This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation ac... See more...

Aliases for CYP26A1 Gene

Aliases for CYP26A1 Gene

  • Cytochrome P450 Family 26 Subfamily A Member 1 2 3 5
  • P450RAI1 2 3 4
  • CYP26 2 3 4
  • Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily XXVIA, Polypeptide 1 2 3
  • Cytochrome P450 Retinoic Acid-Inactivating 1 3 4
  • Retinoic Acid-Metabolizing Cytochrome 3 4
  • Retinoic Acid 4-Hydroxylase 3 4
  • Cytochrome P450 26A1 3 4
  • Cytochrome P450RAI 3 4
  • HP450RAI 3 4
  • P450RAI 2 3
  • CP26 2 3
  • P450, Retinoic Acid-Inactivating, 1 3
  • EC 1.14.13.- 4
  • CYP26A1 5

External Ids for CYP26A1 Gene

Previous GeneCards Identifiers for CYP26A1 Gene

  • GC10P093726
  • GC10P094066
  • GC10P094953
  • GC10P094486
  • GC10P094497
  • GC10P094823
  • GC10P088460

Summaries for CYP26A1 Gene

Entrez Gene Summary for CYP26A1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP26A1 Gene

CYP26A1 (Cytochrome P450 Family 26 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP26A1 include Embryonal Carcinoma and Keratomalacia. Among its related pathways are Signaling by Retinoic Acid and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP26C1.

UniProtKB/Swiss-Prot Summary for CYP26A1 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers (PubMed:22020119, PubMed:9228017, PubMed:9716180). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021).

Tocris Summary for CYP26A1 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

Gene Wiki entry for CYP26A1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP26A1 Gene

Genomics for CYP26A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYP26A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J093071 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 257.1 -0.1 -58 3.2 MYC NCOR1 IKZF1 ZNF600 ZNF592 ZNF10 ZSCAN16 ZIC2 ZBTB10 YY1 CYP26A1 ENSG00000279607 EXOC6 ENSG00000285846 CYP26C1
GH10J093063 Promoter/Enhancer 0.8 EPDnew ENCODE 250.4 -10.7 -10663 0.2 CTCF RAD21 ZNF143 BACH1 ENSG00000226425 ENSG00000285846 CYP26A1 CYP26C1
GH10J093375 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +303.5 303524 2.9 ZNF654 CTCF REST TRIM22 HOMEZ RAD21 IRF4 RFX5 SMC3 MIER3 MYOF CYP26A1 HHEX RF00017-667 MK280144-056
GH10J093106 Enhancer 0.9 ENCODE 11.8 +33.3 33344 0.2 CEBPA YY1 FOXA1 HOMEZ THAP11 FOXA2 KDM6A SMAD4 RXRA SAP130 NIP7P1 lnc-MYOF-3 CYP26A1 piR-38580-042 MYOF
GH10J093267 Enhancer 0.9 Ensembl ENCODE 10.8 +194.5 194450 1.5 BCLAF1 SP1 BCL11A TRIM22 IRF4 EBF1 CBFB BHLHE40 BATF ELF1 CYP26A1 HSALNG0079741 RF00017-666 MYOF
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP26A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP26A1

Top Transcription factor binding sites by QIAGEN in the CYP26A1 gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for CYP26A1 Gene

Latest Assembly
chr10:93,073,475-93,077,885
(GRCh38/hg38)
Size:
4,411 bases
Orientation:
Plus strand

Previous Assembly
chr10:94,833,232-94,837,642
(GRCh37/hg19 by Entrez Gene)
Size:
4,411 bases
Orientation:
Plus strand

chr10:94,833,232-94,837,647
(GRCh37/hg19 by Ensembl)
Size:
4,416 bases
Orientation:
Plus strand

Genomic View for CYP26A1 Gene

Genes around CYP26A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP26A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP26A1 Gene

Proteins for CYP26A1 Gene

  • Protein details for CYP26A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43174-CP26A_HUMAN
    Recommended name:
    Cytochrome P450 26A1
    Protein Accession:
    O43174
    Secondary Accessions:
    • B3KNI4
    • Q5VXH9
    • Q5VXI0

    Protein attributes for CYP26A1 Gene

    Size:
    497 amino acids
    Molecular mass:
    56199 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP26A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP26A1 Gene

Post-translational modifications for CYP26A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP26A1 Gene

Antibodies for research

  • Abcam antibodies for CYP26A1

No data available for DME Specific Peptides for CYP26A1 Gene

Domains & Families for CYP26A1 Gene

Gene Families for CYP26A1 Gene

Protein Domains for CYP26A1 Gene

InterPro:
Blocks:
  • E-class P450 group IV signature

Suggested Antigen Peptide Sequences for CYP26A1 Gene

GenScript: Design optimal peptide antigens:
  • Retinoic acid-metabolizing cytochrome (CP26A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43174

