CYP2A13 Gene (Protein Coding)

Cytochrome P450 Family 2 Subfamily A Member 13

GC19P041088
GIFtS:
42
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(me... See more...

Aliases for CYP2A13 Gene

Aliases for CYP2A13 Gene

  • Cytochrome P450 Family 2 Subfamily A Member 13 2 3 5
  • Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 13 2 3
  • Cytochrome P450, Family 2, Subfamily A, Polypeptide 13 2 3
  • Cytochrome P450 2A13 3 4
  • EC 1.14.14.1 4 50
  • CYPIIA13 3 4
  • CYP2A 2 3
  • CPAD 2 3
  • CYP2A13 5

External Ids for CYP2A13 Gene

Previous GeneCards Identifiers for CYP2A13 Gene

  • GC19P042233
  • GC19P041986
  • GC19P046108
  • GC19P046126
  • GC19P046130
  • GC19P046286
  • GC19P041594
  • GC19P038026

Summaries for CYP2A13 Gene

Entrez Gene Summary for CYP2A13 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2A13 Gene

CYP2A13 (Cytochrome P450 Family 2 Subfamily A Member 13) is a Protein Coding gene. Diseases associated with CYP2A13 include Distal Muscular Dystrophy With Anterior Tibial Onset and Acetaminophen Metabolism. Among its related pathways are Drug metabolism - cytochrome P450 and Androstenedione and testosterone biosynthesis and metabolism p.1. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2A6.

UniProtKB/Swiss-Prot Summary for CYP2A13 Gene

  • Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.

Gene Wiki entry for CYP2A13 Gene

PharmGKB "VIP" Summary for CYP2A13 Gene

Additional gene information for CYP2A13 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP2A13 Gene

Genomics for CYP2A13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CYP2A13 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J041089 Enhancer 0.4 Ensembl 250.7 +1.4 1384 0.9 EGR1 ZNF366 ZBTB6 ZFHX2 CYP2A13 CYP2F1 HSALNG0126164-001 HSALNG0126164-002
GH19J041088 Promoter 0.3 EPDnew 250.7 0.0 -19 0.1 CYP2A13 HSALNG0126164-001 HSALNG0126164-002 ENSG00000271299 lnc-CYP2A7-1 CYP2B6
GH19J041135 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.8 +47.3 47250 2.2 CYP2T3P lnc-CYP2F1-1 piR-57430-002 CYP2F1 CYP2A13 ENSG00000205041 B3GNT8 BCKDHA lnc-TGFB1-7 CYP2S1
GH19J040747 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2 -335.7 -335690 9.8 BCLAF1 SP1 ZNF207 IKZF1 MYC NCOR1 ZNF600 SIX5 ZNF580 ZNF592 SNRPA C19orf54 HNRNPUL1 ENSG00000269843 ZNF780A COQ8B AKT2 CCDC97 ITPKC FBL
GH19J041127 Enhancer 0.8 ENCODE 5.7 +39.5 39461 0.8 IKZF1 NFIC ZIC2 ZBTB10 ZNF341 ZNF217 CTBP1 ZNF610 SP2 RXRA CYP2F1 CYP2A13 CYP2T3P lnc-TGFB1-7 CYP2S1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP2A13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP2A13

Top Transcription factor binding sites by QIAGEN in the CYP2A13 gene promoter:
  • C/EBPalpha
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • Sp1

Genomic Locations for CYP2A13 Gene

Latest Assembly
chr19:41,088,451-41,096,195
(GRCh38/hg38)
Size:
7,745 bases
Orientation:
Plus strand

Previous Assembly
chr19:41,594,356-41,602,100
(GRCh37/hg19 by Entrez Gene)
Size:
7,745 bases
Orientation:
Plus strand

chr19:41,594,377-41,602,100
(GRCh37/hg19 by Ensembl)
Size:
7,724 bases
Orientation:
Plus strand

Genomic View for CYP2A13 Gene

Genes around CYP2A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2A13 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP2A13 Gene

Proteins for CYP2A13 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for CYP2A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16696-CP2AD_HUMAN
    Recommended name:
    Cytochrome P450 2A13
    Protein Accession:
    Q16696
    Secondary Accessions:
    • Q53YR8
    • Q6R569
    • Q6R570
    • Q9H2X2

    Protein attributes for CYP2A13 Gene

    Size:
    494 amino acids
    Molecular mass:
    56688 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2A13 Gene

neXtProt entry for CYP2A13 Gene

Selected DME Specific Peptides for CYP2A13 Gene

Q16696:
  • EIDRVIG
  • DFIAKKVE
  • LFFAGTET
  • IDPTFFLSRTVSNVISS
  • EEFSGRG
  • DKEFLSLLRMMLG
  • SVMKHLPG
  • LGPRRVVVL
  • LLLMKHP
  • PGPTPLP
  • NQRTLDPNSP
  • SPRDFID
  • AVIHEIQR
  • FIDSFLI
  • DRAKMPY
  • EALVDQAE
  • PKGTEVFP
  • GERAKQL
  • KMPYTEAVI
  • PFSIGKR
  • GEGLARME
  • LPFIGNY
  • GKLPPGP
  • EERIQEE
  • VKEALVD
  • GKRYCFGE
  • FFTTIMQNF
  • TLRYGFLL

Post-translational modifications for CYP2A13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2A13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for CYP2A13

Domains & Families for CYP2A13 Gene

Gene Families for CYP2A13 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CYP2A13 Gene

InterPro:
Blocks:
  • E-class P450 group I signature
  • CYP2A P450 family signature

Suggested Antigen Peptide Sequences for CYP2A13 Gene

GenScript: Design optimal peptide antigens:
  • CYPIIA13 (CP2AD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16696

UniProtKB/Swiss-Prot:

CP2AD_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2A13: view

Function for CYP2A13 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for CYP2A13 Gene

UniProtKB/Swiss-Prot Function:
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.7 uM for phenacetin {ECO:0000269|PubMed:18779312};
GENATLAS Biochemistry:
cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 13

Enzyme Numbers (IUBMB) for CYP2A13 Gene

Phenotypes From GWAS Catalog for CYP2A13 Gene

Gene Ontology (GO) - Molecular Function for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS --
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA 21873635
GO:0008395 steroid hydroxylase activity IBA 21873635
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CYP2A13: view
genes like me logo Genes that share phenotypes with CYP2A13: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2A13

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP2A13 Gene

Localization for CYP2A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2A13 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2A13 gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with CYP2A13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP2A13 Gene

Pathways & Interactions for CYP2A13 Gene

genes like me logo Genes that share pathways with CYP2A13: view

Pathways by source for CYP2A13 Gene

1 PharmGKB pathway for CYP2A13 Gene
2 GeneGo (Thomson Reuters) pathways for CYP2A13 Gene
  • Acetaminophen metabolism
  • Androstenedione and testosterone biosynthesis and metabolism p.1

Gene Ontology (GO) - Biological Process for CYP2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IBA 21873635
GO:0006805 xenobiotic metabolic process TAS --
GO:0009804 coumarin metabolic process TAS --
GO:0019373 epoxygenase P450 pathway IBA 21873635
GO:0042738 exogenous drug catabolic process IBA 21873635
genes like me logo Genes that share ontologies with CYP2A13: view

No data available for SIGNOR curated interactions for CYP2A13 Gene

Drugs & Compounds for CYP2A13 Gene

Products:

  1. Drug products for research

(29) Drugs for CYP2A13 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotine Approved Pharma Enzyme, substrate 1617
Methoxsalen Approved Pharma Enzyme, inhibitor 49
Testosterone Approved, Investigational Pharma Enzyme, substrate Endogenous androgen receptor agonist 711
Testosterone cypionate Approved Pharma Enzyme, substrate 0
Testosterone enanthate Approved Pharma Enzyme, substrate 344

(23) Additional Compounds for CYP2A13 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-Epoxyeicosatrienoic acid
  • (11S,12R)-EpETrE
  • (11S,12R)-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
  • (11S,12R)-Epoxy-(5Z,8Z,14Z)-icosatrienoic acid
  • 11(S),12(R)-EET
  • 11(S),12(R)-EpETrE
 123931-40-8
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosatrienoic acid
  • 11,14,15-Trihydroxy-(5Z,8Z,12E)-eicosatrienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoic acid
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
 219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid
genes like me logo Genes that share compounds with CYP2A13: view

Transcripts for CYP2A13 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for CYP2A13 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP2A13

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2A13 Gene

No ASD Table

Relevant External Links for CYP2A13 Gene

GeneLoc Exon Structure for
CYP2A13

Expression for CYP2A13 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP2A13 Gene

mRNA expression in normal human tissues for CYP2A13 Gene
mRNA expression by GTEx for CYP2A13 GenemRNA expression by BioGPS for CYP2A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for CYP2A13 Gene

This gene is overexpressed in Liver (x19.9), Cervix - Ectocervix (x5.5), Testis (x5.3), Minor Salivary Gland (x5.3), and Vagina (x4.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP2A13

SOURCE GeneReport for Unigene cluster for CYP2A13 Gene:

Hs.567252

mRNA Expression by UniProt/SwissProt for CYP2A13 Gene:

Q16696-CP2AD_HUMAN
Tissue specificity: Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.

Evidence on tissue expression from TISSUES for CYP2A13 Gene

  • Liver(3)
genes like me logo Genes that share expression patterns with CYP2A13: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2A13 Gene

Orthologs for CYP2A13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2A13 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia -- 30
  • 92 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia CYP2A13 30 30
  • 88 (a)
 ManyToMany
Mouse
(Mus musculus)
 Mammalia Cyp2a4 30
  • 87 (a)
 ManyToMany
Cyp2a5 29 30
  • 85.49 (n)
 ManyToMany
Cyp2a12 30
  • 74 (a)
 ManyToMany
Cyp2a22 30
  • 73 (a)
 ManyToMany
Chimpanzee
(Pan troglodytes)
 Mammalia -- 30
  • 87 (a)
 ManyToMany
Rat
(Rattus norvegicus)
 Mammalia Cyp2a3 29
  • 85.63 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 46 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 60 (a)
 ManyToMany
-- 30
  • 60 (a)
 ManyToMany
-- 30
  • 60 (a)
 ManyToMany
-- 30
  • 55 (a)
 ManyToMany
-- 30
  • 54 (a)
 ManyToMany
-- 30
  • 54 (a)
 ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC548374 29
  • 58.87 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.43 29
Zebrafish
(Danio rerio)
 Actinopterygii zgc55856 29
Fruit Fly
(Drosophila melanogaster)
 Insecta Cyp303a1 31
  • 28 (a)
Cyp304a1 31
  • 27 (a)
Worm
(Caenorhabditis elegans)
 Secernentea cyp-36A1 29
  • 43.1 (n)
C50H11.15 31
  • 34 (a)
K09A11.3 31
  • 34 (a)
C34B7.3 31
  • 33 (a)
C49C8.4 31
  • 32 (a)
F41B5.3 31
  • 32 (a)
F42A9.5 31
  • 32 (a)
K05D4.4 31
  • 32 (a)
K09A11.2 31
  • 32 (a)
K09A11.4 31
  • 32 (a)
C45H4.17 31
  • 31 (a)
R08F11.3 31
  • 31 (a)
Y49C4A.9 31
  • 31 (a)
B0213.11 31
  • 30 (a)
B0213.15 31
  • 30 (a)
B0304.3 31
  • 30 (a)
C03G6.15 31
  • 30 (a)
F14H3.10 31
  • 30 (a)
F41B5.2 31
  • 30 (a)
F41B5.4 31
  • 30 (a)
F44C8.1 31
  • 30 (a)
K07C6.2 31
  • 30 (a)
K07C6.3 31
  • 30 (a)
T10H4.10 31
  • 30 (a)
T10H4.11 31
  • 30 (a)
B0213.14 31
  • 29 (a)
C49G7.8 31
  • 29 (a)
F41B5.7 31
  • 29 (a)
K07C6.5 31
  • 29 (a)
K09D9.2 31
  • 29 (a)
Y5H2B.6 31
  • 29 (a)
B0213.10 31
  • 28 (a)
C03G6.14 31
  • 28 (a)
C12D5.7 31
  • 27 (a)
C25E10.2 31
  • 27 (a)
C41G6.1 31
  • 26 (a)
Species where no ortholog for CYP2A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CYP2A13 Gene

ENSEMBL:
Gene Tree for CYP2A13 (if available)
TreeFam:
Gene Tree for CYP2A13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP2A13: view image
Alliance of Genome Resources:
Additional Orthologs for CYP2A13

Paralogs for CYP2A13 Gene

Paralogs for CYP2A13 Gene

(25) SIMAP similar genes for CYP2A13 Gene using alignment to 1 proteins:

  • CP2AD_HUMAN

Pseudogenes.org Pseudogenes for CYP2A13 Gene

genes like me logo Genes that share paralogs with CYP2A13: view

Variants for CYP2A13 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2A13 Gene

CP2AD_HUMAN-Q16696
The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP2A13 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs112337232 -- p.Asp158Glu
rs138870349 -- p.Arg494Cys
rs148044792 -- p.Arg101Gln
rs72547590 -- p.Phe453Tyr
rs8192784 -- p.Arg25Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CYP2A13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CYP2A13 Gene

Variant ID Type Subtype PubMed ID
nsv1065684 CNV gain 25217958
nsv1066637 CNV gain 25217958
nsv1125310 OTHER inversion 24896259
nsv2491 CNV deletion 18451855
nsv978819 CNV duplication 23825009

Variation tolerance for CYP2A13 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP2A13 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP2A13
Human Gene Mutation Database (HGMD)
CYP2A13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2A13
Leiden Open Variation Database (LOVD)
CYP2A13

SNP Genotyping and Copy Number Assays for research

Disorders for CYP2A13 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CYP2A13 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
distal muscular dystrophy with anterior tibial onset
  • dmat
acetaminophen metabolism
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP2A13

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CYP2A13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2A13 Gene

Publications for CYP2A13 Gene

  1. Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility. (PMID: 15063809) Cauffiez C … Broly F (Biochemical and biophysical research communications 2004) 3 4 22 40
  2. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PMID: 7668294) Fernandez-Salguero P … Idle JR (American journal of human genetics 1995) 2 3 4 22
  3. CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. (PMID: 19812523) Mohelnikova-Duchonova B … Soucek P (Pancreas 2010) 3 22 40
  4. CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences. (PMID: 19414505) Timofeeva MN … Wichmann HE (Carcinogenesis 2009) 3 22 40
  5. Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China. (PMID: 19303722) Song DK … Qiao BP (Cancer detection and prevention 2009) 3 22 40

ExternalLinks

View latest publications for CYP2A13 gene in Mastermind

Products for CYP2A13 Gene

Sources for CYP2A13 Gene