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Aliases for CYBA Gene

Aliases for CYBA Gene

  • Cytochrome B-245 Alpha Chain 2 3 5
  • Superoxide-Generating NADPH Oxidase Light Chain Subunit 3 4
  • Neutrophil Cytochrome B 22 KDa Polypeptide 3 4
  • Flavocytochrome B-558 Alpha Polypeptide 2 3
  • Cytochrome B-245, Alpha Polypeptide 2 3
  • Cytochrome B(558) Alpha Chain 3 4
  • Cytochrome B558 Subunit Alpha 3 4
  • P22 Phagocyte B-Cytochrome 3 4
  • P22phox 3 4
  • Cytochrome B(558) Alpha-Subunit 3
  • Cytochrome B, Alpha Polypeptide 3
  • Cytochrome B-245 Light Chain 3
  • Cytochrome B Light Chain 3
  • P22-PHOX 3
  • P22-Phox 4

External Ids for CYBA Gene

Previous GeneCards Identifiers for CYBA Gene

  • GC16M080145
  • GC16M089678
  • GC16M088413
  • GC16M088453
  • GC16M087237
  • GC16M088709
  • GC16M074403

Summaries for CYBA Gene

Entrez Gene Summary for CYBA Gene

  • Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYBA Gene

CYBA (Cytochrome B-245 Alpha Chain) is a Protein Coding gene. Diseases associated with CYBA include Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative and Chronic Granulomatous Disease. Among its related pathways are TNFR1 Pathway and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and SH3 domain binding.

UniProtKB/Swiss-Prot for CYBA Gene

  • Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

Gene Wiki entry for CYBA Gene

Additional gene information for CYBA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYBA Gene

Genomics for CYBA Gene

GeneHancer (GH) Regulatory Elements for CYBA Gene

Promoters and enhancers for CYBA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J088649 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 660.7 -0.4 -445 4.7 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 CYBA ANKRD11 BANP LOC101927863 ZC3H18 ENSG00000268218 SNAI3-AS1 ACSF3 RPL13 SNORD68
GH16J088615 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 28.2 +32.7 32660 5.5 PKNOX1 ATF1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 CYBA IL17C ZC3H18 SNAI3 MVD RNF166 ZFPM1
GH16J088633 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +15.5 15529 4.9 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF207 ZNF143 ATF7 RUNX3 ZNF263 CYBA ZC3H18 ANKRD11 ENSG00000268218 BANP SNORD68 RPL13 ACSF3 LOC101927863 GALNS
GH16J088685 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.3 -35.8 -35803 3.6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 CBX5 FOS KLF13 PIR40856 SNAI3 SNORD68 ACSF3 RPL13 ANKRD11 BANP SNAI3-AS1 RNF166 MVD
GH16J088779 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.8 -131.6 -131605 6.7 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 PIEZO1 ANKRD11 ZC3H18 APRT ENSG00000259877 LINC00304 BANP ENSG00000268218 SNORD68 CDT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYBA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYBA gene promoter:
  • p53
  • AP-1
  • Sp1
  • PPAR-gamma2

Genomic Locations for CYBA Gene

Genomic Locations for CYBA Gene
chr16:88,643,283-88,651,152
(GRCh38/hg38)
Size:
7,870 bases
Orientation:
Minus strand
chr16:88,709,691-88,717,560
(GRCh37/hg19)
Size:
7,870 bases
Orientation:
Minus strand

Genomic View for CYBA Gene

Genes around CYBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYBA Gene

Proteins for CYBA Gene

  • Protein details for CYBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13498-CY24A_HUMAN
    Recommended name:
    Cytochrome b-245 light chain
    Protein Accession:
    P13498
    Secondary Accessions:
    • Q14090
    • Q9BR72

    Protein attributes for CYBA Gene

    Size:
    195 amino acids
    Molecular mass:
    21013 Da
    Quaternary structure:
    • Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A (By similarity). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4. Interacts with calprotectin (S100A8/9).

    Three dimensional structures from OCA and Proteopedia for CYBA Gene

neXtProt entry for CYBA Gene

Post-translational modifications for CYBA Gene

  • The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245.
  • Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.
  • Ubiquitinated at Lys-149 likely by RNF145.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYBA Gene

No data available for DME Specific Peptides for CYBA Gene

Domains & Families for CYBA Gene

Gene Families for CYBA Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for CYBA Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYBA Gene

Graphical View of Domain Structure for InterPro Entry

P13498

UniProtKB/Swiss-Prot:

CY24A_HUMAN :
  • Belongs to the p22phox family.
Family:
  • Belongs to the p22phox family.
genes like me logo Genes that share domains with CYBA: view

Function for CYBA Gene

Molecular function for CYBA Gene

UniProtKB/Swiss-Prot Function:
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
GENATLAS Biochemistry:
cytochrome b-558,alpha polypeptide,(22kDa,membrane bound component of the NADPH oxidase system,cypb245),p22-phox,mainly expressed in neutrophiles,oxygen dependent mechanism of phagocytosis

Phenotypes From GWAS Catalog for CYBA Gene

Gene Ontology (GO) - Molecular Function for CYBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 3305576
GO:0009055 electron transfer activity IDA,TAS 2243141
GO:0016175 superoxide-generating NADPH oxidase activity IEA,TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0017124 SH3 domain binding IPI 7938008
genes like me logo Genes that share ontologies with CYBA: view
genes like me logo Genes that share phenotypes with CYBA: view

Human Phenotype Ontology for CYBA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYBA Gene

MGI Knock Outs for CYBA:
  • Cyba Cyba<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for CYBA Gene

miRTarBase miRNAs that target CYBA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYBA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CYBA Gene

Localization for CYBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYBA Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYBA gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
mitochondrion 3
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 2
golgi apparatus 2
endosome 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CYBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with CYBA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYBA Gene

Pathways & Interactions for CYBA Gene

genes like me logo Genes that share pathways with CYBA: view

Gene Ontology (GO) - Biological Process for CYBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0003106 negative regulation of glomerular filtration by angiotensin IEA --
GO:0006801 superoxide metabolic process IMP,IEA 1763037
genes like me logo Genes that share ontologies with CYBA: view

No data available for SIGNOR curated interactions for CYBA Gene

Drugs & Compounds for CYBA Gene

(20) Drugs for CYBA Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dextromethorphan Approved Pharma Target, inhibitor 140
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1828
Idarubicin Approved Pharma 226
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 537
heme Pharma Agonist 0

(12) Additional Compounds for CYBA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with CYBA: view

Transcripts for CYBA Gene

mRNA/cDNA for CYBA Gene

Unigene Clusters for CYBA Gene

Cytochrome b-245, alpha polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYBA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYBA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for CYBA Gene

GeneLoc Exon Structure for
CYBA
ECgene alternative splicing isoforms for
CYBA

Expression for CYBA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYBA Gene

This gene is overexpressed in Whole Blood (x19.7) and Spleen (x5.6).

Protein differential expression in normal tissues from HIPED for CYBA Gene

This gene is overexpressed in Nasal epithelium (24.0), Neutrophil (16.5), and Monocytes (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYBA Gene



Protein tissue co-expression partners for CYBA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYBA Gene:

CYBA

SOURCE GeneReport for Unigene cluster for CYBA Gene:

Hs.513803

Evidence on tissue expression from TISSUES for CYBA Gene

  • Nervous system(4.5)
  • Blood(3.3)
  • Heart(2.8)
  • Kidney(2.8)
  • Intestine(2.7)
  • Muscle(2.6)
  • Bone marrow(2.5)
  • Lung(2.5)
  • Pancreas(2.4)
  • Spleen(2.2)
  • Lymph node(2.1)
  • Stomach(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CYBA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • ear
  • eye
  • face
  • head
  • jaw
  • lacrimal apparatus
  • lip
  • mandible
  • maxilla
  • meninges
  • middle ear
  • mouth
  • neck
  • scalp
  • sinus
  • skull
Thorax:
  • bronchus
  • chest wall
  • clavicle
  • esophagus
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • pelvis
  • rectum
  • ureter
  • urethra
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • bone marrow
  • lymph node
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with CYBA: view

No data available for mRNA Expression by UniProt/SwissProt for CYBA Gene

Orthologs for CYBA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYBA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYBA 34 33
  • 98.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CYBA 34 33
  • 85.51 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyba 33
  • 84.2 (n)
dog
(Canis familiaris)
Mammalia CYBA 34 33
  • 83.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cyba 16 34 33
  • 82.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CYBA 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYBA 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYBA 34
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYBA 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyba 33
  • 64.88 (n)
Str.15394 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5967 33
zebrafish
(Danio rerio)
Actinopterygii cyba 34 33
  • 58.67 (n)
OneToOne
zgc66077 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8225 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for CYBA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYBA Gene

ENSEMBL:
Gene Tree for CYBA (if available)
TreeFam:
Gene Tree for CYBA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYBA: view image

Paralogs for CYBA Gene

No data available for Paralogs for CYBA Gene

Variants for CYBA Gene

Sequence variations from dbSNP and Humsavar for CYBA Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs104894510 pathogenic, Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative, Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD) [MIM:233690] 88,646,761(-) T/C coding_sequence_variant, missense_variant
rs104894511 pathogenic, Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative 88,651,007(-) G/A coding_sequence_variant, stop_gained
rs104894513 pathogenic, Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative, Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD) [MIM:233690] 88,646,773(-) C/T coding_sequence_variant, missense_variant
rs104894514 pathogenic, not-provided, Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative, not provided, Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD) [MIM:233690] 88,646,131(-) G/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs104894515 pathogenic, Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative, Chronic granulomatous disease, Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD) [MIM:233690] 88,643,474(-) G/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CYBA Gene

Variant ID Type Subtype PubMed ID
esv3639554 CNV loss 21293372
nsv1113832 CNV deletion 24896259
nsv1926 CNV insertion 18451855
nsv471113 CNV loss 18288195
nsv482951 CNV loss 15286789
nsv833325 CNV loss 17160897
nsv952070 CNV deletion 24416366

Variation tolerance for CYBA Gene

Gene Damage Index Score: 4.16; 61.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYBA Gene

Human Gene Mutation Database (HGMD)
CYBA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYBA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYBA Gene

Disorders for CYBA Gene

MalaCards: The human disease database

(7) MalaCards diseases for CYBA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
granulomatous disease, chronic, autosomal recessive, cytochrome b-negative
  • cgd, autosomal recessive cytochrome b-negative
chronic granulomatous disease
  • bridges-good syndrome
phagocyte bactericidal dysfunction
  • phagocytic dysfunction
diabetic polyneuropathy
  • diabetes mellitus with polyneuropathy
coronary artery anomaly
  • coronary heart disease
- elite association - COSMIC cancer census association via MalaCards
Search CYBA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CY24A_HUMAN
  • Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD) [MIM:233690]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. {ECO:0000269 PubMed:10759707, ECO:0000269 PubMed:10910929, ECO:0000269 PubMed:10914676, ECO:0000269 PubMed:1415254, ECO:0000269 PubMed:1763037, ECO:0000269 PubMed:18422995, ECO:0000269 PubMed:2243141, ECO:0000269 PubMed:23910690, ECO:0000269 PubMed:7964505, ECO:0000269 PubMed:8168815}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for CYBA Gene

chronic granulomatous disease,autosomal (cypb558 deficiency)

Additional Disease Information for CYBA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYBA: view

Publications for CYBA Gene

  1. Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation. (PMID: 19388116) Bedard K … Krause KH (Human mutation 2009) 3 4 22 44 58
  2. Association of p22phox gene C242T polymorphism with coronary artery disease: a meta-analysis. (PMID: 20100625) Fang S … Jia C (Thrombosis research 2010) 3 22 44 58
  3. Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population. (PMID: 19567155) Liu HG … Xu YJ (Chinese medical journal 2009) 3 22 44 58
  4. Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery disease. (PMID: 19564823) Ueno T … Soma M (Medical science monitor : international medical journal of experimental and clinical research 2009) 3 22 44 58
  5. Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension. (PMID: 19516159) Feairheller DL … Fenty-Stewart NM (Medicine and science in sports and exercise 2009) 3 22 44 58

Products for CYBA Gene

Sources for CYBA Gene

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