Aliases for CYBA Gene
External Ids for CYBA Gene
Previous GeneCards Identifiers for CYBA Gene
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYBA Gene
CYBA (Cytochrome B-245 Alpha Chain) is a Protein Coding gene. Diseases associated with CYBA include Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative and Chronic Granulomatous Disease. Among its related pathways are Cellular Senescence (REACTOME) and Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and SH3 domain binding.
UniProtKB/Swiss-Prot Summary for CYBA Gene
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.