Aliases for CYB561D1 Gene
Aliases for CYB561D1 Gene
External Ids for CYB561D1 Gene
- HGNC: 26804
- Entrez Gene: 284613
- Ensembl: ENSG00000174151
- UniProtKB: Q8N8Q1
Previous GeneCards Identifiers for CYB561D1 Gene
- GC01P109336
- GC01P109749
- GC01P110036
- GC01P107929
Summaries for CYB561D1 Gene
GeneCards Summary for CYB561D1 Gene
CYB561D1 (Cytochrome B561 Family Member D1) is a Protein Coding gene. An important paralog of this gene is CYB561D2.
Additional gene information for CYB561D1 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561D1 Gene
Genomics for CYB561D1 Gene
GeneHancer (GH) Regulatory Elements for CYB561D1 Gene
Promoters and enhancers for CYB561D1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CYB561D1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CYB561D1 gene promoter:
Regulatory Element Products
Genomic Locations for CYB561D1 Gene
Genomic Locations for CYB561D1 Gene
- chr1:109,494,036-109,502,932
- (GRCh38/hg38)
- Size:
- 8,897 bases
- Orientation:
- Plus strand
- chr1:110,036,658-110,045,554
- (GRCh37/hg19)
Genomic View for CYB561D1 Gene
Genes around CYB561D1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by Ensembl
- 1p13.3 by Entrez Gene
- 1p13.3 by HGNC
CYB561D1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYB561D1 Gene
Proteins for CYB561D1 Gene
-
Protein details for CYB561D1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N8Q1-C56D1_HUMAN
- Recommended name:
- Cytochrome b561 domain-containing protein 1
- Protein Accession:
- Q8N8Q1
- B4DH97
- E9PCM8
- Q52M36
- Q5T6C2
- Q5T6C3
Protein attributes for CYB561D1 Gene
- Size:
- 229 amino acids
- Molecular mass:
- 25424 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYB561D1 Gene
Post-translational modifications for CYB561D1 Gene
Other Protein References for CYB561D1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CYB561D1
- Novus Biologicals Antibodies for CYB561D1
- Invitrogen Antibodies for CYB561D1
- Search GeneTex for Antibodies for CYB561D1
Protein Products
-
OriGene Purified Proteins for CYB561D1
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- Search GeneTex for Proteins for CYB561D1
Assay Products
No data available for DME Specific Peptides for CYB561D1 Gene
Domains & Families for CYB561D1 Gene
Gene Families for CYB561D1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CYB561D1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYB561D1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CYB561D1 Gene
Function for CYB561D1 Gene
Phenotypes From GWAS Catalog for CYB561D1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CYB561D1 Gene
- GenomeRNAi human phenotypes for CYB561D1:
Animal Model Products
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-
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CRISPR Products
-
OriGene CRISPR knockouts for CYB561D1
- genomics-online: gRNA clones - Search results for 109 available CYB561D1 gene related products
- Overview of 109 available CYB561D1 gene related products
- Applied Biological Materials CRISPR for CYB561D1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYB561D1
- GenScript: Design CRISPR guide RNA sequences for CYB561D1
miRNA for CYB561D1 Gene
- miRTarBase miRNAs that target CYB561D1
-
- hsa-mir-23b-3p (MIRT046314)
- hsa-mir-106a-5p (MIRT048320)
- hsa-mir-519e-5p (MIRT712532)
- hsa-mir-515-5p (MIRT712533)
- hsa-mir-103a-2-5p (MIRT712534)
- hsa-mir-4290 (MIRT712535)
- hsa-mir-1976 (MIRT712536)
- hsa-mir-5695 (MIRT712537)
- hsa-mir-519d-5p (MIRT712538)
- hsa-mir-6893-3p (MIRT712539)
- hsa-mir-370-3p (MIRT712540)
- hsa-mir-660-3p (MIRT712541)
- hsa-mir-4667-3p (MIRT712542)
- hsa-mir-365b-3p (MIRT712543)
- hsa-mir-365a-3p (MIRT712544)
miRNA Products
- Search ViGene Biosciences for CYB561D1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYB561D1
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- genomics-online: shRNA clones - Search results for 109 available CYB561D1 gene related products
- Overview of 109 available CYB561D1 gene related products
Clone Products
-
OriGene ORF clones in human for CYB561D1
- RC225323L1V
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- RC225080L2V
- RC210795L1V
- RC210795L2V
- RC225323
- RC225323L1
- RC225323L2
- RG225323
- RC225175
- RC225175L1
- RC225175L2
- RG225175
- RC225099
- RC225099L1
- RC225099L2
- RG225099
- RC225080
- RC225080L1
- RC225080L2
- RG225080
- RC210795
- RC210795L1
- RC210795L2
- RG210795
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYB561D1
- VectorBuilder custom plasmid, inducible vectors for CYB561D1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYB561D1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CYB561D1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CYB561D1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYB561D1 Gene
Localization for CYB561D1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYB561D1 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYB561D1 Gene
Pathways & Interactions for CYB561D1 Gene
No Data Available
Interacting Proteins for CYB561D1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CYB561D1 Gene
Drugs & Compounds for CYB561D1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| heme | Pharma | Agonist | 0 |
Transcripts for CYB561D1 Gene
mRNA/cDNA for CYB561D1 Gene
- (12) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (67) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYB561D1 Gene
