This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), som... See more...

Aliases for CYP1A1 Gene

Aliases for CYP1A1 Gene

  • Cytochrome P450 Family 1 Subfamily A Member 1 2 3 5
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
  • Hydroperoxy Icosatetraenoate Dehydratase 3 4
  • Cytochrome P450 Form 6 3 4
  • Cytochrome P450 1A1 3 4
  • Cytochrome P450-P1 3 4
  • Cytochrome P450-C 3 4
  • CYPIA1 3 4
  • Cytochrome P1-450, Dioxin-Inducible 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Xenobiotic Monooxygenase 3
  • EC 1.14.14.1 54
  • EC 1.14.14.- 4
  • EC 4.2.1.152 4
  • P1-450 3
  • P450-C 3
  • P450DX 3
  • AHRR 3
  • CP11 3
  • CYP1 3
  • AHH 3

External Ids for CYP1A1 Gene

Previous HGNC Symbols for CYP1A1 Gene

  • CYP1

Previous GeneCards Identifiers for CYP1A1 Gene

  • GC15M068848
  • GC15M068126
  • GC15M072587
  • GC15M072727
  • GC15M072798
  • GC15M075011
  • GC15M051809

Summaries for CYP1A1 Gene

Entrez Gene Summary for CYP1A1 Gene

  • This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP1A1 Gene

CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Ehrlich Tumor Carcinoma. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A2.

UniProtKB/Swiss-Prot Summary for CYP1A1 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).

Gene Wiki entry for CYP1A1 Gene

Additional gene information for CYP1A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP1A1 Gene

Genomics for CYP1A1 Gene

GeneHancer (GH) Regulatory Elements for CYP1A1 Gene

Promoters and enhancers for CYP1A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J074725 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 754.4 -0.2 -191 2.8 CTCF RBPJ POLR2A NR2F1 NR2F6 AHR SP1 SP7 PRDM1 PPARG CYP1A1 SCAMP5 STOML1 RPP25 ENSG00000260103 ARID3B C15orf39 SCAMP2 piR-36393-182
GH15J074724 Enhancer 0.8 ENCODE 750.6 +1.5 1475 0.2 SP1 ATF1 ZNF280D NKRF SP7 PRDM1 KLF14 RXRA PRDM10 ZNF639 CYP1A1 SCAMP5 SNUPN STOML1 EDC3
GH15J074723 Enhancer 0.6 ENCODE 750.6 +1.8 1795 0.2 ATF1 GATAD2A ZNF205 ZBTB48 ZBTB17 ZGPAT ZNF511 TFAP4 IKZF5 ARID4B CYP1A1 ENSG00000260103 EDC3
GH15J074738 Promoter 0.6 EPDnew 750.4 -12.9 -12877 0.1 EGR1 ZSCAN5C ZFHX2 CYP1A1 CPLX3 ULK3 FAM219B ENSG00000212279 piR-54764-215 CYP1A2
GH15J074775 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -62.5 -62456 25.8 SIN3A ZNF24 SP1 ZBTB40 CTCF FOXA1 LCORL SMARCE1 POLR2A USF2 CSK MIR4513 SIN3A ENSG00000187812 ENSG00000260274 C15orf39 DNM1P35 PML ULK3 SNX33
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP1A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP1A1 gene promoter:
  • Bach2
  • C/EBPbeta
  • GR
  • GR-alpha
  • HNF-4alpha1
  • MZF-1
  • p53
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for CYP1A1 Gene

Genomic Locations for CYP1A1 Gene
chr15:74,719,542-74,725,610
(GRCh38/hg38)
Size:
6,069 bases
Orientation:
Minus strand
chr15:75,011,883-75,017,951
(GRCh37/hg19)
Size:
6,069 bases
Orientation:
Minus strand

Genomic View for CYP1A1 Gene

Genes around CYP1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP1A1 Gene

Proteins for CYP1A1 Gene

  • Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04798-CP1A1_HUMAN
    Recommended name:
    Cytochrome P450 1A1
    Protein Accession:
    P04798
    Secondary Accessions:
    • A4F3V9
    • A4F3W0
    • Q53G18

    Protein attributes for CYP1A1 Gene

    Size:
    512 amino acids
    Molecular mass:
    58165 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.

