenotype Ontology for CYP2C19 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2C19

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2C19 Gene

Localization for CYP2C19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C19 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2C19 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP2C19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2C19 Gene

Pathways & Interactions for CYP2C19 Gene

PathCards logo

SuperPathways for CYP2C19 Gene

SuperPathway Contained pathways
1 Imipramine/Desipramine Pathway, Pharmacokinetics
2 Drug metabolism - cytochrome P450
.31
3 Cytochrome P450 - arranged by substrate type
.01
4 Statin Pathway - Generalized, Pharmacokinetics
5 Phenytoin Pathway, Pharmacokinetics
genes like me logo Genes that share pathways with CYP2C19: view

UniProtKB/Swiss-Prot P33261-CP2CJ_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.
  • Pathway: Terpene metabolism; (4R)-limonene degradation.

Gene Ontology (GO) - Biological Process for CYP2C19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IBA 21873635
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
genes like me logo Genes that share ontologies with CYP2C19: view

No data available for SIGNOR curated interactions for CYP2C19 Gene

Drugs & Compounds for CYP2C19 Gene

(477) Drugs for CYP2C19 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Omeprazole Approved, Investigational, Vet_approved Pharma Activator, Enzyme, substrate, inhibitor H+,K+-ATPase inhibitor 436
Citalopram Approved Pharma Enzyme, substrate, inhibitor 597
Esomeprazole Approved, Investigational Pharma Enzyme, substrate, inhibitor Proton pump inhibitor 413
Fluvoxamine Approved, Investigational Pharma Enzyme, inhibitor 63
Imipramine Approved Pharma Antagonist, Pore Blocker, Enzyme, substrate, inhibitor 34

(74) Additional Compounds for CYP2C19 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-dichloro-4-hydroxyanilino)Phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • (O-(2,6-dichloro-4-hydroxyanilino)Phenyl)acetate
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
Paraxanthine
  • 3,7-dihydro-1,7-Dimethyl-1H-purine-2,6-dione
  • P-Xanthine
  • 1,7-Dimethyl-xanthine
  • 1,7-Dimethylxanthine
611-59-6
(-)-trans-Carveol
  • (-)-(4R,6S)-trans-Carveol
  • (1S,5R)-Carveol
  • Carveol
1197-07-5
(R)-p-Mentha-1,8-dien-7-ol
  • (+)-Perillyl alcohol
  • (R)-(+)-Perillyl alcohol
  • (R)-4-(1-Methylethenyl)-1-cyclohexene-1-methanol
  • (R)-Perillyl alcohol
  • 4-(1-Methylethenyl)-(4R)-1-cyclohexene-1-methanol
57717-97-2, 18457-55-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate

(5) Tocris Compounds for CYP2C19 Gene

Compound Action Cas Number
Anastrozole Potent aromatase (CYP19) inhibitor 120511-73-1
Exemestane Steroidal aromatase (CYP19) inhibitor 107868-30-4
Ketoconazole Cytochrome P450c17 inhibitor 65277-42-1
TMS Cytochrome P450 1B1 inhibitor 24144-92-1
YM 511 Potent aromatase (CYP19) inhibitor 148869-05-0

(4) ApexBio Compounds for CYP2C19 Gene

Compound Action Cas Number
8-Methoxypsoralen CYP inhibitor 298-81-7
Lansoprazole sodium PPI/cytochrome P450 inhibitor 226904-00-3
Omeprazole H+,K+-ATPase inhibitor 73590-58-6
YM 511 148869-05-0
genes like me logo Genes that share compounds with CYP2C19: view

Drug Products

Transcripts for CYP2C19 Gene

mRNA/cDNA for CYP2C19 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2C19

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C19 Gene

No ASD Table

Relevant External Links for CYP2C19 Gene

GeneLoc Exon Structure for
CYP2C19

Expression for CYP2C19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP2C19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C19 Gene

This gene is overexpressed in Liver (x41.6) and Small Intestine - Terminal Ileum (x4.1).

