The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not known. [provided by RefSeq, Sep 2009] See more...

Aliases for CXorf66 Gene

Aliases for CXorf66 Gene

  • Chromosome X Open Reading Frame 66 2 3 5
  • Secreted Glycoprotein, X-Linked 2 3
  • Uncharacterized Protein CXorf66 3 4
  • RP11-35F15.2 2 3
  • SGPX 2 3
  • CXorf66 5

External Ids for CXorf66 Gene

Previous GeneCards Identifiers for CXorf66 Gene

  • GC0XM138866
  • GC0XM139037
  • GC0XM128305

Summaries for CXorf66 Gene

Entrez Gene Summary for CXorf66 Gene

  • The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not known. [provided by RefSeq, Sep 2009]

GeneCards Summary for CXorf66 Gene

CXorf66 (Chromosome X Open Reading Frame 66) is a Protein Coding gene.

Additional gene information for CXorf66 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXorf66 Gene

Genomics for CXorf66 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXorf66 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ139965 Promoter 0.6 EPDnew 600.7 0.0 -20 0.1 CREB1 ATF7 ATF2 CXorf66 LOC728660 LOC389895
GH0XJ139847 Enhancer 0.2 FANTOM5 8.8 +117.8 117816 0 lnc-CXorf66-4 CXorf66 RF00619-041 RNU6ATAC23P ATP11C MCF2
GH0XJ139972 Enhancer 0.5 ENCODE 0.4 -8.3 -8304 2.1 SP1 JUND HNF4A RXRA HLF ATP11C CXorf66 LOC728660 LOC389895
GH0XJ140091 Promoter 1.1 Ensembl CraniofacialAtlas 0.1 -125.9 -125880 1.2 CTCF ARNT ZBTB26 ZBTB17 FOXM1 ZFHX2 ZNF335 VEZF1 KLF16 ZBTB33 ENSG00000230707 LOC389895 RN7SL727P RF00017-8769 lnc-F9-5 CXorf66
GH0XJ140057 Enhancer 0.8 Ensembl ENCODE 0.2 -91.6 -91622 0.5 CTCF PRDM10 ZNF692 RAD21 TRIM22 ZNF561 ZNF444 SMC3 ZBTB17 YY1 ATP11C lnc-CXorf66-3 RN7SL727P RF00017-8769 lnc-F9-5 LOC389895 CXorf66
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXorf66 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXorf66

Genomic Locations for CXorf66 Gene

Genomic Locations for CXorf66 Gene
chrX:139,955,728-139,965,521
(GRCh38/hg38)
Size:
9,794 bases
Orientation:
Minus strand
chrX:139,037,884-139,047,679
(GRCh37/hg19)
Size:
9,796 bases
Orientation:
Minus strand

Genomic View for CXorf66 Gene

Genes around CXorf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf66 Gene

Proteins for CXorf66 Gene

  • Protein details for CXorf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JRM2-CX066_HUMAN
    Recommended name:
    Uncharacterized protein CXorf66
    Protein Accession:
    Q5JRM2

    Protein attributes for CXorf66 Gene

    Size:
    361 amino acids
    Molecular mass:
    39944 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXorf66 Gene

Post-translational modifications for CXorf66 Gene

  • Glycosylation at Asn24
  • Modification sites at PhosphoSitePlus

Other Protein References for CXorf66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXorf66 Gene

Domains & Families for CXorf66 Gene

Gene Families for CXorf66 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CXorf66 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CXorf66: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CXorf66 Gene

Function for CXorf66 Gene

genes like me logo Genes that share phenotypes with CXorf66: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXorf66

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CXorf66 Gene

Localization for CXorf66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXorf66 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf66 gene
Compartment Confidence
extracellular 3
mitochondrion 1
golgi apparatus 1
plasma membrane 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for CXorf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CXorf66: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXorf66 Gene

Pathways & Interactions for CXorf66 Gene

PathCards logo

SuperPathways for CXorf66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CXorf66 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf66 Gene

Drugs & Compounds for CXorf66 Gene

No Compound Related Data Available

Transcripts for CXorf66 Gene

mRNA/cDNA for CXorf66 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXorf66

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf66 Gene

No ASD Table

Relevant External Links for CXorf66 Gene

GeneLoc Exon Structure for
CXorf66

Expression for CXorf66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXorf66 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for CXorf66 Gene

This gene is overexpressed in Testis (x52.3).

Protein differential expression in normal tissues from HIPED for CXorf66 Gene

This gene is overexpressed in Heart (45.7) and Testis (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXorf66 Gene



Protein tissue co-expression partners for CXorf66 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXorf66

SOURCE GeneReport for Unigene cluster for CXorf66 Gene:

Hs.121384
genes like me logo Genes that share expression patterns with CXorf66: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf66 Gene

Orthologs for CXorf66 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXorf66 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CXHXorf66 30
  • 98.61 (n)
CXorf66 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CXHXorf66 30
  • 71.11 (n)
CXorf66 31
  • 44 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm7073 30 17 31
  • 61.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC787011 30
  • 61.06 (n)
CXHXorf66 31 31
  • 36 (a)
OneToMany
-- 31
  • 35 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia LOC688842 30
  • 59.56 (n)
Species where no ortholog for CXorf66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CXorf66 Gene

ENSEMBL:
Gene Tree for CXorf66 (if available)
TreeFam:
Gene Tree for CXorf66 (if available)

Paralogs for CXorf66 Gene

No data available for Paralogs for CXorf66 Gene

Variants for CXorf66 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXorf66 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs5955139 - p.Pro233Leu

Additional dbSNP identifiers (rs#s) for CXorf66 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXorf66 Gene

Variant ID Type Subtype PubMed ID
dgv4302n106 CNV deletion 24896259
esv2672915 CNV deletion 23128226
esv3559395 CNV deletion 23714750
esv3577426 CNV gain 25503493

Variation tolerance for CXorf66 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf66 Gene

Disorders for CXorf66 Gene

Additional Disease Information for CXorf66

No disorders were found for CXorf66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf66 Gene

Publications for CXorf66 Gene

  1. A novel transmembrane glycoprotein cancer biomarker present in the X chromosome. (PMID: 24709545) Delgado AP … Narayanan R (Cancer genomics & proteomics 2014) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang KS … Aragam N (Schizophrenia research 2010) 41
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for CXorf66 Gene

Sources for CXorf66 Gene