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Aliases for CYB561D1 Gene
Aliases for CYB561D1 Gene
External Ids for CYB561D1 Gene
- HGNC: 26804
- Entrez Gene: 284613
- Ensembl: ENSG00000174151
- UniProtKB: Q8N8Q1
Previous GeneCards Identifiers for CYB561D1 Gene
- GC01P109336
- GC01P109749
- GC01P110036
- GC01P107929
Summaries for CYB561D1 Gene
GeneCards Summary for CYB561D1 Gene
CYB561D1 (Cytochrome B561 Family Member D1) is a Protein Coding gene. An important paralog of this gene is CYB561D2.
Additional gene information for CYB561D1 Gene
- HGNC(26804)
- Entrez Gene(284613)
- Ensembl(ENSG00000174151)
- UniProtKB(Q8N8Q1)
- Open Targets Platform(ENSG00000174151)
- Search for CYB561D1 at DataMed
- Search for CYB561D1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CYB561D1 Gene
Genomics for CYB561D1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CYB561D1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CYB561D1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CYB561D1
- Top Transcription factor binding sites by QIAGEN in the CYB561D1 gene promoter:
-
- NRSF form 1
- NRSF form 2
Genomic Locations for CYB561D1 Gene
Genomic Locations for CYB561D1 Gene
- chr1:109,493,606-109,502,932
- (GRCh38/hg38)
- Size:
- 9,327 bases
- Orientation:
- Plus strand
- chr1:110,036,658-110,045,554
- (GRCh37/hg19)
- Size:
- 8,897 bases
- Orientation:
- Plus strand
Genomic View for CYB561D1 Gene
Genes around CYB561D1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
CYB561D1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYB561D1 Gene
Proteins for CYB561D1 Gene
-
Protein details for CYB561D1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N8Q1-C56D1_HUMAN
- Recommended name:
- Cytochrome b561 domain-containing protein 1
- Protein Accession:
- Q8N8Q1
- B4DH97
- E9PCM8
- Q52M36
- Q5T6C2
- Q5T6C3
Protein attributes for CYB561D1 Gene
- Size:
- 229 amino acids
- Molecular mass:
- 25424 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYB561D1 Gene
Post-translational modifications for CYB561D1 Gene
Other Protein References for CYB561D1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CYB561D1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CYB561D1
- Novus Biologicals Antibodies for CYB561D1
- Invitrogen Antibodies for CYB561D1 (AFLGC-CYB561D1)
- antibodies-online: Show 13 available CYB561D1 Antibodies ranked by validation data
-
Boster Bio Antibodies for CYB561D1
- Sino Biological Antibodies for CYB561D1
Protein Products
-
OriGene Purified Proteins for CYB561D1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYB561D1
- Origene Custom Protein Services for CYB561D1
No data available for DME Specific Peptides for CYB561D1 Gene
Domains & Families for CYB561D1 Gene
Gene Families for CYB561D1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CYB561D1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYB561D1 Gene
- GenScript: Design optimal peptide antigens:
-
- Cytochrome b561 domain-containing protein 1 (C56D1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CYB561D1 Gene
Function for CYB561D1 Gene
Phenotypes From GWAS Catalog for CYB561D1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016491 | oxidoreductase activity | IBA | 21873635 |
| GO:0020037 | heme binding | IBA | 21873635 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for CYB561D1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYB561D1 - Select products 50% OFF >
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-
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYB561D1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYB561D1
miRNA for CYB561D1 Gene
- miRTarBase miRNAs that target CYB561D1
-
- hsa-miR-23b-3p (MIRT046314)
- hsa-miR-106a-5p (MIRT048320)
- mmu-miR-1306-5p (MIRT601000)
- hsa-miR-519e-5p (MIRT712532)
- hsa-miR-515-5p (MIRT712533)
- hsa-miR-103a-2-5p (MIRT712534)
- hsa-miR-4290 (MIRT712535)
- hsa-miR-1976 (MIRT712536)
- hsa-miR-5695 (MIRT712537)
- hsa-miR-519d-5p (MIRT712538)
- hsa-miR-6893-3p (MIRT712539)
- hsa-miR-370-3p (MIRT712540)
- hsa-miR-660-3p (MIRT712541)
- hsa-miR-4667-3p (MIRT712542)
- hsa-miR-365b-3p (MIRT712543)
- hsa-miR-365a-3p (MIRT712544)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for CYB561D1 - Select products 50% OFF >
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- RC225175
- RC225175L3
- RC225175L4
- RC225323
- RC225323L3
- RC225323L4
- RG210795
- RG225080
- RG225099
- RG225175
- RG225323
- RR209611
- RR209611L3
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- MR217301L3V
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- RC225175L3V
- RC225175L4V
- RC225323L3V
- RC225323L4V
- RR209611L3V
- RR209611L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYB561D1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYB561D1
Cell Line Products
-
Horizon Cell Lines for CYB561D1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYB561D1 Gene
Localization for CYB561D1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYB561D1 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYB561D1 Gene
Pathways & Interactions for CYB561D1 Gene