Protein differential expression in normal tissues from HIPED for CYP2C19 Gene

This gene is overexpressed in Liver (53.8) and Gallbladder (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP2C19 Gene



Protein tissue co-expression partners for CYP2C19 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP2C19

SOURCE GeneReport for Unigene cluster for CYP2C19 Gene:

Hs.282409

Evidence on tissue expression from TISSUES for CYP2C19 Gene

  • Liver(4.9)
  • Blood(3.4)
  • Intestine(3.3)
  • Stomach(3)
  • Urine(2.8)
  • Kidney(2.7)
  • Nervous system(2.5)
  • Skin(2.4)
  • Heart(2.3)
  • Muscle(2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with CYP2C19: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2C19 Gene

Orthologs for CYP2C19 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC740956 30
  • 98.78 (n)
CYP2C19 31
  • 98 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cyp2c6v1 30
  • 80.3 (n)
Cow
(Bos Taurus)
Mammalia CYP2C18 31
  • 79 (a)
ManyToMany
CYP2C19 30
  • 78.03 (n)
CYP2C87 31
  • 78 (a)
ManyToMany
-- 31
  • 78 (a)
ManyToMany
-- 31
  • 76 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Cyp2c65 31
  • 76 (a)
ManyToMany
Cyp2c29 31
  • 75 (a)
ManyToMany
Cyp2c66 31
  • 75 (a)
ManyToMany
Cyp2c39 31
  • 73 (a)
ManyToMany
Cyp2c37 31
  • 72 (a)
ManyToMany
Cyp2c38 31
  • 72 (a)
ManyToMany
Cyp2c50 31
  • 72 (a)
ManyToMany
Cyp2c54 31
  • 70 (a)
ManyToMany
Cyp2c67 31
  • 66 (a)
ManyToMany
Cyp2c68 31
  • 66 (a)
ManyToMany
Cyp2c69 31
  • 66 (a)
ManyToMany
Cyp2c40 31
  • 62 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia CYP2C18 30
  • 75.71 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 68 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Cyp18a1 32
  • 32 (a)
Cyp303a1 32
  • 26 (a)
Worm
(Caenorhabditis elegans)
Secernentea B0213.11 32
  • 39 (a)
C12D5.7 32
  • 34 (a)
C49C8.4 32
  • 33 (a)
F41B5.3 32
  • 33 (a)
F44C8.1 32
  • 33 (a)
K09A11.2 32
  • 33 (a)
Y49C4A.9 32
  • 33 (a)
B0304.3 32
  • 32 (a)
C45H4.17 32
  • 32 (a)
F41B5.4 32
  • 32 (a)
F41B5.7 32
  • 32 (a)
K09A11.3 32
  • 32 (a)
C45H4.2 32
  • 32 (a)
B0213.14 32
  • 31 (a)
C41G6.1 32
  • 31 (a)
F41B5.2 32
  • 31 (a)
K09D9.2 32
  • 31 (a)
R08F11.3 32
  • 31 (a)
T10H4.10 32
  • 31 (a)
T10H4.11 32
  • 31 (a)
T09H2.1 32
  • 31 (a)
C03G6.15 32
  • 30 (a)
C34B7.3 32
  • 30 (a)
C49G7.8 32
  • 30 (a)
K05D4.4 32
  • 30 (a)
B0213.16 32
  • 30 (a)
K07C6.2 32
  • 29 (a)
K07C6.3 32
  • 29 (a)
K07C6.5 32
  • 29 (a)
C25E10.2 32
  • 27 (a)
Species where no ortholog for CYP2C19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for CYP2C19 Gene

ENSEMBL:
Gene Tree for CYP2C19 (if available)
TreeFam:
Gene Tree for CYP2C19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP2C19: view image

Paralogs for CYP2C19 Gene

(26) SIMAP similar genes for CYP2C19 Gene using alignment to 3 proteins:

  • CP2CJ_HUMAN
  • B0ZDM8_HUMAN
  • Q767A3_HUMAN

Pseudogenes.org Pseudogenes for CYP2C19 Gene

genes like me logo Genes that share paralogs with CYP2C19: view

Variants for CYP2C19 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C19 Gene

