NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010] See more...

Aliases for CYB5R4 Gene

Aliases for CYB5R4 Gene

  • Cytochrome B5 Reductase 4 2 3 4 5
  • N-Terminal Cytochrome B5 And Cytochrome B5 Oxidoreductase Domain-Containing Protein 3 4
  • NADPH Cytochrome B5 Oxidoreductase 2 3
  • Flavohemoprotein B5/B5R 3 4
  • DJ676J13.1 2 3
  • EC 1.6.2.2 4 50
  • Cb5/Cb5R 3 4
  • NCB5OR 3 4
  • B5+B5R 2 4
  • Cytochrome B-Type NAD(P)H Oxidoreductase 3
  • Flavohemoprotein B5+B5R 3
  • CYB5R4 5

External Ids for CYB5R4 Gene

Previous HGNC Symbols for CYB5R4 Gene

  • NCB5OR

Previous GeneCards Identifiers for CYB5R4 Gene

  • GC06P084627
  • GC06P084569
  • GC06P081798

Summaries for CYB5R4 Gene

Entrez Gene Summary for CYB5R4 Gene

  • NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]

GeneCards Summary for CYB5R4 Gene

CYB5R4 (Cytochrome B5 Reductase 4) is a Protein Coding gene. Diseases associated with CYB5R4 include Methemoglobin Reductase Deficiency and Maturity-Onset Diabetes Of The Young. Among its related pathways are Metabolism and PAK Pathway. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and flavin adenine dinucleotide binding. An important paralog of this gene is CYB5R1.

UniProtKB/Swiss-Prot Summary for CYB5R4 Gene

  • NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

Gene Wiki entry for CYB5R4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYB5R4 Gene

Genomics for CYB5R4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CYB5R4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J083859 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.5 545 2.8 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 SSRP1 ZNF580 KLF9 CYB5R4 CEP162 RIPPLY2 DOP1A SNAP91 piR-48364 MRAP2
GH06J083853 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.4 -6.2 -6155 1.4 ZNF600 ZNF580 POLR2A ZIC2 FEZF1 ZNF341 KLF7 SIN3A SP2 ZNF843 RIPPLY2 ENSG00000287705 NONHSAG044256.2 CYB5R4 CEP162 DOP1A
GH06J083884 Enhancer 0.9 Ensembl ENCODE 11.7 +25.0 25045 0.6 BCLAF1 ZNF654 ZNF10 NONO CTCF REST TRIM22 ARNT NFATC3 ELF1 RIPPLY2 CEP162 CYB5R4 RF00994-920 piR-48364 MRAP2
GH06J083866 Enhancer 1.4 FANTOM5 Ensembl ENCODE 6.2 +8.4 8445 3.8 IKZF1 ZNF600 ZNF580 ZNF592 ATF2 ZSCAN16 CEBPB BHLHE40 FEZF1 ZNF639 CEP162 DOP1A UBE3D RWDD2A PGM3 RIPPLY2 CYB5R4 piR-48364 RF00994-920 MRAP2
GH06J083462 Enhancer 1.1 FANTOM5 Ensembl ENCODE 4.9 -393.2 -393156 8.2 ZNF600 BHLHE40 FEZF1 MAFF ZNF316 ZNF843 PRDM6 SPI1 MYC PKNOX1 PRSS35 ME1 CEP162 CYB5R4 piR-38580-293 HSALNG0051610-002 HSALNG0051610-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYB5R4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYB5R4

Top Transcription factor binding sites by QIAGEN in the CYB5R4 gene promoter:
  • Cdc5
  • Ik-2
  • Pax-4a
  • POU3F2 (N-Oct-5a)
  • POU6F1 (c2)
  • S8
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for CYB5R4 Gene

Latest Assembly
chr6:83,859,656-83,967,423
(GRCh38/hg38)
Size:
107,768 bases
Orientation:
Plus strand

Previous Assembly
chr6:84,569,408-84,677,142
(GRCh37/hg19 by Entrez Gene)
Size:
107,735 bases
Orientation:
Plus strand

chr6:84,569,362-84,677,143
(GRCh37/hg19 by Ensembl)
Size:
107,782 bases
Orientation:
Plus strand

Genomic View for CYB5R4 Gene

Genes around CYB5R4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB5R4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB5R4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5R4 Gene