UniProtKB/Swiss-Prot:

CP26A_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP26A1: view

Function for CYP26A1 Gene

Molecular function for CYP26A1 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers (PubMed:22020119, PubMed:9228017, PubMed:9716180). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51492, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134185; Evidence={ECO:0000269|PubMed:22020119};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:51632, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:134185, ChEBI:CHEBI:134233; Evidence={ECO:0000269|PubMed:22020119};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:55856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:139258; Evidence={ECO:0000269|PubMed:22020119};.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=50.1 nM for all-trans-retinoate (4-hydroxylation) {ECO:0000269|PubMed:22020119}; KM=48.9 nM for all-trans-retinoate (18-hydroxylation) {ECO:0000269|PubMed:22020119}; KM=0.24 uM for tazarotenic acid (tazarotenic acid sulfoxide formation) {ECO:0000269|PubMed:26937021}; KM=0.39 uM for tazarotenic acid (hydroxytazarotenic acid formation) {ECO:0000269|PubMed:26937021}; Vmax=9.5 pmol/min/pmol enzyme toward all-trans-retinoate (4-hydroxylation) {ECO:0000269|PubMed:22020119}; Vmax=5.0 pmol/min/pmol enzyme toward all-trans-retinoate (18-hydroxylation) {ECO:0000269|PubMed:22020119};
GENATLAS Biochemistry:
cytochrome p450,family XXVI,involved in extrahepatic metabolism of retinoic acid

Enzyme Numbers (IUBMB) for CYP26A1 Gene

Phenotypes From GWAS Catalog for CYP26A1 Gene

Gene Ontology (GO) - Molecular Function for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 10823918
GO:0004497 monooxygenase activity IBA 21873635
GO:0005506 iron ion binding IEA --
GO:0008401 retinoic acid 4-hydroxylase activity IDA 9228017
GO:0016491 oxidoreductase activity IBA 21873635
genes like me logo Genes that share ontologies with CYP26A1: view
genes like me logo Genes that share phenotypes with CYP26A1: view

Animal Models for CYP26A1 Gene

MGI Knock Outs for CYP26A1:

miRNA for CYP26A1 Gene

miRTarBase miRNAs that target CYP26A1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP26A1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP26A1 Gene

Localization for CYP26A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP26A1 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP26A1 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CYP26A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP26A1 Gene

Pathways & Interactions for CYP26A1 Gene

genes like me logo Genes that share pathways with CYP26A1: view

Gene Ontology (GO) - Biological Process for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006766 vitamin metabolic process TAS --
GO:0006805 xenobiotic metabolic process IDA 26937021
GO:0016125 sterol metabolic process IBA 21873635
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with CYP26A1: view

No data available for SIGNOR curated interactions for CYP26A1 Gene

Drugs & Compounds for CYP26A1 Gene

(12) Drugs for CYP26A1 Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Enzyme, substrate, inducer 747
Ketoconazole Approved, Investigational Pharma Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 196
Tretinoin Approved, Investigational Nutra Target 288
Acitretin Approved Pharma Metabolite of etretinate 33
Anastrozole Approved, Investigational Pharma Aromatase inhibitor, Potent aromatase (CYP19) inhibitor, Aromatase Inhibitors, Hormone therapy 354

(6) Additional Compounds for CYP26A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for CYP26A1 Gene

Compound Action Cas Number
Anastrozole Potent aromatase (CYP19) inhibitor 120511-73-1
Exemestane Steroidal aromatase (CYP19) inhibitor 107868-30-4
Ketoconazole Cytochrome P450c17 inhibitor 65277-42-1
TMS Cytochrome P450 1B1 inhibitor 24144-92-1
YM 511 Potent aromatase (CYP19) inhibitor 148869-05-0
genes like me logo Genes that share compounds with CYP26A1: view

Transcripts for CYP26A1 Gene

mRNA/cDNA for CYP26A1 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP26A1

Alternative Splicing Database (ASD) splice patterns (SP) for CYP26A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: -
SP6:

Relevant External Links for CYP26A1 Gene

GeneLoc Exon Structure for
CYP26A1

Expression for CYP26A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP26A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP26A1 Gene

This gene is overexpressed in Liver (x34.1).

Protein differential expression in normal tissues from HIPED for CYP26A1 Gene

This gene is overexpressed in Breast (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP26A1 Gene



Protein tissue co-expression partners for CYP26A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP26A1

SOURCE GeneReport for Unigene cluster for CYP26A1 Gene:

Hs.150595

mRNA Expression by UniProt/SwissProt for CYP26A1 Gene:

O43174-CP26A_HUMAN
Tissue specificity: Expressed in most fetal and adult tissues with highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain (PubMed:9826557). Expressed at high levels in lung, pancreas, skin and uterus (at protein level) (PubMed:22020119). Lower expression level is detected in spleen, kidney, intestine and adipose tissue (at protein level) (PubMed:22020119).

Evidence on tissue expression from TISSUES for CYP26A1 Gene

  • Liver(2.7)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with CYP26A1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP26A1 Gene

Orthologs for CYP26A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP26A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CYP26A1 30
  • 100 (a)
OneToOne
LOC450614 29
  • 99.8 (n)
Dog
(Canis familiaris)
Mammalia CYP26C1 30
  • 95 (a)
OneToOne
CYP26A1 29
  • 92.42 (n)
Cow
(Bos Taurus)
Mammalia CYP26A1 29 30
  • 91.95 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cyp26a1 29 16 30
  • 89.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cyp26a1 29
  • 87.86 (n)
Oppossum
(Monodelphis domestica)
Mammalia CYP26A1 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CYP26A1 29 30
  • 77.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CYP26A1 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cyp26a1 29
  • 67.85 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398094 29
Zebrafish
(Danio rerio)
Actinopterygii cyp26a1 29 30
  • 65.85 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Cyp313a3 30
  • 20 (a)
ManyToMany
Cyp313a1 30
  • 20 (a)
ManyToMany
Cyp313a4 30
  • 20 (a)
ManyToMany
Cyp313a5 30
  • 20 (a)
ManyToMany
Cyp313a2 30
  • 20 (a)
ManyToMany
Cyp313b1 30
  • 19 (a)
ManyToMany
Cyp318a1 30
  • 15 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG11 30
  • 20 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYP716A2 29
  • 44.56 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0520300 29
  • 45.49 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5303 30
  • 33 (a)
ManyToMany
-- 30
  • 31 (a)
ManyToMany
Species where no ortholog for CYP26A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CYP26A1 Gene

ENSEMBL:
Gene Tree for CYP26A1 (if available)
TreeFam:
Gene Tree for CYP26A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP26A1: view image
Alliance of Genome Resources:
Additional Orthologs for CYP26A1

Paralogs for CYP26A1 Gene

Paralogs for CYP26A1 Gene

(3) SIMAP similar genes for CYP26A1 Gene using alignment to 1 proteins:

  • CP26A_HUMAN
genes like me logo Genes that share paralogs with CYP26A1: view

Variants for CYP26A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP26A1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs35355587 Benign: not provided 93,074,811(+) C/G
NM_000783.4(CYP26A1):c.447C>G (p.Leu149=)
SYNONYMOUS
rs60549655 Benign: not provided 93,074,796(+) C/T
NM_000783.4(CYP26A1):c.432C>T (p.Phe144=)
SYNONYMOUS
rs73319400 Benign: not provided 93,077,001(+) T/C
NM_000783.4(CYP26A1):c.1191T>C (p.Ser397=)
SYNONYMOUS
rs777202473 Not Provided: not provided 93,075,866(+) A/G
NM_000783.4(CYP26A1):c.905A>G (p.His302Arg)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CYP26A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CYP26A1 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP26A1 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP26A1
Human Gene Mutation Database (HGMD)
CYP26A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP26A1
Leiden Open Variation Database (LOVD)
CYP26A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYP26A1 Gene

Disorders for CYP26A1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for CYP26A1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
keratomalacia
  • night blindness
acute promyelocytic leukemia
  • apl
hypervitaminosis a
  • hypervitaminosis a, susceptibility to
neural tube defects
  • neural tube defects, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP26A1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CYP26A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP26A1 Gene

Publications for CYP26A1 Gene

  1. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. (PMID: 9228017) White JA … Petkovich M (The Journal of biological chemistry 1997) 2 3 4 22
  2. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. (PMID: 9716180) Sonneveld E … van der Saag PT (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998) 3 4 22
  3. Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues. (PMID: 9826557) Trofimova-Griffin ME … Juchau MR (Biochemical and biophysical research communications 1998) 3 4 22
  4. Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1. (PMID: 26937021) Foti RS … Douguet D (The Journal of pharmacology and experimental therapeutics 2016) 3 4
  5. Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases. (PMID: 22020119) Topletz AR … Isoherranen N (Biochemical pharmacology 2012) 3 4

Products for CYP26A1 Gene

Sources for CYP26A1 Gene