- Cytochrome b561 family, member D1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CYB561D1
- genomics-online: gRNA clones - Search results for 109 available CYB561D1 gene related products
- Overview of 109 available CYB561D1 gene related products
- Applied Biological Materials CRISPR for CYB561D1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYB561D1
- GenScript: Design CRISPR guide RNA sequences for CYB561D1
miRNA Products
- Search ViGene Biosciences for CYB561D1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYB561D1
- Browse OriGene Inhibitory RNA Products For CYB561D1
- genomics-online: shRNA clones - Search results for 109 available CYB561D1 gene related products
- Overview of 109 available CYB561D1 gene related products
Clone Products
-
OriGene ORF clones in human for CYB561D1
- RC225323L1V
- RC225323L2V
- RC225175L1V
- RC225175L2V
- RC225099L1V
- RC225099L2V
- RC225080L1V
- RC225080L2V
- RC210795L1V
- RC210795L2V
- RC225323
- RC225323L1
- RC225323L2
- RG225323
- RC225175
- RC225175L1
- RC225175L2
- RG225175
- RC225099
- RC225099L1
- RC225099L2
- RG225099
- RC225080
- RC225080L1
- RC225080L2
- RG225080
- RC210795
- RC210795L1
- RC210795L2
- RG210795
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYB561D1
- VectorBuilder custom plasmid, inducible vectors for CYB561D1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYB561D1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CYB561D1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - | - | - | - |
Expression for CYB561D1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYB561D1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CYB561D1 Gene:
CYB561D1SOURCE GeneReport for Unigene cluster for CYB561D1 Gene:
Hs.514682Evidence on tissue expression from TISSUES for CYB561D1 Gene
- Nervous system(4.3)
- Liver(4)
Primer Products
-
OriGene qPCR primer pairs for CYB561D1
- genomics-online: primer clones - Search results for 109 available CYB561D1 gene related products
- Overview of 109 available CYB561D1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYB561D1 Gene
Orthologs for CYB561D1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CYB561D1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CYB561D1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CYB561D1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cyb561d1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cyb561d1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CYB561D1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CYB561D1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101734093 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cyb561d1 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3475 34 |
|
OneToMany |
- Species where no ortholog for CYB561D1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CYB561D1 Gene
Paralogs for CYB561D1 Gene
(1) SIMAP similar genes for CYB561D1 Gene using alignment to 5 proteins:
Variants for CYB561D1 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000348149 | -- | 109,497,244(+) | T/G | 3_prime_UTR_variant | |
| rs1000721964 | -- | 109,492,488(+) | A/G | upstream_transcript_variant | |
| rs1000753328 | -- | 109,492,151(+) | T/C | upstream_transcript_variant | |
| rs1000924584 | -- | 109,497,953(+) | G/A | 3_prime_UTR_variant | |
| rs1000950288 | -- | 109,498,480(+) | C/A | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.40;
27.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYB561D1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CYB561D1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYB561D1 Gene
Disorders for CYB561D1 Gene
Additional Disease Information for CYB561D1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CYB561D1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB561D1 Gene
Publications for CYB561D1 Gene
- Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H … Bérczi A (Antioxidants & redox signaling 2013) 2 3 58
- Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J … Levinson DF (Molecular psychiatry 2011) 3 44 58
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for CYB561D1 Gene
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- RC225323L1V
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYB561D1
- VectorBuilder custom plasmid, inducible vectors for CYB561D1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYB561D1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for CYB561D1
- Search GeneTex for Proteins for CYB561D1
- Search ViGene Biosciences for CYB561D1
- Horizon Cell Lines for CYB561D1
- genomics-online: cdna clones - Search results for 109 available CYB561D1 gene related products
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- Overview of 109 available CYB561D1 gene related products
- genomics-online: gRNA clones - Search results for 109 available CYB561D1 gene related products
- Overview of 109 available CYB561D1 gene related products
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- Overview of 109 available CYB561D1 gene related products
- genomics-online: shRNA clones - Search results for 109 available CYB561D1 gene related products
- Overview of 109 available CYB561D1 gene related products
Sources for CYB561D1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
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