Aliases for CXorf21 Gene

Aliases for CXorf21 Gene

  • Chromosome X Open Reading Frame 21 2 3 5
  • TLR Adaptor Interacting With SLC15A4 On The Lysosome 2 3
  • Protein CXorf21 3 4
  • TASL 2 3
  • Uncharacterized Protein CXorf21 3
  • 5430427O19Rik 3
  • FLJ11577 2
  • CXorf21 5

External Ids for CXorf21 Gene

Previous GeneCards Identifiers for CXorf21 Gene

  • GC0XM029939
  • GC0XM030336
  • GC0XM030486
  • GC0XM028314

Summaries for CXorf21 Gene

GeneCards Summary for CXorf21 Gene

CXorf21 (Chromosome X Open Reading Frame 21) is a Protein Coding gene. Diseases associated with CXorf21 include Systemic Lupus Erythematosus and Potocki-Shaffer Syndrome.

UniProtKB/Swiss-Prot Summary for CXorf21 Gene

  • Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. May be involved in endolysosomal-dependent immune responses.

Additional gene information for CXorf21 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXorf21 Gene

Genomics for CXorf21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXorf21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ030574 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 614.1 +1.5 1530 5.3 SP1 POLR2A BACH1 STAT3 RELA SMAD5 TCF12 IKZF2 RCOR1 PKNOX1 CXorf21 GK HSALNG0137188 NR0B1
GH0XJ030651 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22.5 -80.0 -80001 12.5 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 ZNF512 RFX1 LEF1 IKZF1 GK RF00017-8273 piR-57460-707 CXorf21 GK-AS1 GK-IT1 RF00017-8274 lnc-CXorf21-3 TAB3
GH0XJ030625 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.7 -49.9 -49909 3.5 GATAD2A ATF7 SOX13 RCOR2 FOXA1 RBFOX2 RXRB SP1 SOX6 CEBPA GK CXorf21 FTLP2 lnc-GK-6
GH0XJ030620 Enhancer 1 FANTOM5 ENCODE dbSUPER 22 -43.5 -43467 1 PRDM10 JUND CEBPB JUN FOS MEF2D FOSL1 ZNF395 MAFK ZNF589 GK CXorf21 lnc-GK-6 FTLP2
GH0XJ030886 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 -311.1 -311113 3.8 BRCA1 ARHGAP35 SP1 CREB1 PRDM10 ZNF629 SIX5 IKZF1 BACH1 JUND TAB3 CXorf21 piR-57135-143 HSALNG0137213 GK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXorf21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXorf21

Top Transcription factor binding sites by QIAGEN in the CXorf21 gene promoter:
  • AML1a
  • c-Rel
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B

Genomic Locations for CXorf21 Gene

Genomic Locations for CXorf21 Gene
18,958 bases
Minus strand
19,093 bases
Minus strand

Genomic View for CXorf21 Gene

Genes around CXorf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf21 Gene

Proteins for CXorf21 Gene

  • Protein details for CXorf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein CXorf21
    Protein Accession:

    Protein attributes for CXorf21 Gene

    301 amino acids
    Molecular mass:
    33894 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXorf21 Gene

Post-translational modifications for CXorf21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXorf21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXorf21 Gene

Domains & Families for CXorf21 Gene

Gene Families for CXorf21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CXorf21 Gene

  • Short-chain dehydrogenase/reductase SDR
genes like me logo Genes that share domains with CXorf21: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CXorf21 Gene

Function for CXorf21 Gene

Molecular function for CXorf21 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. May be involved in endolysosomal-dependent immune responses.
UniProtKB/Swiss-Prot Induction:
Escape from X chromosome inactivation results in an increased expression in females (PubMed:31092820, PubMed:31001245). In monocytes and B cells, induced by type I and type II interferons as well as LPS (PubMed:31092820).

