Aliases for CYBRD1 Gene
External Ids for CYBRD1 Gene
Previous GeneCards Identifiers for CYBRD1 Gene
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYBRD1 Gene
CYBRD1 (Cytochrome B Reductase 1) is a Protein Coding gene. Diseases associated with CYBRD1 include Hemochromatosis, Type 1 and Iron Metabolism Disease. Among its related pathways are Insulin receptor recycling and Mineral absorption. Gene Ontology (GO) annotations related to this gene include ferric-chelate reductase activity and oxidoreductase activity, oxidizing metal ions. An important paralog of this gene is CYB561A3.
UniProtKB/Swiss-Prot for CYBRD1 Gene
Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.