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Aliases for CYP1A1 Gene

Aliases for CYP1A1 Gene

  • Cytochrome P450 Family 1 Subfamily A Member 1 2 3 5
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450 Form 6 3 4
  • Cytochrome P450-P1 3 4
  • Cytochrome P450-C 3 4
  • CYPIA1 3 4
  • Cytochrome P1-450, Dioxin-Inducible 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 1A1 3
  • EC 4
  • P1-450 3
  • P450-C 3
  • P450DX 3
  • AHRR 3
  • CP11 3
  • CYP1 3
  • AHH 3

External Ids for CYP1A1 Gene

Previous HGNC Symbols for CYP1A1 Gene

  • CYP1

Previous GeneCards Identifiers for CYP1A1 Gene

  • GC15M068848
  • GC15M068126
  • GC15M072587
  • GC15M072727
  • GC15M072798
  • GC15M075011
  • GC15M051809

Summaries for CYP1A1 Gene

Entrez Gene Summary for CYP1A1 Gene

  • This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP1A1 Gene

CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Colorectal Cancer, Childhood. Among its related pathways are Ovarian steroidogenesis and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A2.

UniProtKB/Swiss-Prot for CYP1A1 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP1A1 Gene

Additional gene information for CYP1A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A1 Gene

Genomics for CYP1A1 Gene

GeneHancer (GH) Regulatory Elements for CYP1A1 Gene

Promoters and enhancers for CYP1A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J074725 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 654.6 -0.6 -623 1.6 PKNOX1 ARNT ARID4B DMAP1 ZNF2 ZNF48 GLIS2 ZNF213 ELK1 ZFP91 CYP1A1 LOC101929333 ARID3B C15orf39 SCAMP2 CYP1A2
GH15J074724 Enhancer 0.9 ENCODE 650.7 +1.5 1475 0.2 HDAC1 NFIB ARID4B NEUROD1 SIN3A DEAF1 KLF14 ZNF2 YY1 EGR1 CYP1A1 EDC3
GH15J074738 Promoter 0.8 EPDnew 650.4 -12.9 -12877 0.1 ZFHX2 EGR1 ZSCAN5C EGR2 CYP1A1 CPLX3 ULK3 FAM219B ENSG00000212279 CYP1A2
GH15J074723 Enhancer 0.6 ENCODE 650.7 +1.8 1795 0.2 GATAD2A TFAP4 ZNF511 ELF1 THRB ZNF205 TEAD3 XRCC5 ZGPAT ZBTB48 CYP1A1 LOC101929333 EDC3
GH15J074775 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -62.6 -62563 26 DMAP1 IRF4 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D GLIS1 RCOR2 CSK MIR4513 SIN3A EDC3 ENSG00000260274 LOC441728 MAN2C1 ULK3 C15orf39 DNM1P35
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYP1A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYP1A1 gene promoter:
  • p53
  • HNF-4alpha1
  • GR-alpha
  • GR
  • MZF-1
  • Bach2
  • C/EBPbeta
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for CYP1A1 Gene

Genomic Locations for CYP1A1 Gene
6,069 bases
Minus strand
6,069 bases
Minus strand

Genomic View for CYP1A1 Gene

Genes around CYP1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP1A1 Gene

Proteins for CYP1A1 Gene

  • Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 1A1
    Protein Accession:
    Secondary Accessions:
    • A4F3V9
    • A4F3W0
    • Q53G18

    Protein attributes for CYP1A1 Gene

    512 amino acids
    Molecular mass:
    58165 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP1A1 Gene

    Alternative splice isoforms for CYP1A1 Gene


neXtProt entry for CYP1A1 Gene

Post-translational modifications for CYP1A1 Gene

  • Glycosylation at Ser67
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYP1A1 Gene

Domains & Families for CYP1A1 Gene

Gene Families for CYP1A1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1A1: view

Function for CYP1A1 Gene

Molecular function for CYP1A1 Gene

UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Induction:
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
GENATLAS Biochemistry:
cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)

Enzyme Numbers (IUBMB) for CYP1A1 Gene

Phenotypes From GWAS Catalog for CYP1A1 Gene

Gene Ontology (GO) - Molecular Function for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004497 monooxygenase activity TAS,IEA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008395 steroid hydroxylase activity IEA --
genes like me logo Genes that share ontologies with CYP1A1: view
genes like me logo Genes that share phenotypes with CYP1A1: view

Animal Models for CYP1A1 Gene

MGI Knock Outs for CYP1A1:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene

Localization for CYP1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP1A1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
nucleus 3
plasma membrane 2
extracellular 2
peroxisome 2
cytosol 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS,IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A1 Gene

Pathways & Interactions for CYP1A1 Gene

genes like me logo Genes that share pathways with CYP1A1: view

Gene Ontology (GO) - Biological Process for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development IEA --
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006778 porphyrin-containing compound metabolic process IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

No data available for SIGNOR curated interactions for CYP1A1 Gene

Drugs & Compounds for CYP1A1 Gene

(202) Drugs for CYP1A1 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Granisetron Approved, Investigational Pharma Enzyme, substrate Serotonin 5-HT3 receptor antagonist 79
Phenobarbital Approved, Investigational Pharma Agonist, Enzyme, inducer 66
Chlorzoxazone Approved Pharma Agonist, Activator, Enzyme, substrate 7
Clofibrate Approved, Investigational Pharma Agonist, Enzyme, inducer 2
Daunorubicin Approved Pharma Enzyme, substrate DNA topoisomerase II inhibitor 291

(98) Additional Compounds for CYP1A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11,12,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,12,15-Trihydroxyicosatrienoate
  • (5Z,8Z,13E)-(15S)-11,12,15-Trihydroxyeicosa-5,8,12-trienoate
11,12-Epoxyeicosatrienoic acid
  • (+/-)11(12)-eet
  • (+/-)11(12)-epetre
  • (+/-)11,12-epetre
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxyicosatrienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • 11-Hydroxy-14,15-eeta
  • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-epoxyeicosatrienoate
  • (9Z)-11-(3-Pentyloxiran-2-yl)undec-9-enoic acids
  • (9Z)-12,13-Epoxyoctadecenoic acid
  • 12(13)-EpOME
  • 12,13-cis-Epoxyoctadecenoic acid
  • 12,13-Epoxy-9(Z)-octadecenoic acid
genes like me logo Genes that share compounds with CYP1A1: view

Transcripts for CYP1A1 Gene

mRNA/cDNA for CYP1A1 Gene

Unigene Clusters for CYP1A1 Gene

Cytochrome P450, family 1, subfamily A, polypeptide 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b

Relevant External Links for CYP1A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene

This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for CYP1A1 Gene

This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1A1 Gene

Protein tissue co-expression partners for CYP1A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP1A1 Gene:


SOURCE GeneReport for Unigene cluster for CYP1A1 Gene:


mRNA Expression by UniProt/SwissProt for CYP1A1 Gene:

Tissue specificity: Lung, lymphocytes and placenta.

Evidence on tissue expression from TISSUES for CYP1A1 Gene

  • Liver(4.8)
  • Blood(4.5)
  • Nervous system(4.4)
  • Lung(3.4)
  • Intestine(2.8)
  • Kidney(2.7)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with CYP1A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A1 Gene

Orthologs for CYP1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYP1A1 34
  • 100 (a)
LOC453744 33
  • 99.67 (n)
(Bos Taurus)
Mammalia CYP1A1 34 33
  • 85.42 (n)
(Canis familiaris)
Mammalia CYP1A1 34 33
  • 84.65 (n)
(Mus musculus)
Mammalia Cyp1a1 16 34 33
  • 82.61 (n)
(Rattus norvegicus)
Mammalia Cyp1a1 33
  • 82.42 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 72 (a)
-- 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Gallus gallus)
Aves CYP1A1 34 33
  • 67.06 (n)
CYP1A4 34
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 60 (a)
-- 34
  • 58 (a)
-- 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp1a1 33
  • 65.14 (n)
Str.2144 33
(Danio rerio)
Actinopterygii cyp1a 34 33
  • 60.88 (n)
cyp1a1 33
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 35
  • 32 (a)
Cyp307a1 35
  • 28 (a)
spo 34
  • 24 (a)
spok 34
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP93D1 33
  • 40.54 (n)
(Oryza sativa)
Liliopsida Os06g0613600 33
  • 45.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
-- 34
  • 21 (a)
Species where no ortholog for CYP1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP1A1 Gene

Gene Tree for CYP1A1 (if available)
Gene Tree for CYP1A1 (if available)
Evolutionary constrained regions (ECRs) for CYP1A1: view image

Paralogs for CYP1A1 Gene

Paralogs for CYP1A1 Gene

(30) SIMAP similar genes for CYP1A1 Gene using alignment to 8 proteins:

  • A0N0X8_HUMAN
  • A4F3V8_HUMAN
  • A4F4K3_HUMAN
  • A4F4K4_HUMAN
  • Q5J9B1_HUMAN Pseudogenes for CYP1A1 Gene

genes like me logo Genes that share paralogs with CYP1A1: view

Variants for CYP1A1 Gene

Sequence variations from dbSNP and Humsavar for CYP1A1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000393848 -- 74,719,252(-) T/G downstream_transcript_variant
rs1000699728 -- 74,724,009(-) T/C intron_variant
rs1000751890 -- 74,723,694(-) T/G intron_variant
rs1001267801 -- 74,724,894(-) G/T intron_variant
rs1001321488 -- 74,725,220(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CYP1A1 Gene

Variant ID Type Subtype PubMed ID
esv2763106 CNV loss 21179565
esv3636907 CNV loss 21293372
nsv1121512 CNV deletion 24896259
nsv817698 CNV gain 17921354
nsv833055 CNV loss 17160897

Variation tolerance for CYP1A1 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYP1A1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene

Disorders for CYP1A1 Gene

MalaCards: The human disease database

(33) MalaCards diseases for CYP1A1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aryl hydrocarbon hydroxylase inducibility
  • ahh inducibility; ahhi
colorectal cancer, childhood
  • childhood colorectal cancer
ehrlich tumor carcinoma
  • ehrlich's tumor
acetaminophen metabolism
oral submucous fibrosis
  • oral cavity submucous fibrosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYP1A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYP1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene

Publications for CYP1A1 Gene

  1. Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. (PMID: 20381444) Ashton KA … Scott RJ (Cancer epidemiology 2010) 3 22 44 58
  2. Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. (PMID: 19608585) Wright CM … Fong KM (The European respiratory journal 2010) 3 22 44 58
  3. Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. (PMID: 19346634) Surekha D … Vishnupriya S (Indian journal of medical sciences 2009) 3 22 44 58
  4. [Relationship between CYP1A1 gene polymorphisms and urinary 1-hydroxypyrene levels in coke oven workers]. (PMID: 19538838) Nie JS … Niu Q (Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2009) 3 22 44 58
  5. Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. (PMID: 19632247) Shah PP … Parmar D (Mutation research 2009) 3 22 44 58

Products for CYP1A1 Gene

Sources for CYP1A1 Gene

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