Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CXorf57 Gene

Aliases for CXorf57 Gene

  • Chromosome X Open Reading Frame 57 2 3 5
  • RPA-Related And RAD51-Antagonist, X-Chromosome 3 4
  • RPA-Related, RAD51-Antagonist On X-Chromosome 3
  • Uncharacterized Protein CXorf57 3
  • RPA-Related Protein RADX 3
  • RADX 3

External Ids for CXorf57 Gene

Previous GeneCards Identifiers for CXorf57 Gene

  • GC0XP105741
  • GC0XP105855
  • GC0XP095482

Summaries for CXorf57 Gene

GeneCards Summary for CXorf57 Gene

CXorf57 (Chromosome X Open Reading Frame 57) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CXorf57 Gene

  • Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897).

Additional gene information for CXorf57 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf57 Gene

Genomics for CXorf57 Gene

GeneHancer (GH) Regulatory Elements for CXorf57 Gene

Promoters and enhancers for CXorf57 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ106611 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +0.4 433 2.2 PKNOX1 RB1 ARID4B RFX5 ZNF335 ZNF121 ZNF366 ZSCAN5C SCRT2 CREM CXorf57 MIR548AN
GH0XJ106725 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 11.9 +117.1 117094 6.5 ELF3 FOXA2 ARID4B DMAP1 ZBTB40 ZNF48 RAD21 RARA YY1 ZNF335 RNF128 CXorf57 TBC1D8B GC0XM106712
GH0XJ106608 Enhancer 0.2 ENCODE 0.7 -3.7 -3664 0.2 CXorf57 GC0XP106598
GH0XJ106603 Enhancer 0.2 FANTOM5 0.4 -8.4 -8431 0.1 CLDN2 CXorf57 GC0XP106598
GH0XJ106672 Enhancer 0.3 ENCODE 0.2 +60.8 60769 0.9 SCRT2 MUM1L1 PIR40777 GC0XP106640 CXorf57
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXorf57 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXorf57 gene promoter:

Genomic Locations for CXorf57 Gene

Genomic Locations for CXorf57 Gene
chrX:106,611,930-106,679,443
(GRCh38/hg38)
Size:
67,514 bases
Orientation:
Plus strand
chrX:105,855,160-105,922,673
(GRCh37/hg19)

Genomic View for CXorf57 Gene

Genes around CXorf57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf57 Gene

Proteins for CXorf57 Gene

  • Protein details for CXorf57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSI4-RADX_HUMAN
    Recommended name:
    RPA-related protein RADX
    Protein Accession:
    Q6NSI4
    Secondary Accessions:
    • H7BY89
    • Q4G0L7
    • Q5JQS1
    • Q5JRF9
    • Q6PHY5
    • Q6PII9
    • Q6PJU8
    • Q9H7W5
    • Q9NWA6

    Protein attributes for CXorf57 Gene

    Size:
    855 amino acids
    Molecular mass:
    97554 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CXorf57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf57 Gene

Post-translational modifications for CXorf57 Gene

  • Ubiquitination at posLast=817817, posLast=689689, Lys651, Lys648, posLast=624624, posLast=483483, and Lys454
  • Modification sites at PhosphoSitePlus

Other Protein References for CXorf57 Gene

No data available for DME Specific Peptides for CXorf57 Gene

Domains & Families for CXorf57 Gene

Gene Families for CXorf57 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf57 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf57: view

No data available for UniProtKB/Swiss-Prot for CXorf57 Gene

Function for CXorf57 Gene

Molecular function for CXorf57 Gene

UniProtKB/Swiss-Prot Function:
Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897).

Phenotypes From GWAS Catalog for CXorf57 Gene

Gene Ontology (GO) - Molecular Function for CXorf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IDA 28735897
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CXorf57: view
genes like me logo Genes that share phenotypes with CXorf57: view

Animal Model Products

miRNA for CXorf57 Gene

miRTarBase miRNAs that target CXorf57

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf57 Gene

Localization for CXorf57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXorf57 Gene

Chromosome. Note=Recruited to replication forks. {ECO:0000269 PubMed:28735897}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf57 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CXorf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005657 replication fork IDA 28735897
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CXorf57: view

Pathways & Interactions for CXorf57 Gene

SuperPathways for CXorf57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CXorf57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000042 negative regulation of double-strand break repair via homologous recombination IDA 28735897
genes like me logo Genes that share ontologies with CXorf57: view

No data available for Pathways by source and SIGNOR curated interactions for CXorf57 Gene

Drugs & Compounds for CXorf57 Gene

No Compound Related Data Available

Transcripts for CXorf57 Gene

mRNA/cDNA for CXorf57 Gene

Unigene Clusters for CXorf57 Gene

Chromosome X open reading frame 57:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf57 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - - - -
SP3:
SP4:
SP5: -

Relevant External Links for CXorf57 Gene

GeneLoc Exon Structure for
CXorf57
ECgene alternative splicing isoforms for
CXorf57

Expression for CXorf57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf57 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf57 Gene

This gene is overexpressed in Brain - Hypothalamus (x8.1) and Pituitary (x6.6).

Protein differential expression in normal tissues from HIPED for CXorf57 Gene

This gene is overexpressed in Stomach (17.3), Lung (12.7), Kidney (12.1), Fetal Brain (9.5), and Esophagus (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXorf57 Gene



NURSA nuclear receptor signaling pathways regulating expression of CXorf57 Gene:

CXorf57

SOURCE GeneReport for Unigene cluster for CXorf57 Gene:

Hs.274267

Evidence on tissue expression from TISSUES for CXorf57 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CXorf57: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf57 Gene

Orthologs for CXorf57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXorf57 34
  • 98 (a)
OneToOne
CXHXorf57 33
  • 98 (n)
dog
(Canis familiaris)
Mammalia CXHXorf57 33
  • 88.77 (n)
CXorf57 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680663 33
  • 83.49 (n)
cow
(Bos Taurus)
Mammalia CXHXorf57 33
  • 82.96 (n)
CXorf57 34
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D330045A20Rik 16 34 33
  • 82.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves C4HXORF57 33
  • 59.69 (n)
CXorf57 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498514 33
  • 55.5 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-26b3.2 33
  • 48.13 (n)
C5HXorf57 34
  • 33 (a)
OneToOne
Species where no ortholog for CXorf57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf57 Gene

ENSEMBL:
Gene Tree for CXorf57 (if available)
TreeFam:
Gene Tree for CXorf57 (if available)

Paralogs for CXorf57 Gene

No data available for Paralogs for CXorf57 Gene

Variants for CXorf57 Gene

Sequence variations from dbSNP and Humsavar for CXorf57 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000081101 -- 106,614,521(+) C/A/T intron_variant
rs1000213973 -- 106,634,633(+) C/T intron_variant
rs1000321538 -- 106,631,195(+) A/G intron_variant
rs1000335469 -- 106,661,316(+) T/C intron_variant
rs1000366615 -- 106,662,077(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf57 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV gain 17911159

Variation tolerance for CXorf57 Gene

Residual Variation Intolerance Score: 8.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf57 Gene

Disorders for CXorf57 Gene

Additional Disease Information for CXorf57

No disorders were found for CXorf57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf57 Gene

Publications for CXorf57 Gene

  1. RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks. (PMID: 28735897) Dungrawala H … Cortez D (Molecular cell 2017) 2 3 4 58
  2. RADX interacts with single-stranded DNA to promote replication fork stability. (PMID: 29021206) Schubert L … Mailand N (EMBO reports 2017) 2 3 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CXorf57 Gene

Sources for CXorf57 Gene

Content
Loading form....