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Aliases for CXorf40A Gene

Aliases for CXorf40A Gene

  • Chromosome X Open Reading Frame 40A 2 3 5
  • Endothelial-Overexpressed Lipopolysaccharide-Associated Factor 1 2 3 4
  • CXorf40 3 4
  • EOLA1 3 4
  • Chromosome X Open Reading Frame 40 2
  • Protein CXorf40A 3

External Ids for CXorf40A Gene

Previous HGNC Symbols for CXorf40A Gene

  • CXorf40

Previous GeneCards Identifiers for CXorf40A Gene

  • GC0XP148328
  • GC0XP148432
  • GC0XP148623
  • GC0XP137575

Summaries for CXorf40A Gene

GeneCards Summary for CXorf40A Gene

CXorf40A (Chromosome X Open Reading Frame 40A) is a Protein Coding gene. An important paralog of this gene is CXorf40B.

UniProtKB/Swiss-Prot for CXorf40A Gene

  • May have an important role of cell protection in inflammation reaction.

Gene Wiki entry for CXorf40A Gene

Additional gene information for CXorf40A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf40A Gene

Genomics for CXorf40A Gene

GeneHancer (GH) Regulatory Elements for CXorf40A Gene

Promoters and enhancers for CXorf40A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ149538 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 664.6 +0.2 180 3.1 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 POLR2B ZNF143 SP3 ZHX2 CXorf40A LINC00893 TMEM185A CXorf40B IDS2
GH0XJ149502 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 28 -35.8 -35828 4.2 HDGF PKNOX1 SIN3A YBX1 ZBTB7B ZNF143 FOS SP3 REST KAT8 GC0XP149503 IDS CXorf40A LINC00893 ENSG00000241489 TMEM185AP1 CXorf40B LINC00894 IDS2
GH0XJ149510 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 25.1 -27.4 -27380 5.1 PKNOX1 RAD21 ZNF143 FOS RUNX3 SMARCA5 ZNF654 CEBPB REST ZFP69B IDS2 CXorf40A ENSG00000241489 LINC00893 IDS GC0XP149503
GH0XJ149630 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10.6 +90.9 90877 2.3 RB1 SIN3A ZNF335 GLIS2 EGR1 SMARCA5 SP3 ZBTB11 ELF1 GLIS1 TMEM185A CXorf40A IDS HSFX2
GH0XJ149516 Enhancer 0.6 ENCODE 24.7 -23.7 -23706 0.6 TAL1 MAFG CBFA2T3 DPF2 GABPA TCF12 ZNF316 NCOR1 IKZF1 CBFA2T2 IDS2 CXorf40A LINC00893 IDS GC0XP149503 ENSG00000241489
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXorf40A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXorf40A gene promoter:
  • AP-1
  • deltaCREB
  • CREB
  • Elk-1
  • Max1
  • Ik-3
  • E47
  • FOXO1
  • FOXO1a

Genomic Locations for CXorf40A Gene

Genomic Locations for CXorf40A Gene
chrX:149,540,355-149,555,340
(GRCh38/hg38)
Size:
14,986 bases
Orientation:
Plus strand
chrX:148,621,900-148,632,086
(GRCh37/hg19)
Size:
10,187 bases
Orientation:
Plus strand

Genomic View for CXorf40A Gene

Genes around CXorf40A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf40A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf40A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf40A Gene

Proteins for CXorf40A Gene

  • Protein details for CXorf40A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE69-CX04A_HUMAN
    Recommended name:
    Protein CXorf40A
    Protein Accession:
    Q8TE69
    Secondary Accessions:
    • A0A0A0MTB5
    • A8K784
    • B7Z6H6
    • B7ZL96
    • D6RA72
    • E7ENU3
    • Q2M3E9

    Protein attributes for CXorf40A Gene

    Size:
    158 amino acids
    Molecular mass:
    17891 Da
    Quaternary structure:
    • Interacts with MT2A.

    Alternative splice isoforms for CXorf40A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf40A Gene

Post-translational modifications for CXorf40A Gene

No Post-translational modifications

No data available for DME Specific Peptides for CXorf40A Gene

Domains & Families for CXorf40A Gene

Gene Families for CXorf40A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf40A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf40A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf40A: view

No data available for UniProtKB/Swiss-Prot for CXorf40A Gene

Function for CXorf40A Gene

Molecular function for CXorf40A Gene

UniProtKB/Swiss-Prot Function:
May have an important role of cell protection in inflammation reaction.

Gene Ontology (GO) - Molecular Function for CXorf40A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15541360
genes like me logo Genes that share ontologies with CXorf40A: view
genes like me logo Genes that share phenotypes with CXorf40A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CXorf40A Gene

Localization for CXorf40A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CXorf40A Gene

Pathways & Interactions for CXorf40A Gene

SuperPathways for CXorf40A Gene

No Data Available

Interacting Proteins for CXorf40A Gene

Gene Ontology (GO) - Biological Process for CXorf40A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf40A Gene

Drugs & Compounds for CXorf40A Gene

No Compound Related Data Available

Transcripts for CXorf40A Gene

Unigene Clusters for CXorf40A Gene

Chromosome X open reading frame 40A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf40A Gene

No ASD Table

Relevant External Links for CXorf40A Gene

GeneLoc Exon Structure for
CXorf40A
ECgene alternative splicing isoforms for
CXorf40A

Expression for CXorf40A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf40A Gene

Protein differential expression in normal tissues from HIPED for CXorf40A Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXorf40A Gene



Protein tissue co-expression partners for CXorf40A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CXorf40A Gene:

CXorf40A

SOURCE GeneReport for Unigene cluster for CXorf40A Gene:

Hs.534641

mRNA Expression by UniProt/SwissProt for CXorf40A Gene:

Q8TE69-CX04A_HUMAN
Tissue specificity: Expressed primarily in heart, skeletal muscle, kidney, liver and placenta. Relatively high level of expression in spleen, colon and small intestine. Almost no expression in brain, thymus, lung and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for CXorf40A Gene

  • Nervous system(3.9)
  • Lung(3.3)
genes like me logo Genes that share expression patterns with CXorf40A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf40A Gene

Orthologs for CXorf40A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf40A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXHXorf40A 33
  • 98.31 (n)
-- 34
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1562747 33
  • 81.53 (n)
mouse
(Mus musculus)
Mammalia 1110012L19Rik 34 33
  • 80.68 (n)
OneToMany
dog
(Canis familiaris)
Mammalia CXHXorf40A 33
  • 80.38 (n)
-- 34
  • 78 (a)
ManyToMany
-- 34
  • 78 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 75 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 60 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC772269 33
  • 66.45 (n)
-- 34
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cxorf40a 33
  • 64.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16160 33
zebrafish
(Danio rerio)
Actinopterygii zgc:110222 33
  • 56.75 (n)
C21HXorf40A 34
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1060 33
Species where no ortholog for CXorf40A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf40A Gene

ENSEMBL:
Gene Tree for CXorf40A (if available)
TreeFam:
Gene Tree for CXorf40A (if available)

Paralogs for CXorf40A Gene

Paralogs for CXorf40A Gene

(1) SIMAP similar genes for CXorf40A Gene using alignment to 4 proteins:

  • CX04A_HUMAN
  • D3DWT5_HUMAN
  • D6RA30_HUMAN
  • D6RH26_HUMAN

Pseudogenes.org Pseudogenes for CXorf40A Gene

genes like me logo Genes that share paralogs with CXorf40A: view

Variants for CXorf40A Gene

Sequence variations from dbSNP and Humsavar for CXorf40A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs10482432 -- 149,554,995(+) C/A/G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs11117532 -- 149,545,209(+) G/C intron_variant
rs111314546 -- 149,540,963(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs111737620 -- 149,555,400(+) G/C downstream_transcript_variant
rs111817192 -- 149,539,255(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf40A Gene

Variant ID Type Subtype PubMed ID
nsv508809 CNV insertion 20534489
nsv518742 CNV gain 19592680
nsv525908 CNV gain 19592680

Variation tolerance for CXorf40A Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf40A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf40A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf40A Gene

Disorders for CXorf40A Gene

Additional Disease Information for CXorf40A

No disorders were found for CXorf40A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf40A Gene

Publications for CXorf40A Gene

  1. [Purification of human endothelial overexpressed lipopolysaccharide-associated factor 1 protein]. (PMID: 16383041) Cai Z … Su YY (Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 2005) 2 3 22 58
  2. Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation. (PMID: 15541360) Liang Z … Yang Z (Biochemical and biophysical research communications 2004) 3 4 22 58
  3. 130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus. (PMID: 8717057) Timms KM … Gibbs RA (Genome research 1995) 2 3 4 58
  4. [The effect of inhibiting EOLA1 expression in ECV304 cells]. (PMID: 17557240) Liang ZW … Wang XM (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2007) 3 22 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58

Products for CXorf40A Gene

Sources for CXorf40A Gene

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