Aliases for CXorf38 Gene

Aliases for CXorf38 Gene

  • Chromosome X Open Reading Frame 38 2 3 5
  • Uncharacterized Protein CXorf38 3 4
  • MGC39350 2
  • CXorf38 5

External Ids for CXorf38 Gene

Previous GeneCards Identifiers for CXorf38 Gene

  • GC0XM040244
  • GC0XM040373
  • GC0XM040488
  • GC0XM038197

Summaries for CXorf38 Gene

GeneCards Summary for CXorf38 Gene

CXorf38 (Chromosome X Open Reading Frame 38) is a Protein Coding gene.

Additional gene information for CXorf38 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXorf38 Gene

Genomics for CXorf38 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXorf38 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXorf38 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXorf38

Top Transcription factor binding sites by QIAGEN in the CXorf38 gene promoter:
  • AML1a
  • AP-4
  • CUTL1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Nkx2-5
  • SRF
  • STAT5A

Genomic Locations for CXorf38 Gene

Genomic Locations for CXorf38 Gene
chrX:40,626,921-40,647,678
(GRCh38/hg38)
Size:
20,758 bases
Orientation:
Minus strand
chrX:40,486,173-40,506,819
(GRCh37/hg19)
Size:
20,647 bases
Orientation:
Minus strand

Genomic View for CXorf38 Gene

Genes around CXorf38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf38 Gene

Proteins for CXorf38 Gene

  • Protein details for CXorf38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB03-CX038_HUMAN
    Recommended name:
    Uncharacterized protein CXorf38
    Protein Accession:
    Q8TB03
    Secondary Accessions:
    • B3KW28
    • D3DWB5
    • Q5JPF5
    • Q8N941

    Protein attributes for CXorf38 Gene

    Size:
    319 amino acids
    Molecular mass:
    36670 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CXorf38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf38 Gene

Post-translational modifications for CXorf38 Gene

  • Ubiquitination at Lys20 and Lys276
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CXorf38 Gene

Domains & Families for CXorf38 Gene

Gene Families for CXorf38 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf38 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CXorf38: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CXorf38 Gene

Function for CXorf38 Gene

genes like me logo Genes that share phenotypes with CXorf38: view

Animal Model Products

CRISPR Products

miRNA for CXorf38 Gene

miRTarBase miRNAs that target CXorf38

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXorf38

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf38 Gene

Localization for CXorf38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf38 gene
Compartment Confidence
cytosol 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CXorf38 Gene

Pathways & Interactions for CXorf38 Gene

PathCards logo

SuperPathways for CXorf38 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CXorf38 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf38 Gene

Drugs & Compounds for CXorf38 Gene

No Compound Related Data Available

Transcripts for CXorf38 Gene

mRNA/cDNA for CXorf38 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXorf38

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf38 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - -
SP4:

Relevant External Links for CXorf38 Gene

GeneLoc Exon Structure for
CXorf38

Expression for CXorf38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXorf38 Gene

mRNA differential expression in normal tissues according to GTEx for CXorf38 Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for CXorf38 Gene

This gene is overexpressed in Serum (36.9) and Bone (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXorf38 Gene



Protein tissue co-expression partners for CXorf38 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXorf38

SOURCE GeneReport for Unigene cluster for CXorf38 Gene:

Hs.495961
genes like me logo Genes that share expression patterns with CXorf38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf38 Gene

Orthologs for CXorf38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf38 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CXorf38 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CXHXorf38 30
  • 89.13 (n)
CXorf38 31
  • 88 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC616298 30
  • 89 (n)
CXorf38 31
  • 87 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 1810030O07Rik 30 17 31
  • 85.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1565685 30
  • 85.06 (n)
Oppossum
(Monodelphis domestica)
Mammalia CXorf38 31
  • 69 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CXorf38 31
  • 49 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cxorf38 30
  • 58.51 (n)
Str.9859 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.33719 30
Zebrafish
(Danio rerio)
Actinopterygii C25HXorf38 (1 of 2) 31
  • 2 (a)
OneToMany
C25HXorf38 (2 of 2) 31
  • 1 (a)
OneToMany
Species where no ortholog for CXorf38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CXorf38 Gene

ENSEMBL:
Gene Tree for CXorf38 (if available)
TreeFam:
Gene Tree for CXorf38 (if available)

Paralogs for CXorf38 Gene

No data available for Paralogs for CXorf38 Gene

Variants for CXorf38 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXorf38 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs17145855 - p.Thr176Ala

Additional dbSNP identifiers (rs#s) for CXorf38 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXorf38 Gene

Variant ID Type Subtype PubMed ID
dgv4229n106 CNV deletion 24896259
esv2550325 CNV deletion 19546169
esv2740109 CNV deletion 23290073
esv33829 CNV loss 17666407
esv3558808 CNV deletion 23714750
esv3576851 CNV gain 25503493
esv5571 CNV loss 19470904
nsv1148760 CNV deletion 26484159
nsv518965 CNV gain 19592680

Variation tolerance for CXorf38 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXorf38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXorf38 Gene

Disorders for CXorf38 Gene

No disorders were found for CXorf38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf38 Gene

Publications for CXorf38 Gene

  1. Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing. (PMID: 23768067) Anantharaman V … Aravind L (Biology direct 2013) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4

Products for CXorf38 Gene

Sources for CXorf38 Gene