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Aliases for CYHR1 Gene

Aliases for CYHR1 Gene

  • Cysteine And Histidine Rich 1 2 3 5
  • Cysteine/Histidine-Rich 1 2 3
  • Cysteine And Histidine-Rich Protein 1 3
  • Cysteine And Histidine Rich Protein 3
  • KIAA0496 4
  • CHRP 3

External Ids for CYHR1 Gene

Previous GeneCards Identifiers for CYHR1 Gene

  • GC08U990106
  • GC08M145646
  • GC08M145660
  • GC08M140788
  • GC08M145674

Summaries for CYHR1 Gene

GeneCards Summary for CYHR1 Gene

CYHR1 (Cysteine And Histidine Rich 1) is a Protein Coding gene.

Additional gene information for CYHR1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYHR1 Gene

Genomics for CYHR1 Gene

GeneHancer (GH) Regulatory Elements for CYHR1 Gene

Promoters and enhancers for CYHR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I144461 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.8 848 7 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 CBX5 CYHR1 KIFC2 ENSG00000254578 CPSF1 PPP1R16A ZNF707 ZNF7 SHARPIN ZNF16 VPS28
GH08I143914 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +528.6 528561 45.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D PLEC ZNF251 ZNF517 ZNF250 ZNF7 LOC105375803 ZNF623 CPSF1 VPS28 LRRC14
GH08I143731 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +728.4 728443 11.1 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A ZBTB7B E2F8 ZNF143 FAM83H ENSG00000254548 FAM83H-AS1 LRRC14 LOC105375803 ZNF696 ZNF623 CYHR1 CPSF1 VPS28
GH08I144407 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +55.5 55522 4.8 HDGF CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CPSF1 ENSG00000272115 ZNF251 ZNF517 ZNF250 LOC105375803 LRRC14 TMED10P1 ENSG00000255164 ZNF34
GH08I144506 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 -43.3 -43278 4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MFSD3 ZNF7 CPSF1 VPS28 ZNF250 ZNF623 ZNF251 ENSG00000254533 LRRC14 ZNF707
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYHR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYHR1 gene promoter:

Genomic Locations for CYHR1 Gene

Genomic Locations for CYHR1 Gene
16,110 bases
Minus strand

Genomic View for CYHR1 Gene

Genes around CYHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYHR1 Gene

Proteins for CYHR1 Gene

  • Protein details for CYHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine and histidine-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KSX0
    • D3DWM3
    • Q9BSF6
    • Q9BSU6

    Protein attributes for CYHR1 Gene

    362 amino acids
    Molecular mass:
    40703 Da
    Quaternary structure:
    • Interacts with LGALS3.
    • Sequence=BAD18724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYHR1 Gene


neXtProt entry for CYHR1 Gene

Post-translational modifications for CYHR1 Gene

  • Ubiquitination at Lys104, Lys292, and Lys349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYHR1 Gene

Domains & Families for CYHR1 Gene

Gene Families for CYHR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CYHR1 Gene

Suggested Antigen Peptide Sequences for CYHR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CYHR1 family.
  • Belongs to the CYHR1 family.
genes like me logo Genes that share domains with CYHR1: view

Function for CYHR1 Gene

Phenotypes From GWAS Catalog for CYHR1 Gene

Gene Ontology (GO) - Molecular Function for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Phenotypes for CYHR1 Gene

genes like me logo Genes that share phenotypes with CYHR1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYHR1 Gene

Localization for CYHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYHR1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Shows a prominent perinuclear and cytoplasmic localization. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYHR1 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Pathways & Interactions for CYHR1 Gene

SuperPathways for CYHR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYHR1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CYHR1 Gene

Drugs & Compounds for CYHR1 Gene

No Compound Related Data Available

Transcripts for CYHR1 Gene

Unigene Clusters for CYHR1 Gene

Cysteine/histidine-rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYHR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: -
SP8: -
SP11: -

Relevant External Links for CYHR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYHR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYHR1 Gene

Protein differential expression in normal tissues from HIPED for CYHR1 Gene

This gene is overexpressed in Testis (13.6), Fetal Brain (9.7), Retina (8.6), Fetal ovary (6.4), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYHR1 Gene

Protein tissue co-expression partners for CYHR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYHR1 Gene:


SOURCE GeneReport for Unigene cluster for CYHR1 Gene:


Evidence on tissue expression from TISSUES for CYHR1 Gene

  • Nervous system(4.7)
  • Lung(4.3)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with CYHR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYHR1 Gene

Orthologs for CYHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYHR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYHR1 33 34
  • 99.3 (n)
(Bos Taurus)
Mammalia CYHR1 33 34
  • 93.55 (n)
(Canis familiaris)
Mammalia CYHR1 33 34
  • 91.44 (n)
(Monodelphis domestica)
Mammalia CYHR1 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CYHR1 34
  • 91 (a)
(Mus musculus)
Mammalia Cyhr1 33 16 34
  • 89.82 (n)
(Rattus norvegicus)
Mammalia Cyhr1 33
  • 85.97 (n)
(Anolis carolinensis)
Reptilia CYHR1 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735269 33
  • 82.63 (n)
(Danio rerio)
Actinopterygii cyhr1 33 34
  • 78.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32486 33 34
  • 58.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002264 33
  • 58.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8507 34
  • 44 (a)
Species where no ortholog for CYHR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYHR1 Gene

Gene Tree for CYHR1 (if available)
Gene Tree for CYHR1 (if available)

Paralogs for CYHR1 Gene

No data available for Paralogs for CYHR1 Gene

Variants for CYHR1 Gene

Sequence variations from dbSNP and Humsavar for CYHR1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000026052 -- 144,459,645(-) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000209806 -- 144,462,357(-) T/C coding_sequence_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, missense_variant
rs1000336116 -- 144,462,617(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, missense_variant
rs1000379339 -- 144,455,239(-) C/T 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000393001 -- 144,466,237(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CYHR1 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12438n54 CNV loss 21841781
dgv12439n54 CNV loss 21841781
dgv12440n54 CNV loss 21841781
dgv3934n106 CNV deletion 24896259
dgv907n27 CNV loss 19166990
esv1003467 CNV deletion 20482838
esv26548 CNV gain 19812545
esv2759652 CNV gain+loss 17122850
esv29999 CNV loss 17803354
nsv1077078 CNV deletion 25765185
nsv1077079 CNV deletion 25765185
nsv1144242 CNV deletion 24896259
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612935 CNV loss 21841781
nsv612936 CNV loss 21841781
nsv612940 CNV loss 21841781
nsv612946 CNV loss 21841781
nsv612947 CNV loss 21841781
nsv831489 CNV loss 17160897

Variation tolerance for CYHR1 Gene

Gene Damage Index Score: 0.38; 8.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYHR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYHR1 Gene

Disorders for CYHR1 Gene

Additional Disease Information for CYHR1

No disorders were found for CYHR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYHR1 Gene

Publications for CYHR1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. (PMID: 10745073) Menon RP … Hughes RC (FEBS letters 2000) 2 3 58
  3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for CYHR1 Gene

Sources for CYHR1 Gene

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