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Aliases for CYB561D1 Gene

Aliases for CYB561D1 Gene

  • Cytochrome B561 Family Member D1 2 3 5
  • Cytochrome B-561 Domain Containing 1 2
  • Cytochrome B561 Family, Member D1 2

External Ids for CYB561D1 Gene

Previous GeneCards Identifiers for CYB561D1 Gene

  • GC01P109336
  • GC01P109749
  • GC01P110036
  • GC01P107929

Summaries for CYB561D1 Gene

GeneCards Summary for CYB561D1 Gene

CYB561D1 (Cytochrome B561 Family Member D1) is a Protein Coding gene. An important paralog of this gene is CYB561D2.

Additional gene information for CYB561D1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYB561D1 Gene

Genomics for CYB561D1 Gene

GeneHancer (GH) Regulatory Elements for CYB561D1 Gene

Promoters and enhancers for CYB561D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I109493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.1 -57 1.6 PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 E2F8 ZNF207 CYB561D1 ENSG00000258634 PRPF38B RPL17P7 SYPL2 STRIP1 RPS27P6 ENSG00000273373 RBM15 ATXN7L2
GH01I109725 Enhancer 1.1 ENCODE dbSUPER 9.2 +232.0 231972 1.6 CLOCK ARNT TCF12 CBX5 GATA2 FOS ATF7 NCOA1 ZNF184 SMARCA4 ENSG00000241720 GSTM3 GSTM5 EPS8L3 ENSG00000228703 AMPD2 AHCYL1 GPR61 ENSG00000225113 AMIGO1
GH01I109718 Enhancer 1.1 ENCODE dbSUPER 8.8 +225.2 225226 1.3 PKNOX1 ATF1 ARNT ZNF766 FOS ATF7 CAVIN1 JUNB REST ZNF592 GSTM5 EPS8L3 AMIGO1 ENSG00000254942 GPR61 CSF1 UBL4B CYB561D1 ENSG00000241720
GH01I109534 Enhancer 0.8 ENCODE dbSUPER 11.5 +41.9 41853 2.5 SMARCA5 USF1 HLF CEBPB ZMYM3 ZNF398 ZNF664 PRDM10 KDM1A AMIGO1 CYB561D1 MIR197 RNU6V SYPL2 GSTM2 GPR61 LOC105378893
GH01I109649 Enhancer 0.7 Ensembl ENCODE 9.3 +155.5 155501 0.9 CTCF ZNF654 POLR2A ZNF10 RAD21 RPL7P8 GPR61 ENSG00000254942 GNAI3 GNAT2 AMPD2 AHCYL1 EPS8L3 GSTM3 MIR197
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CYB561D1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CYB561D1 gene promoter:

Genomic Locations for CYB561D1 Gene

Genomic Locations for CYB561D1 Gene
chr1:109,494,036-109,502,932
(GRCh38/hg38)
Size:
8,897 bases
Orientation:
Plus strand
chr1:110,036,658-110,045,554
(GRCh37/hg19)

Genomic View for CYB561D1 Gene

Genes around CYB561D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYB561D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYB561D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYB561D1 Gene

Proteins for CYB561D1 Gene

  • Protein details for CYB561D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Q1-C56D1_HUMAN
    Recommended name:
    Cytochrome b561 domain-containing protein 1
    Protein Accession:
    Q8N8Q1
    Secondary Accessions:
    • B4DH97
    • E9PCM8
    • Q52M36
    • Q5T6C2
    • Q5T6C3

    Protein attributes for CYB561D1 Gene

    Size:
    229 amino acids
    Molecular mass:
    25424 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYB561D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYB561D1 Gene

Post-translational modifications for CYB561D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYB561D1 Gene

Domains & Families for CYB561D1 Gene

Gene Families for CYB561D1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CYB561D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYB561D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYB561D1: view

No data available for UniProtKB/Swiss-Prot for CYB561D1 Gene

Function for CYB561D1 Gene

Phenotypes From GWAS Catalog for CYB561D1 Gene

Gene Ontology (GO) - Molecular Function for CYB561D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYB561D1: view
genes like me logo Genes that share phenotypes with CYB561D1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYB561D1 Gene

Localization for CYB561D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYB561D1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYB561D1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CYB561D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYB561D1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYB561D1 Gene

Pathways & Interactions for CYB561D1 Gene

SuperPathways for CYB561D1 Gene

No Data Available

Interacting Proteins for CYB561D1 Gene

Gene Ontology (GO) - Biological Process for CYB561D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYB561D1: view

No data available for Pathways by source and SIGNOR curated interactions for CYB561D1 Gene

Drugs & Compounds for CYB561D1 Gene

(1) Drugs for CYB561D1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with CYB561D1: view

Transcripts for CYB561D1 Gene

Unigene Clusters for CYB561D1 Gene

Cytochrome b561 family, member D1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYB561D1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2:
SP3: - - - -

Relevant External Links for CYB561D1 Gene

GeneLoc Exon Structure for
CYB561D1
ECgene alternative splicing isoforms for
CYB561D1

Expression for CYB561D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYB561D1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYB561D1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CYB561D1 Gene:

CYB561D1

SOURCE GeneReport for Unigene cluster for CYB561D1 Gene:

Hs.514682

Evidence on tissue expression from TISSUES for CYB561D1 Gene

  • Nervous system(4.3)
  • Liver(4)
genes like me logo Genes that share expression patterns with CYB561D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYB561D1 Gene

Orthologs for CYB561D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYB561D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYB561D1 33 34
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia CYB561D1 33 34
  • 91.99 (n)
dog
(Canis familiaris)
Mammalia CYB561D1 33 34
  • 90.68 (n)
mouse
(Mus musculus)
Mammalia Cyb561d1 33 16 34
  • 90.25 (n)
rat
(Rattus norvegicus)
Mammalia Cyb561d1 33
  • 90.25 (n)
oppossum
(Monodelphis domestica)
Mammalia CYB561D1 34
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYB561D1 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734093 33
  • 61.16 (n)
zebrafish
(Danio rerio)
Actinopterygii cyb561d1 33 34
  • 56.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3475 34
  • 35 (a)
OneToMany
Species where no ortholog for CYB561D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYB561D1 Gene

ENSEMBL:
Gene Tree for CYB561D1 (if available)
TreeFam:
Gene Tree for CYB561D1 (if available)

Paralogs for CYB561D1 Gene

Paralogs for CYB561D1 Gene

(1) SIMAP similar genes for CYB561D1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CYB561D1: view

Variants for CYB561D1 Gene

Sequence variations from dbSNP and Humsavar for CYB561D1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000348149 -- 109,497,244(+) T/G 3_prime_UTR_variant
rs1000721964 -- 109,492,488(+) A/G upstream_transcript_variant
rs1000753328 -- 109,492,151(+) T/C upstream_transcript_variant
rs1000924584 -- 109,497,953(+) G/A 3_prime_UTR_variant
rs1000950288 -- 109,498,480(+) C/A 3_prime_UTR_variant

Variation tolerance for CYB561D1 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CYB561D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYB561D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYB561D1 Gene

Disorders for CYB561D1 Gene

Additional Disease Information for CYB561D1

No disorders were found for CYB561D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB561D1 Gene

Publications for CYB561D1 Gene

  1. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H … Bérczi A (Antioxidants & redox signaling 2013) 2 3 58
  2. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J … Levinson DF (Molecular psychiatry 2011) 3 44 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for CYB561D1 Gene

Sources for CYB561D1 Gene

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