The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing sp... See more...

Aliases for CXCR1 Gene

Aliases for CXCR1 Gene

  • C-X-C Motif Chemokine Receptor 1 2 3 5
  • CDw128a 2 3 4
  • High Affinity Interleukin-8 Receptor A 3 4
  • Chemokine (C-X-C Motif) Receptor 1 2 3
  • C-X-C Chemokine Receptor Type 1 3 4
  • Interleukin 8 Receptor, Alpha 2 3
  • IL-8 Receptor Type 1 3 4
  • IL-8R A 3 4
  • CMKAR1 3 4
  • CXC-R1 3 4
  • CXCR-1 3 4
  • CD181 2 3
  • CKR-1 2 3
  • IL8RA 3 4
  • Interleukin-8 Receptor Type 1 3
  • Interleukin-8 Receptor Type A 3
  • CD181 Antigen 4
  • C-C-CKR-1 3
  • IL8RBA 3
  • CD128 3
  • IL8R1 3
  • CXCR1 5
  • C-C 3

External Ids for CXCR1 Gene

Previous HGNC Symbols for CXCR1 Gene

  • CMKAR1
  • IL8RA

Previous GeneCards Identifiers for CXCR1 Gene

  • GC02M218736
  • GC02M219028
  • GC02M210880

Summaries for CXCR1 Gene

Entrez Gene Summary for CXCR1 Gene

  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

GeneCards Summary for CXCR1 Gene

CXCR1 (C-X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include Human Immunodeficiency Virus Type 1 and Acute Pyelonephritis. Among its related pathways are Insulin receptor recycling and Cell adhesion_ECM remodeling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and interleukin-8 binding. An important paralog of this gene is CXCR2.

UniProtKB/Swiss-Prot Summary for CXCR1 Gene

  • Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Gene Wiki entry for CXCR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCR1 Gene

Genomics for CXCR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXCR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218171 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 250.7 +0.0 18 0.3 CTCF CXCR1 piR-37170-040 CXCR2
GH02J218167 Promoter 0.4 Ensembl 250.7 +0.9 861 0.2 CEBPB CXCR1 piR-37170-040 CXCR2
GH02J218166 Promoter 0.3 Ensembl 250.7 +0.5 461 0.2 CXCR1 piR-37170-040 CXCR2
GH02J218173 Enhancer 0.3 ENCODE 250.7 -0.5 -545 0.7 CTCF CXCR1 ARPC2 GPBAR1 HSALNG0022231
GH02J218145 Enhancer 1.2 FANTOM5 Ensembl ENCODE 56 +15.4 15362 13.2 CEBPA CTCF THAP11 SMAD4 MIER3 GABPB1 FOSL2 FOXP1 JUND BCL6 CXCR2 CXCR1 ENSG00000261338 ARPC2 TNS1 SLC11A1 GPBAR1 CTDSP1 CATIP piR-37170-040
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCR1

Genomic Locations for CXCR1 Gene

Latest Assembly
chr2:218,162,841-218,166,962
(GRCh38/hg38)
Size:
4,122 bases
Orientation:
Minus strand

Previous Assembly
chr2:219,027,564-219,031,685
(GRCh37/hg19 by Entrez Gene)
Size:
4,122 bases
Orientation:
Minus strand

chr2:219,027,568-219,031,718
(GRCh37/hg19 by Ensembl)
Size:
4,151 bases
Orientation:
Minus strand

Genomic View for CXCR1 Gene

Genes around CXCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR1 Gene

Proteins for CXCR1 Gene

  • Protein details for CXCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25024-CXCR1_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 1
    Protein Accession:
    P25024
    Secondary Accessions:
    • B2R6Q3
    • Q2YEF8
    • Q2YEG4
    • Q2YEG5
    • Q2YEG7
    • Q2YEG8
    • Q53R18
    • Q6IN95
    • Q8N6T6
    • Q9P2T8
    • Q9P2T9
    • Q9P2U0
    • Q9P2U1
    • Q9P2U2

