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Aliases for CYP2C18 Gene

Aliases for CYP2C18 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 18 2 3 5
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 18 2 3
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 18 2 3
  • CYPIIC18 3 4
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 17 3
  • (S)-Mephenytoin Hydroxylase Associated Cytochrome P450 3
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Unspecific Monooxygenase 3
  • Cytochrome P450-6B/29C 3
  • Cytochrome P450-6b/29c 4
  • Cytochrome P450 2C18 3
  • EC 1.14.14.1 4
  • P450-6B/29C 3
  • P450IIC17 3
  • CYP2C17 3
  • CYP2C 3
  • CPCI 3

External Ids for CYP2C18 Gene

Previous HGNC Symbols for CYP2C18 Gene

  • CYP2C17

Previous GeneCards Identifiers for CYP2C18 Gene

  • GC10P095336
  • GC10M095677
  • GC10P096576
  • GC10P096107
  • GC10P096433
  • GC10P090071

Summaries for CYP2C18 Gene

Entrez Gene Summary for CYP2C18 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C18 Gene

CYP2C18 (Cytochrome P450 Family 2 Subfamily C Member 18) is a Protein Coding gene. Diseases associated with CYP2C18 include Hypotrichosis 6 and Paralytic Ileus. Among its related pathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C9.

UniProtKB/Swiss-Prot for CYP2C18 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP2C18 Gene

Additional gene information for CYP2C18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C18 Gene

Genomics for CYP2C18 Gene

GeneHancer (GH) Regulatory Elements for CYP2C18 Gene

Promoters and enhancers for CYP2C18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J094679 Promoter/Enhancer 1.4 EPDnew ENCODE 650.7 -1.3 -1314 5.4 FOXA2 KLF17 RAD21 RARA YY1 ZNF335 EGR1 SCRT2 ATF7 CREM CYP2C18 ACSM6 CYP2C19 MTND4P19 NOC3L CYP2C9 CTBP2P2
GH10J094688 Promoter 0.8 EPDnew 650.7 +4.7 4711 0.1 GATAD2A RXRA FOXA3 HNF4A NR2F6 RARA ENSG00000276490 CYP2C18 GC10P094738
GH10J095271 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.6 +593.6 593631 11.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 FOS SP5 REST PDLIM1 CYP2C8 TBC1D12 ACSM6 CYP2C18 TCTN3 GC10M095264 GC10M095235
GH10J094676 Enhancer 0.7 ENCODE 0.4 -6.2 -6184 1.7 CTCF TAF1 RXRA MAX REST ZNF644 RAD21 YY1 SP1 GATA3 ACSM6 CYP2C18 CTBP2P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP2C18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP2C18 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • MyoD
  • TGIF
  • MZF-1
  • FOXC1
  • NF-AT4
  • NF-AT3

Genomic Locations for CYP2C18 Gene

Genomic Locations for CYP2C18 Gene
chr10:94,683,494-94,736,190
(GRCh38/hg38)
Size:
52,697 bases
Orientation:
Plus strand
chr10:96,443,251-96,495,947
(GRCh37/hg19)
Size:
52,697 bases
Orientation:
Plus strand

Genomic View for CYP2C18 Gene

Genes around CYP2C18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C18 Gene

Proteins for CYP2C18 Gene

  • Protein details for CYP2C18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33260-CP2CI_HUMAN
    Recommended name:
    Cytochrome P450 2C18
    Protein Accession:
    P33260
    Secondary Accessions:
    • B2R8K2
    • Q16703
    • Q16751
    • Q4VAT5
    • Q6GRG1

    Protein attributes for CYP2C18 Gene

    Size:
    490 amino acids
    Molecular mass:
    55711 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C18 Gene

    Alternative splice isoforms for CYP2C18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C18 Gene

Post-translational modifications for CYP2C18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP2C18 Gene

Domains & Families for CYP2C18 Gene

Gene Families for CYP2C18 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CYP2C18 Gene

Suggested Antigen Peptide Sequences for CYP2C18 Gene

Graphical View of Domain Structure for InterPro Entry

P33260

UniProtKB/Swiss-Prot:

