Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008] See more...

Aliases for CYLC2 Gene

Aliases for CYLC2 Gene

  • Cylicin 2 2 3 5
  • Cylicin, Basic Protein Of Sperm Head Cytoskeleton 2 2 3
  • Multiple-Band Polypeptide II 3 4
  • Cylicin II 3 4
  • Cylicin-2 3 4
  • CYLC2 5
  • CYL2 4

External Ids for CYLC2 Gene

Previous GeneCards Identifiers for CYLC2 Gene

  • GC09P096564
  • GC09P097507
  • GC09P099215
  • GC09P101143
  • GC09P101137
  • GC09P102825
  • GC09P104797
  • GC09P105757
  • GC09P075360

Summaries for CYLC2 Gene

Entrez Gene Summary for CYLC2 Gene

  • Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYLC2 Gene

CYLC2 (Cylicin 2) is a Protein Coding gene. Diseases associated with CYLC2 include Retinal Lattice Degeneration and Vitreous Syneresis. Gene Ontology (GO) annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is CYLC1.

UniProtKB/Swiss-Prot Summary for CYLC2 Gene

  • Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

Additional gene information for CYLC2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYLC2 Gene

Genomics for CYLC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYLC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J102995 Promoter 0.4 EPDnew 600.7 +0.0 15 0.1 ATF2 CYLC2 lnc-CYLC2-2
GH09J102985 Enhancer 0.3 Ensembl 0.4 -9.1 -9110 2 ESR1 CYLC2 lnc-CYLC2-3
GH09J102971 Enhancer 0.2 FANTOM5 0.4 -23.9 -23869 0 CYLC2 lnc-CYLC2-3
GH09J102932 Enhancer 0.3 Ensembl 0.2 -62.8 -62810 0.2 USF1 lnc-CYLC2-3 CYLC2
GH09J103037 Enhancer 0.2 Ensembl 0.3 +42.6 42590 1 MN309174-675 lnc-CYLC2-2 CYLC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYLC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYLC2

Top Transcription factor binding sites by QIAGEN in the CYLC2 gene promoter:
  • C/EBPbeta
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx2-2
  • POU3F2
  • POU6F1 (c2)
  • SRF
  • SRF (504 AA)
  • Tal-1

Genomic Locations for CYLC2 Gene

Genomic Locations for CYLC2 Gene
chr9:102,995,311-103,018,488
(GRCh38/hg38)
Size:
23,178 bases
Orientation:
Plus strand
chr9:105,757,593-105,780,770
(GRCh37/hg19)
Size:
23,178 bases
Orientation:
Plus strand

Genomic View for CYLC2 Gene

Genes around CYLC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYLC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYLC2 Gene

Proteins for CYLC2 Gene

  • Protein details for CYLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14093-CYLC2_HUMAN
    Recommended name:
    Cylicin-2
    Protein Accession:
    Q14093
    Secondary Accessions:
    • B2R8F4
    • Q5VVJ9

    Protein attributes for CYLC2 Gene

    Size:
    348 amino acids
    Molecular mass:
    39079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYLC2 Gene

Post-translational modifications for CYLC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYLC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYLC2 Gene

Domains & Families for CYLC2 Gene

Gene Families for CYLC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CYLC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYLC2 Gene

GenScript: Design optimal peptide antigens:
  • Multiple-band polypeptide II (CYLC2_HUMAN)
  • CYLC2 protein (Q6PEJ5_HUMAN)
genes like me logo Genes that share domains with CYLC2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CYLC2 Gene

Function for CYLC2 Gene

Molecular function for CYLC2 Gene

UniProtKB/Swiss-Prot Function:
Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

Phenotypes From GWAS Catalog for CYLC2 Gene

Gene Ontology (GO) - Molecular Function for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS,IEA --
genes like me logo Genes that share ontologies with CYLC2: view
genes like me logo Genes that share phenotypes with CYLC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYLC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYLC2 Gene

Localization for CYLC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYLC2 Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYLC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0033150 cytoskeletal calyx IEA --
genes like me logo Genes that share ontologies with CYLC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYLC2 Gene

Pathways & Interactions for CYLC2 Gene

PathCards logo

SuperPathways for CYLC2 Gene

No Data Available

Interacting Proteins for CYLC2 Gene

Gene Ontology (GO) - Biological Process for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CYLC2: view

No data available for Pathways by source and SIGNOR curated interactions for CYLC2 Gene

Drugs & Compounds for CYLC2 Gene

No Compound Related Data Available

Transcripts for CYLC2 Gene

mRNA/cDNA for CYLC2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYLC2

Alternative Splicing Database (ASD) splice patterns (SP) for CYLC2 Gene

No ASD Table

Relevant External Links for CYLC2 Gene

GeneLoc Exon Structure for
CYLC2

Expression for CYLC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYLC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYLC2 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for CYLC2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYLC2 Gene



Protein tissue co-expression partners for CYLC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYLC2

SOURCE GeneReport for Unigene cluster for CYLC2 Gene:

Hs.3232

mRNA Expression by UniProt/SwissProt for CYLC2 Gene:

Q14093-CYLC2_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with CYLC2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYLC2 Gene

Orthologs for CYLC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYLC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CYLC2 30 31
  • 98.73 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CYLC2 31
  • 48 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CYLC2 31
  • 38 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cylc2 31
  • 37 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 26 (a)
OneToMany
Species where no ortholog for CYLC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CYLC2 Gene

ENSEMBL:
Gene Tree for CYLC2 (if available)
TreeFam:
Gene Tree for CYLC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYLC2: view image

Paralogs for CYLC2 Gene

Paralogs for CYLC2 Gene

(1) SIMAP similar genes for CYLC2 Gene using alignment to 2 proteins:

  • CYLC2_HUMAN
  • Q6PEJ5_HUMAN
genes like me logo Genes that share paralogs with CYLC2: view

Variants for CYLC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYLC2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs10990424 - p.Gly184Asp
rs13293961 - p.Asp146Tyr
rs2298050 - p.Lys190Glu
rs2298051 - p.Gly208Asp
rs3763636 - p.Ala319Glu

Additional dbSNP identifiers (rs#s) for CYLC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYLC2 Gene

Variant ID Type Subtype PubMed ID
dgv1363e199 CNV deletion 23128226
dgv4111n106 CNV deletion 24896259
dgv7692n100 CNV loss 25217958
dgv7693n100 CNV loss 25217958
esv21750 CNV gain 19812545
esv2530008 CNV loss 19546169
esv2660397 CNV deletion 23128226
esv2668100 CNV deletion 23128226
esv2738857 CNV deletion 23290073
esv2738858 CNV deletion 23290073
esv2738859 CNV deletion 23290073
esv2738860 CNV deletion 23290073
esv2738861 CNV deletion 23290073
esv2738863 CNV deletion 23290073
esv2762824 CNV loss 21179565
esv3573326 CNV loss 25503493
esv3576687 CNV gain 25503493
esv3621296 CNV loss 21293372
esv3621301 CNV loss 21293372
esv4412 CNV loss 18987735
nsv1036220 CNV loss 25217958
nsv1043424 CNV loss 25217958
nsv1051679 CNV loss 25217958
nsv1051901 CNV loss 25217958
nsv1075667 CNV deletion 25765185
nsv1075668 CNV deletion 25765185
nsv1128336 CNV deletion 24896259
nsv1134928 CNV tandem duplication 24896259
nsv1141018 CNV deletion 24896259
nsv415530 CNV deletion 16902084
nsv416206 CNV deletion 16902084
nsv466455 CNV gain 19166990
nsv516844 CNV gain+loss 19592680
nsv615027 CNV gain 21841781
nsv615037 CNV loss 21841781
nsv615038 CNV loss 21841781
nsv615039 CNV loss 21841781

Variation tolerance for CYLC2 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYLC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYLC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYLC2 Gene

Disorders for CYLC2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CYLC2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinal lattice degeneration
  • palisade degeneration of retina
vitreous syneresis
  • vitreous degeneration
vitreoretinal dystrophy
  • vitreoretinal dystrophies
amebiasis
  • amoebiasis
chronic closed-angle glaucoma
  • anatomical narrow angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search CYLC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CYLC2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CYLC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYLC2 Gene

Publications for CYLC2 Gene

  1. The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. (PMID: 7737358) Hess H … Franke WW (Experimental cell research 1995) 2 3 4 23
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 41
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for CYLC2 Gene

  • Signalway ELISA kits for CYLC2

Sources for CYLC2 Gene