Phenotypes From GWAS Catalog for CXorf21 Gene

genes like me logo Genes that share phenotypes with CXorf21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXorf21

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXorf21 Gene

Localization for CXorf21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXorf21 Gene

Nucleus. Cytoplasm. Note=May colocalize with TLR7 in the endosomal pathway. {ECO:0000269 PubMed:31092820}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXorf21 gene
Compartment Confidence
nucleus 4
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CXorf21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CXorf21: view

Pathways & Interactions for CXorf21 Gene

PathCards logo

SuperPathways for CXorf21 Gene

No Data Available

Interacting Proteins for CXorf21 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000368245 Q9HAI6-CX021_HUMAN for CXorf21 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CXorf21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035751 regulation of lysosomal lumen pH IDA 31001245
genes like me logo Genes that share ontologies with CXorf21: view

No data available for Pathways by source and SIGNOR curated interactions for CXorf21 Gene

Drugs & Compounds for CXorf21 Gene

No Compound Related Data Available

Transcripts for CXorf21 Gene

mRNA/cDNA for CXorf21 Gene

4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXorf21

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf21 Gene

No ASD Table

Relevant External Links for CXorf21 Gene

GeneLoc Exon Structure for

Expression for CXorf21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXorf21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Blood (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for CXorf21 Gene

This gene is overexpressed in Whole Blood (x15.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXorf21

SOURCE GeneReport for Unigene cluster for CXorf21 Gene:


mRNA Expression by UniProt/SwissProt for CXorf21 Gene:

Tissue specificity: Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level) (PubMed:31092820, PubMed:31001245). Expressed at low levels in T-cells and NK cells (PubMed:31001245).
genes like me logo Genes that share expression patterns with CXorf21: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXorf21 Gene

Orthologs for CXorf21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXorf21 31
  • 100 (a)
CXHXorf21 30
  • 99.56 (n)
(Canis familiaris)
Mammalia CXHXorf21 30
  • 88.96 (n)
CXorf21 31
  • 88 (a)
(Bos Taurus)
Mammalia C9HXorf21 30 31
  • 86.47 (n)
(Rattus norvegicus)
Mammalia RGD1565785 30
  • 85.46 (n)
(Mus musculus)
Mammalia 5430427O19Rik 30 17 31
  • 85.35 (n)
(Monodelphis domestica)
Mammalia CXorf21 31
  • 68 (a)
(Gallus gallus)
Aves C1HXorf21 30
  • 63.99 (n)
CXorf21 31
  • 54 (a)
(Anolis carolinensis)
Reptilia CXorf21 31
  • 52 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490948 30
  • 55.82 (n)
(Danio rerio)
Actinopterygii LOC796876 30
  • 50.16 (n)
Species where no ortholog for CXorf21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CXorf21 Gene

Gene Tree for CXorf21 (if available)
Gene Tree for CXorf21 (if available)

Paralogs for CXorf21 Gene Pseudogenes for CXorf21 Gene

genes like me logo Genes that share paralogs with CXorf21: view

No data available for Paralogs for CXorf21 Gene

Variants for CXorf21 Gene

Additional dbSNP identifiers (rs#s) for CXorf21 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXorf21 Gene

Variant ID Type Subtype PubMed ID
nsv510532 OTHER sequence alteration 20534489

Variation tolerance for CXorf21 Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXorf21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXorf21 Gene

Disorders for CXorf21 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CXorf21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
potocki-shaffer syndrome
  • pss
- elite association - COSMIC cancer census association via MalaCards


  • Note=Some alleles may be associated with systemic lupus erythematosus (SLE); a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Because it evades X-chromosome inactivation, its expression is increased in female immune cells which may be involved to SLE striking sex imbalance towards females. {ECO:0000269 PubMed:31001245, ECO:0000269 PubMed:31092820}.
genes like me logo Genes that share disorders with CXorf21: view

No data available for Genatlas for CXorf21 Gene

Publications for CXorf21 Gene

  1. Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. (PMID: 31092820) Odhams CA … Vyse TJ (Nature communications 2019) 2 3 4
  2. Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21. (PMID: 31001245) Harris VM … Scofield RH (Frontiers in immunology 2019) 2 3 4
  3. TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9. (PMID: 32433612) Heinz LX … Superti-Furga G (Nature 2020) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for CXorf21 Gene

Sources for CXorf21 Gene