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This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]
CYGB (Cytoglobin) is a Protein Coding gene. Diseases associated with CYGB include Retinitis Pigmentosa 36 and Esophageal Diverticulosis. Among its related pathways are eNOS activation and regulation and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is HBZ.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004096 | catalase activity | IEA | -- |
GO:0004601 | peroxidase activity | IEA,ISS | 11320098 |
GO:0005344 | oxygen carrier activity | IEA,NAS | 11919282 |
GO:0005506 | iron ion binding | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0043005 | neuron projection | IEA | -- |
GO:0043025 | neuronal cell body | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | eNOS activation and regulation |
.01
|
|
2 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001666 | response to hypoxia | IEA | -- |
GO:0006979 | response to oxidative stress | ISS | 11320098 |
GO:0010764 | negative regulation of fibroblast migration | IEA | -- |
GO:0015671 | oxygen transport | IEA,TAS | -- |
GO:0019395 | fatty acid oxidation | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CYGB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CYGB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CYGB 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cygb 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cygb 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CYGB 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CYGB 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CYGB 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CYGB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cygb 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cygb2 30 31 |
|
OneToMany | |
CYGB (2 of 3) 31 |
|
OneToMany | |||
cygb1 31 |
|
OneToMany | |||
cygb 30 |
|
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
771500 | Benign: not provided | 76,528,584(-) | C/T | SYNONYMOUS_VARIANT | |
777224 | Benign: not provided | 76,531,128(-) | G/T | SYNONYMOUS_VARIANT | |
799512 | Likely Benign: not provided | 76,540,153(-) | C/G | SYNONYMOUS_VARIANT | |
848892 | Uncertain Significance: not provided | 76,540,206(-) | G/A | MISSENSE_VARIANT | |
849356 | Uncertain Significance: not provided | 76,540,576(-) | A/G | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
retinitis pigmentosa 36 |
|
|
esophageal diverticulosis |
|
|
atrophic vulva |
|
|
geotrichosis |
|
|
deficiency anemia |
|
|