Aliases for CYFIP1 Gene
Aliases for CYFIP1 Gene
External Ids for CYFIP1 Gene
- HGNC: 13759
- Entrez Gene: 23191
- Ensembl: ENSG00000273749
- OMIM: 606322
- UniProtKB: Q7L576
Previous GeneCards Identifiers for CYFIP1 Gene
- GC15P019172
- GC15M015990
- GC15P020311
- GC15P020440
- GC15P020444
- GC15P023697
- GC15P023717
- GC15P001205
- GC15P023748
- GC15P023761
- GC15P023780
- GC15P023809
- GC15P023843
- GC15P023873
- GC15P023905
Summaries for CYFIP1 Gene
-
This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]
GeneCards Summary for CYFIP1 Gene
CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with CYFIP1 include Fragile X Syndrome and Autism. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include protein complex binding and Rac GTPase binding. An important paralog of this gene is CYFIP2.
UniProtKB/Swiss-Prot for CYFIP1 Gene
-
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers.
Additional gene information for CYFIP1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYFIP1 Gene
Genomics for CYFIP1 Gene
GeneHancer (GH) Regulatory Elements for CYFIP1 Gene
Promoters and enhancers for CYFIP1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH15I022978 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 550.8 | +1.0 | 1022 | 2.7 | ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 KLF7 FOS ATF7 ZNF263 | CYFIP1 PIR62908 | |
| GH15I022917 | Promoter | 0.5 | EPDnew | 550.2 | +63.8 | 63819 | 0.1 | CYFIP1 PIR44215 PIR53215 | ||
| GH15I022785 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 15.7 | +194.4 | 194397 | 2.4 | HDGF ATF1 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 YY1 POLR2B | NIPA1 CYFIP1 NIPA2 LOC729900 PIR54317 | |
| GH15I022949 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 22 | +31.3 | 31333 | 2.4 | HDAC1 ATF1 SIN3A TCF12 GLIS2 EGR1 EGR2 SP3 NR2F2 SMARCA4 | CYFIP1 PIR53215 PIR44215 | |
| GH15I022837 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 10.8 | +141.7 | 141665 | 3.8 | HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 | NIPA2 HERC2P7 CYFIP1 ENSG00000259098 PIR62888 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CYFIP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CYFIP1 Gene
Genomic Locations for CYFIP1 Gene
- chr15:22,867,052-22,981,063
- (GRCh38/hg38)
- Size:
- 114,012 bases
- Orientation:
- Minus strand
- chr15:22,892,005-23,006,016
- (GRCh37/hg19)
Genomic View for CYFIP1 Gene
Genes around CYFIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q11.2 by Ensembl
- 15q11.2 by Entrez Gene
- 15q11.2 by HGNC
CYFIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYFIP1 Gene
Proteins for CYFIP1 Gene
-
Protein details for CYFIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L576-CYFP1_HUMAN
- Recommended name:
- Cytoplasmic FMR1-interacting protein 1
- Protein Accession:
- Q7L576
- A8K6D9
- Q14467
- Q5IED0
- Q6ZSX1
- Q9BSD9
- Q9BVC7
Protein attributes for CYFIP1 Gene
- Size:
- 1253 amino acids
- Molecular mass:
- 145182 Da
- Quaternary structure:
-
- Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with FMR1 but does not bind to related proteins FXR1 or FXR2. Interaction with EIF4E stimulates FMR1 binding. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2 (PubMed:16417406). Interacts with the active GTP-bound form of RAC1. Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth. Interacts with NYAP1, NYAP2 and MYO16. Interacts with TMEM108 (via N-terminus); the interaction associates TMEM108 with the WAVE1 complex (By similarity).
- Miscellaneous:
-
- Breakpoint hotspot for the Prader-Willi/Angelman syndromes and may be implicated in autism. Commonly altered in tumors.
