This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons ... See more...

Aliases for CYP1B1 Gene

Aliases for CYP1B1 Gene

  • Cytochrome P450 Family 1 Subfamily B Member 1 2 3 5
  • Cytochrome P450, Subfamily I (Dioxin-Inducible), Polypeptide 1 (Glaucoma 3, Primary Infantile) 2 3
  • Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 2 3
  • Hydroperoxy Icosatetraenoate Dehydratase 3 4
  • Cytochrome P450 1B1 3 4
  • CYPIB1 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Dioxin-Inducible Cytochrome P450 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • EC 1.14.14.1 54
  • EC 1.14.14.- 4
  • EC 4.2.1.152 4
  • P4501B1 3
  • ASGD6 3
  • GLC3A 3
  • CP1B 3

External Ids for CYP1B1 Gene

Previous HGNC Symbols for CYP1B1 Gene

  • GLC3A

Previous GeneCards Identifiers for CYP1B1 Gene

  • GC02M038259
  • GC02M038441
  • GC02M038269
  • GC02M038206
  • GC02M038148
  • GC02M038295

Summaries for CYP1B1 Gene

Entrez Gene Summary for CYP1B1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP1B1 Gene

CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP1B1 include Glaucoma 3, Primary Congenital, A and Anterior Segment Dysgenesis 6. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP1A1.

UniProtKB/Swiss-Prot Summary for CYP1B1 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed:11555828, PubMed:12865317). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed:10426814). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376, PubMed:15258110). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:20972997). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed:21068195). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed:10426814). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity).

Tocris Summary for CYP1B1 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

Gene Wiki entry for CYP1B1 Gene

Additional gene information for CYP1B1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP1B1 Gene

Genomics for CYP1B1 Gene

GeneHancer (GH) Regulatory Elements for CYP1B1 Gene

Promoters and enhancers for CYP1B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP1B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP1B1 gene promoter:
  • AhR
  • Arnt
  • CREB
  • deltaCREB
  • MyoD

Genomic Locations for CYP1B1 Gene

Genomic Locations for CYP1B1 Gene
chr2:38,066,973-38,109,902
(GRCh38/hg38)
Size:
42,930 bases
Orientation:
Minus strand
chr2:38,294,116-38,337,044
(GRCh37/hg19)
Size:
42,929 bases
Orientation:
Minus strand

Genomic View for CYP1B1 Gene

Genes around CYP1B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP1B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP1B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP1B1 Gene

Proteins for CYP1B1 Gene

  • Protein details for CYP1B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16678-CP1B1_HUMAN
    Recommended name:
    Cytochrome P450 1B1
    Protein Accession:
    Q16678
    Secondary Accessions:
    • Q5TZW8
    • Q93089
    • Q9H316

    Protein attributes for CYP1B1 Gene

    Size:
    543 amino acids
    Molecular mass:
    60846 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP1B1 Gene

neXtProt entry for CYP1B1 Gene

Selected DME Specific Peptides for CYP1B1 Gene

Q16678:
  • GKRRCIGE
  • RRYGDVFQIRLGS

Post-translational modifications for CYP1B1 Gene

  • Ubiquitination at Lys142 and Lys275
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP1B1 Gene

Domains & Families for CYP1B1 Gene

Gene Families for CYP1B1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYP1B1 Gene

Suggested Antigen Peptide Sequences for CYP1B1 Gene

GenScript: Design optimal peptide antigens:
  • Cytochrome P450 (C1KDE6_HUMAN)
  • Cytochrome P450 (C1KDE7_HUMAN)
  • Cytochrome P450 (C1KDE8_HUMAN)
  • CYPIB1 (CP1B1_HUMAN)
  • Truncated cytochrome P450 (D0EZN5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16678

UniProtKB/Swiss-Prot:

CP1B1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1B1: view

Function for CYP1B1 Gene

Molecular function for CYP1B1 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:20972997, PubMed:11555828, PubMed:12865317, PubMed:10681376, PubMed:15258110). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position (PubMed:11555828, PubMed:12865317). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (PubMed:10426814). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376, PubMed:15258110). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:20972997). Additionally, displays dehydratase activity toward oxygenated eicosanoids hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (PubMed:21068195). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (PubMed:10426814). Plays an important role in retinal vascular development. Under hyperoxic O2 conditions, promotes retinal angiogenesis and capillary morphogenesis, likely by metabolizing the oxygenated products generated during the oxidative stress. Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269 PubMed:10426814, ECO:0000269 PubMed:11555828, ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:23821647}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47213; Evidence={ECO:0000305 PubMed:10426814, ECO:0000305 PubMed:11555828, ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:23821647};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence={ECO:0000269 PubMed:10426814, ECO:0000269 PubMed:11555828, ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:23821647}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47281; Evidence={ECO:0000305 PubMed:10426814, ECO:0000305 PubMed:11555828, ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:23821647};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47209; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47293; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46296, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17347, ChEBI:CHEBI:34477, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46297; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47252, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17026, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62117; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47253; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47260, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15826, ChEBI:CHEBI:17026, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47261; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42093; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42089; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49884, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131975; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49885; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49881; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49876, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131969; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49877; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49861; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48633; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37948; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48717; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Enzyme activity is increased by liposomes containing anionic phospholipids, phosphatidic acid and cardiolipin. Inhibited by naringenin with an IC(50) of 5 uM (PubMed:22888116, PubMed:22935222). Enzyme activity is increased by cytochrome b5.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.9 uM for 17-beta-estradiol (2-hydroxylation) {ECO:0000269 PubMed:10426814}; KM=5.1 uM for 17-beta-estradiol (4-hydroxylation) {ECO:0000269 PubMed:10426814}; KM=17.0 uM for testosterone(6-beta-hydroxylation) {ECO:0000269 PubMed:10426814}; KM=25.0 uM for progesterone (6-beta-hydroxylation) {ECO:0000269 PubMed:10426814}; KM=23.0 uM for progesterone (16-alpha-hydroxylation) {ECO:0000269 PubMed:10426814}; KM=18.5 uM for all-trans-retinol {ECO:0000269 PubMed:15258110}; KM=11 uM for all-trans retinol {ECO:0000269 PubMed:10681376}; KM=8.5 uM for all-trans-retinal {ECO:0000269 PubMed:15258110}; KM=29.8 uM for arachidonic acid {ECO:0000269 PubMed:15258110}; KM=212.8 uM for 7,12-dimethyltetraphene {ECO:0000269 PubMed:15258110}; Vmax=0.42 nmol/min/nmol enzyme for 17-beta-estradiol (2- hydroxylation) {ECO:0000269 PubMed:10426814}; Vmax=0.91 nmol/min/nmol enzyme for 17-beta-estradiol (4- hydroxylation) {ECO:0000269 PubMed:10426814}; Vmax=2.2 nmol/min/nmol enzyme for testosterone (6-beta- hydroxylation) {ECO:0000269 PubMed:10426814}; Vmax=0.6 nmol/min/nmol enzyme for progesterone (6-beta- hydroxylation) {ECO:0000269 PubMed:10426814}; Vmax=2.3 nmol/min/nmol enzyme for progesterone (16-alpha- hydroxylation) {ECO:0000269 PubMed:10426814}; Vmax=493 pmol/min/nmol enzyme toward all-trans retinol {ECO:0000269 PubMed:10681376}; Note=kcat is 0.15 min(-1) for retinol, 0.77 min(-1) for retinal, 2.86 min(-1) for 7,12-dimethyltetraphene, 0.48 min(-1) for arachidonic acid. {ECO:0000269 PubMed:15258110};
UniProtKB/Swiss-Prot Induction:
By polycyclic aromatic hydrocarbons (PAH) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
GENATLAS Biochemistry:
cytochrome p450,family I (aromatic compound inducible),member B1,expressed in ocular structures of the anterior uveal tract,possibly involved in the metabolism of substances active in the eye growth and differentiation

