This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosy... See more...

Aliases for CYB5R3 Gene

Aliases for CYB5R3 Gene

  • Cytochrome B5 Reductase 3 2 3 5
  • NADH-Cytochrome B5 Reductase 3 2 3 4
  • Diaphorase-1 3 4
  • EC 1.6.2.2 4 52
  • DIA1 3 4
  • B5R 3 4
  • NADH-Cytochrome B5 Reductase 3 Membrane-Bound Form 3
  • Diaphorase (NADH) (Cytochrome B-5 Reductase) 2
  • NADH-Cytochrome B5 Reductase 3 Soluble Form 3
  • Mutant NADH-Cytochrome B5 Reductase 3
  • Cytochrome B5 Reductase 4

External Ids for CYB5R3 Gene

Previous HGNC Symbols for CYB5R3 Gene

  • DIA1

Previous GeneCards Identifiers for CYB5R3 Gene

  • GC22M041340
  • GC22M043014
  • GC22M025974

Summaries for CYB5R3 Gene

Entrez Gene Summary for CYB5R3 Gene

  • This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]

GeneCards Summary for CYB5R3 Gene

CYB5R3 (Cytochrome B5 Reductase 3) is a Protein Coding gene. Diseases associated with CYB5R3 include Methemoglobinemia Due To Deficiency Of Methemoglobin Reductase and Congenital Methemoglobinemia. Among its related pathways are Innate Immune System and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NAD binding. An important paralog of this gene is CYB5R1.

UniProtKB/Swiss-Prot Summary for CYB5R3 Gene

  • Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.

Gene Wiki entry for CYB5R3 Gene

Additional gene information for CYB5R3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYB5R3 Gene

Genomics for CYB5R3 Gene

GeneHancer (GH) Regulatory Elements for CYB5R3 Gene

Promoters and enhancers for CYB5R3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CYB5R3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYB5R3

Top Transcription factor binding sites by QIAGEN in the CYB5R3 gene promoter:
  • GR
  • Sp1
  • SRF
  • SRF (504 AA)

Genomic Locations for CYB5R3 Gene

Genomic Locations for CYB5R3 Gene
chr22:42,617,840-42,649,399
(GRCh38/hg38)
Size:
31,560 bases
Orientation:
Minus strand
chr22:43,013,846-43,045,574
(GRCh37/hg19)
Size:
31,729 bases
Orientation:
Minus strand

Genomic View for CYB5R3 Gene

Genes around CYB5R3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB5R3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB5R3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5R3 Gene

Proteins for CYB5R3 Gene

  • Protein details for CYB5R3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00387-NB5R3_HUMAN
    Recommended name:
    NADH-cytochrome b5 reductase 3
    Protein Accession:
    P00387
    Secondary Accessions:
    • B1AHF2
    • B7Z7L3
    • O75675
    • Q8TDL8
    • Q8WTS8
    • Q9UEN4
    • Q9UEN5
    • Q9UL55
    • Q9UL56

    Protein attributes for CYB5R3 Gene

    Size:
    301 amino acids
    Molecular mass:
    34235 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2.

    Three dimensional structures from OCA and Proteopedia for CYB5R3 Gene

    Alternative splice isoforms for CYB5R3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB5R3 Gene

Selected DME Specific Peptides for CYB5R3 Gene

P00387:
  • LMCGPPPMIQ
  • YLSARIDG
  • PDIKYPLRLID
  • GQHIYLS
  • HILGLPVG
  • SHDTRRF
  • DTRRFRFALPSPQHILGLP
  • GMIAGGTG
  • LLFANQTE
  • LWYTLDR
  • MIAGGTGITPM
  • AGGTGITPMLQ
  • YTPISSD
  • EFRGPSGLL
  • IGDTIEFRGP
  • GGKMSQYL

Post-translational modifications for CYB5R3 Gene

  • Ubiquitination at Lys42, Lys120, Lys126, Lys173, Lys214, and Lys234
  • Modification sites at PhosphoSitePlus

Domains & Families for CYB5R3 Gene

Gene Families for CYB5R3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYB5R3 Gene

Blocks:
  • Oxidoreductase FAD/NAD(P)-binding
  • Flavoprotein pyridine nucleotide cytochrome reductase signature
  • Cytochrome B5 reductase signature
  • Oxidoreductase FAD-binding region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYB5R3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56301, highly similar to NADH-cytochrome b5 reductase (EC 1.6.2.2) (B7Z7L3_HUMAN)
  • Diaphorase-1 (NB5R3_HUMAN)
  • B5R-1S peptide (Q9H325_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P00387

UniProtKB/Swiss-Prot:

NB5R3_HUMAN :
  • Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Family:
  • Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
genes like me logo Genes that share domains with CYB5R3: view

Function for CYB5R3 Gene

Molecular function for CYB5R3 Gene

UniProtKB/Swiss-Prot Function:
Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 [Fe(III)-cytochrome b5] + NADH = 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+); Xref=Rhea:RHEA:46680, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.2.2;.

