Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis. Among its related pathways are Signaling by GPCR and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CXCR2.
Chemokine CXC receptors (CXCRs) predominantly recognize CXC chemokines. CXC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being separated by a single amino acid. There are six chemokine CXC receptors.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004950 | chemokine receptor activity | TAS | 9064356 |
GO:0005515 | protein binding | IPI | 23170857 |
GO:0016493 | C-C chemokine receptor activity | IBA | 21873635 |
GO:0016494 | C-X-C chemokine receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | TAS | 10903743 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 9064356 |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
.34
|
|
2 | Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions | ||
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | Signaling by GPCR | ||
5 | CCR5 Pathway in Macrophages |
Chemokine Signaling
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0002685 | regulation of leukocyte migration | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
GO:0006935 | chemotaxis | IBA | 21873635 |
GO:0006954 | inflammatory response | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
[<sup>125</sup>I]CXCL10 |
|
Agonist, Full agonist |
|
|
||
[<sup>125</sup>I]CXCL11 |
|
Agonist, Full agonist |
|
|
||
SDF-1α |
|
Agonist, Full agonist |
|
Compound | Action | Cas Number |
---|---|---|
(±)-AMG 487 | CXCR3 antagonist | |
AMG 487 | CXCR3 antagonist,potent and selective | 473719-41-4 |
Plerixafor 8HCl (AMD3100 8HCl) | CXCR4 antagonist | 155148-31-5 |
SRT3109 | 1204707-71-0 | |
UNBS 5162 | A pan-antagonist of CXCL chemokines | 956590-23-1 |
WZ811 | Competitive CXR4 antagonist,highly potent | 55778-02-4 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CXCR3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CXCR3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CXCR3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cxcr3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cxcr3 30 17 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CXCR3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485636 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cxcr3.1 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
756288 | Likely Benign: not provided | 71,616,761(-) | G/A | SYNONYMOUS_VARIANT | |
770020 | Benign: not provided | 71,617,490(-) | T/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs139226823 | - | p.Arg292Gln | |||
rs766348940 | - | p.Ala363Thr |
Disorder | Aliases | PubMed IDs |
---|---|---|
cutaneous lupus erythematosus |
|
|
pulmonary sarcoidosis |
|
|
intermediate uveitis |
|
|
allergic contact dermatitis |
|
|
proliferative glomerulonephritis |
|