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Aliases for CXorf66 Gene

Aliases for CXorf66 Gene

  • Chromosome X Open Reading Frame 66 2 3 5
  • Secreted Glycoprotein, X-Linked 2 3
  • Uncharacterized Protein CXorf66 3
  • RP11-35F15.2 3
  • SGPX 3

External Ids for CXorf66 Gene

Previous GeneCards Identifiers for CXorf66 Gene

  • GC0XM138866
  • GC0XM139037
  • GC0XM128305

Summaries for CXorf66 Gene

Entrez Gene Summary for CXorf66 Gene

  • The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not known. [provided by RefSeq, Sep 2009]

GeneCards Summary for CXorf66 Gene

CXorf66 (Chromosome X Open Reading Frame 66) is a Protein Coding gene.

Additional gene information for CXorf66 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf66 Gene

Genomics for CXorf66 Gene

GeneHancer (GH) Regulatory Elements for CXorf66 Gene

Promoters and enhancers for CXorf66 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ139965 Promoter 0.7 EPDnew 650.7 0.0 -21 0.1 CREB1 ATF2 CXorf66 LOC728660
GH0XJ139847 Enhancer 0.2 FANTOM5 8.8 +117.8 117815 0 CXorf66 GC0XP139826 GC0XP139886 ATP11C
GH0XJ139972 Enhancer 0.5 ENCODE 0.4 -8.3 -8305 2.1 SP1 JUND RXRA HLF HNF4A ATP11C CXorf66 LOC728660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXorf66 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CXorf66 Gene

Genomic Locations for CXorf66 Gene
9,796 bases
Minus strand
9,796 bases
Minus strand

Genomic View for CXorf66 Gene

Genes around CXorf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf66 Gene

Proteins for CXorf66 Gene

  • Protein details for CXorf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein CXorf66
    Protein Accession:

    Protein attributes for CXorf66 Gene

    361 amino acids
    Molecular mass:
    39944 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXorf66 Gene

Post-translational modifications for CXorf66 Gene

  • Glycosylation at posLast=2424
  • Modification sites at PhosphoSitePlus

Other Protein References for CXorf66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXorf66 Gene

Domains & Families for CXorf66 Gene

Gene Families for CXorf66 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CXorf66 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf66: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CXorf66 Gene

Function for CXorf66 Gene

genes like me logo Genes that share phenotypes with CXorf66: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CXorf66 Gene

Localization for CXorf66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXorf66 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf66 gene
Compartment Confidence
extracellular 3
plasma membrane 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CXorf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CXorf66: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXorf66 Gene

Pathways & Interactions for CXorf66 Gene

SuperPathways for CXorf66 Gene

No Data Available

Interacting Proteins for CXorf66 Gene

Gene Ontology (GO) - Biological Process for CXorf66 Gene


No data available for Pathways by source and SIGNOR curated interactions for CXorf66 Gene

Drugs & Compounds for CXorf66 Gene

No Compound Related Data Available

Transcripts for CXorf66 Gene

mRNA/cDNA for CXorf66 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXorf66 Gene

Chromosome X open reading frame 66:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf66 Gene

No ASD Table

Relevant External Links for CXorf66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXorf66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf66 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf66 Gene

This gene is overexpressed in Testis (x52.3).

Protein differential expression in normal tissues from HIPED for CXorf66 Gene

This gene is overexpressed in Heart (45.7) and Testis (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXorf66 Gene

Protein tissue co-expression partners for CXorf66 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXorf66 Gene:


SOURCE GeneReport for Unigene cluster for CXorf66 Gene:

genes like me logo Genes that share expression patterns with CXorf66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf66 Gene

Orthologs for CXorf66 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXorf66 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXHXorf66 33
  • 98.61 (n)
CXorf66 34
  • 98 (a)
(Canis familiaris)
Mammalia CXHXorf66 33
  • 71.11 (n)
CXorf66 34
  • 44 (a)
(Mus musculus)
Mammalia Gm7073 16 34 33
  • 61.24 (n)
(Bos Taurus)
Mammalia LOC787011 33
  • 61.06 (n)
CXHXorf66 34 34
  • 36 (a)
-- 34
  • 35 (a)
(Rattus norvegicus)
Mammalia LOC688842 33
  • 59.56 (n)
Species where no ortholog for CXorf66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXorf66 Gene

Gene Tree for CXorf66 (if available)
Gene Tree for CXorf66 (if available)

Paralogs for CXorf66 Gene

No data available for Paralogs for CXorf66 Gene

Variants for CXorf66 Gene

Sequence variations from dbSNP and Humsavar for CXorf66 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000204301 -- 139,958,382(-) T/C intron_variant
rs1000216228 -- 139,967,314(-) G/A upstream_transcript_variant
rs1000297835 -- 139,964,307(-) A/G intron_variant
rs1000400541 -- 139,957,029(-) G/A intron_variant
rs1000478437 -- 139,966,642(-) AATTAATT/AATTAATTAATT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf66 Gene

Variant ID Type Subtype PubMed ID
dgv4302n106 CNV deletion 24896259
esv2672915 CNV deletion 23128226
esv3559395 CNV deletion 23714750
esv3577426 CNV gain 25503493

Variation tolerance for CXorf66 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf66 Gene

Disorders for CXorf66 Gene

Additional Disease Information for CXorf66

No disorders were found for CXorf66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf66 Gene

Publications for CXorf66 Gene

  1. A novel transmembrane glycoprotein cancer biomarker present in the X chromosome. (PMID: 24709545) Delgado AP … Narayanan R (Cancer genomics & proteomics 2014) 2 3 58
  2. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang KS … Aragam N (Schizophrenia research 2010) 44 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CXorf66 Gene

Sources for CXorf66 Gene

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