Aliases for CXCR6 Gene
External Ids for CXCR6 Gene
Previous GeneCards Identifiers for CXCR6 Gene
The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]
GeneCards Summary for CXCR6 Gene
CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Type 1 Diabetes Mellitus 22 and Immune Deficiency Disease. Among its related pathways are Signaling by GPCR and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR6.
UniProtKB/Swiss-Prot Summary for CXCR6 Gene
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.