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This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize ... See more...
Aliases for CYP2B6 Gene
Aliases for CYP2B6 Gene
- Cytochrome P450 Family 2 Subfamily B Member 6 2 3 5
- Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible), Polypeptide 6 2 3
- Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 2 3
- 1,4-Cineole 2-Exo-Monooxygenase 3 4
- Cytochrome P450 IIB1 3 4
- Cytochrome P450 2B6 3 4
- CYPIIB6 3 4
- Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible) 2
- Cytochrome P450, Family 2, Subfamily B 2
External Ids for CYP2B6 Gene
- HGNC: 2615
- Entrez Gene: 1555
- Ensembl: ENSG00000197408
- OMIM: 123930
- UniProtKB: P20813
Previous HGNC Symbols for CYP2B6 Gene
- CYP2B
Previous GeneCards Identifiers for CYP2B6 Gene
- GC19P042136
- GC19P041888
- GC19P046107
- GC19P046123
- GC19P046127
- GC19P046189
- GC19P041497
- GC19P037929
Summaries for CYP2B6 Gene
-
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP2B6 Gene
CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Acute Frontal Sinusitis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Phenytoin Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A13.
UniProtKB/Swiss-Prot Summary for CYP2B6 Gene
-
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Additional gene information for CYP2B6 Gene
- Monarch Initiative
- Search for CYP2B6 at DataMed
- Search for CYP2B6 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP2B6 Gene
Genomics for CYP2B6 Gene
GeneHancer (GH) Regulatory Elements for CYP2B6 Gene
Promoters and enhancers for CYP2B6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CYP2B6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CYP2B6 gene promoter:
-
- ATF
- c-Ets-1
- GR
- GR-alpha
- MRF-2
- NF-kappaB
- NF-kappaB1
- TBP
- TFIID
Genomic Locations for CYP2B6 Gene
Genomic Locations for CYP2B6 Gene
- chr19:40,991,229-41,018,398
- (GRCh38/hg38)
- Size:
- 27,170 bases
- Orientation:
- Plus strand
- chr19:41,497,204-41,524,303
- (GRCh37/hg19)
- Size:
- 27,100 bases
- Orientation:
- Plus strand
Genomic View for CYP2B6 Gene
Genes around CYP2B6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by HGNC
- 19q13.2 by Entrez Gene
- 19q13.2 by Ensembl
CYP2B6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP2B6 Gene
Proteins for CYP2B6 Gene
-
Protein details for CYP2B6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20813-CP2B6_HUMAN
- Recommended name:
- Cytochrome P450 2B6
- Protein Accession:
- P20813
- B4DWP3
- Q2V565
- Q9UK46
Protein attributes for CYP2B6 Gene
- Size:
- 491 amino acids
- Molecular mass:
- 56278 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for CYP2B6 Gene
Protein Expression for CYP2B6 Gene
Selected DME Specific Peptides for CYP2B6 Gene
- P20813:
-
- LFFAGTET
- PGPRPLP
- FGMGKRS
- ELFLFFTTILQ
- LGPRPVV
- DRAKMPY
- KMPYTEAVI
- PEDIDLTP
- EERIQEE
- AEAFSGRG
- TTILQNF
- TTSTTLRY
- AGTETTS
- TLRYGFLL
Post-translational modifications for CYP2B6 Gene
- Phosphorylation is accompanied by a decrease in enzyme activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CYP2B6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-CYP2B6 Antibody
- Novus Biologicals Antibodies for CYP2B6
-
Abcam antibodies for CYP2B6
- Invitrogen Antibodies for CYP2B6 (AFLGC-CYP2B6)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP2B6
Protein Products
-
OriGene Purified Proteins for CYP2B6
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP2B6
- Origene Custom Protein Services for CYP2B6
- antibodies-online: Show 5 available CYP2B6 Proteins ranked by validation data
- Compare Top CYP2B6 Proteins
-
Quality Products:
-
Abcam proteins for CYP2B6
Assay Products
- Aviva Systems Biology CYP2B6 ELISA Kit (Human) (OKEH04159)
- antibodies-online: Show 15 available CYP2B6 Elisa Kits ranked by validation data
- Compare Top CYP2B6 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CYP2B6
Domains & Families for CYP2B6 Gene
Gene Families for CYP2B6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for CYP2B6 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP2B6 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50266, highly similar to Cytochrome P450 2B6 (EC 1.14.14.1) (B4DWP3_HUMAN)
- Cytochrome P450 IIB1 (CP2B6_HUMAN)
- Cytochrome P450 2B6 (F2X1A7_HUMAN)
- Cytochrome P450 2B6 (F2X1B0_HUMAN)
- Cytochrome P450, family 2, subfamily B, polypeptide 6 (Q6NWU1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P20813- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP2B6 Gene
Molecular function for CYP2B6 Gene
- UniProtKB/Swiss-Prot Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=1,4-cineole + H(+) + NADPH + O2 = 2-exo-hydroxy-1,4-cineole + H2O + NADP(+); Xref=Rhea:RHEA:49160, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:80788, ChEBI:CHEBI:90956; Evidence=. ;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=360 uM for 1,4-cineole {ECO:0000269 PubMed:11695850}; Vmax=3.4 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole {ECO:0000269 PubMed:11695850};
- UniProtKB/Swiss-Prot Induction:
- By phenobarbital.
Enzyme Numbers (IUBMB) for CYP2B6 Gene
Phenotypes From GWAS Catalog for CYP2B6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004497 | monooxygenase activity | IDA | 19651758 |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0008392 | arachidonic acid epoxygenase activity | IBA | 21873635 |
| GO:0008395 | steroid hydroxylase activity | IBA | 21873635 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for CYP2B6 Gene
- GenomeRNAi human phenotypes for CYP2B6:
-
- Synthetic lethal with imatinib mesylate
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased Hepatitis C virus replication
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased transferrin (TF) endocytosis
Animal Model Products
-
Taconic Biosciences Mouse Models for CYP2B6
CRISPR Products
-
OriGene CRISPR knockouts for CYP2B6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP2B6
- genomics-online: gRNA clones - Search for available CYP2B6 gRNA products
- Overview of 42 available CYP2B6 gene related products
- Applied Biological Materials (abm): CRISPR Clones for CYP2B6 - Select products 50% OFF >
- * CYP2B6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CYP2B6 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2B6
miRNA for CYP2B6 Gene
- miRTarBase miRNAs that target CYP2B6
-
- hsa-let-7e-5p (MIRT051706)
- hsa-mir-6516-5p (MIRT458531)
- hsa-mir-455-3p (MIRT458532)
- hsa-mir-6763-3p (MIRT458533)
- hsa-mir-7847-3p (MIRT458534)
- hsa-mir-6880-5p (MIRT458535)
- hsa-mir-6745 (MIRT458536)
- hsa-mir-363-5p (MIRT458537)
- hsa-mir-608 (MIRT458538)
- hsa-mir-4651 (MIRT458539)
- hsa-mir-7110-5p (MIRT458540)
- hsa-mir-6842-5p (MIRT458541)
- hsa-mir-6752-5p (MIRT458542)
- hsa-mir-6851-5p (MIRT458543)
- hsa-mir-3689d (MIRT458544)
- hsa-mir-6499-3p (MIRT458545)
- hsa-mir-6086 (MIRT458546)
- hsa-mir-377-5p (MIRT458547)
- hsa-mir-4537 (MIRT458548)
- hsa-mir-4787-5p (MIRT458549)
- hsa-mir-4532 (MIRT458550)
- hsa-mir-5587-3p (MIRT458551)
- hsa-mir-4707-5p (MIRT458552)
- hsa-mir-587 (MIRT626333)
- hsa-mir-3692-3p (MIRT626334)
- hsa-mir-5193 (MIRT626335)
- hsa-mir-5088-3p (MIRT626336)
- hsa-mir-1247-5p (MIRT626337)
- hsa-mir-1224-3p (MIRT626338)
- hsa-mir-6866-3p (MIRT626339)
- hsa-mir-188-5p (MIRT626340)
- hsa-mir-498 (MIRT647546)
- hsa-mir-6867-3p (MIRT647547)
- hsa-mir-20a-3p (MIRT647548)
- hsa-mir-4772-3p (MIRT647549)
- hsa-mir-4685-3p (MIRT647550)
- hsa-mir-4287 (MIRT647551)
- hsa-mir-7113-3p (MIRT647552)
- hsa-mir-660-3p (MIRT647553)
- hsa-mir-4667-3p (MIRT647554)
- hsa-mir-1470 (MIRT647555)
- hsa-mir-6800-3p (MIRT647556)
- hsa-mir-25-3p (MIRT733677)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CYP2B6
- Browse OriGene Inhibitory RNA Products For CYP2B6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2B6
- genomics-online: shRNA clones - Search for available CYP2B6 shRNA products
- Overview of 42 available CYP2B6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CYP2B6
- Addgene plasmids for CYP2B6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP2B6
- genomics-online: cdna clones - Search for available CYP2B6 CDNA products
- Overview of 42 available CYP2B6 gene related products
- orf clones - Search for available CYP2B6 ORF products
- Overview of 42 available CYP2B6 gene related products
- Applied Biological Materials (abm): Clones for CYP2B6 - Select products 50% OFF >
- * CYP2B6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CYP2B6 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for CYP2B6
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2B6 Gene
Localization for CYP2B6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP2B6 Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| mitochondrion | 3 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nuclear membrane (2)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031090 | organelle membrane | IEA | -- |
