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This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Abacavir Allergy. Among its related pathways are Valproic acid pathway and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A13.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004497 | monooxygenase activity | IEA,IDA | 19651758 |
GO:0005506 | iron ion binding | IEA | -- |
GO:0008390 | testosterone 16-alpha-hydroxylase activity | IDA | 21289075 |
GO:0008392 | arachidonic acid epoxygenase activity | IBA | 21873635 |
GO:0008395 | steroid hydroxylase activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031090 | organelle membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
.39
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.01
.01
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2 | Drug metabolism - cytochrome P450 |
Retinol metabolism
.31
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3 | Phenytoin Pathway, Pharmacokinetics | ||
4 | Statin Pathway - Generalized, Pharmacokinetics | ||
5 | Metabolism |
.40
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006082 | organic acid metabolic process | IBA | 21873635 |
GO:0006805 | xenobiotic metabolic process | TAS | -- |
GO:0008202 | steroid metabolic process | IMP | 18356043 |
GO:0017144 | drug metabolic process | IMP | 18356043 |
GO:0019373 | epoxygenase P450 pathway | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bupropion | Approved | Pharma | Enzyme, substrate | 379 | ||
Efavirenz | Approved, Investigational | Pharma | Enzyme, substrate, inducer | Reverse transcriptase inhibitor | 441 | |
Nevirapine | Approved | Pharma | Enzyme, substrate, inducer | 231 | ||
Propofol | Approved, Investigational, Vet_approved | Pharma | Enzyme, substrate | 1563 | ||
Clopidogrel | Approved | Pharma | Enzyme, substrate, inhibitor | P2Y12 receptor antagonist | 934 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
4-Hydroxycyclophosphamide |
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40277-05-2 | ||||
parathion |
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56-38-2 | ||||
11,12,15-THETA |
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11,12-EpETrE |
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81276-02-0 |
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11,14,15-THETA |
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Compound | Action | Cas Number |
---|---|---|
ABT | 1614-12-6 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC456052 30 |
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CYP2B6 31 |
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OneToOne | |||
Cow (Bos Taurus) |
Mammalia | CYP2B6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CYP2B6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cyp2b10 30 17 31 |
|
OneToMany | |
Cyp2b19 31 |
|
OneToMany | |||
Cyp2b23 31 |
|
OneToMany | |||
Cyp2b9 31 |
|
OneToMany | |||
Cyp2b13 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Cyp2b1 30 |
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||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Cyp18a1 32 |
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Cyp303a1 32 |
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Cyp304a1 32 |
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Cyp305a1 32 |
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Worm (Caenorhabditis elegans) |
Secernentea | C50H11.15 32 |
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C12D5.7 32 |
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C45H4.17 32 |
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F41B5.4 32 |
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R08F11.3 32 |
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C45H4.2 32 |
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B0304.3 32 |
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C41G6.1 32 |
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F44C8.1 32 |
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Y49C4A.9 32 |
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B0213.12 32 |
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B0213.14 32 |
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F41B5.2 32 |
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K05D4.4 32 |
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T10H4.11 32 |
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Y5H2B.6 32 |
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B0213.10 32 |
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B0213.11 32 |
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B0213.15 32 |
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C49G7.8 32 |
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K07C6.3 32 |
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T10H4.10 32 |
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B0213.16 32 |
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C03G6.15 32 |
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F14H3.10 32 |
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K07C6.5 32 |
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K09D9.2 32 |
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T09H2.1 32 |
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K07C6.2 32 |
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SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs139801276 | Drug Response: Efavirenz response | 41,004,303(+) | T/C | MISSENSE_VARIANT | |
rs186335453 | Drug Response: Efavirenz response | 41,004,158(+) | G/T | MISSENSE_VARIANT | |
rs2279343 | Drug Response: Efavirenz response; efavirenz response - Metabolism/PK. - | 41,009,358(+) | A/Gp.Lys262Arg | MISSENSE_VARIANT | |
rs2279345 | Drug Response: efavirenz response - Metabolism/PK | 41,009,797(+) | T/C | INTRON_VARIANT | |
rs281864907 | Drug Response: Efavirenz response | 41,004,015(+) | T/A | NONSENSE |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3545n100 | CNV | loss | 25217958 |
dgv3546n100 | CNV | gain | 25217958 |
dgv408n27 | CNV | loss | 19166990 |
dgv55n17 | CNV | loss | 16327808 |
dgv6453n54 | CNV | loss | 21841781 |
esv24009 | CNV | gain | 19812545 |
esv2597443 | CNV | loss | 19546169 |
esv2658055 | CNV | deletion | 23128226 |
esv2718571 | CNV | deletion | 23290073 |
esv2718572 | CNV | deletion | 23290073 |
esv2758762 | CNV | gain+loss | 17122850 |
esv2760505 | CNV | gain+loss | 21179565 |
esv3584954 | CNV | gain | 24956385 |
esv3644370 | CNV | loss | 21293372 |
esv3893208 | CNV | gain | 25118596 |
nsv1058051 | CNV | gain | 25217958 |
nsv1058772 | CNV | gain | 25217958 |
nsv1064140 | CNV | gain+loss | 25217958 |
nsv1065684 | CNV | gain | 25217958 |
nsv1066637 | CNV | gain | 25217958 |
nsv1125310 | OTHER | inversion | 24896259 |
nsv1125483 | CNV | deletion | 24896259 |
nsv1160626 | CNV | deletion | 26073780 |
nsv433319 | CNV | loss | 18776910 |
nsv442461 | CNV | loss | 18776908 |
nsv470141 | CNV | loss | 18288195 |
nsv470142 | CNV | gain | 18288195 |
nsv509743 | CNV | insertion | 20534489 |
nsv517597 | CNV | loss | 19592680 |
nsv523686 | CNV | gain | 19592680 |
nsv963136 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
efavirenz, poor metabolism of |
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abacavir allergy |
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neonatal abstinence syndrome |
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acute frontal sinusitis |
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vitreous abscess |
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