CP2CJ_HUMAN-P33261
Genetic variation in CYP2C19 is responsible for poor drug metabolism [MIM:609535]. Individuals can be characterized as either extensive metabolizers (EM) or poor metabolizers (PM). The PM phenotype is inherited in an autosomal recessive manner, with the EM phenotype comprising both homozygous dominant and heterozygote genotypes. There are marked interracial differences in the frequency of this polymorphism. Poor metabolizers represent 2-5% of Caucasians, 13-23% of Asian populations, and as many as 38-79% of individuals of some of the islands of Polynesia and Micronesia. Different alleles of CYP2C19 are known: CYP2C19*1A CYP2C19*1B, CYP2C19*1C, CYP2C19*2A (CYP2C19m1 or CYP2C19m1A), CYP2C19*2B (CYP2C19m1B), CYP2C19*2C (CYP2C19*21), CYP2C19*3A (CYP2C19m2), CYP2C19*3B (CYP2C19*20), CYP2C19*4 (CYP2C19m3), CYP2C19*5A (CYP2C19m4), CYP2C19*5B, CYP2C19*6, CYP2C19*7, CYP2C19*8, CYP2C19*9, CYP2C19*10, CYP2C19*11 CYP2C19*12, CYP2C19*13, CYP2C19*14 CYP2C19*15, CYP2C19*16, CYP2C19*18, CYP2C19*19. Defective CYP2C19*2 and CYP2C19*3 alleles are characterized by a splice mutation and a stop codon, respectively, and account for most of the PM alleles. The sequence shown is that of allele CYP2C19*1B.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP2C19 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
747762 Likely Benign: not provided 94,849,940(+) C/A SYNONYMOUS_VARIANT
769226 Benign: not provided 94,762,804(+) C/T SYNONYMOUS_VARIANT
rs12248560 Drug Response: citalopram response - Metabolism/PK; clopidogrel response - Dosage, Efficacy, Toxicity/ADR; escitalopram response - Metabolism/PK. Drug Response: CYP2C19: increased function; not provided 94,761,900(+) C/AC/T
rs17884712 Drug Response: CYP2C19: decreased function. - 94,775,489(+) G/Ap.Arg144His MISSENSE_VARIANT
rs28399504 Drug Response: CYP2C19: no function; Mephenytoin, poor metabolism of; clopidogrel response - Efficacy; not provided 94,762,706(+) A/G INITIATIOR_CODON_VARIANT,MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CYP2C19 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP2C19 Gene

Variant ID Type Subtype PubMed ID
dgv1355n54 CNV loss 21841781
dgv1356n54 CNV loss 21841781
dgv160e214 CNV loss 21293372
dgv957n100 CNV loss 25217958
esv2659638 CNV deletion 23128226
esv2674280 CNV deletion 23128226
esv2739707 CNV deletion 23290073
esv2741937 CNV deletion 23290073
esv2761617 CNV loss 21179565
esv3624256 CNV loss 21293372
esv3624258 CNV gain 21293372
esv3624260 CNV loss 21293372
esv3891886 CNV loss 25118596
nsv1035409 CNV loss 25217958
nsv1046308 CNV loss 25217958
nsv1047782 CNV gain 25217958
nsv1052578 CNV loss 25217958
nsv516555 CNV loss 19592680
nsv522538 CNV loss 19592680
nsv523259 CNV gain 19592680
nsv820156 CNV loss 19587683
nsv948145 CNV duplication 23825009

Variation tolerance for CYP2C19 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2C19 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP2C19
Human Gene Mutation Database (HGMD)
CYP2C19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2C19

Disorders for CYP2C19 Gene

MalaCards: The human disease database

(38) MalaCards diseases for CYP2C19 Gene - From: OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
drug metabolism, poor, cyp2c19-related
  • proguanil poor metabolizer
peptic ulcer disease
  • acute peptic ulcer with hemorrhage
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
gastroesophageal reflux
  • ger
gastric ulcer
  • acute gastric ulcer with haemorrhage and perforation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP2C19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CYP2C19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C19 Gene

Publications for CYP2C19 Gene

  1. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 23 41
  2. Double-dosed pantoprazole accelerates the sustained symptomatic response in overweight and obese patients with reflux esophagitis in Los Angeles grades A and B. (PMID: 19904250) Chen WY … Sheu BS (The American journal of gastroenterology 2010) 3 23 41
  3. Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement. (PMID: 20510210) Hochholzer W … Neumann FJ (Journal of the American College of Cardiology 2010) 3 23 41
  4. Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response. (PMID: 19954746) Yadav SS … Parmar D (Mutation research 2010) 3 23 41
  5. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. (PMID: 20179710) Bray J … Boddy AV (British journal of cancer 2010) 3 23 41

Products for CYP2C19 Gene

  • Signalway ELISA kits for CYP2C19
  • Signalway Proteins for CYP2C19

Sources for CYP2C19 Gene