CP2CI_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C18: view

Function for CYP2C18 Gene

Molecular function for CYP2C18 Gene

UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 18

Enzyme Numbers (IUBMB) for CYP2C18 Gene

Phenotypes From GWAS Catalog for CYP2C18 Gene

Gene Ontology (GO) - Molecular Function for CYP2C18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS 8110777
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CYP2C18: view
genes like me logo Genes that share phenotypes with CYP2C18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2C18

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP2C18 Gene

Localization for CYP2C18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C18 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2C18 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1
extracellular 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP2C18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP2C18: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2C18 Gene

Pathways & Interactions for CYP2C18 Gene

genes like me logo Genes that share pathways with CYP2C18: view

Gene Ontology (GO) - Biological Process for CYP2C18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IBA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0019373 epoxygenase P450 pathway IBA --
GO:0042738 exogenous drug catabolic process IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP2C18: view

No data available for SIGNOR curated interactions for CYP2C18 Gene

Drugs & Compounds for CYP2C18 Gene

(51) Drugs for CYP2C18 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tolbutamide Approved, Investigational Pharma Inhibitor, Enzyme, substrate CAMP inhibitor 22
Clobazam Approved, Illicit Pharma Enzyme, substrate 22
Clotiazepam Approved, Illicit Pharma Enzyme, substrate 0
Desipramine Approved, Investigational Pharma Enzyme, substrate 39
Lidocaine Approved, Vet_approved Pharma Antagonist, Pore Blocker, Enzyme, substrate Anasthetic and class Ib antiarrhythmic agent 1477

(35) Additional Compounds for CYP2C18 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-Epoxyeicosatrienoic acid
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
81276-02-0
11,14,15-THETA
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid
genes like me logo Genes that share compounds with CYP2C18: view

Transcripts for CYP2C18 Gene

mRNA/cDNA for CYP2C18 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2C18 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2C18

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C18 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2:
SP3: -
SP4: - -

Relevant External Links for CYP2C18 Gene

GeneLoc Exon Structure for
CYP2C18
ECgene alternative splicing isoforms for
CYP2C18

Expression for CYP2C18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP2C18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C18 Gene

This gene is overexpressed in Liver (x26.5), Esophagus - Mucosa (x8.2), and Small Intestine - Terminal Ileum (x4.9).

Protein differential expression in normal tissues from HIPED for CYP2C18 Gene

This gene is overexpressed in Stomach (55.8) and Liver (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP2C18 Gene



Protein tissue co-expression partners for CYP2C18 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP2C18 Gene:

CYP2C18

SOURCE GeneReport for Unigene cluster for CYP2C18 Gene:

Hs.511872

Evidence on tissue expression from TISSUES for CYP2C18 Gene

  • Liver(4.8)
  • Stomach(4.4)
genes like me logo Genes that share expression patterns with CYP2C18: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2C18 Gene

Orthologs for CYP2C18 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP2C18 34 33
  • 86.27 (n)
ManyToMany
-- 34
  • 79 (a)
ManyToMany
CYP2C87 34
  • 78 (a)
ManyToMany
-- 34
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2c24 33
  • 83.3 (n)
mouse
(Mus musculus)
Mammalia Cyp2c55 16 34 33
  • 82 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
ManyToMany
-- 34
  • 68 (a)
ManyToMany
-- 34
  • 66 (a)
ManyToMany
-- 34
  • 66 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CYP2C45 33
  • 63.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68450 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003067 33
  • 43.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 35
  • 32 (a)
Cyp303a1 35
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.11 35
  • 38 (a)
K09A11.2 35
  • 34 (a)
F44C8.1 35
  • 33 (a)
B0213.10 35
  • 33 (a)
K09A11.4 35
  • 33 (a)
F41B5.3 35
  • 33 (a)
C12D5.7 35
  • 33 (a)
F42A9.5 35
  • 33 (a)
F41B5.4 35
  • 33 (a)
C50H11.15 35
  • 32 (a)
F41B5.2 35
  • 32 (a)
F41B5.7 35
  • 32 (a)
C49C8.4 35
  • 32 (a)
K09A11.3 35
  • 32 (a)
B0213.14 35
  • 32 (a)
C41G6.1 35
  • 32 (a)
B0213.15 35
  • 32 (a)
R08F11.3 35
  • 31 (a)
T10H4.11 35
  • 31 (a)
C34B7.3 35
  • 31 (a)
C45H4.2 35
  • 31 (a)
B0304.3 35
  • 31 (a)
T09H2.1 35
  • 31 (a)
Y49C4A.9 35
  • 31 (a)
C45H4.17 35
  • 30 (a)
K05D4.4 35
  • 30 (a)
B0213.16 35
  • 30 (a)
K07C6.3 35
  • 29 (a)
C25E10.2 35
  • 29 (a)
F14H3.10 35
  • 29 (a)
K07C6.2 35
  • 29 (a)
Y5H2B.6 35
  • 29 (a)
K07C6.5 35
  • 29 (a)
K09D9.2 35
  • 28 (a)
C03G6.15 35
  • 28 (a)
C49G7.8 35
  • 27 (a)
Species where no ortholog for CYP2C18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2C18 Gene

ENSEMBL:
Gene Tree for CYP2C18 (if available)
TreeFam:
Gene Tree for CYP2C18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP2C18: view image

Paralogs for CYP2C18 Gene

(26) SIMAP similar genes for CYP2C18 Gene using alignment to 2 proteins:

  • CP2CI_HUMAN
  • Q2XN56_HUMAN

Pseudogenes.org Pseudogenes for CYP2C18 Gene

genes like me logo Genes that share paralogs with CYP2C18: view

Variants for CYP2C18 Gene

Sequence variations from dbSNP and Humsavar for CYP2C18 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000068655 -- 94,735,516(+) C/T 3_prime_UTR_variant
rs1000196127 -- 94,695,193(+) G/A intron_variant
rs1000398501 -- 94,722,159(+) T/A intron_variant
rs1000610541 -- 94,699,761(+) C/G/T intron_variant
rs1000659112 -- 94,710,144(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2C18 Gene

Variant ID Type Subtype PubMed ID
dgv1355n54 CNV loss 21841781
dgv1356n54 CNV loss 21841781
dgv160e214 CNV loss 21293372
dgv955n100 CNV loss 25217958
dgv956n100 CNV loss 25217958
dgv957n100 CNV loss 25217958
esv2657299 CNV deletion 23128226
esv2672446 CNV deletion 23128226
esv2739707 CNV deletion 23290073
esv2761617 CNV loss 21179565
esv3579076 CNV loss 25503493
esv3624253 CNV loss 21293372
esv3624254 CNV loss 21293372
esv3624256 CNV loss 21293372
esv3624258 CNV gain 21293372
esv3891886 CNV loss 25118596
nsv1035409 CNV loss 25217958
nsv1046308 CNV loss 25217958
nsv478987 CNV novel sequence insertion 20440878
nsv522538 CNV loss 19592680
nsv551954 CNV loss 21841781
nsv7496 CNV insertion 18451855

Variation tolerance for CYP2C18 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.81; 86.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2C18 Gene

Human Gene Mutation Database (HGMD)
CYP2C18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2C18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C18 Gene

Disorders for CYP2C18 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CYP2C18 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hypotrichosis 6
  • hypt6
paralytic ileus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP2C18

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP2C18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C18 Gene

Publications for CYP2C18 Gene

  1. A genome-wide association study of acenocoumarol maintenance dosage. (PMID: 19578179) Teichert M … Stricker BH (Human molecular genetics 2009) 3 22 44 58
  2. Association of warfarin dose with genes involved in its action and metabolism. (PMID: 17048007) Wadelius M … Deloukas P (Human genetics 2007) 3 22 44 58
  3. Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. (PMID: 1896026) Furuya H … Gonzalez FJ (Molecular pharmacology 1991) 2 3 22 58
  4. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. (PMID: 2009263) Romkes M … Goldstein JA (Biochemistry 1991) 2 3 4 58
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58

Products for CYP2C18 Gene

Sources for CYP2C18 Gene

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