CXXC5 Gene (Protein Coding)

CXXC Finger Protein 5

GC05P139647
GIFtS:
38
The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same prote... See more...

Aliases for CXXC5 Gene

Aliases for CXXC5 Gene

  • CXXC Finger Protein 5 2 3 5
  • Retinoid-Inducible Nuclear Factor 2 3 4
  • Putative NF-Kappa-B-Activating Protein 102 3 4
  • Putative MAPK-Activating Protein PM08 3 4
  • WT1-Induced Inhibitor Of Dishevelled 2 3
  • CXXC-Type Zinc Finger Protein 5 3 4
  • RINF 3 4
  • CF5 3 4
  • CXXC Finger 5 Protein 3
  • HSPC195 3
  • WID 3

External Ids for CXXC5 Gene

Previous GeneCards Identifiers for CXXC5 Gene

  • GC05P139057
  • GC05P139008
  • GC05P134203
  • GC05P139026

Summaries for CXXC5 Gene

Entrez Gene Summary for CXXC5 Gene

  • The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for CXXC5 Gene

CXXC5 (CXXC Finger Protein 5) is a Protein Coding gene. Diseases associated with CXXC5 include Wilms Tumor 1. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and obsolete signal transducer activity. An important paralog of this gene is CXXC4.

UniProtKB/Swiss-Prot Summary for CXXC5 Gene

  • May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).

Gene Wiki entry for CXXC5 Gene

Additional gene information for CXXC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXXC5 Gene

Genomics for CXXC5 Gene

GeneHancer (GH) Regulatory Elements for CXXC5 Gene

Promoters and enhancers for CXXC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXXC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXXC5 gene promoter:
  • AREB6
  • CREB
  • deltaCREB
  • GATA-1
  • HEN1
  • NCX
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-alpha

Genomic Locations for CXXC5 Gene

Genomic Locations for CXXC5 Gene
chr5:139,647,299-139,683,882
(GRCh38/hg38)
Size:
36,584 bases
Orientation:
Plus strand
chr5:139,026,884-139,063,467
(GRCh37/hg19)
Size:
36,584 bases
Orientation:
Plus strand

Genomic View for CXXC5 Gene

Genes around CXXC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXXC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXXC5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CXXC5 Gene

Proteins for CXXC5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CXXC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LFL8-CXXC5_HUMAN
    Recommended name:
    CXXC-type zinc finger protein 5
    Protein Accession:
    Q7LFL8
    Secondary Accessions:
    • B3KND0
    • C8CBA8
    • Q8TB79
    • Q9NV51
    • Q9P0S8

    Protein attributes for CXXC5 Gene

    Size:
    322 amino acids
    Molecular mass:
    32977 Da
    Quaternary structure:
    • Interacts with DVL1. Interacts with RBPJ (PubMed:23303788).
    SequenceCaution:
    • Sequence=AAF36115.1; Type=Frameshift; Positions=32, 102, 119, 250, 265; Evidence={ECO:0000305}; Sequence=AAH02490.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH06428.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17439.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH24040.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH41013.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXXC5 Gene

    Alternative splice isoforms for CXXC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXXC5 Gene

Protein Expression for CXXC5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CXXC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXXC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXXC5 Gene

Domains & Families for CXXC5 Gene

Gene Families for CXXC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXXC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXXC5 Gene

GenScript: Design optimal peptide antigens:
  • CXXC finger 5, isoform CRA_a (C8CBA8_HUMAN)
  • Putative NF-kappa-B-activating protein 102 (CXXC5_HUMAN)
genes like me logo Genes that share domains with CXXC5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CXXC5 Gene

Function for CXXC5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CXXC5 Gene

UniProtKB/Swiss-Prot Function:
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Phenotypes From GWAS Catalog for CXXC5 Gene

Gene Ontology (GO) - Molecular Function for CXXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23303788
GO:0008134 transcription factor binding IDA 23303788
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IDA 23303788
genes like me logo Genes that share ontologies with CXXC5: view
genes like me logo Genes that share phenotypes with CXXC5: view

Animal Models for CXXC5 Gene

MGI Knock Outs for CXXC5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXXC5

Clone Products

  • Addgene plasmids for CXXC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXXC5 Gene

Localization for CXXC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXXC5 Gene

Nucleus. Cytoplasm. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXXC5 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CXXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CXXC5: view

Pathways & Interactions for CXXC5 Gene

PathCards logo

SuperPathways for CXXC5 Gene

genes like me logo Genes that share pathways with CXXC5: view

Pathways by source for CXXC5 Gene

1 Cell Signaling Technology pathway for CXXC5 Gene

Gene Ontology (GO) - Biological Process for CXXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 23303788
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP 12761501
genes like me logo Genes that share ontologies with CXXC5: view

No data available for SIGNOR curated interactions for CXXC5 Gene

Drugs & Compounds for CXXC5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CXXC5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CXXC5 Gene

(14) REFSEQ mRNAs :
(28) Additional mRNA sequences :
(469) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXXC5

Clone Products

  • Addgene plasmids for CXXC5

Alternative Splicing Database (ASD) splice patterns (SP) for CXXC5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9:
SP10: - - - -

Relevant External Links for CXXC5 Gene

GeneLoc Exon Structure for
CXXC5
ECgene alternative splicing isoforms for
CXXC5

Expression for CXXC5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXXC5 Gene

mRNA expression in normal human tissues for CXXC5 Gene
mRNA expression by BioGPS for CXXC5 GenemRNA expression by GTEx for CXXC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CXXC5 Gene

This gene is overexpressed in Pancreatic juice (54.7) and Serum (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXXC5 Gene



NURSA nuclear receptor signaling pathways regulating expression of CXXC5 Gene:

CXXC5

SOURCE GeneReport for Unigene cluster for CXXC5 Gene:

Hs.744933

Evidence on tissue expression from TISSUES for CXXC5 Gene

  • Eye(4.4)
  • Muscle(4.4)
  • Nervous system(4.4)
  • Blood(4.3)
  • Lung(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with CXXC5: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXXC5 Gene

Orthologs for CXXC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXXC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CXXC5 33 32
  • 99.38 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia CXXC5 33 32
  • 91.81 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia CXXC5 33 32
  • 90.64 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cxxc5 17 33 32
  • 88.81 (n)
rat
(Rattus norvegicus)
 Mammalia Cxxc5 32
  • 88.05 (n)
oppossum
(Monodelphis domestica)
 Mammalia CXXC5 33
  • 81 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CXXC5 33
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CXXC5 33 32
  • 73.31 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CXXC5 33
  • 67 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii cxxc5a 33 32
  • 65.86 (n)
 OneToOne
Species where no ortholog for CXXC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXXC5 Gene

ENSEMBL:
Gene Tree for CXXC5 (if available)
TreeFam:
Gene Tree for CXXC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXXC5: view image

Paralogs for CXXC5 Gene

Paralogs for CXXC5 Gene

(1) SIMAP similar genes for CXXC5 Gene using alignment to 12 proteins:

  • CXXC5_HUMAN
  • D6R966_HUMAN
  • D6R9V1_HUMAN
  • D6RBE0_HUMAN
  • D6RCN9_HUMAN
  • D6RDY2_HUMAN
  • D6RHC6_HUMAN
  • D6RHG9_HUMAN
  • D6RIR8_HUMAN
  • D6RJC1_HUMAN
  • E7EV55_HUMAN
  • E7EVI8_HUMAN
genes like me logo Genes that share paralogs with CXXC5: view

Variants for CXXC5 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CXXC5 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000029534 -- 139,661,471(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000071704 -- 139,663,996(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000212858 -- 139,655,821(+) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000316909 -- 139,673,241(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000396736 -- 139,661,302(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CXXC5 Gene

Variant ID Type Subtype PubMed ID
nsv1073919 CNV deletion 25765185
nsv1074874 CNV deletion 25765185
nsv1119041 CNV deletion 24896259
nsv1133615 CNV deletion 24896259
nsv1137532 CNV deletion 24896259
nsv462460 CNV loss 19166990
nsv519808 CNV loss 19592680
nsv599820 CNV loss 21841781
nsv830504 CNV gain 17160897
nsv830505 CNV loss 17160897
nsv950412 CNV deletion 24416366

Variation tolerance for CXXC5 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXXC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXXC5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXXC5 Gene

Disorders for CXXC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CXXC5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
wilms tumor 1
  • wt1
- elite association - COSMIC cancer census association via MalaCards
Search CXXC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXXC5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXXC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXXC5 Gene

Publications for CXXC5 Gene

  1. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. (PMID: 19182210) Pendino F … Lillehaug JR (Blood 2009) 2 3 4 56
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 56
  3. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. (PMID: 23303788) Aras S … Grossman LI (Nucleic acids research 2013) 3 4 56
  4. Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. (PMID: 19865112) Carbuccia N … Mozziconacci MJ (Leukemia 2010) 3 43 56
  5. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. (PMID: 20220130) Kim MS … Lee SB (The Journal of biological chemistry 2010) 2 3 56

ExternalLinks

View latest publications for CXXC5 gene in Mastermind

Products for CXXC5 Gene

  • Addgene plasmids for CXXC5

Sources for CXXC5 Gene