CYP2B6 Gene (Protein Coding)

Cytochrome P450 Family 2 Subfamily B Member 6

GC19P040991
GIFtS:
47
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize ... See more...

Aliases for CYP2B6 Gene

Aliases for CYP2B6 Gene

  • Cytochrome P450 Family 2 Subfamily B Member 6 2 3 5
  • CYPIIB6 2 3 4
  • Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible), Polypeptide 6 2 3
  • Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 2 3
  • 1,4-Cineole 2-Exo-Monooxygenase 3 4
  • Cytochrome P450 IIB1 3 4
  • Cytochrome P450 2B6 3 4
  • CPB6 2 3
  • Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible) 2
  • Cytochrome P450, Family 2, Subfamily B 2
  • EC 1.14.14.1 51
  • EC 1.14.13.- 4
  • CYP2B7P 3
  • CYP2B7 3
  • CYP2B6 5
  • CYP2B 3
  • EFVM 3
  • IIB1 3
  • P450 3

External Ids for CYP2B6 Gene

Previous HGNC Symbols for CYP2B6 Gene

  • CYP2B

Previous GeneCards Identifiers for CYP2B6 Gene

  • GC19P042136
  • GC19P041888
  • GC19P046107
  • GC19P046123
  • GC19P046127
  • GC19P046189
  • GC19P041497
  • GC19P037929

Summaries for CYP2B6 Gene

Entrez Gene Summary for CYP2B6 Gene

  • This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2B6 Gene

CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Abacavir Allergy. Among its related pathways are Valproic acid pathway and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A13.

UniProtKB/Swiss-Prot Summary for CYP2B6 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:21289075, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:21289075, PubMed:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850).
  • Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.

Gene Wiki entry for CYP2B6 Gene

PharmGKB "VIP" Summary for CYP2B6 Gene

Additional gene information for CYP2B6 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP2B6 Gene

Genomics for CYP2B6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CYP2B6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J040919 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 600.2 -67.8 -67845 7.6 ZNF221 CREB1 GATAD2A PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ ZNF692 CYP2B7P CYP2B6 ZNF780B SNRPA HNRNPUL1 ENSG00000269843 CCDC97 ZNF780A COQ8B AKT2
GH19J040991 Promoter 0.8 EPDnew 600.7 0.0 -17 0.1 SP1 FOXA2 ATF3 YY1 ZBTB33 JUND NR2F2 HNF4A RXRA MAX CYP2B6 lnc-CYP2B6-1 piR-33905-036 CYP2A7
GH19J040990 Enhancer 0.7 Ensembl 600.7 -1.3 -1281 1.2 PRDM10 SP1 SCRT2 FOXA2 ATF3 YY1 GABPA ZBTB33 JUND NR2F2 CYP2B6 ZNF780A PLEKHA3P1 lnc-CYP2B6-1 piR-33905-036 CYP2A7
GH19J040747 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.6 -238.5 -238521 9.8 BRCA1 SP1 CREB1 GATAD2A PRDM10 REST ZNF629 TFE3 SIX5 LEF1 SNRPA C19orf54 HNRNPUL1 ZNF780A ENSG00000269843 COQ8B AKT2 ZNF780B CCDC97 ITPKC
GH19J040979 Enhancer 0.9 Ensembl ENCODE 5.3 -9.8 -9780 5 ATF7 KDM1A ZSCAN4 PKNOX1 SP1 ZNF239 ZNF311 SCRT2 CEBPB FOXA2 SNRPA HNRNPUL1 ENSG00000269843 CCDC97 COQ8B ZNF780A CYP2B7P CYP2B6 lnc-CYP2B6-1 piR-43583-270
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP2B6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP2B6

Top Transcription factor binding sites by QIAGEN in the CYP2B6 gene promoter:
  • ATF
  • c-Ets-1
  • GR
  • GR-alpha
  • MRF-2
  • NF-kappaB
  • NF-kappaB1
  • TBP
  • TFIID

