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Aliases for CYB5B Gene

Aliases for CYB5B Gene

  • Cytochrome B5 Type B 2 3 5
  • Cytochrome B5 Type B (Outer Mitochondrial Membrane) 2 3
  • Cytochrome B5 Outer Mitochondrial Membrane Isoform 3 4
  • OMB5 3 4
  • Outer Mitochondrial Membrane Cytochrome B5 3
  • Type 2 Cyt-B5 3
  • CYB5-M 3
  • CYPB5M 3
  • CYB5M 4

External Ids for CYB5B Gene

Previous GeneCards Identifiers for CYB5B Gene

  • GC16P068017
  • GC16P069458
  • GC16P055336

Summaries for CYB5B Gene

GeneCards Summary for CYB5B Gene

CYB5B (Cytochrome B5 Type B) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include heme binding and enzyme activator activity. An important paralog of this gene is CYB5A.

UniProtKB/Swiss-Prot for CYB5B Gene

  • Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

Additional gene information for CYB5B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB5B Gene

Genomics for CYB5B Gene

GeneHancer (GH) Regulatory Elements for CYB5B Gene

Promoters and enhancers for CYB5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I069422 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 556.6 +0.1 135 3.3 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CYB5B GC16M069459 GC16M069467 DDX19B PDPR NFAT5 NONOP1 CHTF8 ZFP90 LOC400541
GH16I069479 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 15.5 +56.8 56800 4 HDAC1 ZNF133 KLF17 FEZF1 BATF RAD21 ZNF335 TCF12 KLF7 FOS NFAT5 CYB5B FUK NPIPB14P PDXDC2P-NPIPB14P LOC400541 MIR1538 PDXDC2P EXOSC6 PDPR
GH16I069393 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -27.2 -27182 7.4 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 UTP4 CYB5B NIP7 MIR1538 NFAT5 NQO1 TERF2 GC16M069470
GH16I069476 Enhancer 1.2 Ensembl ENCODE dbSUPER 15.8 +52.7 52742 2.3 HDAC1 FOXA2 FEZF1 BRCA1 RFX5 TCF12 ZNF766 RCOR1 FOS ATF7 UTP4 CYB5B MIR1538 NFAT5 WWP2 ENSG00000252443 SNTB2 TMED6 GC16P069486 ENSG00000260108
GH16I069528 Enhancer 1.6 FANTOM5 Ensembl ENCODE 11.3 +106.7 106682 4.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A IRF4 POLR2B ZNF766 ZNF213 NFAT5 NPIPB14P MIR1538 NONOP1 SNTB2 CHTF8 CYB5B NIP7 SF3B3 DDX19B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYB5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYB5B gene promoter:

Genomic Locations for CYB5B Gene

Genomic Locations for CYB5B Gene
41,742 bases
Plus strand

Genomic View for CYB5B Gene

Genes around CYB5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB5B Gene

Proteins for CYB5B Gene

  • Protein details for CYB5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome b5 type B
    Protein Accession:
    Secondary Accessions:
    • A8K6B1
    • Q96CC3
    • Q9BT35

    Protein attributes for CYB5B Gene

    146 amino acids
    Molecular mass:
    16332 Da
    Quaternary structure:
    • Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2.

    Three dimensional structures from OCA and Proteopedia for CYB5B Gene

neXtProt entry for CYB5B Gene

Post-translational modifications for CYB5B Gene

  • Ubiquitination at posLast=8888
  • Modification sites at PhosphoSitePlus

Other Protein References for CYB5B Gene

No data available for DME Specific Peptides for CYB5B Gene

Domains & Families for CYB5B Gene

Gene Families for CYB5B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CYB5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome b5 family.
  • Belongs to the cytochrome b5 family.
genes like me logo Genes that share domains with CYB5B: view

Function for CYB5B Gene

Molecular function for CYB5B Gene

UniProtKB/Swiss-Prot Function:
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.

