Aliases for CYP1A2 Gene
Aliases for CYP1A2 Gene
- Cytochrome P450 Family 1 Subfamily A Member 2 2 3 5
- Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2 2 3
- Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 2 3
- Cholesterol 25-Hydroxylase 3 4
- Cytochrome P(3)450 3 4
- Cytochrome P450-P3 3 4
- Cytochrome P450 4 3 4
- CYPIA2 3 4
- Flavoprotein-Linked Monooxygenase 3
- Aryl Hydrocarbon Hydroxylase 3
External Ids for CYP1A2 Gene
- HGNC: 2596
- Entrez Gene: 1544
- Ensembl: ENSG00000140505
- OMIM: 124060
- UniProtKB: P05177
Previous GeneCards Identifiers for CYP1A2 Gene
- GC15M070968
- GC15M068160
- GC15P072617
- GC15P072757
- GC15P072828
- GC15P075041
- GC15P051838
Summaries for CYP1A2 Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP1A2 Gene
CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with CYP1A2 include Toxicity Or Absent Response To Clozapine and Acetaminophen Metabolism. Among its related pathways are Drug metabolism - cytochrome P450 and Paroxetine Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A1.
UniProtKB/Swiss-Prot for CYP1A2 Gene
-
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Additional gene information for CYP1A2 Gene
- Monarch Initiative
- Search for CYP1A2 at DataMed
- Search for CYP1A2 at HumanCyc
No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A2 Gene
Genomics for CYP1A2 Gene
GeneHancer (GH) Regulatory Elements for CYP1A2 Gene
Promoters and enhancers for CYP1A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CYP1A2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CYP1A2 gene promoter:
-
- p53
- HNF-4alpha1
- Ik-2
- C/EBPalpha
- MZF-1
- Arnt
- GR-alpha
- GR
- Nkx5-1
- Pax-2
Regulatory Element Products
Genomic Locations for CYP1A2 Gene
Genomic Locations for CYP1A2 Gene
- chr15:74,748,843-74,756,600
- (GRCh38/hg38)
- Size:
- 7,758 bases
- Orientation:
- Plus strand
- chr15:75,041,184-75,048,941
- (GRCh37/hg19)
- Size:
- 7,758 bases
- Orientation:
- Plus strand
Genomic View for CYP1A2 Gene
Genes around CYP1A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.1 by Entrez Gene
- 15q24.1 by HGNC
- 15q24.1 by Ensembl
CYP1A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP1A2 Gene
Proteins for CYP1A2 Gene
-
Protein details for CYP1A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05177-CP1A2_HUMAN
- Recommended name:
- Cytochrome P450 1A2
- Protein Accession:
- P05177
- Q16754
- Q6NWU5
- Q9BXX7
- Q9UK49
Protein attributes for CYP1A2 Gene
- Size:
- 515 amino acids
- Molecular mass:
- 58294 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP1A2 Gene
Post-translational modifications for CYP1A2 Gene
Other Protein References for CYP1A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CYP1A2
- AM05371PU-N
- CF501154
- CF501155
- CF501156
- CF501157
- CF501172
- CF501173
- CF501196
- CF501197
- CF501244
- SP1320A
- TA309532
- TA313311
- TA324397
- TA351484
- TA353117L
- TA353118L
- TA353119L
- TA501154
- TA501155
- TA501155S
- TA501156
- TA501157
- TA501172
- TA501173
- TA501196
- TA501197
- TA501244
- TA600038
- TA600045
- TA700038
- UM500073
- UM500073CF
- UM570073
- Novus Biologicals Antibodies for CYP1A2
-
Abcam antibodies for CYP1A2
- Invitrogen Antibodies for CYP1A2 (AFLGC-CYP1A2)
- GeneTex CYP1A2 Antibody for CYP1A2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A2
Protein Products
-
OriGene Purified Proteins for CYP1A2
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP1A2
- Origene Custom Protein Services for CYP1A2
- Search GeneTex for Proteins for CYP1A2
-
Abcam proteins for CYP1A2
Assay Products
-
Abcam assays for CYP1A2
No data available for DME Specific Peptides for CYP1A2 Gene
Domains & Families for CYP1A2 Gene
Gene Families for CYP1A2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted membrane proteins
Protein Domains for CYP1A2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP1A2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05177- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP1A2 Gene
Molecular function for CYP1A2 Gene
- UniProtKB/Swiss-Prot Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
- UniProtKB/Swiss-Prot CatalyticActivity:
- RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=4 uM for 2-amino-6-methyldipyrido[1,2-a:3,2-d]imidazole {ECO:0000269 PubMed:14725854}; KM=21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline {ECO:0000269 PubMed:14725854}; KM=26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline {ECO:0000269 PubMed:14725854}; KM=27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline {ECO:0000269 PubMed:14725854}; KM=71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine {ECO:0000269 PubMed:14725854}; KM=25 uM for phenacetin {ECO:0000269 PubMed:14725854};
- UniProtKB/Swiss-Prot Induction:
- By nicotine, omeprazole, phenobarbital, primidone and rifampicin.
- GENATLAS Biochemistry:
- cytochrome p450,family I (aromatic compound-inducible),member A2 (see CYP1@)
Enzyme Numbers (IUBMB) for CYP1A2 Gene
Phenotypes From GWAS Catalog for CYP1A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004497 | monooxygenase activity | TAS | -- |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0009055 | electron transfer activity | TAS | 2813353 |
| GO:0016491 | oxidoreductase activity | IDA | 16401082 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | -- |
Phenotypes for CYP1A2 Gene
- MGI mutant phenotypes for CYP1A2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CYP1A2:
Animal Models for CYP1A2 Gene
- MGI Knock Outs for CYP1A2:
-
- Cyp1a2/Cyp1a1 Cyp1a2/Cyp1a1<tm1.1Bra>
- Cyp1a2 Cyp1a2<tm1Gonz>
- Cyp1a2 Cyp1a2<tm1Dwn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYP1A2
-
CRISPR Products
-
OriGene CRISPR knockouts for CYP1A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP1A2
- genomics-online: gRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
- Applied Biological Materials CRISPR for CYP1A2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A2
- GenScript: Design CRISPR guide RNA sequences for CYP1A2
miRNA for CYP1A2 Gene
- miRTarBase miRNAs that target CYP1A2
-
- hsa-let-7b-5p (MIRT052168)
- hsa-mir-7703 (MIRT619665)
- hsa-mir-6720-5p (MIRT619666)
- hsa-mir-6512-3p (MIRT619667)
- hsa-mir-196a-3p (MIRT619668)
- hsa-mir-4252 (MIRT619669)
- hsa-mir-3128 (MIRT619670)
- hsa-mir-4793-3p (MIRT619671)
- hsa-mir-766-3p (MIRT619672)
- hsa-mir-1292-3p (MIRT619673)
- hsa-mir-8073 (MIRT619674)
- hsa-mir-221-5p (MIRT619675)
- hsa-mir-6849-3p (MIRT619676)
- hsa-mir-1273g-3p (MIRT619677)
- hsa-mir-508-5p (MIRT619678)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP1A2
- Browse OriGene Inhibitory RNA Products For CYP1A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A2
- genomics-online: shRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for CYP1A2
- Sino Biological Human cDNA Clone for CYP1A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP1A2
- Applied Biological Materials Clones for CYP1A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CYP1A2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A2 Gene
Localization for CYP1A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP1A2 Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031090 | organelle membrane | IEA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IEA,IDA | 2813353 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A2 Gene
Pathways & Interactions for CYP1A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Paroxetine Pathway, Pharmacokinetics | ||
| 3 | Cytochrome P450 - arranged by substrate type |
.39
.01
|
|
| 4 | superpathway of tryptophan utilization | ||
| 5 | Caffeine Pathway, Pharmacokinetics | ||
Pathways by source for CYP1A2 Gene
19 BioSystems pathways for CYP1A2 Gene
13 Reactome pathways for CYP1A2 Gene
9 KEGG pathways for CYP1A2 Gene
8 GeneGo (Thomson Reuters) pathways for CYP1A2 Gene
1 Cell Signaling Technology pathway for CYP1A2 Gene
Interacting Proteins for CYP1A2 Gene
GPS-Prot Interaction Network for CYP1A2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006706 | steroid catabolic process | IMP | 18356043 |
| GO:0006725 | cellular aromatic compound metabolic process | IEA | -- |
| GO:0006778 | porphyrin-containing compound metabolic process | IEA | -- |
| GO:0006805 | xenobiotic metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for CYP1A2 Gene
Drugs & Compounds for CYP1A2 Gene
(477) Drugs for CYP1A2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Caffeine | Approved | Nutra | Antagonist, Activator, Enzyme, substrate, inhibitor | 434 | ||
| Carbamazepine | Approved, Investigational | Pharma | Enzyme, substrate, inhibitor, inducer | Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant | 134 | |
| Fluvoxamine | Approved, Investigational | Pharma | Enzyme, substrate, inhibitor | 53 | ||
| Ketoconazole | Approved, Investigational | Pharma | Pore Blocker, Enzyme, inhibitor | Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase, Cytochrome P450c17 inhibitor | 179 | |
| Miconazole | Approved, Investigational, Vet_approved | Pharma | Channel blocker, Antagonist, Pore Blocker, Enzyme, inhibitor | 3838 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1,7-Dimethyluric acid |
|
|||||
| 1-Methylxanthine |
|
|||||
| Aflatoxin B1 |
|
1162-65-8 | ||||
| nadph |
|
53-57-6 | ||||
| Paraxanthine |
|
611-59-6 |
Drug Products
Transcripts for CYP1A2 Gene
mRNA/cDNA for CYP1A2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (27) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000343932 2728 bps (uc002ayr.2)
Unigene Clusters for CYP1A2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CYP1A2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP1A2
- genomics-online: gRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
- Applied Biological Materials CRISPR for CYP1A2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A2
- GenScript: Design CRISPR guide RNA sequences for CYP1A2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP1A2
- Browse OriGene Inhibitory RNA Products For CYP1A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A2
- genomics-online: shRNA clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for CYP1A2
- Sino Biological Human cDNA Clone for CYP1A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP1A2
- Applied Biological Materials Clones for CYP1A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CYP1A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Perivenous Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CYP1A2 Gene
This gene is overexpressed in Liver (x51.8).
This gene is overexpressed in Gallbladder (51.2) and Liver (17.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1A2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CYP1A2 Gene:
CYP1A2SOURCE GeneReport for Unigene cluster for CYP1A2 Gene:
Hs.1361mRNA Expression by UniProt/SwissProt for CYP1A2 Gene:
P05177-CP1A2_HUMAN
Tissue specificity:
Liver.
Evidence on tissue expression from TISSUES for CYP1A2 Gene
- Liver(4.8)
- Urine(2.6)
- Blood(2.5)
- Intestine(2.3)
Primer Products
-
OriGene qPCR primer pairs for CYP1A2
-
OriGene qPCR primer pairs and template standards for CYP1A2
- genomics-online: primer clones - Search results for 95 available CYP1A2 gene related products
- Overview of 95 available CYP1A2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A2 Gene
Orthologs for CYP1A2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CYP1A2 34 |
|
OneToOne | |
| LOC735881 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | CYP1A2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CYP1A2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cyp1a2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cyp1a2 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CYP1A1 34 |
|
ManyToMany | |
| CYP1A4 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | cyp1a 34 |
|
OneToMany | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11738 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cyp307a1 35 |
|
|
|
| spok 34 |
|
ManyToMany | |||
| spo 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CYP703A2 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os08g0131100 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for CYP1A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CYP1A2 Gene
- ENSEMBL:
- Gene Tree for CYP1A2 (if available)
- TreeFam:
- Gene Tree for CYP1A2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYP1A2: view image
Paralogs for CYP1A2 Gene
(25) SIMAP similar genes for CYP1A2 Gene using alignment to 2 proteins:
- CP1A2_HUMAN
- Q6NWU3_HUMAN
Variants for CYP1A2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A2 Gene
- CP1A2_HUMAN-P05177
- The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are homozygous for the CYP1A2*1F allele are slow caffeine metabolizers. Thus for these individual increased intake of caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI).
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000539344 | -- | 74,751,037(+) | G/A/T | intron_variant | |
| rs1001162410 | -- | 74,753,008(+) | G/C/T | intron_variant | |
| rs1001244975 | -- | 74,756,353(+) | G/A | 3_prime_UTR_variant | |
| rs1001753001 | -- | 74,749,364(+) | G/A | intron_variant | |
| rs1001805272 | -- | 74,749,647(+) | G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3581763 | CNV | loss | 25503493 |
| nsv1121512 | CNV | deletion | 24896259 |
| nsv833055 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.60;
44.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYP1A2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for CYP1A2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| toxicity or absent response to clozapine |
|
|
| acetaminophen metabolism |
|
|
| porphyria cutanea tarda |
|
|
| extraskeletal mesenchymal chondrosarcoma |
|
|
| cytochrome p450 oxidoreductase deficiency |
|
|
Search CYP1A2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CYP1A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A2 Gene
Publications for CYP1A2 Gene
- Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. (PMID: 19415745) Sangrajrang S … Yoshida T (International journal of cancer 2009) 3 22 44 58
- CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. (PMID: 19843669) Peterson S … Lampe JW (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 44 58
- Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. (PMID: 19450128) Gunes A … Dahl ML (Pharmacogenomics 2009) 3 22 44 58
- [Association of cytochrome P450 genes polymorphisms (CYP1A1 and CYP1A2) with the development of chronic obstructive pulmonary disease in Bashkortostan]. (PMID: 18389617) Korytina GF … Viktorova TV (Molekuliarnaia biologiia 2008) 3 22 44 58
- Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. (PMID: 17429315) Long JR … Zheng W (Pharmacogenetics and genomics 2007) 3 22 44 58
Products for CYP1A2 Gene
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- antibodies-online: Search results for 189 available CYP1A2 Antibodies ranked by validation data
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- Quality Products:
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Sources for CYP1A2 Gene
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- (28) ASD
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- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
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- (42) GenAtlas
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- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
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- (51) HORDE
- (52) HUGE
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- (54) Leiden
- (55) miRBase
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- (58) PubMed
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- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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