Genomic Locations for CYP2B6 Gene

Genomic Locations for CYP2B6 Gene
chr19:40,991,282-41,018,398
(GRCh38/hg38)
Size:
27,117 bases
Orientation:
Plus strand
chr19:41,497,204-41,524,303
(GRCh37/hg19)
Size:
27,100 bases
Orientation:
Plus strand

Genomic View for CYP2B6 Gene

Genes around CYP2B6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2B6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2B6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP2B6 Gene

Proteins for CYP2B6 Gene

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  • Protein details for CYP2B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20813-CP2B6_HUMAN
    Recommended name:
    Cytochrome P450 2B6
    Protein Accession:
    P20813
    Secondary Accessions:
    • B4DWP3
    • Q2V565
    • Q9UK46

    Protein attributes for CYP2B6 Gene

    Size:
    491 amino acids
    Molecular mass:
    56278 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2B6 Gene

    Alternative splice isoforms for CYP2B6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2B6 Gene

Protein Expression for CYP2B6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CYP2B6 Gene

P20813:
  • LFFAGTET
  • PGPRPLP
  • FGMGKRS
  • ELFLFFTTILQ
  • LGPRPVV
  • DRAKMPY
  • KMPYTEAVI
  • PEDIDLTP
  • EERIQEE
  • AEAFSGRG
  • TTILQNF
  • TTSTTLRY
  • AGTETTS
  • TLRYGFLL

Post-translational modifications for CYP2B6 Gene

  • Phosphorylation is accompanied by a decrease in enzyme activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2B6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP2B6 Gene

Gene Families for CYP2B6 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CYP2B6 Gene

InterPro:
Blocks:
  • E-class P450 group I signature
  • CYP2B P450 family signature
ProtoNet:

Suggested Antigen Peptide Sequences for CYP2B6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50266, highly similar to Cytochrome P450 2B6 (EC 1.14.14.1) (B4DWP3_HUMAN)
  • Cytochrome P450 IIB1 (CP2B6_HUMAN)
  • Cytochrome P450 2B6 (F2X1A7_HUMAN)
  • Cytochrome P450 2B6 (F2X1B0_HUMAN)
  • Cytochrome P450, family 2, subfamily B, polypeptide 6 (Q6NWU1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20813

UniProtKB/Swiss-Prot:

CP2B6_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2B6: view

Function for CYP2B6 Gene

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Molecular function for CYP2B6 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:21289075, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:21289075, PubMed:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850).
UniProtKB/Swiss-Prot Function:
Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53148, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136991; Evidence={ECO:0000269|PubMed:21289075};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53144, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136990; Evidence={ECO:0000269|PubMed:21289075};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53140, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136989; Evidence={ECO:0000269|PubMed:21289075};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53196, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:34172, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:21289075};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46304, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:83027; Evidence={ECO:0000269|PubMed:21289075};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49160, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:80788, ChEBI:CHEBI:90956; Evidence={ECO:0000269|PubMed:11695850};.
UniProtKB/Swiss-Prot Induction:
By phenobarbital.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=360 uM for 1,4-cineole {ECO:0000269|PubMed:11695850}; KM=13.3 uM for testosterone (16-alpha-hydroxylation) {ECO:0000269|PubMed:21289075}; KM=27.7 uM for testosterone (16-beta-hydroxylation) {ECO:0000269|PubMed:21289075}; KM=3.6 uM for N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (14,15-epoxidation) {ECO:0000269|PubMed:21289075}; KM=1.32 uM for N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (11,12-epoxidation) {ECO:0000269|PubMed:21289075}; KM=1.21 uM for N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (8,9-epoxidation) {ECO:0000269|PubMed:21289075}; Vmax=3.4 nmol/min/nmol enzyme toward 1,4-cineole {ECO:0000269|PubMed:11695850}; Vmax=2.04 pmol/min/pmol enzyme toward N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (14,15-epoxidation) {ECO:0000269|PubMed:21289075}; Vmax=7.56 pmol/min/pmol enzyme toward N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (11,12-epoxidation) {ECO:0000269|PubMed:21289075}; Vmax=3.12 pmol/min/pmol enzyme toward N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine (8,9-epoxidation) {ECO:0000269|PubMed:21289075};

