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The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same prote... See more...
Aliases for CXXC5 Gene
Aliases for CXXC5 Gene
External Ids for CXXC5 Gene
- HGNC: 26943
- Entrez Gene: 51523
- Ensembl: ENSG00000171604
- OMIM: 612752
- UniProtKB: Q7LFL8
Previous GeneCards Identifiers for CXXC5 Gene
- GC05P139057
- GC05P139008
- GC05P134203
- GC05P139026
Summaries for CXXC5 Gene
-
The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for CXXC5 Gene
CXXC5 (CXXC Finger Protein 5) is a Protein Coding gene. Diseases associated with CXXC5 include Cardiomyopathy, Familial Hypertrophic, 17 and Reading Disorder. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and obsolete signal transducer activity. An important paralog of this gene is CXXC4.
UniProtKB/Swiss-Prot Summary for CXXC5 Gene
-
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034).
Additional gene information for CXXC5 Gene
- HGNC(26943)
- Entrez Gene(51523)
- Ensembl(ENSG00000171604)
- OMIM(612752)
- UniProtKB(Q7LFL8)
- Open Targets Platform(ENSG00000171604)
- Search for CXXC5 at DataMed
- Search for CXXC5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXXC5 Gene
Genomics for CXXC5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CXXC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CXXC5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXXC5
- Top Transcription factor binding sites by QIAGEN in the CXXC5 gene promoter:
-
- AREB6
- CREB
- deltaCREB
- GATA-1
- HEN1
- NCX
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- PPAR-alpha
Genomic Locations for CXXC5 Gene
Genomic Locations for CXXC5 Gene
- chr5:139,647,299-139,683,885
- (GRCh38/hg38)
- Size:
- 36,587 bases
- Orientation:
- Plus strand
- chr5:139,026,884-139,063,467
- (GRCh37/hg19)
- Size:
- 36,584 bases
- Orientation:
- Plus strand
Genomic View for CXXC5 Gene
Genes around CXXC5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.2 by HGNC
- 5q31.2 by Entrez Gene
- 5q31.2 by Ensembl
CXXC5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXXC5 Gene
Proteins for CXXC5 Gene
-
Protein details for CXXC5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7LFL8-CXXC5_HUMAN
- Recommended name:
- CXXC-type zinc finger protein 5
- Protein Accession:
- Q7LFL8
- B3KND0
- C8CBA8
- Q8TB79
- Q9NV51
- Q9P0S8
Protein attributes for CXXC5 Gene
- Size:
- 322 amino acids
- Molecular mass:
- 32977 Da
- Quaternary structure:
-
- Interacts with DVL1. Interacts with RBPJ (PubMed:23303788).
- SequenceCaution:
-
- Sequence=AAF36115.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH02490.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06428.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17439.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH24040.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH41013.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CXXC5 Gene
Post-translational modifications for CXXC5 Gene
Other Protein References for CXXC5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CXXC5 Antibody
- G Biosciences Immunotag™ CXXC5 Antibody
- Creative Diagnostics Anti-CXXC5 monoclonal antibody
- Creative Biolabs Rabbit Anti-CXXC5 Recombinant Antibody (D1O4P)
- Novus Biologicals Antibodies for CXXC5
-
Abcam antibodies for CXXC5
- Invitrogen Antibodies for CXXC5 (AFLGC-CXXC5)
-
Biorbyt antibodies for CXXC5
-
Boster Bio Antibodies for CXXC5
-
Custom Antibody ServicesProSci Antibodies for CXXC5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CXXC5
Protein Products
-
OriGene Purified Proteins for CXXC5
- Search Origene for MassSpec and Protein Over-expression Lysates for CXXC5
- Origene Custom Protein Services for CXXC5
- antibodies-online: Show 7 available CXXC5 Proteins ranked by validation data
- Compare Top CXXC5 Proteins
-
Quality Products:
-
Signalway Proteins for CXXC5
-
Abcam proteins for CXXC5
No data available for DME Specific Peptides for CXXC5 Gene
Domains & Families for CXXC5 Gene
Gene Families for CXXC5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CXXC5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CXXC5 Gene
- GenScript: Design optimal peptide antigens:
-
- CXXC finger 5, isoform CRA_a (C8CBA8_HUMAN)
- Putative NF-kappa-B-activating protein 102 (CXXC5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7LFL8- Domain:
-
- The CXXC zinc finger mediates binding to CpG-DNA.