Pathways & Interactions for CYP2B6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
.01
.01
|
| 2 | Drug metabolism - cytochrome P450 | ||
| 3 | Phenytoin Pathway, Pharmacokinetics | ||
| 4 | Statin Pathway - Generalized, Pharmacokinetics | ||
| 5 | Metabolism |
.40
|
|
Pathways by source for CYP2B6 Gene
10 BioSystems pathways for CYP2B6 Gene
7 Reactome pathways for CYP2B6 Gene
5 KEGG pathways for CYP2B6 Gene
2 GeneGo (Thomson Reuters) pathways for CYP2B6 Gene
Interacting Proteins for CYP2B6 Gene
GPS-Prot Interaction Network for CYP2B6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | IBA | 21873635 |
| GO:0006805 | xenobiotic metabolic process | TAS | -- |
| GO:0008202 | steroid metabolic process | IMP | 18356043 |
| GO:0017144 | drug metabolic process | IMP | 18356043 |
| GO:0019373 | epoxygenase P450 pathway | IBA | 21873635 |
Drugs & Compounds for CYP2B6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bupropion | Approved | Pharma | Enzyme, substrate | 368 | ||
| Efavirenz | Approved, Investigational | Pharma | Enzyme, substrate, inhibitor, inducer | Reverse transcriptase inhibitor | 438 | |
| Nevirapine | Approved | Pharma | Enzyme, substrate, inducer | 230 | ||
| Propofol | Approved, Investigational, Vet_approved | Pharma | Enzyme, substrate | 1441 | ||
| Clopidogrel | Approved | Pharma | Enzyme, substrate, inhibitor | P2Y12 receptor antagonist | 893 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4-Hydroxycyclophosphamide |
|
40277-05-2 | ||||
| nadph |
|
53-57-6 | ||||
| parathion |
|
56-38-2 | ||||
| 11,12,15-THETA |
|
|
||||
| 11,12-EpETrE |
|
81276-02-0 |
|
(1) ApexBio Compounds for CYP2B6 Gene
| Compound | Action | Cas Number |
|---|---|---|
| ABT | 1614-12-6 |
Transcripts for CYP2B6 Gene
mRNA/cDNA for CYP2B6 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (44) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000324071 3071 bps (ENST00000324071.9)
- ENST00000598834 1605 bps (ENST00000598834.2)
- ENST00000593831 1426 bps (ENST00000593831.1)
- ENST00000594187 339 bps (ENST00000594187.1)
- ENST00000597612 1849 bps (ENST00000597612.1)
CRISPR Products
-
OriGene CRISPR knockouts for CYP2B6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP2B6
- genomics-online: gRNA clones - Search for available CYP2B6 gRNA products
- Overview of 42 available CYP2B6 gene related products
- Applied Biological Materials (abm): CRISPR Clones for CYP2B6 - Select products 50% OFF >
- * CYP2B6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CYP2B6 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2B6
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CYP2B6
- Browse OriGene Inhibitory RNA Products For CYP2B6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2B6
- genomics-online: shRNA clones - Search for available CYP2B6 shRNA products
- Overview of 42 available CYP2B6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CYP2B6
- Addgene plasmids for CYP2B6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP2B6
- genomics-online: cdna clones - Search for available CYP2B6 CDNA products
- Overview of 42 available CYP2B6 gene related products
- orf clones - Search for available CYP2B6 ORF products
- Overview of 42 available CYP2B6 gene related products
- Applied Biological Materials (abm): Clones for CYP2B6 - Select products 50% OFF >
- * CYP2B6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CYP2B6 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for CYP2B6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Liver (Hepatobiliary System)
- Adipose (Muscoskeletal System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
- Heart (Cardiovascular System)
- NULL (Uncategorized)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for CYP2B6 Gene
This gene is overexpressed in Liver (x50.3).
This gene is overexpressed in Gallbladder (52.5) and Liver (12.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP2B6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CYP2B6 Gene:
CYP2B6SOURCE GeneReport for Unigene cluster for CYP2B6 Gene:
Hs.1360mRNA Expression by UniProt/SwissProt for CYP2B6 Gene:
P20813-CP2B6_HUMAN
Tissue specificity:
Expressed in liver, lung and heart right ventricle.
Evidence on tissue expression from TISSUES for CYP2B6 Gene
- Liver(4.9)
- Intestine(4.5)
- Lung(3.2)
- Kidney(2.9)
- Adrenal gland(2.8)
- Blood(2.5)
- Nervous system(2.5)
- Heart(2.3)
- Skin(2.1)
- Stomach(2)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for CYP2B6
-
OriGene qPCR primer pairs and template standards for CYP2B6
- genomics-online: primer clones - Search for available CYP2B6 Primer products
- Overview of 42 available CYP2B6 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2B6 Gene
Orthologs for CYP2B6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC456052 32 |
|
||
| CYP2B6 33 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | CYP2B6 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CYP2B6 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cyp2b10 17 33 32 |
|
||
| Cyp2b19 33 |
|
OneToMany | |||
| Cyp2b23 33 |
|
OneToMany | |||
| Cyp2b9 33 |
|
OneToMany | |||
| Cyp2b13 33 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Cyp2b1 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Cyp18a1 34 |
|
|
|
| Cyp303a1 34 |
|
|
|||
| Cyp304a1 34 |
|
|
|||
| Cyp305a1 34 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | C50H11.15 34 |
|
|
|
| R08F11.3 34 |
|
|
|||
| F41B5.4 34 |
|
|
|||
| C45H4.17 34 |
|
|
|||
| C45H4.2 34 |
|
|
|||
| C12D5.7 34 |
|
|
|||
| Y49C4A.9 34 |
|
|
|||
| C41G6.1 34 |
|
|
|||
| B0213.12 34 |
|
|
|||
| B0304.3 34 |
|
|
|||
| F44C8.1 34 |
|
|
|||
| F41B5.2 34 |
|
|
|||
| T10H4.11 34 |
|
|
|||
| B0213.14 34 |
|
|
|||
| Y5H2B.6 34 |
|
|
|||
| K05D4.4 34 |
|
|
|||
| B0213.10 34 |
|
|
|||
| B0213.15 34 |
|
|
|||
| K07C6.3 34 |
|
|
|||
| B0213.11 34 |
|
|
|||
| C49G7.8 34 |
|
|
|||
| T10H4.10 34 |
|
|
|||
| B0213.16 34 |
|
|
|||
| T09H2.1 34 |
|
|
|||
| K07C6.5 34 |
|
|
|||
| K09D9.2 34 |
|
|
|||
| C03G6.15 34 |
|
|
|||
| F14H3.10 34 |
|
|
|||
| K07C6.2 34 |
|
|
- Species where no ortholog for CYP2B6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Evolution for CYP2B6 Gene
- ENSEMBL:
- Gene Tree for CYP2B6 (if available)
- TreeFam:
- Gene Tree for CYP2B6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYP2B6: view image
Paralogs for CYP2B6 Gene
Paralogs for CYP2B6 Gene
(28) SIMAP similar genes for CYP2B6 Gene using alignment to 8 proteins:
- CP2B6_HUMAN
- B4DWP3_HUMAN
- F2X1A7_HUMAN
- F2X1B0_HUMAN
- M0QZJ2_HUMAN
- Q6NWU1_HUMAN
- Q6NWU2_HUMAN
- Q9UNX8_HUMAN
Pseudogenes.org Pseudogenes for CYP2B6 Gene
Variants for CYP2B6 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2B6 Gene
- CP2B6_HUMAN-P20813
- Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIM:614546]. Efavirenz is a non-nucleoside reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz concentration in the plasma.
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs139801276 | drug-response, Efavirenz response | 41,004,303(+) | T/C | coding_sequence_variant, missense_variant | |
| rs186335453 | drug-response, Efavirenz response | 41,004,158(+) | G/C/T | coding_sequence_variant, missense_variant | |
| rs2279343 | benign, drug-response, Efavirenz response, efavirenz response - Metabolism/PK, - | 41,009,358(+) | A/G | coding_sequence_variant, missense_variant | |
| rs2279345 | drug-response, efavirenz response - Metabolism/PK | 41,009,797(+) | T/A/C | intron_variant | |
| rs281864907 | drug-response, Efavirenz response | 41,004,015(+) | T/A | coding_sequence_variant, stop_gained |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3545n100 | CNV | loss | 25217958 |
| dgv3546n100 | CNV | gain | 25217958 |
| dgv408n27 | CNV | loss | 19166990 |
| dgv55n17 | CNV | loss | 16327808 |
| dgv6453n54 | CNV | loss | 21841781 |
| esv24009 | CNV | gain | 19812545 |
| esv2597443 | CNV | loss | 19546169 |
| esv2658055 | CNV | deletion | 23128226 |
| esv2718571 | CNV | deletion | 23290073 |
| esv2718572 | CNV | deletion | 23290073 |
| esv2758762 | CNV | gain+loss | 17122850 |
| esv2760505 | CNV | gain+loss | 21179565 |
| esv3584954 | CNV | gain | 24956385 |
| esv3644370 | CNV | loss | 21293372 |
| esv3893208 | CNV | gain | 25118596 |
| nsv1058051 | CNV | gain | 25217958 |
| nsv1058772 | CNV | gain | 25217958 |
| nsv1064140 | CNV | gain+loss | 25217958 |
| nsv1065684 | CNV | gain | 25217958 |
| nsv1066637 | CNV | gain | 25217958 |
| nsv1125310 | OTHER | inversion | 24896259 |
| nsv1125483 | CNV | deletion | 24896259 |
| nsv1160626 | CNV | deletion | 26073780 |
| nsv433319 | CNV | loss | 18776910 |
| nsv442461 | CNV | loss | 18776908 |
| nsv470141 | CNV | loss | 18288195 |
| nsv470142 | CNV | gain | 18288195 |
| nsv509743 | CNV | insertion | 20534489 |
| nsv517597 | CNV | loss | 19592680 |
| nsv523686 | CNV | gain | 19592680 |
| nsv963136 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.02;
68.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYP2B6 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for CYP2B6 Gene
(19) MalaCards diseases for CYP2B6 Gene - From: HGMD, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| efavirenz, poor metabolism of |
|
|
| acute frontal sinusitis |
|
|
| femoral neuropathy |
|
|
| neonatal abstinence syndrome |
|
|
| kidney cortex necrosis |
|
|
Search CYP2B6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CYP2B6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2B6 Gene
Publications for CYP2B6 Gene
- Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. (PMID: 15622315) Haas DW … Acosta EP (AIDS (London, England) 2004) 3 4 23 43 56
- Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. (PMID: 20860463) Elens L … Haufroid V (Pharmacogenomics 2010) 3 4 43 56
- The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients. (PMID: 20089352) Tan L … Yu Y (Clinical neurology and neurosurgery 2010) 3 23 43 56
- Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. (PMID: 20639527) Carr DF … Cortes CP (The Journal of antimicrobial chemotherapy 2010) 3 4 43 56
- Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans. (PMID: 19239339) Haas DW … Wilkinson GR (The Journal of infectious diseases 2009) 3 23 43 56
ExternalLinks
Products for CYP2B6 Gene
- Custom Antibody ServicesOriGene Antibodies for CYP2B6
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- Taconic Biosciences Mouse Models for CYP2B6
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CYP2B6 (AFLGC-CYP2B6)
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- Addgene plasmids for CYP2B6
- antibodies-online: Show 22 available CYP2B6 Antibodies ranked by validation data
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- Horizon Cell Lines for CYP2B6
- genomics-online: cdna clones - Search for available CYP2B6 CDNA products
- Overview of 42 available CYP2B6 gene related products
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- Overview of 42 available CYP2B6 gene related products
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- Overview of 42 available CYP2B6 gene related products
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- Overview of 42 available CYP2B6 gene related products
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- Overview of 42 available CYP2B6 gene related products
- Browse GeneCopoeia Cell Lines
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Sources for CYP2B6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9)