The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activi... See more...

Aliases for CXCR2 Gene

Aliases for CXCR2 Gene

  • C-X-C Motif Chemokine Receptor 2 2 3 5
  • High Affinity Interleukin-8 Receptor B 3 4
  • C-X-C Chemokine Receptor Type 2 3 4
  • Interleukin 8 Receptor, Beta 2 3
  • IL-8 Receptor Type 2 3 4
  • GRO/MGSA Receptor 3 4
  • CDw128b 3 4
  • IL-8R B 3 4
  • CMKAR2 2 3
  • CXC-R2 3 4
  • CXCR-2 3 4
  • CD182 2 3
  • IL8RB 3 4
  • Chemokine (C-X-C Motif) Receptor 2 2
  • CXCR2 Gene For IL8 Receptor Type B 3
  • Interleukin 8 Receptor Type 2 3
  • Interleukin-8 Receptor Type B 3
  • Chemokine (CXC) Receptor 2 3
  • CD182 Antigen 4
  • IL8R2 3
  • IL8RA 3
  • CXCR2 5

External Ids for CXCR2 Gene

Previous HGNC Symbols for CXCR2 Gene

  • IL8RB

Previous GeneCards Identifiers for CXCR2 Gene

  • GC02P218699
  • GC02P218991
  • GC02P210842
  • GC02P218994
  • GC02P219006
  • GC02P219012
  • GC02P219021

Summaries for CXCR2 Gene

Entrez Gene Summary for CXCR2 Gene

  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

GeneCards Summary for CXCR2 Gene

CXCR2 (C-X-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CXCR2 include Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency and Human Granulocytic Anaplasmosis. Among its related pathways are Insulin receptor recycling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CXCR1.

UniProtKB/Swiss-Prot Summary for CXCR2 Gene

  • Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Tocris Summary for CXCR2 Gene

  • Chemokine CXC receptors (CXCRs) predominantly recognize CXC chemokines. CXC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being separated by a single amino acid. There are six chemokine CXC receptors.

Gene Wiki entry for CXCR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCR2 Gene

Genomics for CXCR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXCR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218124 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 250.7 +0.5 463 2.5 CTCF ZNF341 SPI1 POLR2A REST MNT CXCR2 NONHSAG030514.2 ENSG00000261338 CXCR1 HSALNG0022229
GH02J218128 Promoter 0.8 EPDnew Ensembl 250.7 +4.2 4212 0.6 SPI1 CEBPB CXCR2 HSALNG0022229 ENSG00000261338 NONHSAG030514.2 NONHSAG030515.2 CXCR1
GH02J218145 Enhancer 1.2 FANTOM5 Ensembl ENCODE 89.4 +26.3 26311 13.2 CEBPA CTCF THAP11 SMAD4 MIER3 GABPB1 FOSL2 FOXP1 JUND BCL6 CXCR2 CXCR1 ENSG00000261338 ARPC2 TNS1 SLC11A1 GPBAR1 CTDSP1 CATIP piR-37170-040
GH02J218366 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.3 +244.6 244555 6.9 ZNF207 IKZF1 MYC ZNF592 POLR2A CEBPA NFIC YY1 CTCF SMAD5 CATIP-AS1 lnc-CATIP-1 SLC11A1 ENSG00000261338 ARPC2 CXCR2 CXCR1 CATIP PNKD CNOT9
GH02J217926 Promoter/Enhancer 2.5 VISTA EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.1 -189.7 -189730 18.3 JUND ZMYM3 ATF3 POLR2A ZIC2 CHD4 YY1 HOMEZ CTCF ZNF217 TNS1 SLC11A1 TNS1-AS1 PNKD CXCR2 ARPC2 TMBIM1 HSALNG0022217 MIR6809
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCR2

Genomic Locations for CXCR2 Gene

Latest Assembly
chr2:218,125,289-218,137,253
(GRCh38/hg38)
Size:
11,965 bases
Orientation:
Plus strand

Previous Assembly
chr2:218,990,017-219,001,974
(GRCh37/hg19 by Entrez Gene)
Size:
11,958 bases
Orientation:
Plus strand

chr2:218,990,012-219,001,976
(GRCh37/hg19 by Ensembl)
Size:
11,965 bases
Orientation:
Plus strand

Genomic View for CXCR2 Gene

Genes around CXCR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR2 Gene

Proteins for CXCR2 Gene

  • Protein details for CXCR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25025-CXCR2_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 2
    Protein Accession:
    P25025
    Secondary Accessions:
    • Q8IUZ1
    • Q9P2T6
    • Q9P2T7

    Protein attributes for CXCR2 Gene

    Size:
    360 amino acids
    Molecular mass:
    40759 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCR2 Gene

neXtProt entry for CXCR2 Gene

Post-translational modifications for CXCR2 Gene

  • Phosphorylated upon ligand binding; which is required for desensitization.
  • (Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis.
  • Glycosylation at Asn22
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for CXCR2

No data available for DME Specific Peptides for CXCR2 Gene

Domains & Families for CXCR2 Gene

Gene Families for CXCR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CXCR2 Gene

InterPro:
Blocks:
  • Interleukin-8 receptor signature
  • Interleukin 8B receptor signature

Suggested Antigen Peptide Sequences for CXCR2 Gene

GenScript: Design optimal peptide antigens:
  • IL-8 receptor type 2 (CXCR2_HUMAN)
  • cDNA, FLJ93056, Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNA (Q53PC4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25025

UniProtKB/Swiss-Prot:

CXCR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR2: view

Function for CXCR2 Gene

Molecular function for CXCR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Phenotypes From GWAS Catalog for CXCR2 Gene

Gene Ontology (GO) - Molecular Function for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004918 interleukin-8 receptor activity IDA 10820279
GO:0004930 G protein-coupled receptor activity IEA,IDA 10438939
GO:0005515 protein binding IPI 17435771
GO:0016493 C-C chemokine receptor activity IBA 21873635
GO:0016494 C-X-C chemokine receptor activity IEA,IDA 10878382
genes like me logo Genes that share ontologies with CXCR2: view
genes like me logo Genes that share phenotypes with CXCR2: view

Animal Models for CXCR2 Gene

MGI Knock Outs for CXCR2:
  • Cxcr2 Cxcr2<tm1Mwm>
  • Cxcr2 Cxcr2<tm1a(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR2 Gene

Localization for CXCR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
lysosome 5
cytoskeleton 4
extracellular 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
  • Microtubules (2)
  • Mitotic spindle (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 10438939
GO:0009897 external side of plasma membrane IBA 21873635
GO:0009986 cell surface IDA 10878382
genes like me logo Genes that share ontologies with CXCR2: view

Pathways & Interactions for CXCR2 Gene

genes like me logo Genes that share pathways with CXCR2: view

Pathways by source for CXCR2 Gene

1 GeneGo (Thomson Reuters) pathway for CXCR2 Gene
  • Inhibitory action of Lipoxins on neutrophil migration
8 Qiagen pathways for CXCR2 Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Molecular Mechanisms of Cancer
  • p38 Signaling

SIGNOR curated interactions for CXCR2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CXCR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006935 chemotaxis IEA,IDA 10725748
GO:0006954 inflammatory response TAS 9725262
GO:0006955 immune response IBA 21873635
GO:0006968 cellular defense response IDA 10725748
genes like me logo Genes that share ontologies with CXCR2: view

Drugs & Compounds for CXCR2 Gene

(45) Drugs for CXCR2 Gene - From: ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Reparixin Investigational Pharma Inhibitor of CXCL8 receptor and CXCR1/CXCR2 activation 0
SB 225002 Pharma Antagonist CXCR2 antagonist, potent and selective, Potent and selective CXCR2 antagonist 0
[<sup>125</sup>I]CXCL8 (human) Pharma Agonist, Full agonist 0
CXCL1 Pharma Agonist, Full agonist 0
CXCL2 Pharma Agonist, Full agonist 0

(21) Additional Compounds for CXCR2 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]CXCL1
Agonist, Full agonist
[<sup>125</sup>I]CXCL5
Agonist, Full agonist
[<sup>125</sup>I]CXCL7
Agonist, Full agonist
Lyn peptide inhibitor
222018-18-0
R 7050
303997-35-5

(5) Tocris Compounds for CXCR2 Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8

(9) ApexBio Compounds for CXCR2 Gene

Compound Action Cas Number
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist 155148-31-5
Reparixin Inhibitor of CXCL8 receptor and CXCR1/CXCR2 activation 266359-83-5
Reparixin L-lysine salt CXCR1/CXCR2 inhibitor 266359-93-7
SB 225002 CXCR2 antagonist, potent and selective 182498-32-4
SB 265610 CXCR2 antagonist, potent 211096-49-0
SCH 527123 CXCR1 and CXCR2 receptors antagonist 473727-83-2
SCH 563705 CXCR2/CXCR1 antagonist,potent 473728-58-4
SRT3190 CXCR2 ligand,SIRT1 activator 1204707-73-2
WZ811 Competitive CXR4 antagonist,highly potent 55778-02-4
genes like me logo Genes that share compounds with CXCR2: view

Drug products for research

Transcripts for CXCR2 Gene

mRNA/cDNA for CXCR2 Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCR2

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for CXCR2 Gene

GeneLoc Exon Structure for
CXCR2

Expression for CXCR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCR2 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR2 Gene

This gene is overexpressed in Whole Blood (x48.3).

Protein differential expression in normal tissues from HIPED for CXCR2 Gene

This gene is overexpressed in Nasal epithelium (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCR2 Gene



Protein tissue co-expression partners for CXCR2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCR2

SOURCE GeneReport for Unigene cluster for CXCR2 Gene:

Hs.846

Evidence on tissue expression from TISSUES for CXCR2 Gene

  • Blood(4.8)
  • Nervous system(4.5)
  • Spleen(3.1)
  • Intestine(2.9)
  • Bone marrow(2.7)
  • Lung(2.6)
  • Heart(2.6)
  • Lymph node(2.5)
  • Skin(2.4)
  • Liver(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with CXCR2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR2 Gene

Orthologs for CXCR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CXCR2 29 30
  • 99.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CXCR2 29 30
  • 82.25 (n)
OneToMany
-- 30
  • 73 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia CXCR2 29 30 30
  • 80.73 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Cxcr2 29 16 30
  • 77.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cxcr2 29
  • 76.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 70 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 59 (a)
ManyToMany
-- 30
  • 59 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 57 (a)
ManyToMany
-- 30
  • 56 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101732165 29
  • 65.33 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC796724 29
  • 55.25 (n)
CXCR1 30
  • 43 (a)
OneToMany
Species where no ortholog for CXCR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CXCR2 Gene

ENSEMBL:
Gene Tree for CXCR2 (if available)
TreeFam:
Gene Tree for CXCR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCR2: view image
Alliance of Genome Resources:
Additional Orthologs for CXCR2

Paralogs for CXCR2 Gene

Pseudogenes.org Pseudogenes for CXCR2 Gene

genes like me logo Genes that share paralogs with CXCR2: view

Variants for CXCR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCR2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs11574751 Benign: not provided 218,135,842(+) C/T
NM_001557.4(CXCR2):c.1041C>T (p.Ser347=)
SYNONYMOUS
rs141723765 Likely Benign: not provided 218,135,464(+) C/T
NM_001557.4(CXCR2):c.663C>T (p.Ile221=)
SYNONYMOUS
rs142762038 Benign: not provided 218,134,891(+) C/T
NM_001557.4(CXCR2):c.90C>T (p.Pro30=)
SYNONYMOUS
rs144013681 Uncertain Significance: not provided 218,135,508(+) G/A
NM_001557.4(CXCR2):c.707G>A (p.Arg236His)
MISSENSE
rs148935180 Likely Benign: not provided 218,134,888(+) G/T
NM_001557.4(CXCR2):c.87G>T (p.Leu29=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CXCR2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CXCR2 Gene

Variant ID Type Subtype PubMed ID
nsv961560 CNV duplication 23825009

Variation tolerance for CXCR2 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCR2 Gene

Human Gene Mutation Database (HGMD)
CXCR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCR2
Leiden Open Variation Database (LOVD)
CXCR2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR2 Gene

Disorders for CXCR2 Gene

MalaCards: The human disease database

(29) MalaCards diseases for CXCR2 Gene - From: ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search CXCR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCR2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CXCR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR2 Gene

Publications for CXCR2 Gene

  1. Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. (PMID: 11196695) Kato H … Tokunaga K (Genes and immunity 2000) 3 4 22
  2. Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor. (PMID: 9079638) Mueller SG … Richmond A (The Journal of biological chemistry 1997) 3 4 22
  3. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. (PMID: 7929358) Ahuja SK … Murphy PM (The Journal of biological chemistry 1994) 3 4 22
  4. Characterization of two high affinity human interleukin-8 receptors. (PMID: 1379593) Lee J … Wood WI (The Journal of biological chemistry 1992) 3 4 22
  5. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (PMID: 1427896) Morris SW … Cerretti DP (Genomics 1992) 2 3 22

Products for CXCR2 Gene

  • Addgene plasmids for CXCR2

Sources for CXCR2 Gene