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Aliases for CXorf40B Gene

Aliases for CXorf40B Gene

  • Chromosome X Open Reading Frame 40B 2 3 5
  • Protein CXorf40B 3

External Ids for CXorf40B Gene

Previous GeneCards Identifiers for CXorf40B Gene

  • GC0XU900620
  • GC0XM148851
  • GC0XM149097
  • GC0XM137971

Summaries for CXorf40B Gene

GeneCards Summary for CXorf40B Gene

CXorf40B (Chromosome X Open Reading Frame 40B) is a Protein Coding gene. An important paralog of this gene is CXorf40A.

Additional gene information for CXorf40B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf40B Gene

Genomics for CXorf40B Gene

GeneHancer (GH) Regulatory Elements for CXorf40B Gene

Promoters and enhancers for CXorf40B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ149937 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 671.8 -0.4 -370 3.8 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 CXorf40B LINC00894 XRCC6P2 IDS2 LOC643015 GC0XM150008
GH0XJ150691 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 11.6 -755.8 -755820 6.9 NEUROD1 SIN3A YY1 GLIS2 ELK1 ZNF143 ATF7 RUNX3 SP3 REST MTMR1 LINC00894 CXorf40B MTM1 PIR43679
GH0XJ149502 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.4 +434.3 434323 4.2 HDGF PKNOX1 SIN3A YBX1 ZBTB7B ZNF143 FOS SP3 REST KAT8 GC0XP149503 IDS CXorf40A LINC00893 ENSG00000241489 TMEM185AP1 CXorf40B LINC00894 IDS2
GH0XJ150897 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12.8 -959.9 -959873 2.5 ATF1 BRCA1 YY1 POLR2B GLIS2 GATA2 ATF7 ZNF263 SP3 REST CD99L2 CXorf40B LINC00894 PPIAP91
GH0XJ149538 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.8 +398.3 398315 3.1 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 POLR2B ZNF143 SP3 ZHX2 CXorf40A LINC00893 TMEM185A CXorf40B IDS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXorf40B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXorf40B gene promoter:

Genomic Locations for CXorf40B Gene

Genomic Locations for CXorf40B Gene
chrX:149,924,157-149,938,850
(GRCh38/hg38)
Size:
14,694 bases
Orientation:
Minus strand
chrX:149,097,745-149,107,029
(GRCh37/hg19)

Genomic View for CXorf40B Gene

Genes around CXorf40B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf40B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf40B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf40B Gene

Proteins for CXorf40B Gene

  • Protein details for CXorf40B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DE9-CX04B_HUMAN
    Recommended name:
    Protein CXorf40B
    Protein Accession:
    Q96DE9

    Protein attributes for CXorf40B Gene

    Size:
    158 amino acids
    Molecular mass:
    17780 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXorf40B Gene

Post-translational modifications for CXorf40B Gene

No Post-translational modifications

No data available for DME Specific Peptides for CXorf40B Gene

Domains & Families for CXorf40B Gene

Gene Families for CXorf40B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf40B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf40B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf40B: view

No data available for UniProtKB/Swiss-Prot for CXorf40B Gene

Function for CXorf40B Gene

Phenotypes for CXorf40B Gene

genes like me logo Genes that share phenotypes with CXorf40B: view

Animal Model Products

miRNA for CXorf40B Gene

miRTarBase miRNAs that target CXorf40B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf40B Gene

Localization for CXorf40B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CXorf40B Gene

Pathways & Interactions for CXorf40B Gene

SuperPathways for CXorf40B Gene

No Data Available

Interacting Proteins for CXorf40B Gene

Selected Interacting proteins: Q96DE9-CX04B_HUMAN for CXorf40B Gene via IID

Symbol External ID(s) Details
CXorf40A

Gene Ontology (GO) - Biological Process for CXorf40B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf40B Gene

Drugs & Compounds for CXorf40B Gene

No Compound Related Data Available

Transcripts for CXorf40B Gene

mRNA/cDNA for CXorf40B Gene

(5) Additional mRNA sequences :
(19) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXorf40B Gene

Chromosome X open reading frame 40B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf40B Gene

No ASD Table

Relevant External Links for CXorf40B Gene

GeneLoc Exon Structure for
CXorf40B
ECgene alternative splicing isoforms for
CXorf40B

Expression for CXorf40B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf40B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXorf40B Gene



NURSA nuclear receptor signaling pathways regulating expression of CXorf40B Gene:

CXorf40B

SOURCE GeneReport for Unigene cluster for CXorf40B Gene:

Hs.545950
genes like me logo Genes that share expression patterns with CXorf40B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf40B Gene

Orthologs for CXorf40B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf40B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXHXorf40A 33
  • 98.1 (n)
-- 34
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1562747 33
  • 80.89 (n)
mouse
(Mus musculus)
Mammalia 1110012L19Rik 16 34 33
  • 80.04 (n)
dog
(Canis familiaris)
Mammalia CXHXorf40A 33
  • 79.96 (n)
-- 34
  • 78 (a)
ManyToMany
-- 34
  • 78 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 75 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 60 (a)
ManyToMany
-- 34
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC772269 33
  • 66.01 (n)
-- 34
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cxorf40a 33
  • 64.49 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:110222 33
  • 56.33 (n)
C21HXorf40A 34
  • 52 (a)
OneToMany
Species where no ortholog for CXorf40B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf40B Gene

ENSEMBL:
Gene Tree for CXorf40B (if available)
TreeFam:
Gene Tree for CXorf40B (if available)

Paralogs for CXorf40B Gene

Paralogs for CXorf40B Gene

(1) SIMAP similar genes for CXorf40B Gene using alignment to 4 proteins:

  • CX04B_HUMAN
  • Q5HY62_HUMAN
  • S4R3G8_HUMAN
  • S4R3T8_HUMAN
genes like me logo Genes that share paralogs with CXorf40B: view

Variants for CXorf40B Gene

Sequence variations from dbSNP and Humsavar for CXorf40B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111986465 -- 149,938,629(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs112429616 -- 149,938,764(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs112713909 -- 149,937,414(-) C/T 5_prime_UTR_variant, intron_variant
rs112864494 -- 149,938,835(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs113755057 -- 149,931,043(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf40B Gene

Variant ID Type Subtype PubMed ID
esv3577519 CNV gain 25503493
nsv525908 CNV gain 19592680
nsv7464 OTHER inversion 18451855
nsv9996 CNV gain 18304495

Variation tolerance for CXorf40B Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf40B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf40B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf40B Gene

Disorders for CXorf40B Gene

Additional Disease Information for CXorf40B

No disorders were found for CXorf40B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf40B Gene

Publications for CXorf40B Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. 130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus. (PMID: 8717057) Timms KM … Gibbs RA (Genome research 1995) 3 4 58
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 44 58
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 58

Products for CXorf40B Gene

Sources for CXorf40B Gene

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