Enzyme Numbers (IUBMB) for CYB5R3 Gene

Phenotypes From GWAS Catalog for CYB5R3 Gene

Gene Ontology (GO) - Molecular Function for CYB5R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H IEA --
GO:0005515 protein binding IPI 23123858
GO:0016208 AMP binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0043531 ADP binding IEA --
genes like me logo Genes that share ontologies with CYB5R3: view
genes like me logo Genes that share phenotypes with CYB5R3: view

Human Phenotype Ontology for CYB5R3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYB5R3

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CYB5R3 Gene

Localization for CYB5R3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB5R3 Gene

[Isoform 1]: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side.
[Isoform 2]: Cytoplasm. Note=Produces the soluble form found in erythrocytes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYB5R3 gene
Compartment Confidence
extracellular 5
mitochondrion 5
endoplasmic reticulum 5
cytosol 4
lysosome 4
plasma membrane 2
cytoskeleton 1
peroxisome 1
nucleus 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYB5R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm TAS 9207238
GO:0005739 mitochondrion HDA,IEA 20833797
GO:0005741 mitochondrial outer membrane TAS --
GO:0005783 endoplasmic reticulum IEA,IDA --
genes like me logo Genes that share ontologies with CYB5R3: view

Pathways & Interactions for CYB5R3 Gene

genes like me logo Genes that share pathways with CYB5R3: view

Pathways by source for CYB5R3 Gene

1 BioSystems pathway for CYB5R3 Gene
1 PharmGKB pathway for CYB5R3 Gene
1 KEGG pathway for CYB5R3 Gene
1 GeneGo (Thomson Reuters) pathway for CYB5R3 Gene
  • NAD metabolism
1 Qiagen pathway for CYB5R3 Gene
  • Antioxidant Action of Vitamin-C

Gene Ontology (GO) - Biological Process for CYB5R3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006694 steroid biosynthetic process IEA --
GO:0006695 cholesterol biosynthetic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008015 blood circulation TAS 1400360
genes like me logo Genes that share ontologies with CYB5R3: view

No data available for SIGNOR curated interactions for CYB5R3 Gene

Drugs & Compounds for CYB5R3 Gene

(40) Drugs for CYB5R3 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
FAD Approved Pharma Target 0
Dapsone Approved, Investigational Pharma 69
Copper Approved, Investigational Pharma Target 236
Ceftriaxone Approved Pharma 162

(23) Additional Compounds for CYB5R3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ferrocytochrome
  • 553-12-8 (FREE acid)
  • Ferrocytochrome b-561
  • H2PpIX
  • HEM
  • Kammerer'S porphyrin
1818-68-4
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with CYB5R3: view

Transcripts for CYB5R3 Gene

mRNA/cDNA for CYB5R3 Gene

5 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CYB5R3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5R3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for CYB5R3 Gene

GeneLoc Exon Structure for
CYB5R3

Expression for CYB5R3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYB5R3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYB5R3 Gene



Protein tissue co-expression partners for CYB5R3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYB5R3

SOURCE GeneReport for Unigene cluster for CYB5R3 Gene:

Hs.561064

mRNA Expression by UniProt/SwissProt for CYB5R3 Gene:

P00387-NB5R3_HUMAN
Tissue specificity: Isoform 2 is expressed at late stages of erythroid maturation.

Evidence on tissue expression from TISSUES for CYB5R3 Gene

  • Liver(4.8)
  • Nervous system(4.6)
  • Blood(4.5)
  • Skin(3.3)
  • Intestine(3.2)
  • Lung(2.5)
  • Heart(2.2)
  • Muscle(2.2)
  • Gall bladder(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CYB5R3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
  • meninges
  • neck
  • skull
Thorax:
  • bronchus
  • lung
  • trachea
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with CYB5R3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for CYB5R3 Gene

Orthologs for CYB5R3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB5R3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB5R3 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYB5R3 31
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYB5R3 31
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyb5r3 31
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYB5R3 31
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYB5R3 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYB5R3 31
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYB5R3 31
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cyb5r3 31
  • 72 (a)
OneToOne
-- 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1357 30
fruit fly
(Drosophila melanogaster)
Insecta CG5946 31
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T05H4.4 31
  • 54 (a)
ManyToMany
hpo-19 31
  • 52 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBR1 31
  • 33 (a)
ManyToMany
PGA3 31
  • 29 (a)
ManyToMany
AIM33 31
  • 28 (a)
ManyToMany
corn
(Zea mays)
Liliopsida Zm.4080 30
rice
(Oryza sativa)
Liliopsida Os.4717 30
sea squirt
(Ciona savignyi)
Ascidiacea Cin.4536 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4536 30
Species where no ortholog for CYB5R3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CYB5R3 Gene