Enzyme Numbers (IUBMB) for CYP1B1 Gene

Phenotypes From GWAS Catalog for CYP1B1 Gene

Gene Ontology (GO) - Molecular Function for CYP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA,TAS 9097971
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA 10871058
genes like me logo Genes that share ontologies with CYP1B1: view
genes like me logo Genes that share phenotypes with CYP1B1: view

Human Phenotype Ontology for CYP1B1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYP1B1 Gene

MGI Knock Outs for CYP1B1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CYP1B1 Gene

Localization for CYP1B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1B1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion. Note=Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria. {ECO:0000250 UniProtKB:Q64429}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP1B1 gene
Compartment Confidence
mitochondrion 4
endoplasmic reticulum 4
extracellular 2
nucleus 2
plasma membrane 1
peroxisome 1
cytosol 1
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CYP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP1B1: view

Pathways & Interactions for CYP1B1 Gene

genes like me logo Genes that share pathways with CYP1B1: view

UniProtKB/Swiss-Prot Q16678-CP1B1_HUMAN

  • Pathway: Steroid hormone biosynthesis.
  • Pathway: Cofactor metabolism; retinol metabolism.
  • Pathway: Lipid metabolism; arachidonate metabolism.

SIGNOR curated interactions for CYP1B1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CYP1B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002930 trabecular meshwork development ISS --
GO:0006725 cellular aromatic compound metabolic process IEA --
GO:0006805 xenobiotic metabolic process IDA,IEA 22888116
GO:0006809 nitric oxide biosynthetic process ISS --
genes like me logo Genes that share ontologies with CYP1B1: view

Drugs & Compounds for CYP1B1 Gene

(92) Drugs for CYP1B1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved, Vet_approved Pharma Enzyme, inhibitor Tubulin and Bcl2 inhibitor, Taxanes 3454
Doxorubicin Approved, Investigational Pharma Enzyme, inhibitor, inducer Topo II inhibitor,immunosuppresive antineoplastic antibiotic 2016
Docetaxel Approved, Investigational Pharma Enzyme, binder Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2231
Estradiol Approved, Investigational, Vet_approved Pharma Enzyme, substrate Sex hormone 1379
Estrone Approved Pharma Agonist, Enzyme, substrate Estrogenic hormone 23

(75) Additional Compounds for CYP1B1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
81276-02-0
11,14,15-THETA
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
219535-29-2

(5) Tocris Compounds for CYP1B1 Gene

Compound Action Cas Number
Anastrozole Potent aromatase (CYP19) inhibitor 120511-73-1
Exemestane Steroidal aromatase (CYP19) inhibitor 107868-30-4
Ketoconazole Cytochrome P450c17 inhibitor 65277-42-1
TMS Cytochrome P450 1B1 inhibitor 24144-92-1
YM 511 Potent aromatase (CYP19) inhibitor 148869-05-0

(1) ApexBio Compounds for CYP1B1 Gene

Compound Action Cas Number
8-Methoxypsoralen CYP inhibitor 298-81-7
genes like me logo Genes that share compounds with CYP1B1: view

Transcripts for CYP1B1 Gene

mRNA/cDNA for CYP1B1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1B1 Gene

No ASD Table

Relevant External Links for CYP1B1 Gene

GeneLoc Exon Structure for
CYP1B1
ECgene alternative splicing isoforms for
CYP1B1

Expression for CYP1B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP1B1 Gene

mRNA differential expression in normal tissues according to GTEx for CYP1B1 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for CYP1B1 Gene

This gene is overexpressed in Nasal epithelium (65.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1B1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CYP1B1 Gene:

CYP1B1

SOURCE GeneReport for Unigene cluster for CYP1B1 Gene:

Hs.154654

mRNA Expression by UniProt/SwissProt for CYP1B1 Gene:

Q16678-CP1B1_HUMAN
Tissue specificity: Expressed in heart, brain, lung, skeletal muscle, kidney, spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood leukocytes (PubMed:8175734). Expressed in retinal endothelial cells and umbilical vein endothelial cells (at protein level) (PubMed:19005183).

Evidence on tissue expression from TISSUES for CYP1B1 Gene

  • Lung(4.8)
  • Nervous system(4.1)
  • Skin(3.2)
  • Eye(2.8)
  • Intestine(2.7)
  • Heart(2.6)
  • Liver(2.6)
  • Kidney(2.5)
  • Blood(2.4)
  • Spleen(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1B1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with CYP1B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CYP1B1 Gene

Orthologs for CYP1B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP1B1 33 32
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CYP1B1 33 32
  • 87.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CYP1B1 33 32
  • 85.1 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp1b1 32
  • 82.01 (n)
mouse
(Mus musculus)
Mammalia Cyp1b1 17 33 32
  • 81.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CYP1B1 33
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP1B1 33
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYP1B1 33 32
  • 75.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYP1B1 33
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490477 32
  • 63.02 (n)
zebrafish
(Danio rerio)
Actinopterygii cyp1b1 33 32 32
  • 61.72 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta spo 33
  • 24 (a)
ManyToMany
spok 33
  • 23 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons TT7 32
  • 42.46 (n)
rice
(Oryza sativa)
Liliopsida Os10g0320100 32
  • 47.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 28 (a)
ManyToMany
-- 33
  • 21 (a)
ManyToMany
Species where no ortholog for CYP1B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP1B1 Gene

ENSEMBL:
Gene Tree for CYP1B1 (if available)
TreeFam:
Gene Tree for CYP1B1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP1B1: view image

Paralogs for CYP1B1 Gene

Paralogs for CYP1B1 Gene

(29) SIMAP similar genes for CYP1B1 Gene using alignment to 12 proteins:

  • CP1B1_HUMAN
  • C1KDE6_HUMAN
  • C1KDE7_HUMAN
  • C1KDE8_HUMAN
  • D0EZN5_HUMAN
  • D0EZN6_HUMAN
  • D0EZN7_HUMAN
  • D0EZN8_HUMAN
  • Q2EN00_HUMAN
  • Q2HZ43_HUMAN
  • Q4U3K8_HUMAN
  • Q53TK1_HUMAN
genes like me logo Genes that share paralogs with CYP1B1: view

Variants for CYP1B1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1B1 Gene

CP1B1_HUMAN-Q16678
Various CYP1B1 alleles are known. The sequence shown is that of allele CYP1B1*1.

Sequence variations from dbSNP and Humsavar for CYP1B1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs10012 benign, not specified, Primary congenital glaucoma, - 38,075,247(-) G/C coding_sequence_variant, missense_variant
rs104893622 conflicting-interpretations-of-pathogenicity, Glaucoma 3, primary congenital, A, Glaucoma 3, primary congenital, A (GLC3A) [MIM:231300] 38,071,234(-) C/T coding_sequence_variant, missense_variant
rs104893628 pathogenic, Glaucoma 3, primary congenital, A, Glaucoma 3, primary congenital, A (GLC3A) [MIM:231300] 38,074,695(-) C/G coding_sequence_variant, missense_variant
rs104893629 pathogenic, Glaucoma, primary open angle, juvenile-onset, Glaucoma 3, primary congenital, A, Glaucoma 3, primary congenital, A (GLC3A) [MIM:231300] 38,071,087(-) T/A coding_sequence_variant, missense_variant
rs104894978 not-provided, Glaucoma 3, primary congenital, A 38,074,902(-) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP1B1 Gene

