This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons ... See more...

Aliases for CYP1A2 Gene

Aliases for CYP1A2 Gene

  • Cytochrome P450 Family 1 Subfamily A Member 2 2 3 5
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2 2 3
  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 2 3
  • Hydroperoxy Icosatetraenoate Dehydratase 3 4
  • Cholesterol 25-Hydroxylase 3 4
  • Cytochrome P450 1A2 3 4
  • Cytochrome P(3)450 3 4
  • Cytochrome P450-P3 3 4
  • Cytochrome P450 4 3 4
  • EC 1.14.14.1 4 51
  • CYPIA2 3 4
  • P3-450 2 3
  • CP12 2 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Dioxin-Inducible P3-450 3
  • EC 4.2.1.152 4
  • P450 Form 4 3
  • P450(PA) 3
  • CYP1A2 5

External Ids for CYP1A2 Gene

Previous GeneCards Identifiers for CYP1A2 Gene

  • GC15M070968
  • GC15M068160
  • GC15P072617
  • GC15P072757
  • GC15P072828
  • GC15P075041
  • GC15P051838

Summaries for CYP1A2 Gene

Entrez Gene Summary for CYP1A2 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP1A2 Gene

CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with CYP1A2 include Porphyria Cutanea Tarda and Acetaminophen Metabolism. Among its related pathways are Cytochrome P450 - arranged by substrate type and Imipramine/Desipramine Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A1.

UniProtKB/Swiss-Prot Summary for CYP1A2 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable).

Gene Wiki entry for CYP1A2 Gene

PharmGKB "VIP" Summary for CYP1A2 Gene

No data available for CIViC Summary , Tocris Summary , Rfam classification and piRNA Summary for CYP1A2 Gene

Genomics for CYP1A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYP1A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J074748 Promoter 0.6 EPDnew 600.7 0.0 -19 0.1 SP1 YY1 GATA3 HNF4A RXRA SREBF1 CYP1A2 piR-54764-215 CYP1A1
GH15J074725 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 0.4 -23.0 -23044 2.8 GATAD2A PRDM10 ZNF629 ZNF692 PRDM1 ZIC2 RBFOX2 POLR2A RXRB PATZ1 CYP1A1 RPP25 ENSG00000260103 ARID3B C15orf39 SCAMP2 piR-36393-182 CYP1A2
GH15J074759 Enhancer 1.1 Ensembl ENCODE 0.4 +11.5 11542 1.1 ARHGAP35 GATAD2A TEAD4 SOX13 POLR2A MTA2 HNRNPUL1 RBFOX2 IRF2 ELF4 lnc-CYP1A1-3 SIN3A ENSG00000260274 CLK3 MAN2C1 PML ENSG00000260103 ULK3 EDC3 DNM1P34
GH15J074752 Enhancer 0.6 Ensembl ENCODE dbSUPER 0.7 +4.0 3955 1.2 RXRA CYP1A1 EDC3 LMAN1L CSK CPLX3 ULK3 CLK3 MPI FAM219B ENSG00000212279
GH15J074770 Enhancer 1.1 ENCODE dbSUPER 0.4 +22.6 22555 0.8 CREB1 GATAD2A CTCF PRDM10 ZNF629 SOX13 TARDBP JUND LARP7 PRDM1 ULK3 CPLX3 SCAMP5 PPCDC CSK lnc-CYP1A1-3 CYP1A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP1A2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP1A2

Top Transcription factor binding sites by QIAGEN in the CYP1A2 gene promoter:
  • Arnt
  • C/EBPalpha
  • GR
  • GR-alpha
  • HNF-4alpha1
  • Ik-2
  • MZF-1
  • Nkx5-1
  • p53
  • Pax-2

Genomic Locations for CYP1A2 Gene

Genomic Locations for CYP1A2 Gene
chr15:74,748,845-74,756,607
(GRCh38/hg38)
Size:
7,763 bases
Orientation:
Plus strand
chr15:75,041,184-75,048,941
(GRCh37/hg19)
Size:
7,758 bases
Orientation:
Plus strand

Genomic View for CYP1A2 Gene

Genes around CYP1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP1A2 Gene

Proteins for CYP1A2 Gene

  • Protein details for CYP1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05177-CP1A2_HUMAN
    Recommended name:
    Cytochrome P450 1A2
    Protein Accession:
    P05177
    Secondary Accessions:
    • Q16754
    • Q6NWU3
    • Q6NWU5
    • Q9BXX7
    • Q9UK49

    Protein attributes for CYP1A2 Gene

    Size:
    516 amino acids
    Molecular mass:
    58407 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • Interacts with PGRMC1; the interaction requires PGRMC1 homodimerization.

    Three dimensional structures from OCA and Proteopedia for CYP1A2 Gene

neXtProt entry for CYP1A2 Gene

Selected DME Specific Peptides for CYP1A2 Gene

P05177:
  • LLQQLEFS
  • LEAFILE
  • TTAISWSL
  • QGDDFKGRP
  • CVFVNQWQ
  • YLPNPAL
  • ELDTVIG
  • RRPRLSDR
  • PHSTTRDT
  • YGDVLQI
  • WAARRRLAQ
  • FGAGFDT
  • FSIASDP
  • PILRYLP
  • LQRFKAFNQ
  • PEIQRKIQ
  • GKRRCIGE
  • SATELLL
  • PFTIPHST
  • VIGAMCFG
  • LTLGKNPH
  • TPIYGLT
  • FRPERFLT
  • LNGFYIP
  • DRPQLPY

Post-translational modifications for CYP1A2 Gene

  • Glycosylation at Ser69
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP1A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CYP1A2 Gene

Gene Families for CYP1A2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CYP1A2 Gene

InterPro:
Blocks:
  • E-class P450 group I signature
  • CYP1A P450 family signature
ProtoNet:

Suggested Antigen Peptide Sequences for CYP1A2 Gene

GenScript: Design optimal peptide antigens:
  • Cytochrome P450-P3 (CP1A2_HUMAN)
  • Cytochrome P450, family 1, subfamily A, polypeptide 2 (Q6NWU3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05177

UniProtKB/Swiss-Prot:

CP1A2_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1A2: view

Function for CYP1A2 Gene

Molecular function for CYP1A2 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:9435160};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence={ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50256, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16113, ChEBI:CHEBI:42977, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:21576599};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence={ECO:0000269|PubMed:21068195};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence={ECO:0000269|PubMed:21068195};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence={ECO:0000269|PubMed:21068195};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence={ECO:0000269|PubMed:21068195};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136524; Evidence={ECO:0000269|PubMed:9435160};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence={ECO:0000269|PubMed:9435160};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52284, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30245, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:136522; Evidence={ECO:0000269|PubMed:9435160};.
UniProtKB/Swiss-Prot Induction:
By nicotine, omeprazole, phenobarbital, primidone and rifampicin.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=19 uM for 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:11555828}; KM=9 uM for all-trans retinol {ECO:0000269|PubMed:10681376}; KM=4 uM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole {ECO:0000269|PubMed:14725854}; KM=21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline {ECO:0000269|PubMed:14725854}; KM=26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline {ECO:0000269|PubMed:14725854}; KM=27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline {ECO:0000269|PubMed:14725854}; KM=71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine {ECO:0000269|PubMed:14725854}; KM=25 uM for phenacetin {ECO:0000269|PubMed:14725854}; Vmax=9.2 nmol/min/nmol enzyme toward 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:11555828}; Vmax=491 pmol/min/nmol enzyme toward all-trans retinol {ECO:0000269|PubMed:10681376};
GENATLAS Biochemistry:
cytochrome p450,family I (aromatic compound-inducible),member A2 (see CYP1@)

Enzyme Numbers (IUBMB) for CYP1A2 Gene

Phenotypes From GWAS Catalog for CYP1A2 Gene

Gene Ontology (GO) - Molecular Function for CYP1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA,TAS --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 26988023
GO:0009055 electron transfer activity TAS 2813353
GO:0016491 oxidoreductase activity IDA 16401082
genes like me logo Genes that share ontologies with CYP1A2: view
genes like me logo Genes that share phenotypes with CYP1A2: view

Animal Models for CYP1A2 Gene

MGI Knock Outs for CYP1A2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A2 Gene

Localization for CYP1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A2 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP1A2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
cytosol 2
golgi apparatus 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA,IDA 2813353
genes like me logo Genes that share ontologies with CYP1A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A2 Gene

Pathways & Interactions for CYP1A2 Gene

PathCards logo

SuperPathways for CYP1A2 Gene

SuperPathway Contained pathways
1 Drug metabolism - cytochrome P450
.31
.01
2 Imipramine/Desipramine Pathway, Pharmacokinetics
3 Cytochrome P450 - arranged by substrate type
.01
4 Caffeine Pathway, Pharmacokinetics
5 Acetaminophen Pathway (therapeutic doses), Pharmacokinetics
.42
.31
genes like me logo Genes that share pathways with CYP1A2: view

Pathways by source for CYP1A2 Gene

UniProtKB/Swiss-Prot P05177-CP1A2_HUMAN

  • Pathway: Cofactor metabolism; retinol metabolism.
  • Pathway: Steroid metabolism; cholesterol metabolism.
  • Pathway: Lipid metabolism; arachidonate metabolism.

Gene Ontology (GO) - Biological Process for CYP1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006706 steroid catabolic process IMP 18356043
GO:0006725 cellular aromatic compound metabolic process IEA --
GO:0006778 porphyrin-containing compound metabolic process IEA --
genes like me logo Genes that share ontologies with CYP1A2: view

No data available for SIGNOR curated interactions for CYP1A2 Gene

Drugs & Compounds for CYP1A2 Gene

(499) Drugs for CYP1A2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caffeine Approved Pharma Antagonist, Activator, Enzyme, substrate, inhibitor 603
Carbamazepine Approved, Investigational Pharma Enzyme, inhibitor, inducer Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant 104
Fluvoxamine Approved, Investigational Pharma Enzyme, substrate, inhibitor 63
Ketoconazole Approved, Investigational Pharma Pore Blocker, Enzyme, inhibitor Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor 194
Omeprazole Approved, Investigational, Vet_approved Pharma Activator, Enzyme, inducer H+,K+-ATPase inhibitor 436

(102) Additional Compounds for CYP1A2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,7-Dimethyluric acid
  • 17-Dimethyluric acid
  • 17-Dimethylate
  • 17-Dimethylic acid
  • 1,7-Dimethylate
  • 1,7-Dimethylic acid
1-Methylxanthine
Aflatoxin B1
  • AFB1
  • AFBI
  • HSDB-3453
  • Aflatoxin b
  • Aflatoxin b1, (6ar-cis)-isomer, 14C-labeled
1162-65-8
Paraxanthine
  • 3,7-dihydro-1,7-Dimethyl-1H-purine-2,6-dione
  • P-Xanthine
  • 1,7-Dimethyl-xanthine
  • 1,7-Dimethylxanthine
611-59-6
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate

(7) ApexBio Compounds for CYP1A2 Gene

Compound Action Cas Number
Abiraterone acetate Cytochrome p450 17a1 inhibitor 154229-18-2
Avasimibe ACAT inhibitor,orally bioavailable 166518-60-1
Gemfibrozil 25812-30-0
Ifosfamide Cytostatic agent 3778-73-2
Ketoconazole Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase 65277-42-1
Methoxyresorufin 5725-89-3
Oltipraz An antischistosomal agent 64224-21-1
genes like me logo Genes that share compounds with CYP1A2: view

Drug Products

Transcripts for CYP1A2 Gene

mRNA/cDNA for CYP1A2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A2

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A2 Gene

No ASD Table

Relevant External Links for CYP1A2 Gene

GeneLoc Exon Structure for
CYP1A2

Expression for CYP1A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A2 Gene

This gene is overexpressed in Liver (x51.8).

Protein differential expression in normal tissues from HIPED for CYP1A2 Gene

This gene is overexpressed in Gallbladder (51.2) and Liver (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1A2 Gene



Protein tissue co-expression partners for CYP1A2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP1A2

SOURCE GeneReport for Unigene cluster for CYP1A2 Gene:

Hs.1361

mRNA Expression by UniProt/SwissProt for CYP1A2 Gene:

P05177-CP1A2_HUMAN
Tissue specificity: Liver.

Evidence on tissue expression from TISSUES for CYP1A2 Gene

  • Liver(4.8)
  • Blood(3)
  • Urine(2.9)
  • Intestine(2.9)
  • Heart(2.5)
  • Kidney(2.4)
  • Nervous system(2.4)
  • Skin(2.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CYP1A2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A2 Gene

Orthologs for CYP1A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CYP1A2 31
  • 98 (a)
OneToOne
LOC735881 30
  • 92.81 (n)
Cow
(Bos Taurus)
Mammalia CYP1A2 30 31
  • 85.14 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CYP1A2 30 31
  • 84.31 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cyp1a2 30
  • 80.6 (n)
Mouse
(Mus musculus)
Mammalia Cyp1a2 30 17 31
  • 80.01 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 65 (a)
ManyToMany
-- 31
  • 65 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 65 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CYP1A1 31
  • 60 (a)
ManyToMany
CYP1A4 31
  • 55 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 59 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
-- 31
  • 54 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii cyp1a 31
  • 53 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11738 30
Fruit Fly
(Drosophila melanogaster)
Insecta Cyp307a1 32
  • 26 (a)
spok 31
  • 23 (a)
ManyToMany
spo 31
  • 22 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CYP703A2 30
  • 41.45 (n)
Rice
(Oryza sativa)
Liliopsida Os08g0131100 30
  • 44.3 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
ManyToMany
-- 31
  • 19 (a)
ManyToMany
Species where no ortholog for CYP1A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CYP1A2 Gene

ENSEMBL:
Gene Tree for CYP1A2 (if available)
TreeFam:
Gene Tree for CYP1A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP1A2: view image

Paralogs for CYP1A2 Gene

Paralogs for CYP1A2 Gene

(25) SIMAP similar genes for CYP1A2 Gene using alignment to 2 proteins:

  • CP1A2_HUMAN
  • Q6NWU3_HUMAN
genes like me logo Genes that share paralogs with CYP1A2: view

Variants for CYP1A2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A2 Gene

CP1A2_HUMAN-P05177
The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP1A2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
675798 Benign: not provided 74,755,085(+) T/. NO_SEQUENCE_ALTERATION
713008 Likely Benign: not provided 74,750,131(+) G/A SYNONYMOUS_VARIANT
721012 Likely Benign: not provided 74,751,198(+) C/T MISSENSE_VARIANT
739045 Likely Benign: not provided 74,750,044(+) C/T SYNONYMOUS_VARIANT
742234 Benign: not provided 74,754,996(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CYP1A2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYP1A2 Gene

Variant ID Type Subtype PubMed ID
esv3581763 CNV loss 25503493
nsv1121512 CNV deletion 24896259
nsv833055 CNV loss 17160897

Variation tolerance for CYP1A2 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 44.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP1A2 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP1A2
Human Gene Mutation Database (HGMD)
CYP1A2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP1A2

Disorders for CYP1A2 Gene

MalaCards: The human disease database

(36) MalaCards diseases for CYP1A2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
porphyria cutanea tarda
  • pct
acetaminophen metabolism
antley-bixler syndrome
  • trapezoidocephaly-synostosis syndrome
headache
  • headache disorder
anxiety
  • anxiety disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP1A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CYP1A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A2 Gene

Publications for CYP1A2 Gene

  1. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 23 41
  2. Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. (PMID: 19776291) Ferlin A … Foresta C (Endocrine-related cancer 2010) 3 23 41
  3. CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. (PMID: 19843669) Peterson S … Lampe JW (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 41
  4. Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. (PMID: 19450128) Gunes A … Dahl ML (Pharmacogenomics 2009) 3 23 41
  5. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 23 41

Products for CYP1A2 Gene

  • Signalway ELISA kits for CYP1A2
  • Signalway Proteins for CYP1A2

Sources for CYP1A2 Gene