CYP1A1 Gene (Protein Coding)

Cytochrome P450 Family 1 Subfamily A Member 1

GC15M074719
GIFtS:
48
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), som... See more...

Aliases for CYP1A1 Gene

Aliases for CYP1A1 Gene

  • Cytochrome P450 Family 1 Subfamily A Member 1 2 3 5
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
  • Hydroperoxy Icosatetraenoate Dehydratase 3 4
  • Cytochrome P450 Form 6 3 4
  • Cytochrome P450 1A1 3 4
  • Cytochrome P450-P1 3 4
  • Cytochrome P450-C 3 4
  • EC 1.14.14.1 4 50
  • CYPIA1 3 4
  • P1-450 2 3
  • P450-C 2 3
  • P450DX 2 3
  • CP11 2 3
  • Cytochrome P1-450, Dioxin-Inducible 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Xenobiotic Monooxygenase 3
  • EC 4.2.1.152 4
  • CYP1A1 5
  • AHRR 3
  • CYP1 3
  • AHH 3

External Ids for CYP1A1 Gene

Previous HGNC Symbols for CYP1A1 Gene

  • CYP1

Previous GeneCards Identifiers for CYP1A1 Gene

  • GC15M068848
  • GC15M068126
  • GC15M072587
  • GC15M072727
  • GC15M072798
  • GC15M075011
  • GC15M051809

Summaries for CYP1A1 Gene

Entrez Gene Summary for CYP1A1 Gene

  • This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP1A1 Gene

CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Acne. Among its related pathways are Naphthalene metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A2.

UniProtKB/Swiss-Prot Summary for CYP1A1 Gene

  • A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).

Gene Wiki entry for CYP1A1 Gene

Additional gene information for CYP1A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYP1A1 Gene

Genomics for CYP1A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CYP1A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH15J074725 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 254.5 -0.7 -665 2 CEBPA ZNF10 ZIC2 ZBTB10 CHD2 ZNF341 KLF7 NR2C1 MAX ZNF217 CYP1A1 RPP25 ENSG00000260103 ARID3B C15orf39 SCAMP2 piR-36393-182 CYP1A2
GH15J074724 Enhancer 0.8 ENCODE 250.7 +1.4 1401 0.2 SP1 ZNF580 JUND YY1 ZNF639 ZNF217 SP2 RXRA ZNF511 SAP130 CYP1A1 HSALNG0107213 EDC3
GH15J074723 Enhancer 0.6 ENCODE 250.7 +1.7 1721 0.2 ZNF511 GABPB1 TEAD3 THRB ZNF205 ZBTB48 HBP1 TFAP4 IKZF5 ATF1 CYP1A1 HSALNG0107213 ENSG00000260103 EDC3
GH15J074738 Promoter 0.6 EPDnew 250.4 -13.0 -12951 0.1 EGR1 EGR2 ZFHX2 ZSCAN5C CYP1A1 CPLX3 ULK3 FAM219B ENSG00000212279 piR-54764-215 CYP1A2
GH15J074775 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -62.5 -62530 25.8 BCLAF1 SP1 ZNF207 ZNF654 IKZF1 MYC ZNF600 ZNF580 ZNF592 ZMYM3 CSK MIR4513 ULK3 C15orf39 ENSG00000187812 RPP25 CPLX3 LMAN1L DNM1P35 CYP1A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP1A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYP1A1

Top Transcription factor binding sites by QIAGEN in the CYP1A1 gene promoter:
  • Bach2
  • C/EBPbeta
  • GR
  • GR-alpha
  • HNF-4alpha1
  • MZF-1
  • p53
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for CYP1A1 Gene

Latest Assembly
chr15:74,719,542-74,725,536
(GRCh38/hg38)
Size:
5,995 bases
Orientation:
Minus strand

Previous Assembly
chr15:75,011,883-75,017,869
(GRCh37/hg19 by Entrez Gene)
Size:
5,987 bases
Orientation:
Minus strand

chr15:75,011,883-75,017,951
(GRCh37/hg19 by Ensembl)
Size:
6,069 bases
Orientation:
Minus strand

Genomic View for CYP1A1 Gene

Genes around CYP1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP1A1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP1A1 Gene

Proteins for CYP1A1 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04798-CP1A1_HUMAN
    Recommended name:
    Cytochrome P450 1A1
    Protein Accession:
    P04798
    Secondary Accessions:
    • A4F3V9
    • A4F3W0
    • Q53G18

    Protein attributes for CYP1A1 Gene

    Size:
    512 amino acids
    Molecular mass:
    58165 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • Interacts with cytosolic chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria. Interacts (via mitochondrial targeting signal) with TOMM40 (via N-terminus); this interaction is required for translocation across the mitochondrial outer membrane.

    Three dimensional structures from OCA and Proteopedia for CYP1A1 Gene

    Alternative splice isoforms for CYP1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP1A1 Gene

Protein Expression for CYP1A1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CYP1A1 Gene

P04798:
  • KEHYKTFEKG
  • TTAISWSL
  • FSIASDP
  • QGDDFKGRP
  • CVFVNQWQ
  • VLSGLDTIRQALV
  • PILRYLP
  • LDENANVQ
  • ELDTVIG
  • SGNPADFIPIL
  • EVFLFLA
  • QLSDEKI
  • NVICAICFG
  • VVGSGNPADFIP
  • NQWQINH
  • PFTIPHST
  • RRPRLSDR
  • LTLGKNPH
  • TPIYGLT
  • PHSTTRDT
  • IRDITDSLI
  • YGDVLQI
  • WAARRRLAQ
  • FGAGFDT
  • LPYMEAFILE

Post-translational modifications for CYP1A1 Gene

  • Glycosylation at Ser67
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for CYP1A1 Gene

Gene Families for CYP1A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYP1A1 Gene

InterPro:
Blocks:
  • E-class P450 group I signature
  • CYP1A P450 family signature

Suggested Antigen Peptide Sequences for CYP1A1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94514, Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1(CYP1A1), mRNA (A0N0X8_HUMAN)
  • Cytochrome P450 1A1 (A4F3V8_HUMAN)
  • Cytochrome P450 1A1 (A4F3V9_HUMAN)
  • Cytochrome P450 1A1 (A4F3W0_HUMAN)
  • Cytochrome P450 1A1 (A4F4K3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P04798

UniProtKB/Swiss-Prot:

CP1A1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1A1: view

Function for CYP1A1 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for CYP1A1 Gene

UniProtKB/Swiss-Prot Function:
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:142491; EC=1.14.14.1; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:15805301, ECO:0000269|PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47208, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:1156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47292, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87602; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47308, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87605; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47312, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87618; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47204, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:776, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14559847};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47212, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:28744, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47280, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62845; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47284, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:62847; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47288, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87598; Evidence={ECO:0000269|PubMed:12865317};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:47276, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16469, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:87593; Evidence={ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15805301};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:50076, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:78043, ChEBI:CHEBI:132024; Evidence={ECO:0000269|PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49972, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132019; Evidence={ECO:0000269|PubMed:15041462};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49968, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:132016; Evidence={ECO:0000269|PubMed:15041462};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39811, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:63590; Evidence={ECO:0000269|PubMed:15041462};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39759, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:76627; Evidence={ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:18577768};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39787, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76636; Evidence={ECO:0000269|PubMed:15041462};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49884, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131975; Evidence={ECO:0000269|PubMed:20972997};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49880, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131970; Evidence={ECO:0000269|PubMed:20972997};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49856, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131964; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:49860, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:32395, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:131965; Evidence={ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:20972997};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:39779, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:58562, ChEBI:CHEBI:76634; Evidence={ECO:0000269|PubMed:15041462, ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52124, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136411; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:52120, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:77016, ChEBI:CHEBI:136410; Evidence={ECO:0000269|PubMed:19965576};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42092, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17336, ChEBI:CHEBI:17898, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:42088, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17898, ChEBI:CHEBI:35291, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; Evidence={ECO:0000269|PubMed:10681376};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O; Xref=Rhea:RHEA:48716, ChEBI:CHEBI:15377, ChEBI:CHEBI:57466, ChEBI:CHEBI:90781; Evidence={ECO:0000269|PubMed:21068195};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:37947, ChEBI:CHEBI:15377, ChEBI:CHEBI:57444, ChEBI:CHEBI:75231; EC=4.2.1.152; Evidence={ECO:0000269|PubMed:21068195};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48636, ChEBI:CHEBI:15377, ChEBI:CHEBI:57410, ChEBI:CHEBI:57446; Evidence={ECO:0000269|PubMed:21068195};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O; Xref=Rhea:RHEA:48632, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:65342; Evidence={ECO:0000269|PubMed:21068195};.
UniProtKB/Swiss-Prot Induction:
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for all-trans retinol {ECO:0000269|PubMed:10681376}; KM=9.5 uM for 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=11.8 uM for 17beta-estradiol (4-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=79 uM for 17beta-estradiol (6alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=19.6 uM for 17beta-estradiol (15alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=12.2 uM for estrone (2-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=22.6 uM for estrone (4-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=86 uM for estrone (6alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; KM=85 uM for estrone (15alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=507 pmol/min/nmol enzyme toward all-trans retinol {ECO:0000269|PubMed:10681376}; Vmax=0.6 pmol/min/pmol enzyme toward 17beta-estradiol (2-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.02 pmol/min/pmol enzyme toward 17beta-estradiol (4-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=3.6 pmol/min/pmol enzyme toward 17beta-estradiol (6alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.9 pmol/min/pmol enzyme toward 17beta-estradiol (15alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.4 pmol/min/pmol enzyme toward estrone (2-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.1 pmol/min/pmol enzyme toward estrone (4-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=0.2 pmol/min/pmol enzyme toward estrone (6alpha-hydroxylation) {ECO:0000269|PubMed:15805301}; Vmax=1.2 pmol/min/pmol enzyme toward estrone (15alpha-hydroxylation) {ECO:0000269|PubMed:15805301};
GENATLAS Biochemistry:
cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)

Enzyme Numbers (IUBMB) for CYP1A1 Gene

Phenotypes From GWAS Catalog for CYP1A1 Gene

Gene Ontology (GO) - Molecular Function for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004497 monooxygenase activity IEA,TAS --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008391 arachidonic acid monooxygenase activity IDA 15041462
genes like me logo Genes that share ontologies with CYP1A1: view
genes like me logo Genes that share phenotypes with CYP1A1: view

Animal Models for CYP1A1 Gene

MGI Knock Outs for CYP1A1:
  • Cyp1a1 Cyp1a1<tm1.1Dwn>
  • Cyp1a1 Cyp1a1<tm2025.1(CYP1A1)Arte>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene

Localization for CYP1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene

Endoplasmic reticulum membrane. Peripheral membrane protein. Mitochondrion inner membrane. Peripheral membrane protein. Microsome membrane. Peripheral membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP1A1 gene
Compartment Confidence
mitochondrion 4
extracellular 3
nucleus 3
endoplasmic reticulum 3
cytosol 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
lysosome 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane ISS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
genes like me logo Genes that share ontologies with CYP1A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A1 Gene

Pathways & Interactions for CYP1A1 Gene

genes like me logo Genes that share pathways with CYP1A1: view

Pathways by source for CYP1A1 Gene

7 GeneGo (Thomson Reuters) pathways for CYP1A1 Gene
  • 2-Naphthylamine and 2-Nitronaphtalene metabolism
  • Acetaminophen metabolism
  • Androstenedione and testosterone biosynthesis and metabolism p.1
  • Benzo[a]pyrene metabolism
  • Estradiol metabolism

UniProtKB/Swiss-Prot P04798-CP1A1_HUMAN

  • Pathway: Steroid hormone biosynthesis.
  • Pathway: Lipid metabolism; fatty acid metabolism.
  • Pathway: Cofactor metabolism; retinol metabolism.

SIGNOR curated interactions for CYP1A1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development IEA --
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006306 DNA methylation IEA --
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

Drugs & Compounds for CYP1A1 Gene

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(200) Drugs for CYP1A1 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Granisetron Approved, Investigational Pharma Enzyme, substrate Serotonin 5-HT3 receptor antagonist 101
Phenobarbital Approved, Investigational Pharma Enzyme, inducer 56
Caffeine Approved Pharma Enzyme, inhibitor 658
Chlorzoxazone Approved Pharma Enzyme, substrate 8
Clofibrate Approved, Investigational Pharma Enzyme, inducer 2

(93) Additional Compounds for CYP1A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-Epoxyeicosatrienoic acid
  • (11S,12R)-EpETrE
  • (11S,12R)-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
  • (11S,12R)-Epoxy-(5Z,8Z,14Z)-icosatrienoic acid
  • 11(S),12(R)-EET
  • 11(S),12(R)-EpETrE
 123931-40-8
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosatrienoic acid
  • 11,14,15-Trihydroxy-(5Z,8Z,12E)-eicosatrienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoic acid
11H-14,15-EETA
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
 219535-29-2
12,13-EpOME
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid

(4) ApexBio Compounds for CYP1A1 Gene

Compound Action Cas Number
7-Ethoxyresorufin Specific subtrate of CYP1A 5725-91-7
Diosmetin CYP1A1 inhibitor 520-34-3
Methoxyresorufin 5725-89-3
Pentoxyresorufin 87687-03-4
genes like me logo Genes that share compounds with CYP1A1: view

Drug products for research

Transcripts for CYP1A1 Gene

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  3. Inhibitory RNAs for research
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mRNA/cDNA for CYP1A1 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A1

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:

Relevant External Links for CYP1A1 Gene

GeneLoc Exon Structure for
CYP1A1

Expression for CYP1A1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYP1A1 Gene

mRNA expression in normal human tissues for CYP1A1 Gene
mRNA expression by BioGPS for CYP1A1 GenemRNA expression by GTEx for CYP1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene

This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for CYP1A1 Gene

This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1A1 Gene



Protein tissue co-expression partners for CYP1A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYP1A1

SOURCE GeneReport for Unigene cluster for CYP1A1 Gene:

Hs.72912

mRNA Expression by UniProt/SwissProt for CYP1A1 Gene:

P04798-CP1A1_HUMAN
Tissue specificity: Lung, lymphocytes and placenta.

Evidence on tissue expression from TISSUES for CYP1A1 Gene

  • Liver(4.7)
  • Blood(4.5)
  • Nervous system(4.5)
  • Lung(3.1)
  • Intestine(2.9)
  • Kidney(2.9)
  • Skin(2.3)
  • Stomach(2.2)
  • Heart(2.1)
  • Urine(2.1)
  • Thyroid gland(2.1)
  • Gall bladder(2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with CYP1A1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A1 Gene

Orthologs for CYP1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CYP1A1 30
  • 100 (a)
 OneToOne
LOC453744 29
  • 99.67 (n)
Cow
(Bos Taurus)
 Mammalia CYP1A1 29 30
  • 85.42 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia CYP1A1 29 30
  • 84.65 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Cyp1a1 29 16 30
  • 82.61 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Cyp1a1 29
  • 82.42 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 72 (a)
 ManyToMany
-- 30
  • 59 (a)
 ManyToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 70 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves CYP1A1 29 30
  • 67.06 (n)
 ManyToMany
CYP1A4 30
  • 58 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 60 (a)
 ManyToMany
-- 30
  • 58 (a)
 ManyToMany
-- 30
  • 55 (a)
 ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia cyp1a1 29
  • 65.14 (n)
Str.2144 29
Zebrafish
(Danio rerio)
 Actinopterygii cyp1a 29 30
  • 60.88 (n)
 OneToMany
cyp1a1 29
Fruit Fly
(Drosophila melanogaster)
 Insecta Cyp18a1 31
  • 32 (a)
Cyp307a1 31
  • 28 (a)
spo 30
  • 24 (a)
 ManyToMany
spok 30
  • 22 (a)
 ManyToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons CYP93D1 29
  • 40.54 (n)
Rice
(Oryza sativa)
 Liliopsida Os06g0613600 29
  • 45.38 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 31 (a)
 ManyToMany
-- 30
  • 21 (a)
 ManyToMany
Species where no ortholog for CYP1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CYP1A1 Gene

ENSEMBL:
Gene Tree for CYP1A1 (if available)
TreeFam:
Gene Tree for CYP1A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYP1A1: view image
Alliance of Genome Resources:
Additional Orthologs for CYP1A1

Paralogs for CYP1A1 Gene

Paralogs for CYP1A1 Gene

(30) SIMAP similar genes for CYP1A1 Gene using alignment to 8 proteins:

  • CP1A1_HUMAN
  • A0N0X8_HUMAN
  • A4F3V8_HUMAN
  • A4F4K3_HUMAN
  • A4F4K4_HUMAN
  • E7EMT5_HUMAN
  • Q0VHD5_HUMAN
  • Q5J9B1_HUMAN

Pseudogenes.org Pseudogenes for CYP1A1 Gene

genes like me logo Genes that share paralogs with CYP1A1: view

Variants for CYP1A1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYP1A1 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs145198866 Likely Benign: not provided 74,720,710(-) C/T
NM_001319217.2(CYP1A1):c.1318G>A (p.Asp440Asn) 		MISSENSE
rs147033233 Likely Benign: not provided 74,720,654(-) G/A
NM_001319217.2(CYP1A1):c.1374C>T (p.Ile458=) 		SYNONYMOUS
rs17861094 Benign: not provided 74,722,865(-) A/Gp.Ile78Thr
NM_001319217.2(CYP1A1):c.233T>C (p.Ile78Thr) 		MISSENSE
rs41279188 Benign: not provided 74,720,638(-) G/Tp.Arg464Cysp.Arg464Ser
NM_001319217.2(CYP1A1):c.1390C>A (p.Arg464Ser) 		MISSENSE
rs45460597 Benign: not provided 74,720,555(-) G/A
NM_001319217.2(CYP1A1):c.1473C>T (p.Thr491=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CYP1A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CYP1A1 Gene

Variant ID Type Subtype PubMed ID
esv2763106 CNV loss 21179565
esv3636907 CNV loss 21293372
nsv1121512 CNV deletion 24896259
nsv817698 CNV gain 17921354
nsv833055 CNV loss 17160897

Variation tolerance for CYP1A1 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP1A1 Gene

The Human Cytochrome P450 Allele Nomenclature Database
CYP1A1
Human Gene Mutation Database (HGMD)
CYP1A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP1A1
Leiden Open Variation Database (LOVD)
CYP1A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene

Disorders for CYP1A1 Gene

MalaCards: The human disease database

(66) MalaCards diseases for CYP1A1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
aryl hydrocarbon hydroxylase inducibility
  • ahh inducibility; ahhi
acne
  • acne varioliformis
paranasal sinus sarcoma
  • sarcoma of accessory sinus
phimosis
  • tight foreskin
gastroschisis
  • congenital fissure of the abdominal cavity
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP1A1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CYP1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene

Publications for CYP1A1 Gene

  1. Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. (PMID: 20381444) Ashton KA … Scott RJ (Cancer epidemiology 2010) 3 22 40
  2. Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population. (PMID: 20226777) Zhang J … Wan J (Clinica chimica acta; international journal of clinical chemistry 2010) 3 22 40
  3. [Analysis of genetic predisposition to pulmonary tuberculosis in native Russians]. (PMID: 20297661) Gra OA … Litvinov VI (Genetika 2010) 3 22 40
  4. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women. (PMID: 19424794) MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk (Breast cancer research and treatment 2010) 3 22 40
  5. Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. (PMID: 19608585) Wright CM … Fong KM (The European respiratory journal 2010) 3 22 40

ExternalLinks

View latest publications for CYP1A1 gene in Mastermind

Products for CYP1A1 Gene

Sources for CYP1A1 Gene