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Aliases for CXCR6 Gene

Aliases for CXCR6 Gene

  • C-X-C Motif Chemokine Receptor 6 2 3 5
  • Chemokine (C-X-C Motif) Receptor 6 2 3
  • G-Protein Coupled Receptor STRL33 3 4
  • G-Protein Coupled Receptor Bonzo 3 4
  • CDw186 3 4
  • CXC-R6 3 4
  • CXCR-6 3 4
  • STRL33 3 4
  • TYMSTR 3 4
  • BONZO 3 4
  • C-X-C Chemokine Receptor Type 6 3
  • G Protein-Coupled Receptor 3
  • CD186 Antigen 4
  • CD186 3

External Ids for CXCR6 Gene

Previous GeneCards Identifiers for CXCR6 Gene

  • GC03P045225
  • GC03P045804
  • GC03P045945
  • GC03P045959

Summaries for CXCR6 Gene

GeneCards Summary for CXCR6 Gene

CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Sarcoidosis 1 and Xanthogranulomatous Cholecystitis. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR6.

UniProtKB/Swiss-Prot for CXCR6 Gene

  • Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Gene Wiki entry for CXCR6 Gene

Additional gene information for CXCR6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR6 Gene

Genomics for CXCR6 Gene

GeneHancer (GH) Regulatory Elements for CXCR6 Gene

Promoters and enhancers for CXCR6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J045941 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 668.4 +6.9 6918 11.2 CTCF GATA3 MAFG NFE2 NFE2L2 CXCR6 FYCO1 CCR1
GH03J045938 Enhancer 1 ENCODE dbSUPER 669.3 -0.9 -859 2.2 HDGF CTCF TFAP4 USF1 RB1 MAX SIN3A EBF1 IRF4 RAD21 CXCR6 FYCO1 LZTFL1
GH03J045983 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 32.6 +46.6 46581 6.2 FOXA2 SIN3A DNMT3B ZNF48 RAD21 RARA YY1 EGR1 FOS THAP11 CXCR6 CCRL2 FYCO1 LZTFL1 CCR2 CCR5 CCR1 CCR3
GH03J045991 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.4 +53.6 53555 5.3 HDGF PKNOX1 ARID4B SIN3A IRF4 YY1 SLC30A9 POLR2B ZNF766 ZNF207 FYCO1 LOC105377063 CXCR6 CCDC12 SACM1L RN7SL145P CCR1 CCR5 CCR2
GH03J046088 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27.7 +154.9 154902 13.4 HDGF PKNOX1 STAT5A BMI1 BATF RAD21 IRF4 ZNF143 ATF7 FOS CCR1 CCRL2 CXCR6 FYCO1 CCR5 LOC102724297 CCR2 CCR3 CCDC12 LIMD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCR6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCR6 gene promoter:
  • E4BP4
  • HNF-1A
  • HNF-1
  • RORalpha1
  • AML1a
  • HFH-3
  • FOXI1
  • ATF-2

Genomic Locations for CXCR6 Gene

Genomic Locations for CXCR6 Gene
7,956 bases
Plus strand
7,421 bases
Plus strand

Genomic View for CXCR6 Gene

Genes around CXCR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR6 Gene

Proteins for CXCR6 Gene

  • Protein details for CXCR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C chemokine receptor type 6
    Protein Accession:
    Secondary Accessions:
    • O00575
    • Q9HCA5

    Protein attributes for CXCR6 Gene

    342 amino acids
    Molecular mass:
    39280 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCR6 Gene

Post-translational modifications for CXCR6 Gene

  • Glycosylation at posLast=1616
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR6 Gene

No data available for DME Specific Peptides for CXCR6 Gene

Domains & Families for CXCR6 Gene

Gene Families for CXCR6 Gene

Human Protein Atlas (HPA):
  • CD markers
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CXCR6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR6: view

Function for CXCR6 Gene

Molecular function for CXCR6 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Phenotypes From GWAS Catalog for CXCR6 Gene

Gene Ontology (GO) - Molecular Function for CXCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9166430
GO:0004950 chemokine receptor activity IEA --
GO:0015026 coreceptor activity TAS,IEA --
GO:0016494 C-X-C chemokine receptor activity IEA --
GO:0019958 C-X-C chemokine binding IEA --
genes like me logo Genes that share ontologies with CXCR6: view
genes like me logo Genes that share phenotypes with CXCR6: view

Animal Models for CXCR6 Gene

MGI Knock Outs for CXCR6:

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCR6

Clone Products

  • Addgene plasmids for CXCR6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR6 Gene

Localization for CXCR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR6 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for CXCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9166430
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CXCR6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCR6 Gene

Pathways & Interactions for CXCR6 Gene

genes like me logo Genes that share pathways with CXCR6: view

Gene Ontology (GO) - Biological Process for CXCR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0019079 viral genome replication TAS 9230441
genes like me logo Genes that share ontologies with CXCR6: view

No data available for SIGNOR curated interactions for CXCR6 Gene

Drugs & Compounds for CXCR6 Gene

(6) Drugs for CXCR6 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CXCL16 Pharma Full agonist, Agonist 0
Plerixafor 8HCl (AMD3100 8HCl) Pharma CXCR4 antagonist 0
WZ811 Pharma Competitive CXR4 antagonist,highly potent 0
[<SUP>125</SUP>I]CXCL16 (HUMAN) Pharma 0

(2) Additional Compounds for CXCR6 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
genes like me logo Genes that share compounds with CXCR6: view

Transcripts for CXCR6 Gene

mRNA/cDNA for CXCR6 Gene

Unigene Clusters for CXCR6 Gene

Chemokine (C-X-C motif) receptor 6:
Representative Sequences:

Clone Products

  • Addgene plasmids for CXCR6

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR6 Gene

No ASD Table

Relevant External Links for CXCR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCR6 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR6 Gene

This gene is overexpressed in Spleen (x8.9), Muscle - Skeletal (x5.6), Whole Blood (x5.3), and Small Intestine - Terminal Ileum (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of CXCR6 Gene:


SOURCE GeneReport for Unigene cluster for CXCR6 Gene:


mRNA Expression by UniProt/SwissProt for CXCR6 Gene:

Tissue specificity: Expressed in lymphoid tissues and activated T cells.

Evidence on tissue expression from TISSUES for CXCR6 Gene

  • Blood(4.4)
  • Pancreas(4)
  • Lymph node(2.4)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CXCR6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR6 Gene

Orthologs for CXCR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXCR6 34 33
  • 99.81 (n)
(Canis familiaris)
Mammalia CXCR6 34 33
  • 84.75 (n)
(Bos Taurus)
Mammalia CXCR6 34 33
  • 82.25 (n)
(Mus musculus)
Mammalia Cxcr6 16 34 33
  • 79.18 (n)
(Rattus norvegicus)
Mammalia Cxcr6 33
  • 78.04 (n)
(Monodelphis domestica)
Mammalia CXCR6 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia CXCR6 34
  • 53 (a)
(Anolis carolinensis)
Reptilia CXCR6 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cxcr6 33
  • 55.63 (n)
Species where no ortholog for CXCR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCR6 Gene

Gene Tree for CXCR6 (if available)
Gene Tree for CXCR6 (if available)
Evolutionary constrained regions (ECRs) for CXCR6: view image

Paralogs for CXCR6 Gene

(35) SIMAP similar genes for CXCR6 Gene using alignment to 2 proteins:

  • A0N0N3_HUMAN
genes like me logo Genes that share paralogs with CXCR6: view

Variants for CXCR6 Gene

Sequence variations from dbSNP and Humsavar for CXCR6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000801105 -- 45,943,382(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001167944 -- 45,940,976(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1001450996 -- 45,940,582(+) C/G upstream_transcript_variant
rs1001481492 -- 45,940,365(+) G/A upstream_transcript_variant
rs1001494356 -- 45,943,894(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCR6 Gene

Variant ID Type Subtype PubMed ID
nsv476148 CNV novel sequence insertion 20440878
nsv834678 CNV gain 17160897

Variation tolerance for CXCR6 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCR6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR6 Gene

Disorders for CXCR6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CXCR6 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
sarcoidosis 1
  • sarcoidosis, susceptibility to, 1
xanthogranulomatous cholecystitis
  • cx
- elite association - COSMIC cancer census association via MalaCards
Search CXCR6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCR6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR6 Gene

Publications for CXCR6 Gene

  1. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. (PMID: 9166430) Liao F … Farber JM (The Journal of experimental medicine 1997) 2 3 4 22 58
  2. Expression cloning of new receptors used by simian and human immunodeficiency viruses. (PMID: 9230441) Deng HK … Littman DR (Nature 1997) 2 3 4 58
  3. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. (PMID: 9285716) Loetscher M … Moser B (Current biology : CB 1997) 3 4 22 58
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58

Products for CXCR6 Gene

Sources for CXCR6 Gene

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