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The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
CXXC5 (CXXC Finger Protein 5) is a Protein Coding gene. Diseases associated with CXXC5 include Cardiomyopathy, Familial Hypertrophic, 17 and Reading Disorder. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and obsolete signal transducer activity. An important paralog of this gene is CXXC4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 23303788 |
GO:0008134 | transcription factor binding | IDA | 23303788 |
GO:0008270 | zinc ion binding | IDA | 29276034 |
GO:0008327 | methyl-CpG binding | IDA | 29276034 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chromatin Regulation / Acetylation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 23303788 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | HMP | 12761501 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||
SP10: | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CXXC5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CXXC5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CXXC5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cxxc5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cxxc5 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CXXC5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CXXC5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CXXC5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CXXC5 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | cxxc5a 30 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1073919 | CNV | deletion | 25765185 |
nsv1074874 | CNV | deletion | 25765185 |
nsv1119041 | CNV | deletion | 24896259 |
nsv1133615 | CNV | deletion | 24896259 |
nsv1137532 | CNV | deletion | 24896259 |
nsv462460 | CNV | loss | 19166990 |
nsv519808 | CNV | loss | 19592680 |
nsv599820 | CNV | loss | 21841781 |
nsv830504 | CNV | gain | 17160897 |
nsv830505 | CNV | loss | 17160897 |
nsv950412 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cardiomyopathy, familial hypertrophic, 17 |
|
|
reading disorder |
|
|
wilms tumor 1 |
|
|
dyslexia |
|
|