ENSEMBL:
Gene Tree for CYB5R3 (if available)
TreeFam:
Gene Tree for CYB5R3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CYB5R3: view image

Paralogs for CYB5R3 Gene

Paralogs for CYB5R3 Gene

(4) SIMAP similar genes for CYB5R3 Gene using alignment to 2 proteins:

  • NB5R3_HUMAN
  • B1AHF3_HUMAN
genes like me logo Genes that share paralogs with CYB5R3: view

Variants for CYB5R3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYB5R3 Gene

NB5R3_HUMAN-P00387
Ser-117 seems to only be found in persons of African origin. The allele frequency is 0.23 in African Americans. It was not found in Caucasians, Asians, Indo-Aryans, or Arabs. There seems to be no effect on the enzyme activity.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CYB5R3 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
694657 Conflicting Interpretations: Neurodevelopmental delay; not specified; not provided 42,619,789(-) C/T MISSENSE_VARIANT
708160 Likely Benign: not provided 42,619,953(-) G/A INTRON_VARIANT
708905 Likely Benign: not provided 42,636,748(-) G/A SYNONYMOUS_VARIANT
709007 Likely Benign: not provided 42,627,598(-) C/T INTRON_VARIANT
709324 Likely Benign: not provided 42,627,373(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CYB5R3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CYB5R3 Gene

Variant ID Type Subtype PubMed ID
dgv260n21 CNV loss 19592680
esv2438931 CNV deletion 19546169
esv2758839 CNV gain+loss 17122850
nsv1127922 CNV deletion 24896259
nsv428391 CNV gain 18775914
nsv524028 CNV loss 19592680

Variation tolerance for CYB5R3 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYB5R3 Gene

Human Gene Mutation Database (HGMD)
CYB5R3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYB5R3

Disorders for CYB5R3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CYB5R3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
methemoglobinemia due to deficiency of methemoglobin reductase
  • nadh-dependent methemoglobin reductase deficiency
congenital methemoglobinemia
  • hereditary methemoglobinemia
dihydrolipoamide dehydrogenase deficiency
  • dldd
methemoglobinemia
monkeypox
  • monkeypox virus infection
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NB5R3_HUMAN
  • Methemoglobinemia CYB5R3-related (METHB-CYB5R3) [MIM:250800]: A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia. There are two types of methemoglobinemia CYB5R3-related. In type 1, the defect affects the soluble form of the enzyme, is restricted to red blood cells, and causes well-tolerated methemoglobinemia. In type 2, the defect affects both the soluble and microsomal forms of the enzyme and is thus generalized, affecting red cells, leukocytes and all body tissues. Type 2 methemoglobinemia is associated with mental deficiency and other neurologic symptoms. {ECO:0000269 PubMed:10807796, ECO:0000269 PubMed:12393396, ECO:0000269 PubMed:1400360, ECO:0000269 PubMed:15622768, ECO:0000269 PubMed:15953014, ECO:0000269 PubMed:1707593, ECO:0000269 PubMed:1898726, ECO:0000269 PubMed:7718898, ECO:0000269 PubMed:8119939, ECO:0000269 PubMed:9695975, ECO:0000269 PubMed:9886302}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CYB5R3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CYB5R3: view

No data available for Genatlas for CYB5R3 Gene

Publications for CYB5R3 Gene

  1. Structure of human erythrocyte NADH-cytochrome b5 reductase. (PMID: 15502298) Bando S … Nakagawa A (Acta crystallographica. Section D, Biological crystallography 2004) 3 4 23 54
  2. A novel mutation in the NADH-cytochrome b5 reductase gene of a Chinese patient with recessive congenital methemoglobinemia. (PMID: 10807796) Wang Y … Zhu ZY (Blood 2000) 3 4 23 54
  3. Molecular basis of hereditary methaemoglobinaemia, types I and II: two novel mutations in the NADH-cytochrome b5 reductase gene. (PMID: 9886302) Higasa K … Fukumaki Y (British journal of haematology 1998) 3 4 23 54
  4. Identification of a novel point mutation (Leu72Pro) in the NADH-cytochrome b5 reductase gene of a patient with hereditary methaemoglobinaemia type I. (PMID: 9695975) Wu YS … Zhu ZY (British journal of haematology 1998) 3 4 23 54
  5. An erythroid-specific transcript generates the soluble form of NADH-cytochrome b5 reductase in humans. (PMID: 9639531) Bulbarelli A … Borgese N (Blood 1998) 3 4 23 54

Products for CYB5R3 Gene

  • Signalway ELISA kits for CYB5R3
  • Signalway Proteins for CYB5R3

Sources for CYB5R3 Gene