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Aliases for CXorf56 Gene

Aliases for CXorf56 Gene

  • Chromosome X Open Reading Frame 56 2 3 5

External Ids for CXorf56 Gene

Previous GeneCards Identifiers for CXorf56 Gene

  • GC0XM118556
  • GC0XM118672
  • GC0XM108165

Summaries for CXorf56 Gene

Entrez Gene Summary for CXorf56 Gene

  • While this gene is well-supported by transcript data, no functional information on its protein products is currently available. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for CXorf56 Gene

CXorf56 (Chromosome X Open Reading Frame 56) is a Protein Coding gene.

Additional gene information for CXorf56 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf56 Gene

Genomics for CXorf56 Gene

GeneHancer (GH) Regulatory Elements for CXorf56 Gene

Promoters and enhancers for CXorf56 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI119564 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556 +0.2 210 1.6 CLOCK ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 SP3 NFYC CXorf56 SLC25A5 GC0XM119539
GH0XI119572 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.4 -9.0 -9034 3 SMAD1 FOXA2 ARID4B SIN3A ZNF2 POLR2B SP3 REST KAT8 ZNF610 UBE2A GC0XP119576 GC0XP119575 CXorf56 ZCCHC12 EEF1A1P30
GH0XI119466 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 18.3 +96.2 96225 4.6 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 SP3 SLC25A5-AS1 SLC25A5 PIR58034 SLC25A43 CXorf56 ENSG00000237903 RNU1-67P EEF1A1P30 NKAP NKAPP1
GH0XI119500 Enhancer 1.2 Ensembl ENCODE dbSUPER 31.5 +61.8 61847 6.3 ELF3 PKNOX1 FOXA2 SIN3A DMAP1 RAD21 YY1 ZNF121 CREM MIXL1 CXorf56 SLC25A43 SLC25A5 GC0XM119476 GC0XM119539
GH0XI119512 Enhancer 1.1 Ensembl ENCODE dbSUPER 33.1 +52.9 52942 0.6 CTCF ZNF654 RB1 ZNF449 ARID4B ZNF384 REST RAD21 SP1 ZNF121 CXorf56 SLC25A43 SLC25A5-AS1 SLC25A5 RNU1-67P ENSG00000237903 ENSG00000226661 GC0XM119539 GC0XM119476
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXorf56 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXorf56 gene promoter:

Genomic Locations for CXorf56 Gene

Genomic Locations for CXorf56 Gene
27,286 bases
Minus strand

Genomic View for CXorf56 Gene

Genes around CXorf56 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf56 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf56 Gene

Proteins for CXorf56 Gene

  • Protein details for CXorf56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0428 protein CXorf56
    Protein Accession:
    Secondary Accessions:
    • A8MPX7
    • B4DQN2
    • D3DWH9
    • F5GWL7
    • O43351

    Protein attributes for CXorf56 Gene

    222 amino acids
    Molecular mass:
    25625 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB96348.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CXorf56 Gene


neXtProt entry for CXorf56 Gene

Post-translational modifications for CXorf56 Gene

  • Ubiquitination at posLast=6767, Lys121, and Lys128
  • Modification sites at PhosphoSitePlus

Other Protein References for CXorf56 Gene

No data available for DME Specific Peptides for CXorf56 Gene

Domains & Families for CXorf56 Gene

Gene Families for CXorf56 Gene

Protein Domains for CXorf56 Gene

Suggested Antigen Peptide Sequences for CXorf56 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0428 family.
  • Belongs to the UPF0428 family.
genes like me logo Genes that share domains with CXorf56: view

Function for CXorf56 Gene

Phenotypes for CXorf56 Gene

genes like me logo Genes that share phenotypes with CXorf56: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf56 Gene

Localization for CXorf56 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf56 gene
Compartment Confidence
nucleus 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CXorf56 Gene

Pathways & Interactions for CXorf56 Gene

SuperPathways for CXorf56 Gene

No Data Available

Interacting Proteins for CXorf56 Gene

Gene Ontology (GO) - Biological Process for CXorf56 Gene


No data available for Pathways by source and SIGNOR curated interactions for CXorf56 Gene

Drugs & Compounds for CXorf56 Gene

No Compound Related Data Available

Transcripts for CXorf56 Gene

mRNA/cDNA for CXorf56 Gene

Unigene Clusters for CXorf56 Gene

Chromosome X open reading frame 56:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf56 Gene

No ASD Table

Relevant External Links for CXorf56 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXorf56 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf56 Gene

Protein differential expression in normal tissues from HIPED for CXorf56 Gene

This gene is overexpressed in Bone (33.7) and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXorf56 Gene

Protein tissue co-expression partners for CXorf56 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CXorf56 Gene:


SOURCE GeneReport for Unigene cluster for CXorf56 Gene:


Evidence on tissue expression from TISSUES for CXorf56 Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with CXorf56: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf56 Gene

Orthologs for CXorf56 Gene

This gene was present in the common ancestor of animals.

Orthologs for CXorf56 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
CXHXorf56 33
  • 96.49 (n)
-- 34
  • 96 (a)
(Bos Taurus)
Mammalia CXorf56 34
  • 99 (a)
CXHXorf56 33
  • 93.39 (n)
(Canis familiaris)
Mammalia CXorf56 34
  • 95 (a)
CXHXorf56 33
  • 92.34 (n)
(Monodelphis domestica)
Mammalia CXorf56 34
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia CXorf56 34
  • 93 (a)
(Mus musculus)
Mammalia C330007P06Rik 33 16 34
  • 92.04 (n)
(Rattus norvegicus)
Mammalia RGD1564541 33
  • 91.89 (n)
(Gallus gallus)
Aves CXorf56 34
  • 95 (a)
CXORF56 33
  • 82.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cxorf56 33
  • 79.13 (n)
MGC76077 33
African clawed frog
(Xenopus laevis)
Amphibia c330007p06-A-prov 33
(Danio rerio)
Actinopterygii C5HXorf56 34
  • 88 (a)
zgc:103697 33
  • 77.63 (n)
Dr.17887 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2208 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005769 33
  • 59.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16865 33 34
  • 58.46 (n)
(Caenorhabditis elegans)
Secernentea Y66D12A.8 33 34
  • 52.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6041 33
Species where no ortholog for CXorf56 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CXorf56 Gene

Gene Tree for CXorf56 (if available)
Gene Tree for CXorf56 (if available)

Paralogs for CXorf56 Gene Pseudogenes for CXorf56 Gene

genes like me logo Genes that share paralogs with CXorf56: view

No data available for Paralogs for CXorf56 Gene

Variants for CXorf56 Gene

Sequence variations from dbSNP and Humsavar for CXorf56 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000028074 -- 119,562,757(-) A/T intron_variant
rs1000089773 -- 119,549,363(-) T/C intron_variant
rs1000137636 -- 119,554,025(-) G/C intron_variant
rs1000170705 -- 119,553,601(-) A/T intron_variant
rs1000374092 -- 119,544,662(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf56 Gene

Variant ID Type Subtype PubMed ID
esv3574414 CNV loss 25503493
nsv525652 CNV gain 19592680

Variation tolerance for CXorf56 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf56 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf56 Gene

Disorders for CXorf56 Gene

Additional Disease Information for CXorf56

No disorders were found for CXorf56 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf56 Gene

Publications for CXorf56 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz CC … Taylor CT (PLoS biology 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CXorf56 Gene

Sources for CXorf56 Gene

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