Aliases for CYP2B6 Gene
- Cytochrome P450 Family 2 Subfamily B Member 6 2 3 5
- CYPIIB6 2 3 4
- Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible), Polypeptide 6 2 3
- Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 2 3
- 1,4-Cineole 2-Exo-Monooxygenase 3 4
- Cytochrome P450 IIB1 3 4
- Cytochrome P450 2B6 3 4
- CPB6 2 3
- Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible) 2
External Ids for CYP2B6 Gene
Previous HGNC Symbols for CYP2B6 Gene
Previous GeneCards Identifiers for CYP2B6 Gene
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP2B6 Gene
CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Abacavir Allergy. Among its related pathways are Valproic acid pathway and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A13.
UniProtKB/Swiss-Prot Summary for CYP2B6 Gene
A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:21289075, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:21289075, PubMed:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850).
Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.