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Aliases for CYP20A1 Gene

Aliases for CYP20A1 Gene

  • Cytochrome P450 Family 20 Subfamily A Member 1 2 3 5
  • Cytochrome P450, Family 20, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450 Monooxygenase 3
  • Cytochrome P450 20A1 3
  • EC 1.14.-.- 4
  • CYP-M 3

External Ids for CYP20A1 Gene

Previous GeneCards Identifiers for CYP20A1 Gene

  • GC02P202828
  • GC02P204067
  • GC02P204305
  • GC02P203928
  • GC02P203811
  • GC02P195951
  • GC02P204103

Summaries for CYP20A1 Gene

Entrez Gene Summary for CYP20A1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP20A1 Gene

CYP20A1 (Cytochrome P450 Family 20 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.

Gene Wiki entry for CYP20A1 Gene

Additional gene information for CYP20A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP20A1 Gene

Genomics for CYP20A1 Gene

GeneHancer (GH) Regulatory Elements for CYP20A1 Gene

Promoters and enhancers for CYP20A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J203237 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.2 +0.8 829 3.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 POLR2B CYP20A1 PIR57218 GC02M203237 NOP58 CARF ICA1L
GH02J202264 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -972.1 -972135 3.9 HDGF HNRNPUL1 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NOP58 LOC100420110 NBEAL1 RPL12P16 CYP20A1 ENSG00000273456 FAM117B PIR47513 GC02P202236
GH02J204108 Enhancer 1 Ensembl ENCODE 11.9 +872.2 872181 4.3 PKNOX1 NEUROD1 SIN3A NFXL1 BMI1 BATF RAD21 EGR1 ZSCAN5C ATF7 RPL12P16 CYP20A1 GC02P204110 ENSG00000234714 ENSG00000237271
GH02J202910 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.8 -326.4 -326440 3.2 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF207 CARF GC02M202910 WDR12 NBEAL1 NOP58 RPL12P16 CYP20A1 GC02M202888
GH02J203327 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.6 +90.2 90198 3.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SP3 SP5 ENSG00000256458 ABI2 GC02P203326 ICA1L CYP20A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYP20A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP20A1 gene promoter:

Genomic Locations for CYP20A1 Gene

Genomic Locations for CYP20A1 Gene
chr2:203,238,441-203,305,840
(GRCh38/hg38)
Size:
67,400 bases
Orientation:
Plus strand
chr2:204,103,164-204,170,563
(GRCh37/hg19)

Genomic View for CYP20A1 Gene

Genes around CYP20A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP20A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP20A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP20A1 Gene

Proteins for CYP20A1 Gene

  • Protein details for CYP20A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW02-CP20A_HUMAN
    Recommended name:
    Cytochrome P450 20A1
    Protein Accession:
    Q6UW02
    Secondary Accessions:
    • Q4ZG61
    • Q8N4Q8
    • Q8WWA9
    • Q9HC04

    Protein attributes for CYP20A1 Gene

    Size:
    462 amino acids
    Molecular mass:
    52432 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP20A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP20A1 Gene

Post-translational modifications for CYP20A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYP20A1 Gene

Domains & Families for CYP20A1 Gene

Gene Families for CYP20A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CYP20A1 Gene

Suggested Antigen Peptide Sequences for CYP20A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UW02

UniProtKB/Swiss-Prot:

CP20A_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP20A1: view

Function for CYP20A1 Gene

Molecular function for CYP20A1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Enzyme Numbers (IUBMB) for CYP20A1 Gene

Phenotypes From GWAS Catalog for CYP20A1 Gene

Gene Ontology (GO) - Molecular Function for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP20A1: view
genes like me logo Genes that share phenotypes with CYP20A1: view

Animal Models for CYP20A1 Gene

MGI Knock Outs for CYP20A1:
  • Cyp20a1 Cyp20a1<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for CYP20A1 Gene

miRTarBase miRNAs that target CYP20A1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP20A1 Gene

Localization for CYP20A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP20A1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP20A1 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
cytoskeleton 2
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cell Junctions (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Pathways & Interactions for CYP20A1 Gene

genes like me logo Genes that share pathways with CYP20A1: view

Pathways by source for CYP20A1 Gene

2 BioSystems pathways for CYP20A1 Gene

Gene Ontology (GO) - Biological Process for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