    Three dimensional structures from OCA and Proteopedia for CYP1A1 Gene

    Alternative splice isoforms for CYP1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP1A1 Gene

Selected DME Specific Peptides for CYP1A1 Gene

P04798:
  • KEHYKTFEKG
  • TTAISWSL
  • FSIASDP
  • QGDDFKGRP
  • CVFVNQWQ
  • VLSGLDTIRQALV
  • PILRYLP
  • LDENANVQ
  • ELDTVIG
  • SGNPADFIPIL
  • EVFLFLA
  • QLSDEKI
  • NVICAICFG
  • VVGSGNPADFIP
  • NQWQINH
  • PFTIPHST
  • RRPRLSDR
  • LTLGKNPH
  • TPIYGLT
  • PHSTTRDT
  • IRDITDSLI
  • YGDVLQI
  • WAARRRLAQ
  • FGAGFDT
  • LPYMEAFILE

Post-translational modifications for CYP1A1 Gene

  • Glycosylation at Ser67
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for CYP1A1 Gene

Gene Families for CYP1A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CYP1A1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94514, Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1(CYP1A1), mRNA (A0N0X8_HUMAN)
  • Cytochrome P450 1A1 (A4F3V8_HUMAN)
  • Cytochrome P450 1A1 (A4F3V9_HUMAN)
  • Cytochrome P450 1A1 (A4F3W0_HUMAN)
  • Cytochrome P450 1A1 (A4F4K3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04798

UniProtKB/Swiss-Prot:

CP1A1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1A1: view

Function for CYP1A1 Gene

Molecular function for CYP1A1 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:15805301}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47209; Evidence={ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence={ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:15805301}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47293; Evidence={ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47308, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87605; Evidence={ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:15805301}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47309; Evidence={ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47312, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87618; Evidence={ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:15805301}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47313; Evidence={ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47204, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:14559847}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47205; Evidence={ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:14559847};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269 PubMed:11555828, ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:15805301}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47213; Evidence={ECO:0000305 PubMed:11555828, ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47281; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47284, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62847; Evidence={ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:15805301}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47285; Evidence={ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47288, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87598; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47289; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47276, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87593; Evidence={ECO:0000269 PubMed:12865317, ECO:0000269 PubMed:15805301}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47277; Evidence={ECO:0000305 PubMed:12865317, ECO:0000305 PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50076, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78043, ChEBI:CHEBI:132024; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50077; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49972, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132019; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49973; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49968, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132016; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49969; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39811, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:63590; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39812; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence={ECO:0000269 PubMed:15041462, ECO:0000269 PubMed:18577768}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39760; Evidence={ECO:0000305 PubMed:15041462, ECO:0000305 PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39788; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49884, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131975; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49885; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49881; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49857; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence={ECO:0000269 PubMed:19965576, ECO:0000269 PubMed:20972997}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:49861; Evidence={ECO:0000305 PubMed:19965576, ECO:0000305 PubMed:20972997};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence={ECO:0000269 PubMed:15041462, ECO:0000269 PubMed:19965576}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39780; Evidence={ECO:0000305 PubMed:15041462, ECO:0000305 PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136411; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52125; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52121; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42093; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42089; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48717; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:37948; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48637; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48633; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for all-trans retinol {ECO:0000269 PubMed:10681376}; KM=9.5 uM for 17beta-estradiol (2-hydroxylation) {ECO:0000269 PubMed:15805301}; KM=11.8 uM for 17beta-estradiol (4-hydroxylation) {ECO:0000269 PubMed:15805301}; KM=79 uM for 17beta-estradiol (6alpha-hydroxylation) {ECO:0000269 PubMed:15805301}; KM=19.6 uM for 17beta-estradiol (15alpha-hydroxylation) {ECO:0000269 PubMed:15805301}; KM=12.2 uM for estrone (2-hydroxylation) {ECO:0000269 PubMed:15805301}; KM=22.6 uM for estrone (4-hydroxylation) {ECO:0000269 PubMed:15805301}; KM=86 uM for estrone (6alpha-hydroxylation) {ECO:0000269 PubMed:15805301}; KM=85 uM for estrone (15alpha-hydroxylation) {ECO:0000269 PubMed:15805301}; Vmax=507 pmol/min/nmol enzyme toward all-trans retinol {ECO:0000269 PubMed:10681376}; Vmax=0.6 pmol/min/pmol enzyme toward 17beta-estradiol (2- hydroxylation) {ECO:0000269 PubMed:15805301}; Vmax=0.02 pmol/min/pmol enzyme toward 17beta-estradiol (4- hydroxylation) {ECO:0000269 PubMed:15805301}; Vmax=3.6 pmol/min/pmol enzyme toward 17beta-estradiol (6alpha- hydroxylation) {ECO:0000269 PubMed:15805301}; Vmax=0.9 pmol/min/pmol enzyme toward 17beta-estradiol (15alpha- hydroxylation) {ECO:0000269 PubMed:15805301}; Vmax=0.4 pmol/min/pmol enzyme toward estrone (2-hydroxylation) {ECO:0000269 PubMed:15805301}; Vmax=0.1 pmol/min/pmol enzyme toward estrone (4-hydroxylation) {ECO:0000269 PubMed:15805301}; Vmax=0.2 pmol/min/pmol enzyme toward estrone (6alpha- hydroxylation) {ECO:0000269 PubMed:15805301}; Vmax=1.2 pmol/min/pmol enzyme toward estrone (15alpha- hydroxylation) {ECO:0000269 PubMed:15805301};
UniProtKB/Swiss-Prot Induction:
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
GENATLAS Biochemistry:
cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)

Enzyme Numbers (IUBMB) for CYP1A1 Gene

Phenotypes From GWAS Catalog for CYP1A1 Gene

Gene Ontology (GO) - Molecular Function for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004497 monooxygenase activity TAS,IEA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008391 arachidonic acid monooxygenase activity IDA 15041462
genes like me logo Genes that share ontologies with CYP1A1: view
genes like me logo Genes that share phenotypes with CYP1A1: view

Animal Models for CYP1A1 Gene

MGI Knock Outs for CYP1A1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene

Localization for CYP1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP1A1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 4
nucleus 3
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane ISS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS,IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A1 Gene

Pathways & Interactions for CYP1A1 Gene

genes like me logo Genes that share pathways with CYP1A1: view

UniProtKB/Swiss-Prot P04798-CP1A1_HUMAN

  • Pathway: Steroid hormone biosynthesis.
  • Pathway: Lipid metabolism; fatty acid metabolism.
  • Pathway: Cofactor metabolism; retinol metabolism.

SIGNOR curated interactions for CYP1A1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development IEA --
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006631 fatty acid metabolic process IEA,IDA 15041462
GO:0006778 porphyrin-containing compound metabolic process IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

Drugs & Compounds for CYP1A1 Gene

(195) Drugs for CYP1A1 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Granisetron Approved, Investigational Pharma Enzyme, substrate Serotonin 5-HT3 receptor antagonist 89
Phenobarbital Approved, Investigational Pharma Agonist, Enzyme, inducer 87
Caffeine Approved Pharma Antagonist, Activator, Enzyme, inhibitor 541
Chlorzoxazone Approved Pharma Agonist, Activator, Enzyme, substrate 8
Clofibrate Approved, Investigational Pharma Agonist, Enzyme, inducer 2

(96) Additional Compounds for CYP1A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-EpETrE
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
81276-02-0
11,14,15-THETA
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid

(4) ApexBio Compounds for CYP1A1 Gene

Compound Action Cas Number
7-Ethoxyresorufin Specific subtrate of CYP1A 5725-91-7
Diosmetin CYP1A1 inhibitor 520-34-3
Methoxyresorufin 5725-89-3
Pentoxyresorufin 87687-03-4
genes like me logo Genes that share compounds with CYP1A1: view

Transcripts for CYP1A1 Gene

mRNA/cDNA for CYP1A1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:

Relevant External Links for CYP1A1 Gene

GeneLoc Exon Structure for
CYP1A1
ECgene alternative splicing isoforms for
CYP1A1

Expression for CYP1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene

This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for CYP1A1 Gene

This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1A1 Gene



Protein tissue co-expression partners for CYP1A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP1A1 Gene:

CYP1A1

SOURCE GeneReport for Unigene cluster for CYP1A1 Gene:

Hs.72912

mRNA Expression by UniProt/SwissProt for CYP1A1 Gene:

P04798-CP1A1_HUMAN
Tissue specificity: Lung, lymphocytes and placenta.