Enzyme Numbers (IUBMB) for CYP2B6 Gene

Phenotypes From GWAS Catalog for CYP2B6 Gene

Gene Ontology (GO) - Molecular Function for CYP2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA,IDA 19651758
GO:0005506 iron ion binding IEA --
GO:0008390 testosterone 16-alpha-hydroxylase activity IDA 21289075
GO:0008392 arachidonic acid epoxygenase activity IBA 21873635
GO:0008395 steroid hydroxylase activity IBA 21873635
genes like me logo Genes that share ontologies with CYP2B6: view
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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2B6 Gene

Localization for CYP2B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2B6 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2B6 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
cytosol 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYP2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP2B6: view

Pathways & Interactions for CYP2B6 Gene

genes like me logo Genes that share pathways with CYP2B6: view

SIGNOR curated interactions for CYP2B6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CYP2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IBA 21873635
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0017144 drug metabolic process IMP 18356043
GO:0019373 epoxygenase P450 pathway IBA 21873635
genes like me logo Genes that share ontologies with CYP2B6: view

Drugs & Compounds for CYP2B6 Gene

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(285) Drugs for CYP2B6 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bupropion Approved Pharma Enzyme, substrate 379
Efavirenz Approved, Investigational Pharma Enzyme, substrate, inducer Reverse transcriptase inhibitor 441
Nevirapine Approved Pharma Enzyme, substrate, inducer 231
Propofol Approved, Investigational, Vet_approved Pharma Enzyme, substrate 1563
Clopidogrel Approved Pharma Enzyme, substrate, inhibitor P2Y12 receptor antagonist 934

(82) Additional Compounds for CYP2B6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxycyclophosphamide
  • tetrahydro-2-(Bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
  • 4-Hydroxycyclophosphamide, (cis)-isomer
  • 4-Hydroxycyclophosphamide, (trans)-isomer
 40277-05-2
parathion
  • Diethyl P-nitrophenyl thiophosphate
  • Diethyl parathion
  • DNTP
  • Ethyl parathion
  • O,O-Diethyl O-(4-nitrophenyl) thiophosphate
 56-38-2
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
 81276-02-0
11,14,15-THETA
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate

(1) ApexBio Compounds for CYP2B6 Gene

Compound Action Cas Number
ABT 1614-12-6
genes like me logo Genes that share compounds with CYP2B6: view

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Transcripts for CYP2B6 Gene

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mRNA/cDNA for CYP2B6 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

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Alternative Splicing Database (ASD) splice patterns (SP) for CYP2B6 Gene

No ASD Table

Relevant External Links for CYP2B6 Gene

GeneLoc Exon Structure for
CYP2B6

Expression for CYP2B6 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP2B6 Gene

mRNA expression in normal human tissues for CYP2B6 Gene
mRNA expression by GTEx for CYP2B6 GenemRNA expression by BioGPS for CYP2B6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2B6 Gene

This gene is overexpressed in Liver (x50.3).

Protein differential expression in normal tissues from HIPED for CYP2B6 Gene

This gene is overexpressed in Gallbladder (52.5) and Liver (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP2B6 Gene



Protein tissue co-expression partners for CYP2B6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP2B6

SOURCE GeneReport for Unigene cluster for CYP2B6 Gene:

Hs.1360

mRNA Expression by UniProt/SwissProt for CYP2B6 Gene:

P20813-CP2B6_HUMAN
Tissue specificity: Expressed in liver, lung and heart right ventricle.

Evidence on tissue expression from TISSUES for CYP2B6 Gene

  • Liver(4.9)
  • Intestine(4.6)
  • Kidney(3.1)
  • Nervous system(3)
  • Heart(3)
  • Lung(2.9)
  • Blood(2.9)
  • Adrenal gland(2.9)
  • Thyroid gland(2.6)
  • Urine(2.5)
  • Stomach(2.5)
  • Skin(2.5)
  • Pancreas(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CYP2B6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2B6 Gene

Orthologs for CYP2B6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2B6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC456052 30
  • 95.97 (n)
CYP2B6 31
  • 93 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CYP2B6 30 31
  • 83.21 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CYP2B6 30 31
  • 83.02 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cyp2b10 30 17 31
  • 79.41 (n)
 OneToMany
Cyp2b19 31
  • 75 (a)
 OneToMany
Cyp2b23 31
  • 75 (a)
 OneToMany
Cyp2b9 31
  • 72 (a)
 OneToMany
Cyp2b13 31
  • 71 (a)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Cyp2b1 30
  • 79.03 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 70 (a)
 OneToMany
-- 31
  • 61 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 46 (a)
 ManyToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta Cyp18a1 32
  • 32 (a)
Cyp303a1 32
  • 31 (a)
Cyp304a1 32
  • 29 (a)
Cyp305a1 32
  • 29 (a)
Worm
(Caenorhabditis elegans)
 Secernentea C50H11.15 32
  • 34 (a)
C12D5.7 32
  • 33 (a)
C45H4.17 32
  • 33 (a)
F41B5.4 32
  • 33 (a)
R08F11.3 32
  • 33 (a)
C45H4.2 32
  • 33 (a)
B0304.3 32
  • 32 (a)
C41G6.1 32
  • 32 (a)
F44C8.1 32
  • 32 (a)
Y49C4A.9 32
  • 32 (a)
B0213.12 32
  • 32 (a)
B0213.14 32
  • 31 (a)
F41B5.2 32
  • 31 (a)
K05D4.4 32
  • 31 (a)
T10H4.11 32
  • 31 (a)
Y5H2B.6 32
  • 31 (a)
B0213.10 32
  • 30 (a)
B0213.11 32
  • 30 (a)
B0213.15 32
  • 30 (a)
C49G7.8 32
  • 30 (a)
K07C6.3 32
  • 30 (a)
T10H4.10 32
  • 30 (a)
B0213.16 32
  • 30 (a)
C03G6.15 32
  • 29 (a)
F14H3.10 32
  • 29 (a)
K07C6.5 32
  • 29 (a)
K09D9.2 32
  • 29 (a)
T09H2.1 32
  • 29 (a)
K07C6.2 32
  • 28 (a)
Species where no ortholog for CYP2B6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for CYP2B6 Gene

ENSEMBL:
Gene Tree for CYP2B6 (if available)
TreeFam:
Gene Tree for CYP2B6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP2B6: view image

Paralogs for CYP2B6 Gene

Paralogs for CYP2B6 Gene

(28) SIMAP similar genes for CYP2B6 Gene using alignment to 8 proteins:

  • CP2B6_HUMAN
  • B4DWP3_HUMAN
  • F2X1A7_HUMAN
  • F2X1B0_HUMAN
  • M0QZJ2_HUMAN
  • Q6NWU1_HUMAN
  • Q6NWU2_HUMAN
  • Q9UNX8_HUMAN

Pseudogenes.org Pseudogenes for CYP2B6 Gene

genes like me logo Genes that share paralogs with CYP2B6: view

Variants for CYP2B6 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2B6 Gene

CP2B6_HUMAN-P20813
Variability among CYP2B6 alleles may account for differential metabolism of endogenous steroids and endocannabinoids among individuals. For 16-alpha hydroxylation of testosterone, Vmax/Km values between alleles decrease in the following order: 2B6*1 > 2B6*6 > 2B6*9 > 2B7*4. For 16-beta hydroxylation of testosterone, 2B6*6 has the highest catalytic efficiency. For anandamide metabolism, 2B6*6 and 2B6*9 alleles show significantly lower rates of epoxidation (PubMed:21289075). Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIM:614546]. Efavirenz is a non-nucleoside reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz concentration in the plasma. Patients homozygous for 2B6*6 have significantly higher plasma efavirenz levels when compared to 2B6*6 heterozygous ones (PubMed:15622315, PubMed:15194512, PubMed:20639527).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP2B6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs139801276 Drug Response: Efavirenz response 41,004,303(+) T/C MISSENSE_VARIANT
rs186335453 Drug Response: Efavirenz response 41,004,158(+) G/T MISSENSE_VARIANT
rs2279343 Drug Response: Efavirenz response; efavirenz response - Metabolism/PK. - 41,009,358(+) A/Gp.Lys262Arg MISSENSE_VARIANT
rs2279345 Drug Response: efavirenz response - Metabolism/PK 41,009,797(+) T/C INTRON_VARIANT
rs281864907 Drug Response: Efavirenz response 41,004,015(+) T/A NONSENSE

Additional dbSNP identifiers (rs#s) for CYP2B6 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP2B6 Gene

Variant ID Type Subtype PubMed ID
dgv3545n100 CNV loss 25217958
dgv3546n100 CNV gain 25217958
dgv408n27 CNV loss 19166990
dgv55n17 CNV loss 16327808
dgv6453n54 CNV loss 21841781
esv24009 CNV gain 19812545
esv2597443 CNV loss 19546169
esv2658055 CNV deletion 23128226
esv2718571 CNV deletion 23290073
esv2718572 CNV deletion 23290073
esv2758762 CNV gain+loss 17122850
esv2760505 CNV gain+loss 21179565
esv3584954 CNV gain 24956385
esv3644370 CNV loss 21293372
esv3893208 CNV gain 25118596
nsv1058051 CNV gain 25217958
nsv1058772 CNV gain 25217958
nsv1064140 CNV gain+loss 25217958
nsv1065684 CNV gain 25217958
nsv1066637 CNV gain 25217958
nsv1125310 OTHER inversion 24896259
nsv1125483 CNV deletion 24896259
nsv1160626 CNV deletion 26073780
nsv433319 CNV loss 18776910
nsv442461 CNV loss 18776908
nsv470141 CNV loss 18288195
nsv470142 CNV gain 18288195
nsv509743 CNV insertion 20534489
nsv517597 CNV loss 19592680
nsv523686 CNV gain 19592680
nsv963136 CNV duplication 23825009

Variation tolerance for CYP2B6 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2B6 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP2B6
Human Gene Mutation Database (HGMD)
CYP2B6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2B6

Disorders for CYP2B6 Gene

MalaCards: The human disease database

(17) MalaCards diseases for CYP2B6 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
efavirenz, poor metabolism of
  • efavirenz central nervous system toxicity, susceptibility to
abacavir allergy
  • abc allergy
neonatal abstinence syndrome
  • drug withdrawal syndrome in newborn
acute frontal sinusitis
vitreous abscess
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP2B6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CYP2B6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2B6 Gene

Publications for CYP2B6 Gene

  1. Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens. (PMID: 15194512) Tsuchiya K … Oka S (Biochemical and biophysical research communications 2004) 3 4 23 41
  2. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. (PMID: 15622315) Haas DW … Acosta EP (AIDS (London, England) 2004) 3 4 23 41
  3. Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. (PMID: 20639527) Carr DF … Cortes CP (The Journal of antimicrobial chemotherapy 2010) 3 4 41
  4. Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. (PMID: 20860463) Elens L … Haufroid V (Pharmacogenomics 2010) 3 4 41
  5. The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients. (PMID: 20089352) Tan L … Yu Y (Clinical neurology and neurosurgery 2010) 3 23 41

ExternalLinks

View latest publications for CYP2B6 gene in Mastermind

Products for CYP2B6 Gene

  • Signalway ELISA kits for CYP2B6
  • Signalway Proteins for CYP2B6

Sources for CYP2B6 Gene