Variant ID Type Subtype PubMed ID
esv2659660 CNV deletion 23128226

Variation tolerance for CYP1B1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.01; 92.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP1B1 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP1B1
Human Gene Mutation Database (HGMD)
CYP1B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP1B1

Disorders for CYP1B1 Gene

MalaCards: The human disease database

(39) MalaCards diseases for CYP1B1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CP1B1_HUMAN
  • Anterior segment dysgenesis 6 (ASGD6) [MIM:617315]: A form of anterior segment dysgenesis, a group of defects affecting anterior structures of the eye including cornea, iris, lens, trabecular meshwork, and Schlemm canal. Anterior segment dysgeneses result from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to components of the anterior chamber during eye development. Different anterior segment anomalies may exist alone or in combination, including iris hypoplasia, enlarged or reduced corneal diameter, corneal vascularization and opacity, posterior embryotoxon, corectopia, polycoria, abnormal iridocorneal angle, ectopia lentis, and anterior synechiae between the iris and posterior corneal surface. Clinical conditions falling within the phenotypic spectrum of anterior segment dysgeneses include aniridia, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis. ASGD6 patients predominantly manifest Peters anomaly. Peters anomaly consists of corneal leukoma, defects in the posterior structures of the cornea such as absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iridocorneal and/or keratolenticular adhesions. Over 50% of patients develop glaucoma in childhood. {ECO:0000269 PubMed:11403040}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Glaucoma 3, primary congenital, A (GLC3A) [MIM:231300]: An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. {ECO:0000269 PubMed:10227395, ECO:0000269 PubMed:10655546, ECO:0000269 PubMed:11184479, ECO:0000269 PubMed:11527932, ECO:0000269 PubMed:11774072, ECO:0000269 PubMed:11980847, ECO:0000269 PubMed:12036985, ECO:0000269 PubMed:12525557, ECO:0000269 PubMed:14635112, ECO:0000269 PubMed:14640114, ECO:0000269 PubMed:15255109, ECO:0000269 PubMed:15342693, ECO:0000269 PubMed:15475877, ECO:0000269 PubMed:16490498, ECO:0000269 PubMed:16688110, ECO:0000269 PubMed:16735994, ECO:0000269 PubMed:16862072, ECO:0000269 PubMed:18470941, ECO:0000269 PubMed:9463332, ECO:0000269 PubMed:9497261}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
  • Glaucoma 1, open angle, A (GLC1A) [MIM:137750]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269 PubMed:11774072}. Note=The gene represented in this entry acts as a disease modifier. Digenic mutations in CYP1B1 and MYOC have been found in a family segregating both primary adult-onset and juvenile forms of open angle glaucoma (PubMed:11774072). All affected family members with mutations in both MYOC and CYP1B1 had juvenile glaucoma, whereas those with only the MYOC mutation had the adult-onset form (PubMed:11774072). {ECO:0000269 PubMed:11774072}.

Additional Disease Information for CYP1B1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP1B1: view

No data available for Genatlas for CYP1B1 Gene

Publications for CYP1B1 Gene

  1. Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population. (PMID: 11854439) Aklillu E … Ingelman-Sundberg M (Molecular pharmacology 2002) 3 4 23 43 56
  2. Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene. (PMID: 11774072) Vincent AL … Héon E (American journal of human genetics 2002) 3 4 23 43 56
  3. Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer. (PMID: 9823305) Bailey LR … Parl FF (Cancer research 1998) 3 4 23 43 56
  4. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. (PMID: 8175734) Sutter TR … Greenlee WF (The Journal of biological chemistry 1994) 2 3 4 23 56
  5. Polymorphisms of estrogen-related genes jointly confer susceptibility to human spermatogenic defect. (PMID: 18980759) Su MT … Kuo PL (Fertility and sterility 2010) 3 23 43 56

Products for CYP1B1 Gene

Sources for CYP1B1 Gene