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This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), som... See more...
Aliases for CYP1A1 Gene
Aliases for CYP1A1 Gene
- Cytochrome P450 Family 1 Subfamily A Member 1 2 3 5
- Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
- Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
- Hydroperoxy Icosatetraenoate Dehydratase 3 4
- Cytochrome P450 Form 6 3 4
- Cytochrome P450 1A1 3 4
- Cytochrome P450-P1 3 4
- Cytochrome P450-C 3 4
- EC 1.14.14.1 4 51
- CYPIA1 3 4
- P1-450 2 3
External Ids for CYP1A1 Gene
- HGNC: 2595
- Entrez Gene: 1543
- Ensembl: ENSG00000140465
- OMIM: 108330
- UniProtKB: P04798
Previous HGNC Symbols for CYP1A1 Gene
- CYP1
Previous GeneCards Identifiers for CYP1A1 Gene
- GC15M068848
- GC15M068126
- GC15M072587
- GC15M072727
- GC15M072798
- GC15M075011
- GC15M051809
Summaries for CYP1A1 Gene
-
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
GeneCards Summary for CYP1A1 Gene
CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Gastroschisis. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A2.
UniProtKB/Swiss-Prot Summary for CYP1A1 Gene
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A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).
Additional gene information for CYP1A1 Gene
- HGNC(2595)
- Entrez Gene(1543)
- Ensembl(ENSG00000140465)
- OMIM(108330)
- UniProtKB(P04798)
- Open Targets Platform(ENSG00000140465)
- Monarch Initiative
- Search for CYP1A1 at DataMed
- Search for CYP1A1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP1A1 Gene
Genomics for CYP1A1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CYP1A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CYP1A1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP1A1
- Top Transcription factor binding sites by QIAGEN in the CYP1A1 gene promoter:
-
- Bach2
- C/EBPbeta
- GR
- GR-alpha
- HNF-4alpha1
- MZF-1
- p53
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for CYP1A1 Gene
Genomic Locations for CYP1A1 Gene
- chr15:74,719,542-74,725,536
- (GRCh38/hg38)
- Size:
- 5,995 bases
- Orientation:
- Minus strand
- chr15:75,011,883-75,017,951
- (GRCh37/hg19)
- Size:
- 6,069 bases
- Orientation:
- Minus strand
Genomic View for CYP1A1 Gene
Genes around CYP1A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.1 by HGNC
- 15q24.1 by Entrez Gene
- 15q24.1 by Ensembl
CYP1A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP1A1 Gene
Proteins for CYP1A1 Gene
-
Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04798-CP1A1_HUMAN
- Recommended name:
- Cytochrome P450 1A1
- Protein Accession:
- P04798
- A4F3V9
- A4F3W0
- Q53G18
Protein attributes for CYP1A1 Gene
- Size:
- 512 amino acids
- Molecular mass:
- 58165 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
-
- Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.
Three dimensional structures from OCA and Proteopedia for CYP1A1 Gene
Protein Expression for CYP1A1 Gene
Selected DME Specific Peptides for CYP1A1 Gene
- P04798:
-
- KEHYKTFEKG
- TTAISWSL
- FSIASDP
- QGDDFKGRP
- CVFVNQWQ
- VLSGLDTIRQALV
- PILRYLP
- LDENANVQ
- ELDTVIG
- SGNPADFIPIL
- EVFLFLA
- QLSDEKI
- NVICAICFG
- VVGSGNPADFIP
- NQWQINH
- PFTIPHST
- RRPRLSDR
- LTLGKNPH
- TPIYGLT
- PHSTTRDT
- IRDITDSLI
- YGDVLQI
- WAARRRLAQ
- FGAGFDT
- LPYMEAFILE
Post-translational modifications for CYP1A1 Gene
Other Protein References for CYP1A1 Gene
Antibody Products
- G Biosciences Immunotag™ CYP1A1 Antibody
- NSJ Bioreagents CYP1A1 Antibody
- Creative Diagnostics Anti-Cytochrome P450 1A1 / 1A2 (aa 282-296) polyclonal antibody
- GeneTex Anti-CYP1A1 antibody
-
Custom Antibody ServicesOriGene Antibodies for CYP1A1
- Novus Biologicals Antibodies for CYP1A1
-
Abcam antibodies for CYP1A1
- Invitrogen Antibodies for CYP1A1 (AFLGC-CYP1A1)
-
Boster Bio Antibodies for CYP1A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A1
Protein Products
- Creative Biomart Recombinant Human CYP1A1
-
OriGene Purified Proteins for CYP1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP1A1
- Origene Custom Protein Services for CYP1A1
-
Abcam proteins for CYP1A1
Assay Products
- antibodies-online: Show 44 available CYP1A1 Elisa Kits ranked by validation data
- Compare Top CYP1A1 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for CYP1A1
Domains & Families for CYP1A1 Gene
Gene Families for CYP1A1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CYP1A1 Gene
- InterPro:
- Blocks:
-
- E-class P450 group I signature
- CYP1A P450 family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP1A1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ94514, Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1(CYP1A1), mRNA (A0N0X8_HUMAN)
- Cytochrome P450 1A1 (A4F3V8_HUMAN)
- Cytochrome P450 1A1 (A4F3V9_HUMAN)
- Cytochrome P450 1A1 (A4F3W0_HUMAN)
- Cytochrome P450 1A1 (A4F4K3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P04798- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP1A1 Gene
Molecular function for CYP1A1 Gene
- UniProtKB/Swiss-Prot Function:
- A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:15805301, ECO:0000269|PubMed:18577768};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47308, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87605; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47312, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87618; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47204, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence={ECO:0000269|PubMed:12865317};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47284, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62847; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47288, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87598; Evidence={ECO:0000269|PubMed:12865317};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47276, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87593; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50076, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78043, ChEBI:CHEBI:132024; Evidence={ECO:0000269|PubMed:18577768};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49972, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132019; Evidence={ECO:0000269|PubMed:15041462};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49968, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132016; Evidence={ECO:0000269|PubMed:15041462};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39811, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:63590; Evidence={ECO:0000269|PubMed:15041462};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence={ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:18577768};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence={ECO:0000269|PubMed:15041462};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49884, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131975; Evidence={ECO:0000269|PubMed:20972997};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence={ECO:0000269|PubMed:20972997};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence={ECO:0000269|PubMed:19965576};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence={ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence={ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:19965576};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136411; Evidence={ECO:0000269|PubMed:19965576};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence={ECO:0000269|PubMed:19965576};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence={ECO:0000269|PubMed:21068195};.
- UniProtKB/Swiss-Prot Induction:
- By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=8 uM for all-trans retinol {ECO:0000269|PubMed:10681376}; KM=9.5 uM for 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=11.8 uM for 17beta-estradiol (4-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=79 uM for 17beta-estradiol (6alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=19.6 uM for 17beta-estradiol (15alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=12.2 uM for estrone (2-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=22.6 uM for estrone (4-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=86 uM for estrone (6alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=85 uM for estrone (15alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=507 pmol/min/nmol enzyme toward all-trans retinol {ECO:0000269|PubMed:10681376}; Vmax=0.6 pmol/min/pmol enzyme toward 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.02 pmol/min/pmol enzyme toward 17beta-estradiol (4-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=3.6 pmol/min/pmol enzyme toward 17beta-estradiol (6alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.9 pmol/min/pmol enzyme toward 17beta-estradiol (15alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.4 pmol/min/pmol enzyme toward estrone (2-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.1 pmol/min/pmol enzyme toward estrone (4-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.2 pmol/min/pmol enzyme toward estrone (6alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=1.2 pmol/min/pmol enzyme toward estrone (15alpha-hydroxylation) {ECO:0000269|PubMed:15805301};
- GENATLAS Biochemistry:
- cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)
Enzyme Numbers (IUBMB) for CYP1A1 Gene
Phenotypes From GWAS Catalog for CYP1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004497 | monooxygenase activity | IEA,TAS | -- |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008391 | arachidonic acid monooxygenase activity | IDA | 15041462 |
Phenotypes for CYP1A1 Gene
- MGI mutant phenotypes for CYP1A1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CYP1A1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased shRNA abundance
- Inconclusive
- Weakly decreased NFAT1-GFP nuclear translocation
- Negative genetic interaction between PTEN-/- and PTEN+/+
Animal Models for CYP1A1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYP1A1 - Select products 50% OFF >
- * CYP1A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CYP1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP1A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A1
miRNA for CYP1A1 Gene
- miRTarBase miRNAs that target CYP1A1
-
- hsa-miR-296-3p (MIRT038448)
- hsa-miR-6809-3p (MIRT489671)
- hsa-miR-6833-3p (MIRT489672)
- hsa-miR-4768-5p (MIRT489673)
- hsa-miR-3191-5p (MIRT489674)
- hsa-miR-4294 (MIRT489675)
- hsa-miR-4680-5p (MIRT489676)
- hsa-miR-4679 (MIRT489677)
- hsa-miR-4677-3p (MIRT489678)
- hsa-miR-3664-5p (MIRT489679)
- hsa-miR-1231 (MIRT497714)
- hsa-miR-632 (MIRT497715)
- hsa-miR-6888-3p (MIRT497716)
- hsa-miR-4288 (MIRT497717)
- hsa-miR-155-5p (MIRT497718)
- hsa-miR-655-3p (MIRT497719)
- hsa-miR-374c-5p (MIRT497720)
- hsa-miR-3120-5p (MIRT497721)
- hsa-miR-892c-3p (MIRT497722)
- hsa-miR-4676-3p (MIRT497723)
- hsa-miR-452-5p (MIRT497724)
- hsa-miR-429 (MIRT497725)
- hsa-miR-200c-3p (MIRT497726)
- hsa-miR-8084 (MIRT497727)
- hsa-miR-200b-3p (MIRT497728)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP1A1
- Browse OriGene Inhibitory RNA Products For CYP1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A1
Clone Products
- Applied Biological Materials (abm): Clones for CYP1A1 - Select products 50% OFF >
- * CYP1A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CYP1A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP1A1
Cell Line Products
-
Horizon Cell Lines for CYP1A1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene
Localization for CYP1A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene
- Endoplasmic reticulum membrane. Peripheral membrane protein. Mitochondrion inner membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein. Cytoplasm.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| mitochondrion | 4 |
| extracellular | 3 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005743 | mitochondrial inner membrane | ISS | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A1 Gene
Pathways & Interactions for CYP1A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
Estradiol metabolism
.01
|
| 2 | Drug metabolism - cytochrome P450 |
Retinol metabolism
.31
Benzo[a]pyrene metabolism
.01
|
|
| 3 | Arachidonic acid metabolism | ||
| 4 | Metabolism |
.40
|
|
| 5 | Erlotinib Pathway, Pharmacokinetics | ||
Pathways by source for CYP1A1 Gene
12 BioSystems pathways for CYP1A1 Gene
12 Reactome pathways for CYP1A1 Gene
7 KEGG pathways for CYP1A1 Gene
7 GeneGo (Thomson Reuters) pathways for CYP1A1 Gene
- 2-Naphthylamine and 2-Nitronaphtalene metabolism
- Acetaminophen metabolism
- Androstenedione and testosterone biosynthesis and metabolism p.1
- Benzo[a]pyrene metabolism
- Estradiol metabolism
UniProtKB/Swiss-Prot P04798-CP1A1_HUMAN
- Pathway: Steroid hormone biosynthesis.
- Pathway: Lipid metabolism; fatty acid metabolism.
- Pathway: Cofactor metabolism; retinol metabolism.
Interacting Proteins for CYP1A1 Gene
Selected Interacting proteins:
P04798-CP1A1_HUMAN
ENSP00000369050
for CYP1A1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CYP1A1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001889 | liver development | IEA | -- |
| GO:0002933 | lipid hydroxylation | IDA | 14559847 |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA,IDA | 15041462 |
Drugs & Compounds for CYP1A1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Granisetron | Approved, Investigational | Pharma | Enzyme, substrate | Serotonin 5-HT3 receptor antagonist | 95 | |
| Phenobarbital | Approved, Investigational | Pharma | Agonist, Enzyme, inducer | 54 | ||
| Caffeine | Approved | Pharma | Antagonist, Activator, Enzyme, inhibitor | 603 | ||
| Chlorzoxazone | Approved | Pharma | Activator, Agonist, Enzyme, substrate | 8 | ||
| Clofibrate | Approved, Investigational | Pharma | Agonist, Enzyme, inducer | 2 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 11,12,15-THETA |
|
|
||||
| 11,12-EpETrE |
|
81276-02-0 |
|
|||
| 11,14,15-THETA |
|
|
||||
| 11H-14,15-EETA |
|
219535-29-2 |
|
|||
| 12,13-EpOME |
|
|
(4) ApexBio Compounds for CYP1A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 7-Ethoxyresorufin | Specific subtrate of CYP1A | 5725-91-7 |
| Diosmetin | CYP1A1 inhibitor | 520-34-3 |
| Methoxyresorufin | 5725-89-3 | |
| Pentoxyresorufin | 87687-03-4 |
Transcripts for CYP1A1 Gene
mRNA/cDNA for CYP1A1 Gene
- 3 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000379727 2603 nts (view in UCSC)
- ENST00000567032 2107 nts (view in UCSC)
- ENST00000395049 1594 nts (view in UCSC)
- ENST00000564596 988 nts (view in UCSC)
- ENST00000569630 1544 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYP1A1 - Select products 50% OFF >
- * CYP1A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CYP1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP1A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP1A1
- Browse OriGene Inhibitory RNA Products For CYP1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A1
Clone Products
- Applied Biological Materials (abm): Clones for CYP1A1 - Select products 50% OFF >
- * CYP1A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CYP1A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP1A1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: |
Relevant External Links for CYP1A1 Gene
- GeneLoc Exon Structure for
- CYP1A1
Expression for CYP1A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
- Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene
This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).
