Aliases for CXXC1 Gene
External Ids for CXXC1 Gene
Previous GeneCards Identifiers for CXXC1 Gene
This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015]
GeneCards Summary for CXXC1 Gene
CXXC1 (CXXC Finger Protein 1) is a Protein Coding gene. Diseases associated with CXXC1 include Zinc Finger Protein 1 and Gait Apraxia. Among its related pathways are Chromatin Regulation / Acetylation and Unfolded Protein Response (UPR). Gene Ontology (GO) annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and unmethylated CpG binding. An important paralog of this gene is TAF3.
UniProtKB/Swiss-Prot Summary for CXXC1 Gene
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.