This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoform... See more...

Aliases for CXCR5 Gene

Aliases for CXCR5 Gene

  • C-X-C Motif Chemokine Receptor 5 2 3 5
  • MDR15 2 3 4
  • Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C Motif) Receptor 5) 2 3
  • Burkitt Lymphoma Receptor 1, GTP-Binding Protein 2 3
  • Chemokine (C-X-C Motif) Receptor 5 2 3
  • C-X-C Chemokine Receptor Type 5 3 4
  • Monocyte-Derived Receptor 15 3 4
  • CXC-R5 3 4
  • CXCR-5 3 4
  • MDR-15 3 4
  • CD185 2 3
  • BLR1 3 4
  • Burkitt Lymphoma Receptor 1 4
  • CD185 Antigen 4
  • CXCR5 5

External Ids for CXCR5 Gene

Previous HGNC Symbols for CXCR5 Gene

  • BLR1

Previous GeneCards Identifiers for CXCR5 Gene

  • GC11P118260
  • GC11P118754
  • GC11P114694
  • GC11P118884
  • GC11P118886
  • GC11P118892
  • GC11P118898
  • GC11P118901

Summaries for CXCR5 Gene

Entrez Gene Summary for CXCR5 Gene

  • This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CXCR5 Gene

CXCR5 (C-X-C Motif Chemokine Receptor 5) is a Protein Coding gene. Diseases associated with CXCR5 include Intraocular Lymphoma and Lymphoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR3.

UniProtKB/Swiss-Prot Summary for CXCR5 Gene

  • Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Gene Wiki entry for CXCR5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCR5 Gene

Genomics for CXCR5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXCR5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCR5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCR5

Top Transcription factor binding sites by QIAGEN in the CXCR5 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • STAT1

Genomic Locations for CXCR5 Gene

Latest Assembly
chr11:118,883,892-118,897,787
(GRCh38/hg38)
Size:
13,896 bases
Orientation:
Plus strand

Previous Assembly
chr11:118,754,601-118,768,496
(GRCh37/hg19 by Entrez Gene)
Size:
13,896 bases
Orientation:
Plus strand

chr11:118,754,475-118,768,508
(GRCh37/hg19 by Ensembl)
Size:
14,034 bases
Orientation:
Plus strand

Genomic View for CXCR5 Gene

Genes around CXCR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR5 Gene

Proteins for CXCR5 Gene

  • Protein details for CXCR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32302-CXCR5_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 5
    Protein Accession:
    P32302
    Secondary Accessions:
    • Q14811

    Protein attributes for CXCR5 Gene

    Size:
    372 amino acids
    Molecular mass:
    41955 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CXCR5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXCR5 Gene

Post-translational modifications for CXCR5 Gene

  • Glycosylation at Asn28 and Asn196
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for CXCR5
  • Santa Cruz Biotechnology (SCBT) Antibodies for CXCR5

No data available for DME Specific Peptides for CXCR5 Gene

Domains & Families for CXCR5 Gene

Gene Families for CXCR5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for CXCR5 Gene

InterPro:
Blocks:
  • Burkitt's lymphoma receptor signature

Suggested Antigen Peptide Sequences for CXCR5 Gene

GenScript: Design optimal peptide antigens:
  • C-x-c chemokine receptor type 5 (A0N0R2_HUMAN)
  • Monocyte-derived receptor 15 (CXCR5_HUMAN)
  • Chemokine (C-X-C motif) receptor 5 (Q2YD84_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32302

UniProtKB/Swiss-Prot:

CXCR5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR5: view

Function for CXCR5 Gene

Molecular function for CXCR5 Gene

UniProtKB/Swiss-Prot Function:
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Phenotypes From GWAS Catalog for CXCR5 Gene

Gene Ontology (GO) - Molecular Function for CXCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 1425907
GO:0005515 protein binding IPI 23773523
GO:0016493 C-C chemokine receptor activity IBA 21873635
GO:0016494 C-X-C chemokine receptor activity IEA --
GO:0019957 C-C chemokine binding IBA 21873635
genes like me logo Genes that share ontologies with CXCR5: view
genes like me logo Genes that share phenotypes with CXCR5: view

Animal Models for CXCR5 Gene

MGI Knock Outs for CXCR5:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCR5

Clone products for research

  • Addgene plasmids for CXCR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR5 Gene

Localization for CXCR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR5 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CXCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1425907
GO:0009897 external side of plasma membrane IEA,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CXCR5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCR5 Gene

Pathways & Interactions for CXCR5 Gene

genes like me logo Genes that share pathways with CXCR5: view

Gene Ontology (GO) - Biological Process for CXCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis IEA --
GO:0006955 immune response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IBA 21873635
genes like me logo Genes that share ontologies with CXCR5: view

No data available for SIGNOR curated interactions for CXCR5 Gene

Drugs & Compounds for CXCR5 Gene

(7) Drugs for CXCR5 Gene - From: ClinicalTrials, ApexBio, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Procaine Approved, Investigational, Vet_approved Pharma 52
CXCL13 Pharma Agonist, Full agonist 0
Anti-Retroviral Agents Pharma 4650
Plerixafor 8HCl (AMD3100 8HCl) Pharma CXCR4 antagonist 0
WZ811 Pharma Competitive CXR4 antagonist,highly potent 0

(4) Additional Compounds for CXCR5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for CXCR5 Gene

Compound Action Cas Number
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist 155148-31-5
WZ811 Competitive CXR4 antagonist,highly potent 55778-02-4
genes like me logo Genes that share compounds with CXCR5: view

Drug products for research

Transcripts for CXCR5 Gene

mRNA/cDNA for CXCR5 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCR5

Clone products for research

  • Addgene plasmids for CXCR5

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR5 Gene

No ASD Table

Relevant External Links for CXCR5 Gene

GeneLoc Exon Structure for
CXCR5

Expression for CXCR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCR5 Gene

This gene is overexpressed in Whole Blood (x14.9), Spleen (x14.1), and Small Intestine - Terminal Ileum (x9.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCR5

SOURCE GeneReport for Unigene cluster for CXCR5 Gene:

Hs.113916

mRNA Expression by UniProt/SwissProt for CXCR5 Gene:

P32302-CXCR5_HUMAN
Tissue specificity: Expression in mature B-cells and Burkitt lymphoma cells.

Evidence on tissue expression from TISSUES for CXCR5 Gene

  • Blood(4.7)
  • Spleen(3.8)
  • Lymph node(3.4)
  • Bone marrow(2.9)
  • Intestine(2.5)
  • Kidney(2.4)
  • Liver(2.2)
  • Nervous system(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CXCR5: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR5 Gene

Orthologs for CXCR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CXCR5 29 30
  • 99.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CXCR5 29 30
  • 87.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CXCR5 29
  • 86.56 (n)
BLR1 30
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cxcr5 29 16 30
  • 81.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cxcr5 29
  • 81 (n)
Oppossum
(Monodelphis domestica)
Mammalia CXCR5 30
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CXCR5 29 30
  • 58.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CXCR5 30
  • 44 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cxcr5 29
  • 53.63 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100537421 29
  • 52.93 (n)
CXCR5 30
  • 39 (a)
OneToOne
Species where no ortholog for CXCR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CXCR5 Gene

ENSEMBL:
Gene Tree for CXCR5 (if available)
TreeFam:
Gene Tree for CXCR5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCR5: view image
Alliance of Genome Resources:
Additional Orthologs for CXCR5

Paralogs for CXCR5 Gene

(31) SIMAP similar genes for CXCR5 Gene using alignment to 2 proteins:

  • CXCR5_HUMAN
  • Q2YD84_HUMAN
genes like me logo Genes that share paralogs with CXCR5: view

Variants for CXCR5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCR5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11574669 Benign: not provided 118,893,589(+) C/G
NM_001716.5(CXCR5):c.52-7C>G
FIVE_PRIME_UTR_VARIANT,INTRON
rs187389271 Likely Benign: not provided 118,894,456(+) C/T
NM_001716.5(CXCR5):c.912C>T (p.Ile304=)
SYNONYMOUS_VARIANT,THREE_PRIME_UTR
rs2230320 Benign: not provided 118,894,372(+) C/T
NM_001716.5(CXCR5):c.828C>T (p.His276=)
SYNONYMOUS_VARIANT,THREE_PRIME_UTR
VAR_035757 A breast cancer sample p.Glu34Lys
rs665648 -- p.Gly344Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CXCR5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CXCR5 Gene

Variant ID Type Subtype PubMed ID
nsv471861 CNV novel sequence insertion 20440878
nsv952743 CNV deletion 24416366

Variation tolerance for CXCR5 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCR5
Leiden Open Variation Database (LOVD)
CXCR5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR5 Gene

Disorders for CXCR5 Gene

MalaCards: The human disease database

(31) MalaCards diseases for CXCR5 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search CXCR5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCR5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CXCR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR5 Gene

Publications for CXCR5 Gene

  1. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. (PMID: 1425907) Dobner T … Lipp M (European journal of immunology 1992) 2 3 4 22
  2. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. (PMID: 9463416) Legler DF … Moser B (The Journal of experimental medicine 1998) 3 4 22
  3. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation. (PMID: 7639692) Barella L … Moser B (The Biochemical journal 1995) 3 4 22
  4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 40
  5. PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells. (PMID: 20412587) El Haibi CP … Lillard JW (Molecular cancer 2010) 3 22

Products for CXCR5 Gene

Sources for CXCR5 Gene