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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons ... See more...
Aliases for CYP1A2 Gene
Aliases for CYP1A2 Gene
- Cytochrome P450 Family 1 Subfamily A Member 2 2 3 5
- Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2 2 3
- Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 2 3
- Hydroperoxy Icosatetraenoate Dehydratase 3 4
- Cholesterol 25-Hydroxylase 3 4
- Cytochrome P450 1A2 3 4
- Cytochrome P(3)450 3 4
- Cytochrome P450-P3 3 4
- Cytochrome P450 4 3 4
- EC 1.14.14.1 4 51
- CYPIA2 3 4
External Ids for CYP1A2 Gene
- HGNC: 2596
- Entrez Gene: 1544
- Ensembl: ENSG00000140505
- OMIM: 124060
- UniProtKB: P05177
Previous GeneCards Identifiers for CYP1A2 Gene
- GC15M070968
- GC15M068160
- GC15P072617
- GC15P072757
- GC15P072828
- GC15P075041
- GC15P051838
Summaries for CYP1A2 Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP1A2 Gene
CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with CYP1A2 include Porphyria Cutanea Tarda and Acetaminophen Metabolism. Among its related pathways are Cytochrome P450 - arranged by substrate type and Imipramine/Desipramine Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A1.
UniProtKB/Swiss-Prot Summary for CYP1A2 Gene
-
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable).
Additional gene information for CYP1A2 Gene
- HGNC(2596)
- Entrez Gene(1544)
- Ensembl(ENSG00000140505)
- OMIM(124060)
- UniProtKB(P05177)
- Open Targets Platform(ENSG00000140505)
- Monarch Initiative
- Search for CYP1A2 at DataMed
- Search for CYP1A2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP1A2 Gene
Genomics for CYP1A2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CYP1A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CYP1A2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP1A2
- Top Transcription factor binding sites by QIAGEN in the CYP1A2 gene promoter:
-
- Arnt
- C/EBPalpha
- GR
- GR-alpha
- HNF-4alpha1
- Ik-2
- MZF-1
- Nkx5-1
- p53
- Pax-2
Genomic Locations for CYP1A2 Gene
Genomic Locations for CYP1A2 Gene
- chr15:74,748,845-74,756,607
- (GRCh38/hg38)
- Size:
- 7,763 bases
- Orientation:
- Plus strand
- chr15:75,041,184-75,048,941
- (GRCh37/hg19)
- Size:
- 7,758 bases
- Orientation:
- Plus strand
Genomic View for CYP1A2 Gene
Genes around CYP1A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.1 by HGNC
- 15q24.1 by Entrez Gene
- 15q24.1 by Ensembl
CYP1A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP1A2 Gene
Proteins for CYP1A2 Gene
-
Protein details for CYP1A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05177-CP1A2_HUMAN
- Recommended name:
- Cytochrome P450 1A2
- Protein Accession:
- P05177
- Q16754
- Q6NWU3
- Q6NWU5
- Q9BXX7
- Q9UK49
Protein attributes for CYP1A2 Gene
- Size:
- 516 amino acids
- Molecular mass:
- 58407 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
-
- Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.
Protein Expression for CYP1A2 Gene
Selected DME Specific Peptides for CYP1A2 Gene
- P05177:
-
- LLQQLEFS
- LEAFILE
- TTAISWSL
- QGDDFKGRP
- CVFVNQWQ
- YLPNPAL
- ELDTVIG
- RRPRLSDR
- PHSTTRDT
- YGDVLQI
- WAARRRLAQ
- FGAGFDT
- FSIASDP
- PILRYLP
- LQRFKAFNQ
- PEIQRKIQ
- GKRRCIGE
- SATELLL
- PFTIPHST
- VIGAMCFG
- LTLGKNPH
- TPIYGLT
- FRPERFLT
- LNGFYIP
- DRPQLPY
Post-translational modifications for CYP1A2 Gene
Other Protein References for CYP1A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Cytochrome P450 1A2 Antibody
- NSJ Bioreagents CYP1A2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CYP1A2
- AM05371PU-N
- CF501154
- CF501155
- CF501156
- CF501157
- CF501172
- CF501173
- CF501196
- CF501197
- CF501244
- SP1320A
- TA309532
- TA313311
- TA324397
- TA351484
- TA353117L
- TA353118L
- TA353119L
- TA501154
- TA501154S
- TA501155
- TA501155S
- TA501156
- TA501156S
- TA501157
- TA501157S
- TA501172
- TA501172S
- TA501173
- TA501173S
- TA501196
- TA501196S
- TA501197
- TA501197S
- TA501244
- TA501244S
- TA600038
- TA600045
- TA700038
- UM500073
- UM500073CF
- UM570073
- Novus Biologicals Antibodies for CYP1A2
-
Abcam antibodies for CYP1A2
- Invitrogen Antibodies for CYP1A2 (AFLGC-Cyp1a2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP1A2
- Origene Custom Protein Services for CYP1A2
-
Signalway Proteins for CYP1A2
-
Abcam proteins for CYP1A2
Assay Products
-
Signalway ELISA kits for CYP1A2
-
Abcam assays for CYP1A2
Domains & Families for CYP1A2 Gene
Gene Families for CYP1A2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted membrane proteins
Protein Domains for CYP1A2 Gene
- InterPro:
- Blocks:
-
- E-class P450 group I signature
- CYP1A P450 family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP1A2 Gene
- GenScript: Design optimal peptide antigens:
-
- Cytochrome P450-P3 (CP1A2_HUMAN)
- Cytochrome P450, family 1, subfamily A, polypeptide 2 (Q6NWU3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P05177- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP1A2 Gene
Molecular function for CYP1A2 Gene
- UniProtKB/Swiss-Prot Function:
- A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:9435160};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence={ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence={ECO:0000269|PubMed:12865317};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50256, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:42977, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:21576599};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence={ECO:0000269|PubMed:19965576};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence={ECO:0000269|PubMed:19965576};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence={ECO:0000269|PubMed:19965576};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence={ECO:0000269|PubMed:19965576};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136524; Evidence={ECO:0000269|PubMed:9435160};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence={ECO:0000269|PubMed:9435160};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52284, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136522; Evidence={ECO:0000269|PubMed:9435160};.
- UniProtKB/Swiss-Prot Induction:
- By nicotine, omeprazole, phenobarbital, primidone and rifampicin.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=19 uM for 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:11555828}; KM=9 uM for all-trans retinol {ECO:0000269|PubMed:10681376}; KM=4 uM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole {ECO:0000269|PubMed:14725854}; KM=21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline {ECO:0000269|PubMed:14725854}; KM=26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline {ECO:0000269|PubMed:14725854}; KM=27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline {ECO:0000269|PubMed:14725854}; KM=71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine {ECO:0000269|PubMed:14725854}; KM=25 uM for phenacetin {ECO:0000269|PubMed:14725854}; Vmax=9.2 nmol/min/nmol enzyme toward 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:11555828}; Vmax=491 pmol/min/nmol enzyme toward all-trans retinol {ECO:0000269|PubMed:10681376};
- GENATLAS Biochemistry:
- cytochrome p450,family I (aromatic compound-inducible),member A2 (see CYP1@)
Enzyme Numbers (IUBMB) for CYP1A2 Gene
Phenotypes From GWAS Catalog for CYP1A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004497 | monooxygenase activity | IDA,TAS | -- |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 26988023 |
| GO:0009055 | electron transfer activity | TAS | 2813353 |
| GO:0016491 | oxidoreductase activity | IDA | 16401082 |
Phenotypes for CYP1A2 Gene
- MGI mutant phenotypes for CYP1A2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CYP1A2:
Animal Models for CYP1A2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYP1A2 - Select products 50% OFF >
- * CYP1A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for CYP1A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP1A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A2
miRNA for CYP1A2 Gene
- miRTarBase miRNAs that target CYP1A2
-
- hsa-let-7b-5p (MIRT052168)
- mmu-miR-320-3p (MIRT579005)
- hsa-miR-7703 (MIRT619665)
- hsa-miR-6720-5p (MIRT619666)
- hsa-miR-6512-3p (MIRT619667)
- hsa-miR-196a-3p (MIRT619668)
- hsa-miR-4252 (MIRT619669)
- hsa-miR-3128 (MIRT619670)
- hsa-miR-4793-3p (MIRT619671)
- hsa-miR-766-3p (MIRT619672)
- hsa-miR-1292-3p (MIRT619673)
- hsa-miR-8073 (MIRT619674)
- hsa-miR-221-5p (MIRT619675)
- hsa-miR-6849-3p (MIRT619676)
- hsa-miR-1273g-3p (MIRT619677)
- hsa-miR-508-5p (MIRT619678)
miRNA Products
Inhibitory RNA Products
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- Browse OriGene Inhibitory RNA Products For CYP1A2
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Clone Products
- Applied Biological Materials (abm): Clones for CYP1A2 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for CYP1A2
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Cell Line Products
-
Horizon Cell Lines for CYP1A2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A2 Gene
Localization for CYP1A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP1A2 Gene
- Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| extracellular | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031090 | organelle membrane | IEA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IBA,IDA | 2813353 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A2 Gene
Pathways & Interactions for CYP1A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 |
Retinol metabolism
.31
|
Benzo[a]pyrene metabolism
.01
|
| 2 | Imipramine/Desipramine Pathway, Pharmacokinetics | ||
| 3 | Cytochrome P450 - arranged by substrate type |
.39
|
.01
Estradiol metabolism
.01
|
| 4 | Caffeine Pathway, Pharmacokinetics | ||
| 5 | Acetaminophen Pathway (therapeutic doses), Pharmacokinetics |
Acetaminophen metabolism
.42
|
2-Naphthylamine and 2-Nitronaphtalene metabolism
.31
|
Pathways by source for CYP1A2 Gene
19 BioSystems pathways for CYP1A2 Gene
13 Reactome pathways for CYP1A2 Gene
9 KEGG pathways for CYP1A2 Gene
8 GeneGo (Thomson Reuters) pathways for CYP1A2 Gene
- 2-Naphthylamine and 2-Nitronaphtalene metabolism
- Acetaminophen metabolism
- Androstenedione and testosterone biosynthesis and metabolism p.1
- Benzo[a]pyrene metabolism
- Estradiol metabolism
1 Cell Signaling Technology pathway for CYP1A2 Gene
UniProtKB/Swiss-Prot P05177-CP1A2_HUMAN
- Pathway: Cofactor metabolism; retinol metabolism.
- Pathway: Steroid metabolism; cholesterol metabolism.
- Pathway: Lipid metabolism; arachidonate metabolism.
Interacting Proteins for CYP1A2 Gene
Selected Interacting proteins:
P05177-CP1A2_HUMAN
ENSP00000342007
for CYP1A2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CYP1A2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006706 | steroid catabolic process | IMP | 18356043 |
| GO:0006725 | cellular aromatic compound metabolic process | IEA | -- |
| GO:0006778 | porphyrin-containing compound metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for CYP1A2 Gene
Drugs & Compounds for CYP1A2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Caffeine | Approved | Pharma | Antagonist, Activator, Enzyme, substrate, inhibitor | 603 | ||
| Carbamazepine | Approved, Investigational | Pharma | Enzyme, inhibitor, inducer | Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant | 104 | |
| Fluvoxamine | Approved, Investigational | Pharma | Enzyme, substrate, inhibitor | 63 | ||
| Ketoconazole | Approved, Investigational | Pharma | Pore Blocker, Enzyme, inhibitor | Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor | 194 | |
| Omeprazole | Approved, Investigational, Vet_approved | Pharma | Activator, Enzyme, inducer | H+,K+-ATPase inhibitor | 436 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1,7-Dimethyluric acid |
|
|||||
| 1-Methylxanthine |
|
|||||
| Aflatoxin B1 |
|
1162-65-8 | ||||
| Paraxanthine |
|
611-59-6 | ||||
| 11,12,15-THETA |
|
|
(7) ApexBio Compounds for CYP1A2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Abiraterone acetate | Cytochrome p450 17a1 inhibitor | 154229-18-2 |
| Avasimibe | ACAT inhibitor,orally bioavailable | 166518-60-1 |
| Gemfibrozil | 25812-30-0 | |
| Ifosfamide | Cytostatic agent | 3778-73-2 |
| Ketoconazole | Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase | 65277-42-1 |
| Methoxyresorufin | 5725-89-3 | |
| Oltipraz | An antischistosomal agent | 64224-21-1 |
Transcripts for CYP1A2 Gene
mRNA/cDNA for CYP1A2 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343932 3132 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYP1A2 - Select products 50% OFF >
- * CYP1A2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CYP1A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP1A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP1A2
- Browse OriGene Inhibitory RNA Products For CYP1A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A2
Clone Products
- Applied Biological Materials (abm): Clones for CYP1A2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CYP1A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP1A2
Relevant External Links for CYP1A2 Gene
- GeneLoc Exon Structure for
- CYP1A2
Expression for CYP1A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Perivenous Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CYP1A2 Gene
This gene is overexpressed in Liver (x51.8).
This gene is overexpressed in Gallbladder (51.2) and Liver (17.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1A2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP1A2
SOURCE GeneReport for Unigene cluster for CYP1A2 Gene:
Hs.1361mRNA Expression by UniProt/SwissProt for CYP1A2 Gene:
P05177-CP1A2_HUMAN
Tissue specificity:
Liver.
Evidence on tissue expression from TISSUES for CYP1A2 Gene
- Liver(4.8)
- Blood(3)
- Urine(2.9)
- Intestine(2.9)
- Heart(2.5)
- Kidney(2.4)
- Nervous system(2.4)
- Skin(2.3)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for CYP1A2
-
OriGene qPCR primer pairs and template standards for CYP1A2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A2 Gene
Orthologs for CYP1A2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CYP1A2 31 |
|
OneToOne | |
| LOC735881 30 |
|
||||
| Cow (Bos Taurus) |
Mammalia | CYP1A2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CYP1A2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cyp1a2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cyp1a2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | CYP1A1 31 |
|
ManyToMany | |
| CYP1A4 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Zebrafish (Danio rerio) |
Actinopterygii | cyp1a 31 |
|
OneToMany | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11738 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cyp307a1 32 |
|
|
|
| spok 31 |
|
ManyToMany | |||
| spo 31 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CYP703A2 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os08g0131100 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CYP1A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CYP1A2 Gene
- ENSEMBL:
- Gene Tree for CYP1A2 (if available)
- TreeFam:
- Gene Tree for CYP1A2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYP1A2: view image
Paralogs for CYP1A2 Gene
(25) SIMAP similar genes for CYP1A2 Gene using alignment to 2 proteins:
- CP1A2_HUMAN
- Q6NWU3_HUMAN
Variants for CYP1A2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A2 Gene
- CP1A2_HUMAN-P05177
- The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP1A2 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 675798 | Benign: not provided | 74,755,085(+) | T/. | NO_SEQUENCE_ALTERATION | |
| 713008 | Likely Benign: not provided | 74,750,131(+) | G/A | SYNONYMOUS_VARIANT | |
| 721012 | Likely Benign: not provided | 74,751,198(+) | C/T | MISSENSE_VARIANT | |
| 739045 | Likely Benign: not provided | 74,750,044(+) | C/T | SYNONYMOUS_VARIANT | |
| 742234 | Benign: not provided | 74,754,996(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3581763 | CNV | loss | 25503493 |
| nsv1121512 | CNV | deletion | 24896259 |
| nsv833055 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.60;
44.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYP1A2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for CYP1A2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| porphyria cutanea tarda |
|
|
| acetaminophen metabolism |
|
|
| antley-bixler syndrome |
|
|
| headache |
|
|
| anxiety |
|
|
Search CYP1A2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CYP1A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A2 Gene
Publications for CYP1A2 Gene
- Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 23 41
- Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. (PMID: 19776291) Ferlin A … Foresta C (Endocrine-related cancer 2010) 3 23 41
- CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. (PMID: 19843669) Peterson S … Lampe JW (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 41
- Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. (PMID: 19450128) Gunes A … Dahl ML (Pharmacogenomics 2009) 3 23 41
- Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 23 41
ExternalLinks
Products for CYP1A2 Gene
- Custom Antibody ServicesOriGene Antibodies for CYP1A2
- AM05371PU-N
- CF501154
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- CF501196
- CF501197
- CF501244
- SP1320A
- TA309532
- TA313311
- TA324397
- TA351484
- TA353117L
- TA353118L
- TA353119L
- TA501154
- TA501154S
- TA501155
- TA501155S
- TA501156
- TA501156S
- TA501157
- TA501157S
- TA501172
- TA501172S
- TA501173
- TA501173S
- TA501196
- TA501196S
- TA501197
- TA501197S
- TA501244
- TA501244S
- TA600038
- TA600045
- TA700038
- UM500073
- UM500073CF
- UM570073
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- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for CYP1A2
- Abcam proteins for CYP1A2
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- Browse Primary Antibodies
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- Invitrogen Antibodies for CYP1A2 (AFLGC-Cyp1a2)
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- VectorBuilder Custom and pre-made DNA vectors for CYP1A2 (ie. gene expression, shRNA knockdown, CRISPR)
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Sources for CYP1A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
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- (114) NINDS
- (115) NCBI Bookshelf
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- (117) Gene Damage Index
- (118) HPO
- (119) UDN
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB