Aliases for CYP1A1 Gene
Aliases for CYP1A1 Gene
- Cytochrome P450 Family 1 Subfamily A Member 1 2 3 5
- Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
- Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
- Cytochrome P450 Form 6 3 4
- Cytochrome P450-P1 3 4
- Cytochrome P450-C 3 4
- CYPIA1 3 4
- Cytochrome P1-450, Dioxin-Inducible 3
- Flavoprotein-Linked Monooxygenase 3
- Aryl Hydrocarbon Hydroxylase 3
- Xenobiotic Monooxygenase 3
External Ids for CYP1A1 Gene
- HGNC: 2595
- Entrez Gene: 1543
- Ensembl: ENSG00000140465
- OMIM: 108330
- UniProtKB: P04798
Previous HGNC Symbols for CYP1A1 Gene
- CYP1
Previous GeneCards Identifiers for CYP1A1 Gene
- GC15M068848
- GC15M068126
- GC15M072587
- GC15M072727
- GC15M072798
- GC15M075011
- GC15M051809
Summaries for CYP1A1 Gene
-
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
GeneCards Summary for CYP1A1 Gene
CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Colorectal Cancer, Childhood. Among its related pathways are Ovarian steroidogenesis and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A2.
UniProtKB/Swiss-Prot for CYP1A1 Gene
-
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Additional gene information for CYP1A1 Gene
- Monarch Initiative
- Search for CYP1A1 at DataMed
- Search for CYP1A1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A1 Gene
Genomics for CYP1A1 Gene
GeneHancer (GH) Regulatory Elements for CYP1A1 Gene
Promoters and enhancers for CYP1A1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH15J074725 | Promoter/Enhancer | 2.2 | EPDnew FANTOM5 Ensembl ENCODE | 654.6 | -0.6 | -623 | 1.6 | PKNOX1 ARNT ARID4B DMAP1 ZNF2 ZNF48 GLIS2 ZNF213 ELK1 ZFP91 | CYP1A1 LOC101929333 ARID3B C15orf39 SCAMP2 CYP1A2 | |
| GH15J074724 | Enhancer | 0.9 | ENCODE | 650.7 | +1.5 | 1475 | 0.2 | HDAC1 NFIB ARID4B NEUROD1 SIN3A DEAF1 KLF14 ZNF2 YY1 EGR1 | CYP1A1 EDC3 | |
| GH15J074738 | Promoter | 0.8 | EPDnew | 650.4 | -12.9 | -12877 | 0.1 | ZFHX2 EGR1 ZSCAN5C EGR2 | CYP1A1 CPLX3 ULK3 FAM219B ENSG00000212279 CYP1A2 | |
| GH15J074723 | Enhancer | 0.6 | ENCODE | 650.7 | +1.8 | 1795 | 0.2 | GATAD2A TFAP4 ZNF511 ELF1 THRB ZNF205 TEAD3 XRCC5 ZGPAT ZBTB48 | CYP1A1 LOC101929333 EDC3 | |
| GH15J074775 | Promoter/Enhancer | 2.8 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 10.7 | -62.6 | -62563 | 26 | DMAP1 IRF4 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D GLIS1 RCOR2 | CSK MIR4513 SIN3A EDC3 ENSG00000260274 LOC441728 MAN2C1 ULK3 C15orf39 DNM1P35 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CYP1A1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CYP1A1 Gene
Genomic Locations for CYP1A1 Gene
- chr15:74,719,542-74,725,610
- (GRCh38/hg38)
- Size:
- 6,069 bases
- Orientation:
- Minus strand
- chr15:75,011,883-75,017,951
- (GRCh37/hg19)
Genomic View for CYP1A1 Gene
Genes around CYP1A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.1 by Entrez Gene
- 15q24.1 by HGNC
- 15q24.1 by Ensembl
CYP1A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP1A1 Gene
Proteins for CYP1A1 Gene
-
Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04798-CP1A1_HUMAN
- Recommended name:
- Cytochrome P450 1A1
- Protein Accession:
- P04798
- A4F3V9
- A4F3W0
- Q53G18
Protein attributes for CYP1A1 Gene
- Size:
- 512 amino acids
- Molecular mass:
- 58165 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP1A1 Gene
Post-translational modifications for CYP1A1 Gene
Other Protein References for CYP1A1 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CYP1A1
- Novus Biologicals Antibodies for CYP1A1
- Invitrogen Antibodies for CYP1A1
- GeneTex Cyp1a1 Antibody for CYP1A1
-
Boster Bio Antibodies for CYP1A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A1
Protein Products
-
OriGene Purified Proteins for CYP1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP1A1
- Origene Custom Protein Services for CYP1A1
- Search GeneTex for Proteins for CYP1A1
Assay Products
No data available for DME Specific Peptides for CYP1A1 Gene
Domains & Families for CYP1A1 Gene
Gene Families for CYP1A1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CYP1A1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP1A1 Gene
Graphical View of Domain Structure for InterPro Entry
P04798- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP1A1 Gene
Molecular function for CYP1A1 Gene
- UniProtKB/Swiss-Prot Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- UniProtKB/Swiss-Prot CatalyticActivity:
- RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
- UniProtKB/Swiss-Prot Induction:
- By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
- GENATLAS Biochemistry:
- cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)
Enzyme Numbers (IUBMB) for CYP1A1 Gene
Phenotypes From GWAS Catalog for CYP1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004497 | monooxygenase activity | TAS,IEA | -- |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008395 | steroid hydroxylase activity | IEA | -- |
Phenotypes for CYP1A1 Gene
- MGI mutant phenotypes for CYP1A1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CYP1A1:
-
- Moderately decreased NFAT1-GFP nuclear translocation
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for CYP1A1 Gene
- MGI Knock Outs for CYP1A1:
-
- Cyp1a2/Cyp1a1 Cyp1a2/Cyp1a1<tm1.1Bra>
- Cyp1a1 Cyp1a1<tm1.1Dwn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYP1A1
-
CRISPR Products
-
OriGene CRISPR knockouts for CYP1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP1A1
- genomics-online: gRNA clones - Search results for 117 available CYP1A1 gene related products
- Overview of 117 available CYP1A1 gene related products
- Applied Biological Materials CRISPR for CYP1A1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A1
- GenScript: Design CRISPR guide RNA sequences for CYP1A1
miRNA for CYP1A1 Gene
- miRTarBase miRNAs that target CYP1A1
-
- hsa-mir-296-3p (MIRT038448)
- hsa-mir-6809-3p (MIRT489671)
- hsa-mir-6833-3p (MIRT489672)
- hsa-mir-4768-5p (MIRT489673)
- hsa-mir-3191-5p (MIRT489674)
- hsa-mir-4294 (MIRT489675)
- hsa-mir-4680-5p (MIRT489676)
- hsa-mir-4679 (MIRT489677)
- hsa-mir-4677-3p (MIRT489678)
- hsa-mir-3664-5p (MIRT489679)
- hsa-mir-1231 (MIRT497714)
- hsa-mir-632 (MIRT497715)
- hsa-mir-6888-3p (MIRT497716)
- hsa-mir-4288 (MIRT497717)
- hsa-mir-155-5p (MIRT497718)
- hsa-mir-655-3p (MIRT497719)
- hsa-mir-374c-5p (MIRT497720)
- hsa-mir-3120-5p (MIRT497721)
- hsa-mir-892c-3p (MIRT497722)
- hsa-mir-4676-3p (MIRT497723)
- hsa-mir-452-5p (MIRT497724)
- hsa-mir-429 (MIRT497725)
- hsa-mir-200c-3p (MIRT497726)
- hsa-mir-8084 (MIRT497727)
- hsa-mir-200b-3p (MIRT497728)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP1A1
- Browse OriGene Inhibitory RNA Products For CYP1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A1
- genomics-online: shRNA clones - Search results for 117 available CYP1A1 gene related products
- Overview of 117 available CYP1A1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CYP1A1
- VectorBuilder custom plasmid, inducible vectors for CYP1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP1A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP1A1
- Applied Biological Materials Clones for CYP1A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CYP1A1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene
Localization for CYP1A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| peroxisome | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS,IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP1A1 Gene
Pathways & Interactions for CYP1A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
|
| 2 | Drug metabolism - cytochrome P450 | ||
| 3 | Arachidonic acid metabolism | ||
| 4 | Metabolism |
.37
|
|
| 5 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
Pathways by source for CYP1A1 Gene
12 BioSystems pathways for CYP1A1 Gene
12 Reactome pathways for CYP1A1 Gene
7 KEGG pathways for CYP1A1 Gene
7 GeneGo (Thomson Reuters) pathways for CYP1A1 Gene
Interacting Proteins for CYP1A1 Gene
Selected Interacting proteins:
P04798-CP1A1_HUMAN
ENSP00000369050
for CYP1A1 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for CYP1A1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001889 | liver development | IEA | -- |
| GO:0002933 | lipid hydroxylation | IDA | 14559847 |
| GO:0006778 | porphyrin-containing compound metabolic process | IEA | -- |
| GO:0007568 | aging | IEA | -- |
No data available for SIGNOR curated interactions for CYP1A1 Gene
Drugs & Compounds for CYP1A1 Gene
(202) Drugs for CYP1A1 Gene - From: DrugBank, PharmGKB, ApexBio, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Granisetron | Approved, Investigational | Pharma | Enzyme, substrate | Serotonin 5-HT3 receptor antagonist | 79 | |
| Phenobarbital | Approved, Investigational | Pharma | Agonist, Enzyme, inducer | 66 | ||
| Chlorzoxazone | Approved | Pharma | Agonist, Activator, Enzyme, substrate | 7 | ||
| Clofibrate | Approved, Investigational | Pharma | Agonist, Enzyme, inducer | 2 | ||
| Daunorubicin | Approved | Pharma | Enzyme, substrate | DNA topoisomerase II inhibitor | 291 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 11,12,15-THETA |
|
|
||||
| 11,12-Epoxyeicosatrienoic acid |
|
81276-02-0 |
|
|||
| 11,14,15-THETA |
|
|
||||
| 11H-14,15-EETA |
|
219535-29-2 |
|
|||
| 12,13-EpOME |
|
|
(4) ApexBio Compounds for CYP1A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 7-Ethoxyresorufin | Specific subtrate of CYP1A | 5725-91-7 |
| Diosmetin | CYP1A1 inhibitor | 520-34-3 |
| Methoxyresorufin | 5725-89-3 | |
| Pentoxyresorufin | 87687-03-4 |
Transcripts for CYP1A1 Gene
mRNA/cDNA for CYP1A1 Gene
- (52) Selected AceView cDNA sequences:
- (15) Additional mRNA sequences :
- (3) REFSEQ mRNAs :
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000379727 2685 bps (uc002ayq.5)
- ENST00000395048 2608 bps (uc002ayp.4)
- ENST00000395049 1594 bps (uc010bjy.4)
- ENST00000562201 1192 bps (uc059lkp.1)
- ENST00000564596 988 bps (uc059lkq.1)
Unigene Clusters for CYP1A1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CYP1A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYP1A1
- genomics-online: gRNA clones - Search results for 117 available CYP1A1 gene related products
- Overview of 117 available CYP1A1 gene related products
- Applied Biological Materials CRISPR for CYP1A1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A1
- GenScript: Design CRISPR guide RNA sequences for CYP1A1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYP1A1
- Browse OriGene Inhibitory RNA Products For CYP1A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYP1A1
- genomics-online: shRNA clones - Search results for 117 available CYP1A1 gene related products
- Overview of 117 available CYP1A1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CYP1A1
- VectorBuilder custom plasmid, inducible vectors for CYP1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP1A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYP1A1
- Applied Biological Materials Clones for CYP1A1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: |
Expression for CYP1A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
- Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene
This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).
This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYP1A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CYP1A1 Gene:
CYP1A1SOURCE GeneReport for Unigene cluster for CYP1A1 Gene:
Hs.72912mRNA Expression by UniProt/SwissProt for CYP1A1 Gene:
P04798-CP1A1_HUMAN
Tissue specificity:
Lung, lymphocytes and placenta.
Evidence on tissue expression from TISSUES for CYP1A1 Gene
- Liver(4.8)
- Blood(4.5)
- Nervous system(4.4)
- Lung(3.4)
- Intestine(2.8)
- Kidney(2.7)
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for CYP1A1
-
OriGene qPCR primer pairs for CYP1A1
- genomics-online: primer clones - Search results for 117 available CYP1A1 gene related products
- Overview of 117 available CYP1A1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A1 Gene
Orthologs for CYP1A1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CYP1A1 34 |
|
OneToOne | |
| LOC453744 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | CYP1A1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CYP1A1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cyp1a1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cyp1a1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CYP1A1 34 33 |
|
ManyToMany | |
| CYP1A4 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cyp1a1 33 |
|
||
| Str.2144 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cyp1a 34 33 |
|
OneToMany | |
| cyp1a1 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Cyp18a1 35 |
|
|
|
| Cyp307a1 35 |
|
|
|||
| spo 34 |
|
ManyToMany | |||
| spok 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CYP93D1 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0613600 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for CYP1A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CYP1A1 Gene
- ENSEMBL:
- Gene Tree for CYP1A1 (if available)
- TreeFam:
- Gene Tree for CYP1A1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYP1A1: view image
Paralogs for CYP1A1 Gene
(30) SIMAP similar genes for CYP1A1 Gene using alignment to 8 proteins:
- CP1A1_HUMAN
- A0N0X8_HUMAN
- A4F3V8_HUMAN
- A4F4K3_HUMAN
- A4F4K4_HUMAN
- E7EMT5_HUMAN
- Q0VHD5_HUMAN
- Q5J9B1_HUMAN
Pseudogenes.org Pseudogenes for CYP1A1 Gene
Variants for CYP1A1 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000393848 | -- | 74,719,252(-) | T/G | downstream_transcript_variant | |
| rs1000699728 | -- | 74,724,009(-) | T/C | intron_variant | |
| rs1000751890 | -- | 74,723,694(-) | T/G | intron_variant | |
| rs1001267801 | -- | 74,724,894(-) | G/T | intron_variant | |
| rs1001321488 | -- | 74,725,220(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2763106 | CNV | loss | 21179565 |
| esv3636907 | CNV | loss | 21293372 |
| nsv1121512 | CNV | deletion | 24896259 |
| nsv817698 | CNV | gain | 17921354 |
| nsv833055 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.23;
84.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYP1A1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene
Disorders for CYP1A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| aryl hydrocarbon hydroxylase inducibility |
|
|
| colorectal cancer, childhood |
|
|
| ehrlich tumor carcinoma |
|
|
| acetaminophen metabolism |
|
|
| oral submucous fibrosis |
|
|
Search CYP1A1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CYP1A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene
Publications for CYP1A1 Gene
- Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. (PMID: 20381444) Ashton KA … Scott RJ (Cancer epidemiology 2010) 3 22 44 58
- Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. (PMID: 19608585) Wright CM … Fong KM (The European respiratory journal 2010) 3 22 44 58
- Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women. (PMID: 19963114) Klinchid J … Cressey R (Cancer genetics and cytogenetics 2009) 3 22 44 58
- Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. (PMID: 19346634) Surekha D … Vishnupriya S (Indian journal of medical sciences 2009) 3 22 44 58
- [Relationship between CYP1A1 gene polymorphisms and urinary 1-hydroxypyrene levels in coke oven workers]. (PMID: 19538838) Nie JS … Niu Q (Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2009) 3 22 44 58
Products for CYP1A1 Gene
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- Invitrogen Antibodies for CYP1A1
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- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 132 available CYP1A1 Antibodies ranked by validation data
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- GeneTex Cyp1a1 Antibody for CYP1A1
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- genomics-online: cdna clones - Search results for 117 available CYP1A1 gene related products
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- Boster Bio Antibodies for CYP1A1
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Sources for CYP1A1 Gene
- (1) GeneCards
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- (8) Gene Wiki
- (9) UCSC
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- (33) HomoloGene
- (34) PanEnsembl
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- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
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- (42) GenAtlas
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- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
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- (53) IMGT
- (54) Leiden
- (55) miRBase
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- (57) OriGene
- (58) PubMed
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- (66) GenScript
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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