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Aliases for CXorf38 Gene

Aliases for CXorf38 Gene

  • Chromosome X Open Reading Frame 38 2 3 5
  • Uncharacterized Protein CXorf38 3

External Ids for CXorf38 Gene

Previous GeneCards Identifiers for CXorf38 Gene

  • GC0XM040244
  • GC0XM040373
  • GC0XM040488
  • GC0XM038197

Summaries for CXorf38 Gene

GeneCards Summary for CXorf38 Gene

CXorf38 (Chromosome X Open Reading Frame 38) is a Protein Coding gene.

Additional gene information for CXorf38 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf38 Gene

Genomics for CXorf38 Gene

GeneHancer (GH) Regulatory Elements for CXorf38 Gene

Promoters and enhancers for CXorf38 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ040643 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +1.6 1588 5.6 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A IRF4 ZNF48 YY1 GLIS2 CXorf38 MED14OS MPC1L MED14
GH0XJ041329 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.6 -686.1 -686139 7.8 CLOCK FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 DDX3X CASK-AS1 CXorf38 USP9X MED14 NYX PIR48586
GH0XJ040727 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 22.4 -84.7 -84671 10.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B MED14 CXorf38 CASK-AS1 MED14OS DDX3X BCOR USP9X
GH0XJ041083 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 15.1 -439.0 -438957 6.1 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 USP9X CASK-AS1 BCOR DDX3X MED14 CXorf38 LOC100132831 MPC1L IMPDH1P2 ENSG00000233103
GH0XJ040166 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.9 +475.1 475092 11.8 PKNOX1 FOXA2 SMAD1 ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 POLR2B BCOR LOC105373181 CXorf38 ATP6AP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXorf38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXorf38 gene promoter:

Genomic Locations for CXorf38 Gene

Genomic Locations for CXorf38 Gene
chrX:40,626,921-40,647,567
(GRCh38/hg38)
Size:
20,647 bases
Orientation:
Minus strand
chrX:40,486,173-40,506,819
(GRCh37/hg19)

Genomic View for CXorf38 Gene

Genes around CXorf38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf38 Gene

Proteins for CXorf38 Gene

  • Protein details for CXorf38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB03-CX038_HUMAN
    Recommended name:
    Uncharacterized protein CXorf38
    Protein Accession:
    Q8TB03
    Secondary Accessions:
    • B3KW28
    • D3DWB5
    • Q5JPF5
    • Q8N941

    Protein attributes for CXorf38 Gene

    Size:
    319 amino acids
    Molecular mass:
    36670 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CXorf38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf38 Gene

Post-translational modifications for CXorf38 Gene

  • Ubiquitination at posLast=276276 and Lys20
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CXorf38 Gene

Domains & Families for CXorf38 Gene

Gene Families for CXorf38 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf38 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf38: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CXorf38 Gene

Function for CXorf38 Gene

genes like me logo Genes that share phenotypes with CXorf38: view

Animal Model Products

miRNA for CXorf38 Gene

miRTarBase miRNAs that target CXorf38

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf38 Gene

Localization for CXorf38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf38 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CXorf38 Gene

Pathways & Interactions for CXorf38 Gene

SuperPathways for CXorf38 Gene

No Data Available

Interacting Proteins for CXorf38 Gene

Gene Ontology (GO) - Biological Process for CXorf38 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf38 Gene

Drugs & Compounds for CXorf38 Gene

No Compound Related Data Available

Transcripts for CXorf38 Gene

Unigene Clusters for CXorf38 Gene

Chromosome X open reading frame 38:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf38 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for CXorf38 Gene

GeneLoc Exon Structure for
CXorf38
ECgene alternative splicing isoforms for
CXorf38

Expression for CXorf38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf38 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf38 Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for CXorf38 Gene

This gene is overexpressed in Serum (36.9) and Bone (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXorf38 Gene



Protein tissue co-expression partners for CXorf38 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXorf38 Gene:

CXorf38

SOURCE GeneReport for Unigene cluster for CXorf38 Gene:

Hs.495961
genes like me logo Genes that share expression patterns with CXorf38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf38 Gene

Orthologs for CXorf38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXorf38 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXHXorf38 33
  • 89.13 (n)
CXorf38 34
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC616298 33
  • 89 (n)
CXorf38 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1810030O07Rik 16 34 33
  • 85.89 (n)
rat
(Rattus norvegicus)
Mammalia RGD1565685 33
  • 85.06 (n)
oppossum
(Monodelphis domestica)
Mammalia CXorf38 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXorf38 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxorf38 33
  • 58.51 (n)
Str.9859 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33719 33
zebrafish
(Danio rerio)
Actinopterygii C25HXorf38 (1 of 2) 34
  • 2 (a)
OneToMany
C25HXorf38 (2 of 2) 34
  • 1 (a)
OneToMany
Species where no ortholog for CXorf38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf38 Gene

ENSEMBL:
Gene Tree for CXorf38 (if available)
TreeFam:
Gene Tree for CXorf38 (if available)

Paralogs for CXorf38 Gene

No data available for Paralogs for CXorf38 Gene

Variants for CXorf38 Gene

Sequence variations from dbSNP and Humsavar for CXorf38 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000755724 -- 40,640,813(-) G/A intron_variant
rs1001147065 -- 40,640,246(-) T/A 5_prime_UTR_variant, intron_variant
rs1001585051 -- 40,639,836(-) C/T 5_prime_UTR_variant, intron_variant
rs1001638601 -- 40,627,903(-) G/T 3_prime_UTR_variant
rs1001684998 -- 40,634,984(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf38 Gene

Variant ID Type Subtype PubMed ID
dgv4229n106 CNV deletion 24896259
esv2550325 CNV deletion 19546169
esv2740109 CNV deletion 23290073
esv33829 CNV loss 17666407
esv3558808 CNV deletion 23714750
esv3576851 CNV gain 25503493
esv5571 CNV loss 19470904
nsv1148760 CNV deletion 26484159
nsv518965 CNV gain 19592680

Variation tolerance for CXorf38 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf38 Gene

Disorders for CXorf38 Gene

Additional Disease Information for CXorf38

No disorders were found for CXorf38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf38 Gene

Publications for CXorf38 Gene

  1. Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing. (PMID: 23768067) Anantharaman V … Aravind L (Biology direct 2013) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58

Products for CXorf38 Gene

Sources for CXorf38 Gene

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