Function for CXXC5 Gene
Molecular function for CXXC5 Gene
- UniProtKB/Swiss-Prot Function:
- May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034).
- UniProtKB/Swiss-Prot Induction:
- By retinoic acid.
Phenotypes From GWAS Catalog for CXXC5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 23303788 |
| GO:0008134 | transcription factor binding | IDA | 23303788 |
| GO:0008270 | zinc ion binding | IDA | 29276034 |
| GO:0008327 | methyl-CpG binding | IDA | 29276034 |
Phenotypes for CXXC5 Gene
- MGI mutant phenotypes for CXXC5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CXXC5:
Animal Models for CXXC5 Gene
- MGI Knock Outs for CXXC5:
-
- Cxxc5 Cxxc5<tm1Kych>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CXXC5 - Select products 50% OFF >
- * CXXC5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CXXC5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXXC5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXXC5
miRNA for CXXC5 Gene
- miRTarBase miRNAs that target CXXC5
-
- mmu-miR-9-5p (MIRT015447)
- hsa-miR-9-5p (MIRT021344)
- hsa-miR-324-3p (MIRT043013)
- mmu-miR-3065-5p (MIRT587531)
- mmu-miR-344d-3p (MIRT587532)
- mmu-miR-410-3p (MIRT587533)
- mmu-miR-344e-3p (MIRT587534)
- hsa-miR-3907 (MIRT659212)
- hsa-miR-7106-3p (MIRT659213)
- hsa-miR-3182 (MIRT659214)
- hsa-miR-4679 (MIRT659215)
- hsa-miR-4677-3p (MIRT659216)
- hsa-miR-548q (MIRT659217)
- hsa-miR-4469 (MIRT659218)
- hsa-miR-1237-3p (MIRT659219)
- hsa-miR-5088-3p (MIRT659220)
- hsa-miR-4667-3p (MIRT659221)
- hsa-miR-1470 (MIRT659222)
- hsa-miR-6756-3p (MIRT659223)
- hsa-miR-3127-3p (MIRT659224)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXXC5
- Browse OriGene Inhibitory RNA Products For CXXC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXXC5
Clone Products
- Applied Biological Materials (abm): Clones for CXXC5 - Select products 50% OFF >
- * CXXC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CXXC5
- Addgene plasmids for CXXC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXXC5
Cell Line Products
-
Horizon Cell Lines for CXXC5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXXC5 Gene
Localization for CXXC5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CXXC5 Gene
- Nucleus. Cytoplasm. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250 UniProtKB:Q5XIQ3}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoplasm (3)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for CXXC5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin Regulation / Acetylation | ||
Pathways by source for CXXC5 Gene
1 Cell Signaling Technology pathway for CXXC5 Gene
Interacting Proteins for CXXC5 Gene
Selected Interacting proteins:
Q7LFL8-CXXC5_HUMAN
ENSP00000302543
for CXXC5 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for CXXC5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 23303788 |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | HMP | 12761501 |
No data available for SIGNOR curated interactions for CXXC5 Gene
Transcripts for CXXC5 Gene
mRNA/cDNA for CXXC5 Gene
- 14 REFSEQ mRNAs :
- 28 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000502295 503 nts (view in UCSC)
- ENST00000504944 568 nts (view in UCSC)
- ENST00000302517 2601 nts (view in UCSC)
- ENST00000507139 472 nts (view in UCSC)
- ENST00000504844 777 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CXXC5 - Select products 50% OFF >
- * CXXC5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CXXC5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXXC5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXXC5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXXC5
- Browse OriGene Inhibitory RNA Products For CXXC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXXC5
Clone Products
- Applied Biological Materials (abm): Clones for CXXC5 - Select products 50% OFF >
- * CXXC5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CXXC5
- Addgene plasmids for CXXC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXXC5
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - |
Relevant External Links for CXXC5 Gene
- GeneLoc Exon Structure for
- CXXC5
Expression for CXXC5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Pancreatic juice (54.7) and Serum (9.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXXC5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXXC5
SOURCE GeneReport for Unigene cluster for CXXC5 Gene:
Hs.744933Evidence on tissue expression from TISSUES for CXXC5 Gene
- Muscle(4.5)
- Eye(4.5)
- Nervous system(4.5)
- Skin(4.5)
- Lung(4.4)
- Blood(4.4)