Interacting Proteins for CYB561D1 Gene
Selected Interacting proteins:
Q8N8Q1-C56D1_HUMAN
ENSP00000358884
for CYB561D1 Gene via
UniProtKB
STRING
GPS-Prot Interaction Network for CYB561D1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CYB561D1 Gene
Drugs & Compounds for CYB561D1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| heme | Pharma | Agonist | 0 |
Transcripts for CYB561D1 Gene
mRNA/cDNA for CYB561D1 Gene
- 5 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000393709 620 nts (view in UCSC)
- ENST00000496961 3424 nts (view in UCSC)
- ENST00000533024 913 nts (view in UCSC)
- ENST00000310611 5009 nts (view in UCSC)
- ENST00000527072 892 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CYB561D1 - Select products 50% OFF >
- * CYB561D1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CYB561D1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYB561D1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYB561D1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CYB561D1
- Browse OriGene Inhibitory RNA Products For CYB561D1
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Clone Products
- Applied Biological Materials (abm): Clones for CYB561D1 - Select products 50% OFF >
- * CYB561D1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG217301
- MG218652
- MR217301
- MR217301L3
- MR217301L4
- MR218652
- MR218652L3
- MR218652L4
- RC210795
- RC210795L3
- RC210795L4
- RC225080
- RC225080L3
- RC225080L4
- RC225099
- RC225099L3
- RC225099L4
- RC225175
- RC225175L3
- RC225175L4
- RC225323
- RC225323L3
- RC225323L4
- RG210795
- RG225080
- RG225099
- RG225175
- RG225323
- RR209611
- RR209611L3
- RR209611L4
- RR216097
- MR217301L3V
- MR217301L4V
- MR218652L3V
- MR218652L4V
- RC210795L3V
- RC210795L4V
- RC225080L3V
- RC225080L4V
- RC225099L3V
- RC225099L4V
- RC225175L3V
- RC225175L4V
- RC225323L3V
- RC225323L4V
- RR209611L3V
- RR209611L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYB561D1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CYB561D1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - | - | - | - |
Relevant External Links for CYB561D1 Gene
- GeneLoc Exon Structure for
- CYB561D1
Expression for CYB561D1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CYB561D1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CYB561D1
SOURCE GeneReport for Unigene cluster for CYB561D1 Gene:
Hs.514682Evidence on tissue expression from TISSUES for CYB561D1 Gene
- Nervous system(4.3)
- Liver(4)
Primer Products
-
OriGene qPCR primer pairs for CYB561D1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYB561D1 Gene
Orthologs for CYB561D1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CYB561D1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CYB561D1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CYB561D1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cyb561d1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cyb561d1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CYB561D1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CYB561D1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101734093 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cyb561d1 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3475 31 |
|
OneToMany |
- Species where no ortholog for CYB561D1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CYB561D1 Gene
- ENSEMBL:
- Gene Tree for CYB561D1 (if available)
- TreeFam:
- Gene Tree for CYB561D1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CYB561D1: view image
Paralogs for CYB561D1 Gene
Variants for CYB561D1 Gene
Residual Variation Intolerance Score:
47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.40;
27.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CYB561D1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CYB561D1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for CYB561D1 Gene
Disorders for CYB561D1 Gene
Additional Disease Information for CYB561D1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CYB561D1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYB561D1 Gene
Publications for CYB561D1 Gene
- Cytochromes b561: ascorbate-mediated trans-membrane electron transport. (PMID: 23249217) Asard H … Bérczi A (Antioxidants & redox signaling 2013) 2 3
- Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J … Levinson DF (Molecular psychiatry 2011) 3 41
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for CYB561D1 Gene
- Custom Antibody ServicesOriGene Antibodies for CYB561D1
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- MG217301
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- antibodies-online: Show 13 available CYB561D1 Antibodies ranked by validation data
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- Horizon Cell Lines for CYB561D1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CYB561D1
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- Boster Bio Antibodies for CYB561D1
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Sources for CYB561D1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
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