Evidence on tissue expression from TISSUES for CYP1A1 Gene

  • Liver(4.8)
  • Blood(4.5)
  • Nervous system(4.4)
  • Lung(3.4)
  • Intestine(2.8)
  • Kidney(2.7)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with CYP1A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A1 Gene

Orthologs for CYP1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP1A1 33
  • 100 (a)
OneToOne
LOC453744 32
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia CYP1A1 33 32
  • 85.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CYP1A1 33 32
  • 84.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp1a1 17 33 32
  • 82.61 (n)
rat
(Rattus norvegicus)
Mammalia Cyp1a1 32
  • 82.42 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 72 (a)
ManyToMany
-- 33
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves CYP1A1 33 32
  • 67.06 (n)
ManyToMany
CYP1A4 33
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 60 (a)
ManyToMany
-- 33
  • 58 (a)
ManyToMany
-- 33
  • 55 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp1a1 32
  • 65.14 (n)
Str.2144 32
zebrafish
(Danio rerio)
Actinopterygii cyp1a 33 32
  • 60.88 (n)
OneToMany
cyp1a1 32
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 34
  • 32 (a)
Cyp307a1 34
  • 28 (a)
spo 33
  • 24 (a)
ManyToMany
spok 33
  • 22 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP93D1 32
  • 40.54 (n)
rice
(Oryza sativa)
Liliopsida Os06g0613600 32
  • 45.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 31 (a)
ManyToMany
-- 33
  • 21 (a)
ManyToMany
Species where no ortholog for CYP1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP1A1 Gene

ENSEMBL:
Gene Tree for CYP1A1 (if available)
TreeFam:
Gene Tree for CYP1A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP1A1: view image

Paralogs for CYP1A1 Gene

Paralogs for CYP1A1 Gene

(30) SIMAP similar genes for CYP1A1 Gene using alignment to 8 proteins:

  • CP1A1_HUMAN
  • A0N0X8_HUMAN
  • A4F3V8_HUMAN
  • A4F4K3_HUMAN
  • A4F4K4_HUMAN
  • E7EMT5_HUMAN
  • Q0VHD5_HUMAN
  • Q5J9B1_HUMAN

Pseudogenes.org Pseudogenes for CYP1A1 Gene

genes like me logo Genes that share paralogs with CYP1A1: view

Variants for CYP1A1 Gene

Sequence variations from dbSNP and Humsavar for CYP1A1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000393848 -- 74,719,252(-) T/G downstream_transcript_variant
rs1000699728 -- 74,724,009(-) T/C intron_variant
rs1000751890 -- 74,723,694(-) T/G intron_variant
rs1001267801 -- 74,724,894(-) G/T intron_variant
rs1001321488 -- 74,725,220(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP1A1 Gene

Variant ID Type Subtype PubMed ID
esv2763106 CNV loss 21179565
esv3636907 CNV loss 21293372
nsv1121512 CNV deletion 24896259
nsv817698 CNV gain 17921354
nsv833055 CNV loss 17160897

Variation tolerance for CYP1A1 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP1A1 Gene

Human Gene Mutation Database (HGMD)
CYP1A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene

Disorders for CYP1A1 Gene

MalaCards: The human disease database

(38) MalaCards diseases for CYP1A1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aryl hydrocarbon hydroxylase inducibility
  • ahh inducibility; ahhi
ehrlich tumor carcinoma
  • ehrlich's tumor
phimosis
  • tight foreskin
toxic oil syndrome
acetaminophen metabolism
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP1A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene

Publications for CYP1A1 Gene

  1. Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. (PMID: 20381444) Ashton KA … Scott RJ (Cancer epidemiology 2010) 3 23 43 56
  2. Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. (PMID: 19608585) Wright CM … Fong KM (The European respiratory journal 2010) 3 23 43 56
  3. [Relationship between CYP1A1 gene polymorphisms and urinary 1-hydroxypyrene levels in coke oven workers]. (PMID: 19538838) Nie JS … Niu Q (Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2009) 3 23 43 56
  4. Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. (PMID: 19632247) Shah PP … Parmar D (Mutation research 2009) 3 23 43 56
  5. Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. (PMID: 19346634) Surekha D … Vishnupriya S (Indian journal of medical sciences 2009) 3 23 43 56

Products for CYP1A1 Gene

Sources for CYP1A1 Gene