Phenotypes From GWAS Catalog for CYB5B Gene

Gene Ontology (GO) - Molecular Function for CYB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25616068
GO:0008047 enzyme activator activity IEA --
GO:0020037 heme binding IEA,IDA 20861021
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB5B: view
genes like me logo Genes that share phenotypes with CYB5B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYB5B Gene

Localization for CYB5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB5B Gene

Mitochondrion outer membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYB5B gene
Compartment Confidence
mitochondrion 5
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 1
peroxisome 1
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CYB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane TAS,IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYB5B: view

Pathways & Interactions for CYB5B Gene

genes like me logo Genes that share pathways with CYB5B: view

Pathways by source for CYB5B Gene

1 BioSystems pathway for CYB5B Gene

Gene Ontology (GO) - Biological Process for CYB5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYB5B: view

No data available for SIGNOR curated interactions for CYB5B Gene

Drugs & Compounds for CYB5B Gene

(3) Drugs for CYB5B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra 0
Phenethyl isothiocyanate Investigational Pharma Target 12
heme Pharma Agonist 0
genes like me logo Genes that share compounds with CYB5B: view

Transcripts for CYB5B Gene

Unigene Clusters for CYB5B Gene

Cytochrome b5 type B (outer mitochondrial membrane):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYB5B Gene

No ASD Table

Relevant External Links for CYB5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYB5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYB5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYB5B Gene

This gene is overexpressed in Adrenal Gland (x6.5).

Protein differential expression in normal tissues from HIPED for CYB5B Gene

This gene is overexpressed in Nasal epithelium (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYB5B Gene

Protein tissue co-expression partners for CYB5B Gene

NURSA nuclear receptor signaling pathways regulating expression of CYB5B Gene:


SOURCE GeneReport for Unigene cluster for CYB5B Gene:


Evidence on tissue expression from TISSUES for CYB5B Gene

  • Liver(4.3)
  • Pancreas(4.2)
  • Nervous system(4.2)
  • Intestine(2.6)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with CYB5B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYB5B Gene

Orthologs for CYB5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYB5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYB5B 33 34
  • 99.56 (n)
(Bos Taurus)
Mammalia CYB5B 33 34
  • 84.02 (n)
(Rattus norvegicus)
Mammalia Cyb5b 33
  • 82.42 (n)
(Mus musculus)
Mammalia Cyb5b 33 16 34
  • 80.82 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
-- 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia CYB5B 34
  • 60 (a)
(Canis familiaris)
Mammalia -- 34
  • 47 (a)
(Gallus gallus)
Aves CYB5B 33 34
  • 71.82 (n)
(Anolis carolinensis)
Reptilia CYB5B 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyb5b 33
  • 62.08 (n)
(Danio rerio)
Actinopterygii cyb5b 33 34
  • 57.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3566 34
  • 45 (a)
CG5157 34
  • 40 (a)
Cyt-b5 34
  • 40 (a)
CG6870 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea cytb-5.2 33 34
  • 54.87 (n)
cytb-5.1 34
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL223W 33
  • 50.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYB5 33 34 36
  • 49.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23672g 33
  • 48.54 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CB5-D 33
  • 51.28 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03910 33
  • 56.81 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes oca8 33
  • 51.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7428 34
  • 51 (a)
Species where no ortholog for CYB5B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYB5B Gene

Gene Tree for CYB5B (if available)
Gene Tree for CYB5B (if available)

Paralogs for CYB5B Gene

Paralogs for CYB5B Gene

(5) SIMAP similar genes for CYB5B Gene using alignment to 5 proteins: Pseudogenes for CYB5B Gene

genes like me logo Genes that share paralogs with CYB5B: view

Variants for CYB5B Gene

Sequence variations from dbSNP and Humsavar for CYB5B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000103820 -- 69,465,038(+) C/T 3_prime_UTR_variant
rs1000175284 -- 69,454,924(+) C/T intron_variant
rs1000204390 -- 69,440,904(+) C/G intron_variant
rs1000251785 -- 69,427,873(+) G/A intron_variant
rs1000276251 -- 69,422,636(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CYB5B Gene

Variant ID Type Subtype PubMed ID
nsv476678 CNV novel sequence insertion 20440878
nsv509629 CNV insertion 20534489

Variation tolerance for CYB5B Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYB5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYB5B Gene

Disorders for CYB5B Gene

Additional Disease Information for CYB5B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CYB5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB5B Gene

Publications for CYB5B Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Mammalian mitochondrial and microsomal cytochromes b(5) exhibit divergent structural and biophysical characteristics. (PMID: 14733950) Altuve A … Rivera M (Biochemical and biophysical research communications 2004) 2 3 58
  5. Assessment of the ability of type 2 cytochrome b5 to modulate 17,20-lyase activity of human P450c17. (PMID: 11867265) Soucy P … Luu-The V (The Journal of steroid biochemistry and molecular biology 2002) 2 3 58

Products for CYB5B Gene

Sources for CYB5B Gene

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