Aliases for CXCR3 Gene
Aliases for CXCR3 Gene
External Ids for CXCR3 Gene
- HGNC: 4540
- Entrez Gene: 2833
- Ensembl: ENSG00000186810
- OMIM: 300574
- UniProtKB: P49682
Previous HGNC Symbols for CXCR3 Gene
- GPR9
Previous GeneCards Identifiers for CXCR3 Gene
- GC0XM067009
- GC0XM068313
- GC0XM069068
- GC0XM069702
- GC0XM070618
- GC0XM070752
- GC0XM064650
- GC0XM070835
Summaries for CXCR3 Gene
-
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
GeneCards Summary for CXCR3 Gene
CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis. Among its related pathways are GPCRs, Other and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR10.
UniProtKB/Swiss-Prot for CXCR3 Gene
-
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
-
Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
-
Isoform 3: Mediates the activity of CXCL11.
-
Chemokine CXC receptors (CXCRs) predominantly recognize CXC chemokines. CXC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being separated by a single amino acid. There are six chemokine CXC receptors.
Additional gene information for CXCR3 Gene
- Monarch Initiative
- Search for CXCR3 at DataMed
- Search for CXCR3 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR3 Gene
Genomics for CXCR3 Gene
GeneHancer (GH) Regulatory Elements for CXCR3 Gene
Promoters and enhancers for CXCR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CXCR3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CXCR3 gene promoter:
-
- NF-kappaB1
- E2F-5
- E2F-4
- E2F-3a
- E2F-2
- E2F-1
- E2F
- En-1
- Lmo2
- PPAR-gamma2
Regulatory Element Products
Genomic Locations for CXCR3 Gene
Genomic Locations for CXCR3 Gene
- chrX:71,615,914-71,618,517
- (GRCh38/hg38)
- Size:
- 2,604 bases
- Orientation:
- Minus strand
- chrX:70,835,766-70,838,367
- (GRCh37/hg19)
- Size:
- 2,602 bases
- Orientation:
- Minus strand
Genomic View for CXCR3 Gene
Genes around CXCR3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq13.1 by Entrez Gene
- Xq13.1 by HGNC
- Xq13.1 by Ensembl
CXCR3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CXCR3 Gene
Proteins for CXCR3 Gene
-
Protein details for CXCR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49682-CXCR3_HUMAN
- Recommended name:
- C-X-C chemokine receptor type 3
- Protein Accession:
- P49682
- B2R982
- O15185
- Q7Z710
- Q9P2T4
- Q9P2T5
Protein attributes for CXCR3 Gene
- Size:
- 368 amino acids
- Molecular mass:
- 40660 Da
- Quaternary structure:
-
- Homomer. Forms heteromers with ACKR4.
Protein Expression for CXCR3 Gene
Post-translational modifications for CXCR3 Gene
- Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.
- N-glycosylated.
- Glycosylation at posLast=3232 and posLast=2222
- Modification sites at PhosphoSitePlus
Other Protein References for CXCR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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- Sino Biological Antibodies for CXCR3
Protein Products
-
OriGene Purified Proteins for CXCR3
- Search Origene for MassSpec and Protein Over-expression Lysates for CXCR3
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- antibodies-online: Search results for 7 available CXCR3 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for CXCR3
Assay Products
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No data available for DME Specific Peptides for CXCR3 Gene
Domains & Families for CXCR3 Gene
Gene Families for CXCR3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for CXCR3 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CXCR3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P49682- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for CXCR3 Gene
Molecular function for CXCR3 Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
- UniProtKB/Swiss-Prot Function:
- Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
- UniProtKB/Swiss-Prot Function:
- Isoform 3: Mediates the activity of CXCL11.
- GENATLAS Biochemistry:
- chemokine receptor 3 for the interferon gamma inducible proteins INP10,MIG mediating a rapid induction of effector in T lymphocytes,G protein coupled receptor superfamily
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | obsolete signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004950 | chemokine receptor activity | TAS | 9064356 |
| GO:0016494 | C-X-C chemokine receptor activity | IEA | -- |
| GO:0019956 | chemokine binding | IPI | 11554781 |
Phenotypes for CXCR3 Gene
- MGI mutant phenotypes for CXCR3:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CXCR3:
-
- Decreased viability ratio
- Synthetic lethal with imatinib mesylate
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased viability with neratinib
- Decreased viability
- no effect
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Increased cell number in S
- Increased transferrin (TF) endocytosis
Animal Models for CXCR3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CXCR3
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-
CRISPR Products
-
OriGene CRISPR knockouts for CXCR3
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- Overview of 119 available CXCR3 gene related products
- Applied Biological Materials CRISPR for CXCR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCR3
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miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCR3
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- genomics-online: shRNA clones - Search results for 119 available CXCR3 gene related products
- Overview of 119 available CXCR3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CXCR3
- Addgene plasmids for CXCR3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCR3
- Applied Biological Materials Clones for CXCR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CXCR3
Cell Line Products
-
Horizon Cell Lines for CXCR3
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CXCR3 Gene
Localization for CXCR3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CXCR3 Gene
- Isoform 1: Cell membrane; Multi-pass membrane protein.
- Isoform 2: Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 10903743 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 9064356 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCR3 Gene
Pathways & Interactions for CXCR3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors |
.34
|
|
| 2 | Akt Signaling |
.60
.60
|
|
| 3 | Signaling by GPCR | ||
| 4 | CCR5 Pathway in Macrophages | ||
| 5 | PEDF Induced Signaling |
.47
|
|
Pathways by source for CXCR3 Gene
4 BioSystems pathways for CXCR3 Gene
8 Reactome pathways for CXCR3 Gene
2 KEGG pathways for CXCR3 Gene
2 R&D Systems pathways for CXCR3 Gene
8 Qiagen pathways for CXCR3 Gene
Interacting Proteins for CXCR3 Gene
Selected Interacting proteins:
ENSP00000362795
P49682-CXCR3_HUMAN
for CXCR3 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for CXCR3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0002685 | regulation of leukocyte migration | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006935 | chemotaxis | TAS | 10903763 |
| GO:0006954 | inflammatory response | IEA | -- |
No data available for SIGNOR curated interactions for CXCR3 Gene
Drugs & Compounds for CXCR3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [<sup>125</sup>I]CXCL10 |
|
Full agonist, Agonist |
|
|
||
| [<sup>125</sup>I]CXCL11 |
|
Full agonist, Agonist |
|
|
||
| SDF-1alpha |
|
Agonist, Full agonist |
|
Drug Products
Transcripts for CXCR3 Gene
mRNA/cDNA for CXCR3 Gene
- (6) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (15) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000373691 1861 bps (uc011mpx.3)
- ENST00000373693 1624 bps (uc004eaf.3)
Unigene Clusters for CXCR3 Gene
- Chemokine (C-X-C motif) receptor 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CXCR3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CXCR3
- genomics-online: gRNA clones - Search results for 119 available CXCR3 gene related products
- Overview of 119 available CXCR3 gene related products
- Applied Biological Materials CRISPR for CXCR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CXCR3
- GenScript: Design CRISPR guide RNA sequences for CXCR3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CXCR3
- Browse OriGene Inhibitory RNA Products For CXCR3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCR3
- genomics-online: shRNA clones - Search results for 119 available CXCR3 gene related products
- Overview of 119 available CXCR3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CXCR3
- Addgene plasmids for CXCR3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CXCR3
- Applied Biological Materials Clones for CXCR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CXCR3
Expression for CXCR3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CXCR3 Gene
This gene is overexpressed in Whole Blood (x8.8), Spleen (x7.7), and Small Intestine - Terminal Ileum (x5.2).
This gene is overexpressed in CD8 Tcells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCR3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CXCR3 Gene:
CXCR3SOURCE GeneReport for Unigene cluster for CXCR3 Gene:
Hs.198252mRNA Expression by UniProt/SwissProt for CXCR3 Gene:
P49682-CXCR3_HUMAN
Tissue specificity:
Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).
Evidence on tissue expression from TISSUES for CXCR3 Gene
- Blood(4.6)
- Intestine(4.4)
- Lung(4.4)
- Nervous system(4.4)
- Heart(4.3)
- Lymph node(2.9)
- Spleen(2.7)
- Skin(2.1)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for CXCR3
-
OriGene qPCR primer pairs and template standards for CXCR3
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR3 Gene
Orthologs for CXCR3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CXCR3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CXCR3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CXCR3 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cxcr3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cxcr3 16 34 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CXCR3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100485636 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cxcr3.1 34 33 |
|
OneToOne |
- Species where no ortholog for CXCR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CXCR3 Gene
- ENSEMBL:
- Gene Tree for CXCR3 (if available)
- TreeFam:
- Gene Tree for CXCR3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CXCR3: view image
Paralogs for CXCR3 Gene
Paralogs for CXCR3 Gene
(34) SIMAP similar genes for CXCR3 Gene using alignment to 1 proteins:
- CXCR3_HUMAN
Variants for CXCR3 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1003951195 | -- | 71,619,088(-) | C/T | upstream_transcript_variant | |
| rs1004086764 | -- | 71,618,592(-) | C/G | upstream_transcript_variant | |
| rs1004470882 | -- | 71,617,658(-) | T/C | 5_prime_UTR_variant, intron_variant | |
| rs1005095693 | -- | 71,615,500(-) | G/T | downstream_transcript_variant | |
| rs1005472899 | -- | 71,620,010(-) | C/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.14;
3.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CXCR3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR3 Gene
Disorders for CXCR3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cutaneous lupus erythematosus |
|
|
| pulmonary sarcoidosis |
|
|
| intermediate uveitis |
|
|
| mycosis fungoides |
|
|
| allergic contact dermatitis |
|
Search CXCR3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CXCR3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR3 Gene
Publications for CXCR3 Gene
- CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. (PMID: 16847335) Colvin RA … Luster AD (Molecular and cellular biology 2006) 3 4 22 58
- An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. (PMID: 12782716) Lasagni L … Romagnani P (The Journal of experimental medicine 2003) 3 4 22 58
- Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. (PMID: 11196695) Kato H … Tokunaga K (Genes and immunity 2000) 3 4 44 58
- Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. (PMID: 9625760) Cole KE … Neote K (The Journal of experimental medicine 1998) 3 4 22 58
- Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PMID: 9064356) Loetscher M … Moser B (The Journal of experimental medicine 1996) 2 3 4 58
Products for CXCR3 Gene
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Sources for CXCR3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt