CYLC1 Gene (Protein Coding)

Cylicin 1

GC0XP083861
GIFtS:
32
This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] See more...

Aliases for CYLC1 Gene

Aliases for CYLC1 Gene

  • Cylicin 1 2 3 5
  • Cylicin, Basic Protein Of Sperm Head Cytoskeleton 1 2 3
  • Multiple-Band Polypeptide I 3 4
  • Cylicin I 3 4
  • Cylicin-1 3 4
  • CYCL1 3
  • CYL1 4
  • CYL 4

External Ids for CYLC1 Gene

Previous GeneCards Identifiers for CYLC1 Gene

  • GC0XP078495
  • GC0XP080192
  • GC0XP081163
  • GC0XP081888
  • GC0XP082922
  • GC0XP083116
  • GC0XP076689

Summaries for CYLC1 Gene

Entrez Gene Summary for CYLC1 Gene

  • This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for CYLC1 Gene

CYLC1 (Cylicin 1) is a Protein Coding gene. Diseases associated with CYLC1 include Regular Astigmatism and Ametropic Amblyopia. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is CYLC2.

UniProtKB/Swiss-Prot Summary for CYLC1 Gene

  • Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

Additional gene information for CYLC1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYLC1 Gene

Genomics for CYLC1 Gene

GeneHancer (GH) Regulatory Elements for CYLC1 Gene

Promoters and enhancers for CYLC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ083861 Promoter 0.4 EPDnew 500.7 +0.0 1 0.1 ATF2 CYLC1 piR-56341-260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYLC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYLC1

Top Transcription factor binding sites by QIAGEN in the CYLC1 gene promoter:
  • Bach1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • LCR-F1

Genomic Locations for CYLC1 Gene

Genomic Locations for CYLC1 Gene
chrX:83,861,126-83,886,700
(GRCh38/hg38)
Size:
25,575 bases
Orientation:
Plus strand
chrX:83,116,154-83,141,705
(GRCh37/hg19)
Size:
25,552 bases
Orientation:
Plus strand

Genomic View for CYLC1 Gene

Genes around CYLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYLC1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYLC1 Gene

Proteins for CYLC1 Gene

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  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CYLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35663-CYLC1_HUMAN
    Recommended name:
    Cylicin-1
    Protein Accession:
    P35663
    Secondary Accessions:
    • A0AVQ8
    • Q5JQQ9

    Protein attributes for CYLC1 Gene

    Size:
    651 amino acids
    Molecular mass:
    74242 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYLC1 Gene

Protein Expression for CYLC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CYLC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYLC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYLC1 Gene

Domains & Families for CYLC1 Gene

Gene Families for CYLC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CYLC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYLC1 Gene

GenScript: Design optimal peptide antigens:
  • Multiple-band polypeptide I (CYLC1_HUMAN)
  • CYLC1 protein (Q3ZCV3_HUMAN)
  • CYLC1 protein (Q6NS94_HUMAN)
  • CYLC1 protein (Q6PEK4_HUMAN)
genes like me logo Genes that share domains with CYLC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CYLC1 Gene

Function for CYLC1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
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  6. Cell Line

Molecular function for CYLC1 Gene

UniProtKB/Swiss-Prot Function:
Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

Phenotypes From GWAS Catalog for CYLC1 Gene

Gene Ontology (GO) - Molecular Function for CYLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 8354692
GO:0005200 structural constituent of cytoskeleton IEA --
genes like me logo Genes that share ontologies with CYLC1: view
genes like me logo Genes that share phenotypes with CYLC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYLC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYLC1 Gene

Localization for CYLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYLC1 Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYLC1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3
extracellular 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0033150 cytoskeletal calyx IEA --
GO:0043159 acrosomal matrix IDA 8354692
genes like me logo Genes that share ontologies with CYLC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYLC1 Gene

Pathways & Interactions for CYLC1 Gene

PathCards logo

SuperPathways for CYLC1 Gene

No Data Available

Interacting Proteins for CYLC1 Gene

Selected Interacting proteins: P35663-CYLC1_HUMAN for CYLC1 Gene via IID

GPS-Prot Interaction Network for CYLC1
;

Gene Ontology (GO) - Biological Process for CYLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 8354692
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CYLC1: view

No data available for Pathways by source and SIGNOR curated interactions for CYLC1 Gene

Drugs & Compounds for CYLC1 Gene

Products:

  1. Drug

(1) Additional Compounds for CYLC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CYLC1: view

Transcripts for CYLC1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for CYLC1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYLC1

Alternative Splicing Database (ASD) splice patterns (SP) for CYLC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1:
SP2:
SP3: - - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for CYLC1 Gene

GeneLoc Exon Structure for
CYLC1

Expression for CYLC1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYLC1 Gene

mRNA expression in normal human tissues for CYLC1 Gene
mRNA expression by BioGPS for CYLC1 GenemRNA expression by GTEx for CYLC1 Gene

mRNA differential expression in normal tissues according to GTEx for CYLC1 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for CYLC1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYLC1 Gene



Protein tissue co-expression partners for CYLC1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYLC1

SOURCE GeneReport for Unigene cluster for CYLC1 Gene:

Hs.444230

mRNA Expression by UniProt/SwissProt for CYLC1 Gene:

P35663-CYLC1_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for CYLC1 Gene

  • Eye(2.1)
genes like me logo Genes that share expression patterns with CYLC1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYLC1 Gene

Orthologs for CYLC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYLC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CYLC1 31 30
  • 98.92 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CYLC1 31 30
  • 76.7 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CYLC1 31 30
  • 74.33 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cylc1 31
  • 39 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 24 (a)
 OneToMany
Species where no ortholog for CYLC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYLC1 Gene

ENSEMBL:
Gene Tree for CYLC1 (if available)
TreeFam:
Gene Tree for CYLC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYLC1: view image

Paralogs for CYLC1 Gene

Paralogs for CYLC1 Gene

(1) SIMAP similar genes for CYLC1 Gene using alignment to 4 proteins:

  • CYLC1_HUMAN
  • Q3ZCV3_HUMAN
  • Q6NS94_HUMAN
  • Q6PEK4_HUMAN
genes like me logo Genes that share paralogs with CYLC1: view

Variants for CYLC1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYLC1 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs12008888 - p.Asp399His

Additional dbSNP identifiers (rs#s) for CYLC1 Gene

Variation tolerance for CYLC1 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYLC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYLC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYLC1 Gene

Disorders for CYLC1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for CYLC1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CYLC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CYLC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYLC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYLC1 Gene

Publications for CYLC1 Gene

  1. Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton. (PMID: 8354692) Hess H … Franke WW (The Journal of cell biology 1993) 2 3 4 23 54
  2. The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. (PMID: 7737358) Hess H … Franke WW (Experimental cell research 1995) 2 3 23 54
  3. X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. (PMID: 19679225) Siddiqui RA … Platzer M (American journal of human genetics 2009) 3 41 54
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

ExternalLinks

View latest publications for CYLC1 gene in Mastermind

Products for CYLC1 Gene

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