- Kidney(2.5)
- Liver(2.4)
- Intestine(2.2)
- Heart(2.2)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for CXXC5
-
OriGene qPCR primer pairs and template standards for CXXC5
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXXC5 Gene
Orthologs for CXXC5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CXXC5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CXXC5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CXXC5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cxxc5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cxxc5 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CXXC5 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CXXC5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CXXC5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CXXC5 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | cxxc5a 30 31 |
|
OneToOne |
- Species where no ortholog for CXXC5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CXXC5 Gene
- ENSEMBL:
- Gene Tree for CXXC5 (if available)
- TreeFam:
- Gene Tree for CXXC5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CXXC5: view image
Paralogs for CXXC5 Gene
(1) SIMAP similar genes for CXXC5 Gene using alignment to 12 proteins:
- CXXC5_HUMAN
- D6R966_HUMAN
- D6R9V1_HUMAN
- D6RBE0_HUMAN
- D6RCN9_HUMAN
- D6RDY2_HUMAN
- D6RHC6_HUMAN
- D6RHG9_HUMAN
- D6RIR8_HUMAN
- D6RJC1_HUMAN
- E7EV55_HUMAN
- E7EVI8_HUMAN
Variants for CXXC5 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1073919 | CNV | deletion | 25765185 |
| nsv1074874 | CNV | deletion | 25765185 |
| nsv1119041 | CNV | deletion | 24896259 |
| nsv1133615 | CNV | deletion | 24896259 |
| nsv1137532 | CNV | deletion | 24896259 |
| nsv462460 | CNV | loss | 19166990 |
| nsv519808 | CNV | loss | 19592680 |
| nsv599820 | CNV | loss | 21841781 |
| nsv830504 | CNV | gain | 17160897 |
| nsv830505 | CNV | loss | 17160897 |
| nsv950412 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.42;
9.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CXXC5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CXXC5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXXC5 Gene
Disorders for CXXC5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cardiomyopathy, familial hypertrophic, 17 |
|
|
| reading disorder |
|
|
| wilms tumor 1 |
|
|
| dyslexia |
|
|
Search CXXC5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CXXC5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CXXC5 Gene
Publications for CXXC5 Gene
- Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. (PMID: 19182210) Pendino F … Lillehaug JR (Blood 2009) 2 3 4
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
- DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. (PMID: 29276034) Xu C … Min J (Structure (London, England : 1993) 2018) 3 4
- Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. (PMID: 23303788) Aras S … Grossman LI (Nucleic acids research 2013) 3 4
- Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. (PMID: 19865112) Carbuccia N … Mozziconacci MJ (Leukemia 2010) 3 41
ExternalLinks
Products for CXXC5 Gene
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- Browse Recombinant Antibodies
- Invitrogen Antibodies for CXXC5 (AFLGC-CXXC5)
- VectorBuilder Custom and pre-made DNA vectors for CXXC5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CXXC5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CXXC5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CXXC5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CXXC5
- Addgene plasmids for CXXC5
- antibodies-online: Show 50 available CXXC5 Antibodies ranked by validation data
- Compare Top CXXC5 Antibodies
- antibodies-online: Search results for available CXXC5 related products ranked by validation data
- antibodies-online: Show 7 available CXXC5 Proteins ranked by validation data
- Compare Top CXXC5 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for CXXC5
- Search Santa Cruz Biotechnology (SCBT) for CXXC5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CXXC5
- Custom Antibody ServicesProSci Antibodies for CXXC5
- Search for CXXC5 Proteins at ProSci
- Horizon Cell Lines for CXXC5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXXC5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXXC5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CXXC5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXXC5
- Boster Bio Antibodies for CXXC5
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for CXXC5
- Signalway Proteins for CXXC5
Sources for CXXC5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB