Free for academic non-profit institutions. Other users need a Commercial license
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Ehrlich Tumor Carcinoma. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004497 | monooxygenase activity | TAS,IEA | -- |
GO:0005506 | iron ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008391 | arachidonic acid monooxygenase activity | IDA | 15041462 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005743 | mitochondrial inner membrane | ISS | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS,IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
.39
|
|
2 | Drug metabolism - cytochrome P450 | ||
3 | Arachidonic acid metabolism | ||
4 | Metabolism |
.40
|
|
5 | Erlotinib Pathway, Pharmacokinetics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEA | -- |
GO:0001889 | liver development | IEA | -- |
GO:0002933 | lipid hydroxylation | IDA | 14559847 |
GO:0006631 | fatty acid metabolic process | IEA,IDA | 15041462 |
GO:0006778 | porphyrin-containing compound metabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Granisetron | Approved, Investigational | Pharma | Enzyme, substrate | Serotonin 5-HT3 receptor antagonist | 89 | |
Phenobarbital | Approved, Investigational | Pharma | Agonist, Enzyme, inducer | 87 | ||
Caffeine | Approved | Pharma | Antagonist, Activator, Enzyme, inhibitor | 541 | ||
Chlorzoxazone | Approved | Pharma | Agonist, Activator, Enzyme, substrate | 8 | ||
Clofibrate | Approved, Investigational | Pharma | Agonist, Enzyme, inducer | 2 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
11,12,15-THETA |
|
|
||||
11,12-EpETrE |
|
81276-02-0 |
|
|||
11,14,15-THETA |
|
|
||||
11H-14,15-EETA |
|
219535-29-2 |
|
|||
12,13-EpOME |
|
|
Compound | Action | Cas Number |
---|---|---|
7-Ethoxyresorufin | Specific subtrate of CYP1A | 5725-91-7 |
Diosmetin | CYP1A1 inhibitor | 520-34-3 |
Methoxyresorufin | 5725-89-3 | |
Pentoxyresorufin | 87687-03-4 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||
SP2: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CYP1A1 33 |
|
OneToOne | |
LOC453744 32 |
|
||||
cow (Bos Taurus) |
Mammalia | CYP1A1 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CYP1A1 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Cyp1a1 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cyp1a1 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | CYP1A1 33 32 |
|
ManyToMany | |
CYP1A4 33 |
|
ManyToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany | |||
-- 33 |
|
ManyToMany | |||
tropical clawed frog (Silurana tropicalis) |
Amphibia | cyp1a1 32 |
|
||
Str.2144 32 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | cyp1a 33 32 |
|
OneToMany | |
cyp1a1 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | Cyp18a1 34 |
|
|
|
Cyp307a1 34 |
|
|
|||
spo 33 |
|
ManyToMany | |||
spok 33 |
|
ManyToMany | |||
thale cress (Arabidopsis thaliana) |
eudicotyledons | CYP93D1 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os06g0613600 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
ManyToMany | |
-- 33 |
|
ManyToMany |
SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000393848 | -- | 74,719,252(-) | T/G | downstream_transcript_variant | |
rs1000699728 | -- | 74,724,009(-) | T/C | intron_variant | |
rs1000751890 | -- | 74,723,694(-) | T/G | intron_variant | |
rs1001267801 | -- | 74,724,894(-) | G/T | intron_variant | |
rs1001321488 | -- | 74,725,220(-) | T/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2763106 | CNV | loss | 21179565 |
esv3636907 | CNV | loss | 21293372 |
nsv1121512 | CNV | deletion | 24896259 |
nsv817698 | CNV | gain | 17921354 |
nsv833055 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
aryl hydrocarbon hydroxylase inducibility |
|
|
ehrlich tumor carcinoma |
|
|
phimosis |
|
|
toxic oil syndrome |
|
|
acetaminophen metabolism |
|
|