- SequenceCaution:
-
- Sequence=BAA07552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for CYFIP1 Gene
Post-translational modifications for CYFIP1 Gene
- Ubiquitination at posLast=10531053 and Lys1210
Other Protein References for CYFIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CYFIP1
- Novus Biologicals Antibodies for CYFIP1
-
Abcam antibodies for CYFIP1
- Invitrogen Antibodies for CYFIP1
- GeneTex CYFIP1 antibody for CYFIP1
Protein Products
-
OriGene Purified Proteins for CYFIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYFIP1
- Origene Custom Protein Services for CYFIP1
- antibodies-online: Search results for 4 available CYFIP1 Proteins ranked by validation data
- Compare Top CYFIP1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CYFIP1
-
Abcam proteins for CYFIP1
Assay Products
- antibodies-online: Search results for 3 available CYFIP1 Elisa Kits ranked by validation data
- Compare Top CYFIP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CYFIP1 Gene
Domains & Families for CYFIP1 Gene
Gene Families for CYFIP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CYFIP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYFIP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7L576- Family:
-
- Belongs to the CYFIP family.
Function for CYFIP1 Gene
Molecular function for CYFIP1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). May act as an invasion suppressor in cancers.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000340 | RNA 7-methylguanosine cap binding | IEA | -- |
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 11438699 |
| GO:0032403 | protein complex binding | IMP | 21107423 |
| GO:0048365 | Rac GTPase binding | ISS | -- |
Phenotypes for CYFIP1 Gene
- MGI mutant phenotypes for CYFIP1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CYFIP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYFIP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CYFIP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYFIP1 gene
- Search ViGene Biosciences for CYFIP1
CRISPR Products
-
OriGene CRISPR knockouts for CYFIP1
- genomics-online: gRNA clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
- Applied Biological Materials CRISPR for CYFIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYFIP1
- GenScript: Design CRISPR guide RNA sequences for CYFIP1
miRNA for CYFIP1 Gene
- miRTarBase miRNAs that target CYFIP1
miRNA Products
- Search ViGene Biosciences for CYFIP1
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CYFIP1
- Browse OriGene Inhibitory RNA Products For CYFIP1
- genomics-online: shRNA clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CYFIP1 gene
Clone Products
- Sino Biological Human cDNA Clone for CYFIP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYFIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYFIP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CYFIP1
- Applied Biological Materials Clones for CYFIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CYFIP1
-
ViGene Biosciences adenoviral particle packaged cDNA for CYFIP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CYFIP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYFIP1 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYFIP1 Gene
Localization for CYFIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYFIP1 Gene
- Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, synapse, synaptosome. Note=Highly expressed in the perinuclear region (By similarity). Enriched in synaptosomes (By similarity). Also enriched in membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250 UniProtKB:Q7TMB8}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001726 | ruffle | ISS | -- |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005845 | mRNA cap binding complex | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYFIP1 Gene
Pathways & Interactions for CYFIP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of actin dynamics for phagocytic cup formation | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Signaling by Rho GTPases | ||
| 4 | RET signaling | ||
| 5 | Regulation of actin cytoskeleton | ||
Pathways by source for CYFIP1 Gene
2 BioSystems pathways for CYFIP1 Gene
11 Reactome pathways for CYFIP1 Gene
2 KEGG pathways for CYFIP1 Gene
2 Qiagen pathways for CYFIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0008360 | regulation of cell shape | IEA | -- |
| GO:0016601 | Rac protein signal transduction | IMP | 21107423 |
No data available for SIGNOR curated interactions for CYFIP1 Gene
Drugs & Compounds for CYFIP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for CYFIP1 Gene
mRNA/cDNA for CYFIP1 Gene
- (15) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (429) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYFIP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CYFIP1
- genomics-online: gRNA clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
- Applied Biological Materials CRISPR for CYFIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYFIP1
- GenScript: Design CRISPR guide RNA sequences for CYFIP1
miRNA Products
- Search ViGene Biosciences for CYFIP1
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CYFIP1
- Browse OriGene Inhibitory RNA Products For CYFIP1
- genomics-online: shRNA clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CYFIP1 gene
Clone Products
- Sino Biological Human cDNA Clone for CYFIP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYFIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYFIP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CYFIP1
- Applied Biological Materials Clones for CYFIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CYFIP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Head Mesenchyme (Muscoskeletal System)
This gene is overexpressed in Peripheral blood mononuclear cells (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYFIP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CYFIP1 Gene:
CYFIP1SOURCE GeneReport for Unigene cluster for CYFIP1 Gene:
Hs.26704Evidence on tissue expression from TISSUES for CYFIP1 Gene
- Nervous system(4.7)
- Liver(4.2)
- Skin(2.6)
- Intestine(2.5)
- Lung(2.4)
Primer Products
-
OriGene qPCR primer pairs for CYFIP1
-
OriGene qPCR primer pairs and template standards for CYFIP1
- genomics-online: primer clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYFIP1 Gene
Orthologs for CYFIP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CYFIP1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CYFIP1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cyfip1 33 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cyfip1 33 |
|
||
| chicken (Gallus gallus) |
Aves | CYFIP1 33 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cyfip1 33 |
|
||
| Str.15568 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cyfip1 33 |
|
||
| Dr.1164 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5585 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Sra-1 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | gex-2 33 |
|
- Species where no ortholog for CYFIP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CYFIP1 Gene
(2) SIMAP similar genes for CYFIP1 Gene using alignment to 7 proteins:
Variants for CYFIP1 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000047677 | -- | 22,897,596(-) | G/A | intron_variant | |
| rs1000050554 | -- | 22,917,952(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000081339 | -- | 22,978,462(-) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000117353 | -- | 22,898,827(-) | C/T | intron_variant | |
| rs1000118346 | -- | 22,953,587(-) | T/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
0.777% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.00;
90.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYFIP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYFIP1 Gene
Disorders for CYFIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fragile x syndrome |
|
|
| autism |
|
|
| schizophrenia |
|
|
Search CYFIP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CYFIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CYFIP1 Gene
Publications for CYFIP1 Gene
- A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. (PMID: 11438699) Schenck A … Mandel JL (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 22 58
- Structure and control of the actin regulatory WAVE complex. (PMID: 21107423) Chen Z … Rosen MK (Nature 2010) 3 4 58
- Confirmed rare copy number variants implicate novel genes in schizophrenia. (PMID: 20298200) Tam GW … Grant SG (Biochemical Society transactions 2010) 3 22 58
- Cyfip1 is a putative invasion suppressor in epithelial cancers. (PMID: 19524508) Silva JM … Hannon GJ (Cell 2009) 3 4 58
- The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. (PMID: 18805096) Napoli I … Bagni C (Cell 2008) 3 22 58
Products for CYFIP1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CYFIP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CYFIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYFIP1
- Origene Custom Protein Services for CYFIP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYFIP1
- Browse OriGene Inhibitory RNA Products For CYFIP1
- OriGene qPCR primer pairs and template standards for CYFIP1
- OriGene qPCR primer pairs for CYFIP1
- OriGene CRISPR knockouts for CYFIP1
- OriGene ORF clones in human for CYFIP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CYFIP1
- GenScript: Next-day shipping of latest version cDNA ORF clones for CYFIP1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CYFIP1
- GenScript Custom Assay Services for CYFIP1
- GenScript Custom overexpressing Cell Line Services for CYFIP1
- GenScript: Design CRISPR guide RNA sequences for CYFIP1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CYFIP1
- Sino Biological Human cDNA Clone for CYFIP1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CYFIP1
- Novus Biologicals lysates and proteins for CYFIP1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CYFIP1
- Abcam proteins for CYFIP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CYFIP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYFIP1
- VectorBuilder custom plasmid, inducible vectors for CYFIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYFIP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CYFIP1
- antibodies-online: Search results for 24 available CYFIP1 Antibodies ranked by validation data
- Compare Top CYFIP1 Antibodies
- antibodies-online: Search results for 3 available CYFIP1 Elisa Kits ranked by validation data
- Compare Top CYFIP1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 4 available CYFIP1 Proteins ranked by validation data
- Compare Top CYFIP1 Proteins
- Quality Products:
- GeneTex CYFIP1 antibody for CYFIP1
- Search GeneTex for Proteins for CYFIP1
- ViGene Biosciences adenoviral particle packaged cDNA for CYFIP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CYFIP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CYFIP1 gene
- Search ViGene Biosciences for CYFIP1
- Horizon Cell Lines for CYFIP1
- genomics-online: cdna clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
- orf clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
- genomics-online: gRNA clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
- genomics-online: primer clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
- genomics-online: shRNA clones - Search results for 106 available CYFIP1 gene related products
- Overview of 106 available CYFIP1 gene related products
Sources for CYFIP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew