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CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Diabetes Mellitus, Insulin-Dependent, 22 and Sarcoidosis 1. Among its related pathways are Signaling by GPCR and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | TAS | 9166430 |
GO:0004950 | chemokine receptor activity | IEA | -- |
GO:0015026 | coreceptor activity | TAS,IEA | -- |
GO:0016493 | C-C chemokine receptor activity | IBA | 21873635 |
GO:0016494 | C-X-C chemokine receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 9166430 |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
.34
|
|
2 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
3 | Signaling by GPCR | ||
4 | CCR5 Pathway in Macrophages |
Chemokine Signaling
.33
|
|
5 | PEDF Induced Signaling |
STAT3 Pathway
.47
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006935 | chemotaxis | IBA | 21873635 |
GO:0006954 | inflammatory response | IEA | -- |
GO:0006955 | immune response | IBA | 21873635 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[<sup>125</sup>I]CXCL16 |
|
Agonist, Full agonist |
|
|
Compound | Action | Cas Number |
---|---|---|
Plerixafor 8HCl (AMD3100 8HCl) | CXCR4 antagonist | 155148-31-5 |
WZ811 | Competitive CXR4 antagonist,highly potent | 55778-02-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CXCR6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CXCR6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CXCR6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cxcr6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cxcr6 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CXCR6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CXCR6 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CXCR6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cxcr6 30 |
|
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716101 | Benign: not provided | 45,947,183(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
756060 | Likely Benign: not provided | 45,946,712(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
771134 | Benign: not provided | 45,947,033(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs2234355 | - | p.Glu3Lys | |||
VAR_003506 | - | p.Asp25Ala |
Disorder | Aliases | PubMed IDs |
---|---|---|
diabetes mellitus, insulin-dependent, 22 |
|
|
sarcoidosis 1 |
|
|
immune deficiency disease |
|