Aliases for CXCR4 Gene
- C-X-C Motif Chemokine Receptor 4 2 3 5
- LESTR 2 3 4
- Fusin 2 3 4
- HM89 2 3 4
- Leukocyte-Derived Seven Transmembrane Domain Receptor 3 4
- Lipopolysaccharide-Associated Protein 3 3 4
- Stromal Cell-Derived Factor 1 Receptor 3 4
- Chemokine (C-X-C Motif) Receptor 4 2 3
- C-X-C Chemokine Receptor Type 4 3 4
- LPS-Associated Protein 3 3 4
- SDF-1 Receptor 3 4
- CD184 Antigen 3 4
- D2S201E 2 3
- HSY3RR 2 3
- NPYY3R 2 3
- CD184 2 3
External Ids for CXCR4 Gene
Previous GeneCards Identifiers for CXCR4 Gene
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for CXCR4 Gene
CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome and Macroglobulinemia. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and fMLP Pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is CXCR2.
UniProtKB/Swiss-Prot Summary for CXCR4 Gene
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity).
(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus (PubMed:8849450, PubMed:8929542, PubMed:9427609, PubMed:10074122, PubMed:10756055).
Chemokine receptors are 7-transmembrane G protein-coupled receptors that are activated by the binding of one or more chemokines. Chemokines are a family of chemoattractant molecules with more than 50 having been identified to date. They are categorized according to the number and spacing of conserved cysteines into four main groups: CXC, CC, CX3C and C.