This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1A1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP1A1
SOURCE GeneReport for Unigene cluster for CYP1A1 Gene:
Hs.72912mRNA Expression by UniProt/SwissProt for CYP1A1 Gene:
P04798-CP1A1_HUMAN
Tissue specificity:
Lung, lymphocytes and placenta.
Evidence on tissue expression from TISSUES for CYP1A1 Gene
- Liver(4.8)
- Blood(4.6)
- Nervous system(4.5)
- Lung(3.3)
- Intestine(3.1)
- Kidney(3.1)
- Skin(2.6)
- Heart(2.4)
- Urine(2.4)
- Stomach(2.4)
- Thyroid gland(2.3)
- Adrenal gland(2.2)
- Muscle(2.2)
- Pancreas(2.1)
- Gall bladder(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for CYP1A1
-
OriGene qPCR primer pairs and template standards for CYP1A1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A1 Gene
Orthologs for CYP1A1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CYP1A1 31 |
|
OneToOne | |
| LOC453744 30 |
|
||||
| Cow (Bos Taurus) |
Mammalia | CYP1A1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CYP1A1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cyp1a1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cyp1a1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | CYP1A1 30 31 |
|
ManyToMany | |
| CYP1A4 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cyp1a1 30 |
|
||
| Str.2144 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | cyp1a 30 31 |
|
OneToMany | |
| cyp1a1 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cyp18a1 32 |
|
|
|
| Cyp307a1 32 |
|
|
|||
| spo 31 |
|
ManyToMany | |||
| spok 31 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | CYP93D1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os06g0613600 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for CYP1A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CYP1A1 Gene
- ENSEMBL:
- Gene Tree for CYP1A1 (if available)
- TreeFam:
- Gene Tree for CYP1A1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYP1A1: view image
Paralogs for CYP1A1 Gene
(30) SIMAP similar genes for CYP1A1 Gene using alignment to 8 proteins:
- CP1A1_HUMAN
- A0N0X8_HUMAN
- A4F3V8_HUMAN
- A4F4K3_HUMAN
- A4F4K4_HUMAN
- E7EMT5_HUMAN
- Q0VHD5_HUMAN
- Q5J9B1_HUMAN
Pseudogenes.org Pseudogenes for CYP1A1 Gene
Variants for CYP1A1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP1A1 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 717748 | Benign: not provided | 74,720,638(-) | G/T | MISSENSE_VARIANT | |
| 776931 | Benign: not provided | 74,722,865(-) | A/G | MISSENSE_VARIANT | |
| 777698 | Likely Benign: not provided | 74,720,710(-) | C/T | MISSENSE_VARIANT | |
| 782007 | Benign: not provided | 74,721,686(-) | A/G | MISSENSE_VARIANT | |
| 782008 | Benign: not provided | 74,722,386(-) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2763106 | CNV | loss | 21179565 |
| esv3636907 | CNV | loss | 21293372 |
| nsv1121512 | CNV | deletion | 24896259 |
| nsv817698 | CNV | gain | 17921354 |
| nsv833055 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.23;
84.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYP1A1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene
Disorders for CYP1A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| aryl hydrocarbon hydroxylase inducibility |
|
|
| gastroschisis |
|
|
| phimosis |
|
|
| oral cavity cancer |
|
|
| oral cancer |
|
Search CYP1A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CYP1A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene
Publications for CYP1A1 Gene
- Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 23 41
- Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. (PMID: 19608585) Wright CM … Fong KM (The European respiratory journal 2010) 3 23 41
- Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. (PMID: 20381444) Ashton KA … Scott RJ (Cancer epidemiology 2010) 3 23 41
- Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population. (PMID: 20226777) Zhang J … Wan J (Clinica chimica acta; international journal of clinical chemistry 2010) 3 23 41
- [Analysis of genetic predisposition to pulmonary tuberculosis in native Russians]. (PMID: 20297661) Gra OA … Litvinov VI (Genetika 2010) 3 23 41
ExternalLinks
Products for CYP1A1 Gene
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Sources for CYP1A1 Gene
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