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Aliases for CXorf65 Gene

Aliases for CXorf65 Gene

  • Chromosome X Open Reading Frame 65 2 3 5
  • Uncharacterized Protein CXorf65 3

External Ids for CXorf65 Gene

Previous GeneCards Identifiers for CXorf65 Gene

  • GC0XM070241
  • GC0XM070245
  • GC0XM070323
  • GC0XM064144

Summaries for CXorf65 Gene

GeneCards Summary for CXorf65 Gene

CXorf65 (Chromosome X Open Reading Frame 65) is a Protein Coding gene. Diseases associated with CXorf65 include Combined Immunodeficiency, X-Linked.

Additional gene information for CXorf65 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf65 Gene

Genomics for CXorf65 Gene

GeneHancer (GH) Regulatory Elements for CXorf65 Gene

Promoters and enhancers for CXorf65 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ071100 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 664.7 -0.6 -563 13.4 HDGF PKNOX1 ATF1 SMAD1 ARNT IRF4 TCF12 ZNF121 E2F8 ZNF207 CXorf65 IL2RG MED12 SNX12 ENSG00000285171 FOXO4
GH0XJ071095 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 13.2 +9.4 9430 5.1 FOXA2 ZNF2 YY1 ETS1 TCF12 POLR2B GLIS2 GATA2 ZNF143 ZFP91 FOXO4 MED12 CXorf65 SNX12 IL2RG
GH0XJ071153 Promoter/Enhancer 0.7 EPDnew dbSUPER 22.1 -46.4 -46422 0.1 NLGN3 CXorf65 MED12 IL2RG SNX12 ENSG00000228427
GH0XJ071074 Enhancer 0.8 Ensembl ENCODE 12.4 +33.6 33586 0.4 RFX1 HLF MAX CEBPB CEBPG EP300 ZNF148 NFIL3 ATF4 CEBPA SNX12 IL2RG MED12 CXorf65 RNU1-56P NUTF2P7 GC0XM071059
GH0XJ071128 Enhancer 0.7 ENCODE 11.4 -22.0 -21999 1.9 CTCF MXI1 RB1 ARID4B MAX RAD21 ZNF207 SMC3 ZNF143 ZNF444 CXorf65 IL2RG GC0XP071138 MED12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXorf65 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXorf65 gene promoter:
  • IRF-7A
  • HOXA5
  • Evi-1
  • GR
  • GR-alpha
  • GR-beta
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2

Genomic Locations for CXorf65 Gene

Genomic Locations for CXorf65 Gene
chrX:71,103,889-71,106,972
(GRCh38/hg38)
Size:
3,084 bases
Orientation:
Minus strand
chrX:70,323,739-70,326,638
(GRCh37/hg19)
Size:
2,900 bases
Orientation:
Minus strand

Genomic View for CXorf65 Gene

Genes around CXorf65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf65 Gene

Proteins for CXorf65 Gene

  • Protein details for CXorf65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NEN9-CX065_HUMAN
    Recommended name:
    Uncharacterized protein CXorf65
    Protein Accession:
    A6NEN9

    Protein attributes for CXorf65 Gene

    Size:
    183 amino acids
    Molecular mass:
    21305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXorf65 Gene

Post-translational modifications for CXorf65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXorf65 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXorf65 Gene

Domains & Families for CXorf65 Gene

Gene Families for CXorf65 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf65 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf65: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CXorf65 Gene

Function for CXorf65 Gene

Phenotypes for CXorf65 Gene

genes like me logo Genes that share phenotypes with CXorf65: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CXorf65 Gene

Localization for CXorf65 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf65 gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CXorf65 Gene

Pathways & Interactions for CXorf65 Gene

SuperPathways for CXorf65 Gene

No Data Available

Interacting Proteins for CXorf65 Gene

Gene Ontology (GO) - Biological Process for CXorf65 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf65 Gene

Drugs & Compounds for CXorf65 Gene

No Compound Related Data Available

Transcripts for CXorf65 Gene

mRNA/cDNA for CXorf65 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXorf65 Gene

Chromosome X open reading frame 65:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf65 Gene

No ASD Table

Relevant External Links for CXorf65 Gene

GeneLoc Exon Structure for
CXorf65
ECgene alternative splicing isoforms for
CXorf65

Expression for CXorf65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf65 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf65 Gene

This gene is overexpressed in Testis (x19.3), Whole Blood (x14.5), and Spleen (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of CXorf65 Gene:

CXorf65

SOURCE GeneReport for Unigene cluster for CXorf65 Gene:

Hs.443936
genes like me logo Genes that share expression patterns with CXorf65: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf65 Gene

Orthologs for CXorf65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXHXorf65 33
  • 99.64 (n)
CXorf65 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXHXorf65 33
  • 80.04 (n)
cow
(Bos Taurus)
Mammalia CXHXorf65 33
  • 79.84 (n)
CXorf65 34
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm614 16 34 33
  • 73.85 (n)
chicken
(Gallus gallus)
Aves C4HXorf65 33
  • 55.7 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC570432 33
  • 50.85 (n)
CXorf65 34
  • 30 (a)
OneToOne
Species where no ortholog for CXorf65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf65 Gene

ENSEMBL:
Gene Tree for CXorf65 (if available)
TreeFam:
Gene Tree for CXorf65 (if available)

Paralogs for CXorf65 Gene

No data available for Paralogs for CXorf65 Gene

Variants for CXorf65 Gene

Sequence variations from dbSNP and Humsavar for CXorf65 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111033617 pathogenic, X-linked severe combined immunodeficiency 71,108,599(-) C/T upstream_transcript_variant
rs137852508 pathogenic, X-linked severe combined immunodeficiency, not provided 71,108,336(-) G/A upstream_transcript_variant
rs137852509 pathogenic, X-linked severe combined immunodeficiency 71,108,278(-) G/A/T upstream_transcript_variant
rs137852510 pathogenic, Combined immunodeficiency, X-linked 71,108,323(-) A/G/T upstream_transcript_variant
rs148001866 likely-benign, Severe Combined Immune Deficiency 71,108,343(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf65 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv33082 CNV loss 17666407

Variation tolerance for CXorf65 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf65 Gene

Disorders for CXorf65 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXorf65 Gene - From: GeneCards

Disorder Aliases PubMed IDs
combined immunodeficiency, x-linked
  • cidx
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CXorf65

genes like me logo Genes that share disorders with CXorf65: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXorf65 Gene

Publications for CXorf65 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  3. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier LD … Marra M (Genome research 1996) 3 58

Products for CXorf65 Gene

Sources for CXorf65 Gene

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