No data available for SIGNOR curated interactions for CYP20A1 Gene

Drugs & Compounds for CYP20A1 Gene

(20) Drugs for CYP20A1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
heme Pharma Agonist 0

(22) Additional Compounds for CYP20A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CYP20A1: view

Transcripts for CYP20A1 Gene

Unigene Clusters for CYP20A1 Gene

Cytochrome P450, family 20, subfamily A, polypeptide 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP20A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: -

Relevant External Links for CYP20A1 Gene

GeneLoc Exon Structure for
CYP20A1
ECgene alternative splicing isoforms for
CYP20A1

Expression for CYP20A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP20A1 Gene

Protein differential expression in normal tissues from HIPED for CYP20A1 Gene

This gene is overexpressed in Nasal epithelium (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP20A1 Gene



Protein tissue co-expression partners for CYP20A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP20A1 Gene:

CYP20A1

SOURCE GeneReport for Unigene cluster for CYP20A1 Gene:

Hs.446065

Evidence on tissue expression from TISSUES for CYP20A1 Gene

  • Liver(4.4)
  • Blood(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CYP20A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP20A1 Gene

Orthologs for CYP20A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP20A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP20A1 34 33
  • 99.57 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100686469 33
  • 90.73 (n)
CYP20A1 34
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYP20A1 34 33
  • 90.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp20a1 16 34 33
  • 84.63 (n)
rat
(Rattus norvegicus)
Mammalia Cyp20a1 33
  • 83.77 (n)
oppossum
(Monodelphis domestica)
Mammalia CYP20A1 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves CYP20A1 34 33
  • 72.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYP20A1 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp20a1 33
  • 69.92 (n)
Str.3243 33
African clawed frog
(Xenopus laevis)
Amphibia MGC52842 33
zebrafish
(Danio rerio)
Actinopterygii cyp20a1 34 33
  • 64.28 (n)
OneToOne
wufa10c06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9531 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1645 34
  • 26 (a)
OneToMany
-- 34
  • 26 (a)
OneToMany
Species where no ortholog for CYP20A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP20A1 Gene

ENSEMBL:
Gene Tree for CYP20A1 (if available)
TreeFam:
Gene Tree for CYP20A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP20A1: view image

Paralogs for CYP20A1 Gene

(1) SIMAP similar genes for CYP20A1 Gene using alignment to 8 proteins:

  • CP20A_HUMAN
  • C9J8K7_HUMAN
  • E9PHG5_HUMAN
  • F2Z3K6_HUMAN
  • F8WBE2_HUMAN
  • Q53RS5_HUMAN
  • Q567U3_HUMAN
  • Q9HC04_HUMAN
genes like me logo Genes that share paralogs with CYP20A1: view

No data available for Paralogs for CYP20A1 Gene

Variants for CYP20A1 Gene

Sequence variations from dbSNP and Humsavar for CYP20A1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000065184 -- 203,297,639(+) C/A/G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000080031 -- 203,274,172(+) A/C intron_variant
rs1000088013 -- 203,281,945(+) T/A intron_variant
rs1000101987 -- 203,261,973(+) C/A intron_variant
rs1000352902 -- 203,268,987(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP20A1 Gene

Variant ID Type Subtype PubMed ID
esv2721371 CNV deletion 23290073
esv3362872 CNV insertion 20981092
esv3426487 CNV insertion 20981092
esv3594009 CNV loss 21293372
esv3594010 CNV loss 21293372
esv3594011 CNV loss 21293372
nsv1001799 CNV gain 25217958
nsv1142294 CNV tandem duplication 24896259

Variation tolerance for CYP20A1 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.76; 94.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP20A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP20A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP20A1 Gene

Disorders for CYP20A1 Gene

Additional Disease Information for CYP20A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYP20A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP20A1 Gene

Publications for CYP20A1 Gene

  1. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka DC … Mohlke KL (Obesity (Silver Spring, Md.) 2011) 3 44 58
  2. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross CJ … CPNDS Consortium (Nature genetics 2009) 3 44 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for CYP20A1 Gene

Sources for CYP20A1 Gene

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