Proteins for CYB5R4 Gene

  • Protein details for CYB5R4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L1T6-NB5R4_HUMAN
    Recommended name:
    Cytochrome b5 reductase 4
    Protein Accession:
    Q7L1T6
    Secondary Accessions:
    • B1AEM2
    • Q5TGI9
    • Q9NUE4
    • Q9UHI9

    Protein attributes for CYB5R4 Gene

    Size:
    521 amino acids
    Molecular mass:
    59474 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF04812.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CYB5R4 Gene

neXtProt entry for CYB5R4 Gene

Selected DME Specific Peptides for CYB5R4 Gene

Q7L1T6:
  • LAAGTGFTPM
  • DCWICIRG
  • DWIRLTKSG
  • RLTKSGKD
  • PYMEYHPGGE
  • SKEDVTHDT
  • VHRWVNYESMLKECLVGRMA

Post-translational modifications for CYB5R4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYB5R4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYB5R4 Gene

Gene Families for CYB5R4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CYB5R4 Gene

InterPro:
Blocks:
  • Cytochrome b5
  • Oxidoreductase FAD/NAD(P)-binding
  • Cytochrome B5 reductase signature
  • Oxidoreductase FAD-binding region
  • CS domain

Suggested Antigen Peptide Sequences for CYB5R4 Gene

GenScript: Design optimal peptide antigens:
  • cb5/cb5R (NB5R4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7L1T6

UniProtKB/Swiss-Prot:

NB5R4_HUMAN :
  • Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Family:
  • Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with CYB5R4: view

Function for CYB5R4 Gene

Molecular function for CYB5R4 Gene

UniProtKB/Swiss-Prot Function:
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 [Fe(III)-cytochrome b5] + NADH = 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=25 mM for O(2); Redox potential: E(0) is -108 mV.;

Enzyme Numbers (IUBMB) for CYB5R4 Gene

Phenotypes From GWAS Catalog for CYB5R4 Gene

Gene Ontology (GO) - Molecular Function for CYB5R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H IBA,IDA 10611283
GO:0016174 NOT NAD(P)H oxidase activity IDA 15131110
GO:0016491 oxidoreductase activity IEA --
GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IDA 15131110
GO:0020037 heme binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with CYB5R4: view
genes like me logo Genes that share phenotypes with CYB5R4: view

Animal Models for CYB5R4 Gene

MGI Knock Outs for CYB5R4:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYB5R4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYB5R4 Gene

Localization for CYB5R4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB5R4 Gene

Endoplasmic reticulum. Note=Soluble protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYB5R4 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
cytosol 2
plasma membrane 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CYB5R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA,IDA 15131110
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0048471 perinuclear region of cytoplasm IDA 10611283
genes like me logo Genes that share ontologies with CYB5R4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYB5R4 Gene

Pathways & Interactions for CYB5R4 Gene

genes like me logo Genes that share pathways with CYB5R4: view

Pathways by source for CYB5R4 Gene

1 KEGG pathway for CYB5R4 Gene
1 Qiagen pathway for CYB5R4 Gene
  • Antioxidant Action of Vitamin-C

Gene Ontology (GO) - Biological Process for CYB5R4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003032 detection of oxygen NAS 10611283
GO:0006091 generation of precursor metabolites and energy IBA,IDA 10611283
GO:0006801 superoxide metabolic process IBA,IDA 10611283
GO:0015701 bicarbonate transport TAS --
GO:0030073 insulin secretion IEA,ISS --
genes like me logo Genes that share ontologies with CYB5R4: view

No data available for SIGNOR curated interactions for CYB5R4 Gene

Drugs & Compounds for CYB5R4 Gene

(9) Drugs for CYB5R4 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isosorbide Dinitrate Approved, Investigational Pharma 92
Isosorbide Mononitrate Approved Pharma 0
Metoclopramide Approved, Investigational Pharma Dopamine receptor antagonist 161
Primaquine Approved Pharma 102
Rasburicase Approved, Investigational Pharma 31

(1) Additional Compounds for CYB5R4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen Ion
  • H+
  • H(+)
  • Hydron
  • Hydrogen cation
  • Proton
genes like me logo Genes that share compounds with CYB5R4: view

Transcripts for CYB5R4 Gene

mRNA/cDNA for CYB5R4 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYB5R4

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5R4 Gene

No ASD Table

Relevant External Links for CYB5R4 Gene

GeneLoc Exon Structure for
CYB5R4

Expression for CYB5R4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYB5R4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYB5R4 Gene

This gene is overexpressed in Whole Blood (x11.4).

Protein differential expression in normal tissues from HIPED for CYB5R4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.8), Platelet (10.4), Tlymphocyte (9.5), Lymph node (9.3), and Monocytes (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYB5R4 Gene



Protein tissue co-expression partners for CYB5R4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYB5R4

SOURCE GeneReport for Unigene cluster for CYB5R4 Gene:

Hs.5741

mRNA Expression by UniProt/SwissProt for CYB5R4 Gene:

Q7L1T6-NB5R4_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for CYB5R4 Gene

  • Pancreas(2.1)
  • Liver(2.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CYB5R4: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYB5R4 Gene

Orthologs for CYB5R4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CYB5R4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CYB5R4 29 30
  • 99.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CYB5R4 29 30
  • 91.97 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CYB5R4 29 30
  • 90.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cyb5r4 29
  • 85.71 (n)
Mouse
(Mus musculus)
Mammalia Cyb5r4 29 16 30
  • 84.42 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CYB5R4 30
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CYB5R4 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CYB5R4 29 30
  • 70.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CYB5R4 30
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cyb5r4 29
  • 65.22 (n)
Zebrafish
(Danio rerio)
Actinopterygii cyb5r4 29 30
  • 56.9 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG11257 29 30
  • 44.98 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011314 29
  • 44.07 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_Y52B11A.3 29
  • 46.21 (n)
Y52B11A.3 30
  • 30 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBR1 30
  • 27 (a)
ManyToMany
AIM33 30
  • 21 (a)
ManyToMany
PGA3 30
  • 21 (a)
ManyToMany
IRC21 32
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 35 (a)
OneToOne
Species where no ortholog for CYB5R4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CYB5R4 Gene

ENSEMBL:
Gene Tree for CYB5R4 (if available)
TreeFam:
Gene Tree for CYB5R4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYB5R4: view image
Alliance of Genome Resources:
Additional Orthologs for CYB5R4

Paralogs for CYB5R4 Gene

Paralogs for CYB5R4 Gene

(3) SIMAP similar genes for CYB5R4 Gene using alignment to 1 proteins:

  • NB5R4_HUMAN
genes like me logo Genes that share paralogs with CYB5R4: view

Variants for CYB5R4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYB5R4 Gene

NB5R4_HUMAN-Q7L1T6
Variants Arg-187 and Arg-223 do not influence the pathogenesis of non-autoimmune diabetes.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYB5R4 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs61382555 Benign: not provided 83,924,577(+) C/Gp.Pro267Ala
NM_016230.4(CYB5R4):c.799C>G (p.Pro267Ala)
MISSENSE
VAR_036240 A breast cancer sample p.Asp371Tyr
VAR_036241 A breast cancer sample p.Leu390Met
rs10080628 -- p.Ser282Prop.Pro316Ser
rs141290525 -- p.His223Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CYB5R4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CYB5R4 Gene

Variant ID Type Subtype PubMed ID
esv2669183 CNV deletion 23128226
esv3609786 CNV loss 21293372
nsv1025798 CNV gain 25217958
nsv1068710 OTHER inversion 25765185
nsv1153488 OTHER inversion 26484159
nsv830718 CNV gain+loss 17160897
nsv830719 CNV gain 17160897

Variation tolerance for CYB5R4 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYB5R4 Gene

Human Gene Mutation Database (HGMD)
CYB5R4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYB5R4
Leiden Open Variation Database (LOVD)
CYB5R4

SNP Genotyping and Copy Number Assays for research

Disorders for CYB5R4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CYB5R4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
methemoglobin reductase deficiency
  • nadph-dependent methemoglobin reductase deficiency
maturity-onset diabetes of the young
  • mody
hemoglobinopathy
  • hemoglobinopathies
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CYB5R4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CYB5R4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYB5R4 Gene

Publications for CYB5R4 Gene

  1. Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. (PMID: 10611283) Zhu H … Bunn HF (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22
  2. Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus. (PMID: 15504981) Andersen G … Pedersen O (Diabetes 2004) 3 4 40
  3. NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum. (PMID: 15131110) Zhu H … Bunn HF (The Journal of biological chemistry 2004) 3 4 22
  4. Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain. (PMID: 20630863) Deng B … Zhu H (The Journal of biological chemistry 2010) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40

Products for CYB5R4 Gene

Sources for CYB5R4 Gene