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Aliases for CXorf36 Gene

Aliases for CXorf36 Gene

  • Chromosome X Open Reading Frame 36 2 3 5
  • DIA1R 3 4
  • Deleted In Autism-1 Related Protein 3
  • Deleted In Autism-Related Protein 1 3
  • UPF0672 Protein CXorf36 3
  • 4930578C19Rik 3
  • HCG1981635 3
  • BA435K1.1 3
  • EPQL1862 3
  • PRO3743 3

External Ids for CXorf36 Gene

Previous GeneCards Identifiers for CXorf36 Gene

  • GC0XM044765
  • GC0XM044892
  • GC0XM045007
  • GC0XM042724

Summaries for CXorf36 Gene

GeneCards Summary for CXorf36 Gene

CXorf36 (Chromosome X Open Reading Frame 36) is a Protein Coding gene. Diseases associated with CXorf36 include Autism. An important paralog of this gene is C3orf58.

Gene Wiki entry for CXorf36 Gene

Additional gene information for CXorf36 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf36 Gene

Genomics for CXorf36 Gene

GeneHancer (GH) Regulatory Elements for CXorf36 Gene

Promoters and enhancers for CXorf36 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ045200 Promoter 0.6 EPDnew 650.7 +0.0 25 0.1 POLR2A CXorf36 LOC105373191 GC0XM044696
GH0XJ044973 Enhancer 0.9 Ensembl ENCODE 6.2 +225.8 225787 2.4 KLF1 TFAP4 FOXA2 JUN HIC1 FOSL2 FOS GATAD2A ZNF680 FOXA3 CXorf36 KDM6A GC0XP045033 GC0XM044696
GH0XJ045199 Enhancer 0.4 FANTOM5 13.5 +2.0 2004 0.3 POLR2A CXorf36 LOC105373191 GC0XM044696
GH0XJ045128 Enhancer 0.4 ENCODE 11.6 +71.8 71846 1.7 ZNF316 MAFK CXorf36 LOC105373191 GC0XP045033 GC0XM044696
GH0XJ045191 Enhancer 0.7 Ensembl ENCODE 5.9 +9.2 9198 1 IKZF1 BATF IKZF2 RUNX3 CXorf36 LOC105373191 GC0XM044696
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXorf36 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXorf36 gene promoter:
  • Nkx2-5
  • POU2F1a
  • POU2F1
  • POU2F1b
  • POU2F1c
  • E2F-1
  • E2F
  • HOXA9

Genomic Locations for CXorf36 Gene

Genomic Locations for CXorf36 Gene
chrX:45,148,373-45,200,901
(GRCh38/hg38)
Size:
52,529 bases
Orientation:
Minus strand
chrX:45,007,618-45,060,146
(GRCh37/hg19)
Size:
52,529 bases
Orientation:
Minus strand

Genomic View for CXorf36 Gene

Genes around CXorf36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf36 Gene

Proteins for CXorf36 Gene

  • Protein details for CXorf36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7Y0-DIA1R_HUMAN
    Recommended name:
    Deleted in autism-related protein 1
    Protein Accession:
    Q9H7Y0
    Secondary Accessions:
    • A8MUU5
    • B2RPN7
    • Q6UWJ5

    Protein attributes for CXorf36 Gene

    Size:
    433 amino acids
    Molecular mass:
    48555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CXorf36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf36 Gene

Post-translational modifications for CXorf36 Gene

  • Glycosylation at Asn100
  • Modification sites at PhosphoSitePlus

Other Protein References for CXorf36 Gene

No data available for DME Specific Peptides for CXorf36 Gene

Domains & Families for CXorf36 Gene

Gene Families for CXorf36 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for CXorf36 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7Y0

UniProtKB/Swiss-Prot:

DIA1R_HUMAN :
  • Belongs to the DIA1 family.
Family:
  • Belongs to the DIA1 family.
genes like me logo Genes that share domains with CXorf36: view

Function for CXorf36 Gene

genes like me logo Genes that share phenotypes with CXorf36: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf36 Gene

Localization for CXorf36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXorf36 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf36 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CXorf36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CXorf36: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXorf36 Gene

Pathways & Interactions for CXorf36 Gene

SuperPathways for CXorf36 Gene

No Data Available

Interacting Proteins for CXorf36 Gene

Selected Interacting proteins: Q9H7Y0-DIA1R_HUMAN for CXorf36 Gene via IID

Gene Ontology (GO) - Biological Process for CXorf36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IBA --
genes like me logo Genes that share ontologies with CXorf36: view

No data available for Pathways by source and SIGNOR curated interactions for CXorf36 Gene

Drugs & Compounds for CXorf36 Gene

No Compound Related Data Available

Transcripts for CXorf36 Gene

mRNA/cDNA for CXorf36 Gene

Unigene Clusters for CXorf36 Gene

Chromosome X open reading frame 36:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf36 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5: - - - - -
SP6: - - - - - - - -
SP7:

Relevant External Links for CXorf36 Gene

GeneLoc Exon Structure for
CXorf36
ECgene alternative splicing isoforms for
CXorf36

Expression for CXorf36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXorf36 Gene

Protein differential expression in normal tissues from HIPED for CXorf36 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXorf36 Gene



Protein tissue co-expression partners for CXorf36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CXorf36 Gene:

CXorf36

SOURCE GeneReport for Unigene cluster for CXorf36 Gene:

Hs.98321

Evidence on tissue expression from TISSUES for CXorf36 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with CXorf36: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf36 Gene

Orthologs for CXorf36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXHXorf36 33
  • 99.46 (n)
CXorf36 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXHXorf36 33
  • 86.37 (n)
CXorf36 34
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CXHXorf36 34 33
  • 85.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 4930578C19Rik 16 34 33
  • 83.76 (n)
rat
(Rattus norvegicus)
Mammalia RGD1559731 33
  • 81.79 (n)
oppossum
(Monodelphis domestica)
Mammalia CXorf36 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXorf36 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1HXORF36 33
  • 67.87 (n)
CXorf36 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXorf36 34
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch73-147f11.1 33
  • 55.85 (n)
C9HXorf36 34
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
OneToMany
Species where no ortholog for CXorf36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf36 Gene

ENSEMBL:
Gene Tree for CXorf36 (if available)
TreeFam:
Gene Tree for CXorf36 (if available)

Paralogs for CXorf36 Gene

Paralogs for CXorf36 Gene

(1) SIMAP similar genes for CXorf36 Gene using alignment to 1 proteins:

  • DIA1R_HUMAN
genes like me logo Genes that share paralogs with CXorf36: view

Variants for CXorf36 Gene

Sequence variations from dbSNP and Humsavar for CXorf36 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000015820 -- 45,174,940(-) G/A intron_variant
rs1000054423 -- 45,161,114(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000203805 -- 45,186,130(-) C/T intron_variant
rs1000297403 -- 45,165,371(-) C/T intron_variant
rs1000358348 -- 45,191,629(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CXorf36 Gene

Variant ID Type Subtype PubMed ID
esv3558843 CNV deletion 23714750
nsv508765 CNV insertion 20534489
nsv524833 CNV gain 19592680

Variation tolerance for CXorf36 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.81; 91.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf36 Gene

Human Gene Mutation Database (HGMD)
CXorf36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf36 Gene

Disorders for CXorf36 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXorf36 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
autism
  • autistic disorder
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DIA1R_HUMAN
  • Note=Genetic variations in CXorf36 may be associated with susceptibility to autism. {ECO:0000269 PubMed:21264219}.

Additional Disease Information for CXorf36

genes like me logo Genes that share disorders with CXorf36: view

No data available for Genatlas for CXorf36 Gene

Publications for CXorf36 Gene

  1. A novel predicted calcium-regulated kinase family implicated in neurological disorders. (PMID: 23840464) Dudkiewicz M … Pawłowski K (PloS one 2013) 2 3 58
  2. Characterization of the deleted in autism 1 protein family: implications for studying cognitive disorders. (PMID: 21283809) Aziz A … Bishop NE (PloS one 2011) 2 3 58
  3. DIA1R is an X-linked gene related to Deleted In Autism-1. (PMID: 21264219) Aziz A … Bishop NE (PloS one 2011) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for CXorf36 Gene

Sources for CXorf36 Gene

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