    Protein attributes for CXCR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    39791 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCR1 Gene

neXtProt entry for CXCR1 Gene

Post-translational modifications for CXCR1 Gene

  • Glycosylation at Asn3 and Asn16
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for CXCR1
  • Santa Cruz Biotechnology (SCBT) Antibodies for CXCR1

No data available for DME Specific Peptides for CXCR1 Gene

Domains & Families for CXCR1 Gene

Gene Families for CXCR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for CXCR1 Gene

InterPro:
Blocks:
  • Interleukin-8 receptor signature
  • Interleukin 8A receptor signature

Suggested Antigen Peptide Sequences for CXCR1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51527, moderately similar to High affinity interleukin-8 receptor A (B4DQ59_HUMAN)
  • IL-8 receptor type 1 (CXCR1_HUMAN)
  • Interleukin-8 receptor type A (Q6LCZ9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25024

UniProtKB/Swiss-Prot:

CXCR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR1: view

Function for CXCR1 Gene

Molecular function for CXCR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Phenotypes From GWAS Catalog for CXCR1 Gene

Gene Ontology (GO) - Molecular Function for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004918 interleukin-8 receptor activity IDA 10734056
GO:0004930 G protein-coupled receptor activity TAS 8381837
GO:0004950 chemokine receptor activity TAS 1840701
GO:0005515 protein binding IPI 32296183
GO:0016493 C-C chemokine receptor activity IBA 21873635
genes like me logo Genes that share ontologies with CXCR1: view
genes like me logo Genes that share phenotypes with CXCR1: view

Animal Models for CXCR1 Gene

MGI Knock Outs for CXCR1:
  • Cxcr1 Cxcr1<tm1Dgen>
  • Cxcr1 Cxcr1<tm1a(EUCOMM)Wtsi>

miRNA for CXCR1 Gene

miRTarBase miRNAs that target CXCR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR1 Gene

Localization for CXCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with CXCR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCR1 Gene

Pathways & Interactions for CXCR1 Gene

genes like me logo Genes that share pathways with CXCR1: view

Pathways by source for CXCR1 Gene

3 GeneGo (Thomson Reuters) pathways for CXCR1 Gene
  • Cell adhesion_ECM remodeling
  • Inhibitory action of Lipoxins on neutrophil migration
  • Inhibitory action of Lipoxins on Superoxide production in neutrophils
8 Qiagen pathways for CXCR1 Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Molecular Mechanisms of Cancer
  • p38 Signaling

SIGNOR curated interactions for CXCR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006935 chemotaxis IEA --
GO:0006955 immune response IBA 21873635
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IDA 10734056
genes like me logo Genes that share ontologies with CXCR1: view

Drugs & Compounds for CXCR1 Gene

(35) Drugs for CXCR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ketoprofen Approved, Vet_approved Pharma Target, other 102
Reparixin Investigational Pharma Inhibitor of CXCL8 receptor and CXCR1/CXCR2 activation 0
[<sup>125</sup>I]CXCL8 (human) Pharma Agonist, Full agonist 0
[<sup>125</sup>I]mini-TyrRS Pharma Agonist, Full agonist 0
CXCL1 Pharma Agonist, Full agonist 0

(23) Additional Compounds for CXCR1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lyn peptide inhibitor
222018-18-0
R 7050
303997-35-5

(5) Tocris Compounds for CXCR1 Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8

(6) ApexBio Compounds for CXCR1 Gene

Compound Action Cas Number
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist 155148-31-5
Reparixin Inhibitor of CXCL8 receptor and CXCR1/CXCR2 activation 266359-83-5
Reparixin L-lysine salt CXCR1/CXCR2 inhibitor 266359-93-7
SCH 527123 CXCR1 and CXCR2 receptors antagonist 473727-83-2
SCH 563705 CXCR2/CXCR1 antagonist,potent 473728-58-4
WZ811 Competitive CXR4 antagonist,highly potent 55778-02-4
genes like me logo Genes that share compounds with CXCR1: view

Drug products for research

Transcripts for CXCR1 Gene

mRNA/cDNA for CXCR1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCR1

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR1 Gene

No ASD Table

Relevant External Links for CXCR1 Gene

GeneLoc Exon Structure for
CXCR1

Expression for CXCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR1 Gene

This gene is overexpressed in Whole Blood (x50.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCR1

SOURCE GeneReport for Unigene cluster for CXCR1 Gene:

Hs.194778

Evidence on tissue expression from TISSUES for CXCR1 Gene

  • Blood(5)
  • Spleen(3.3)
  • Intestine(2.7)
  • Heart(2.5)
  • Bone marrow(2.4)
  • Lung(2.3)
  • Pancreas(2.2)
  • Kidney(2.2)
  • Lymph node(2.2)
  • Muscle(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with CXCR1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR1 Gene

Orthologs for CXCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CXCR1 29 30
  • 99.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cxcr1 29 16 30
  • 75.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cxcr1 29
  • 75.64 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 69 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 59 (a)
ManyToMany
-- 30
  • 59 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves CXCR2 29
  • 62.12 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 57 (a)
ManyToMany
-- 30
  • 56 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia CXCR2 29
Zebrafish
(Danio rerio)
Actinopterygii CXCR1 30
  • 43 (a)
OneToMany
Species where no ortholog for CXCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CXCR1 Gene

ENSEMBL:
Gene Tree for CXCR1 (if available)
TreeFam:
Gene Tree for CXCR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCR1: view image
Alliance of Genome Resources:
Additional Orthologs for CXCR1

Paralogs for CXCR1 Gene

Variants for CXCR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCR1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
992524 Uncertain Significance: Human immunodeficiency virus type 1, susceptibility to 218,165,209(-) C/T
NM_000634.3(CXCR1):c.3G>A (p.Met1Ile)
INITIATIOR_CODON_VARIANT,MISSENSE
rs142076386 Benign: not provided 218,164,579(-) G/T
NM_000634.3(CXCR1):c.633C>A (p.Phe211Leu)
MISSENSE
rs16858806 Benign: not provided 218,164,187(-) G/Ap.Ser342Leu
NM_000634.3(CXCR1):c.1025C>T (p.Ser342Leu)
MISSENSE
rs3092972 Benign: not provided 218,164,924(-) G/A
NM_000634.3(CXCR1):c.288C>T (p.Ala96=)
SYNONYMOUS
rs538588993 Uncertain Significance: not provided 218,164,604(-) C/T
NM_000634.3(CXCR1):c.608G>A (p.Arg203Gln)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CXCR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CXCR1 Gene

Variant ID Type Subtype PubMed ID
esv3594329 CNV gain 21293372
esv3594330 CNV gain 21293372
nsv3164 CNV insertion 18451855

Variation tolerance for CXCR1 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCR1 Gene

Human Gene Mutation Database (HGMD)
CXCR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCR1
Leiden Open Variation Database (LOVD)
CXCR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR1 Gene

Disorders for CXCR1 Gene

MalaCards: The human disease database

(23) MalaCards diseases for CXCR1 Gene - From: OMI, GTR, COP, and GCD

Disorder Aliases PubMed IDs
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
acute pyelonephritis
bacteriuria
pyelonephritis
aggressive nk-cell leukemia
  • aggressive nk-cell leukaemia
- elite association - COSMIC cancer census association via MalaCards
Search CXCR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CXCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR1 Gene

Publications for CXCR1 Gene

  1. Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils. (PMID: 16205979) Liu Y … Su B (Journal of molecular evolution 2005) 3 4 22
  2. Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. (PMID: 11196695) Kato H … Tokunaga K (Genes and immunity 2000) 3 4 22
  3. Characterization of two high affinity human interleukin-8 receptors. (PMID: 1379593) Lee J … Wood WI (The Journal of biological chemistry 1992) 3 4 22
  4. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (PMID: 1427896) Morris SW … Cerretti DP (Genomics 1992) 2 3 22
  5. Structure and functional expression of a human interleukin-8 receptor. (PMID: 1840701) Holmes WE … Wood WI (Science (New York, N.Y.) 1991) 3 4 22

Products for CXCR1 Gene

  • Addgene plasmids for CXCR1

Sources for CXCR1 Gene