Aliases for CXCR1 Gene
External Ids for CXCR1 Gene
Previous HGNC Symbols for CXCR1 Gene
Previous GeneCards Identifiers for CXCR1 Gene
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
GeneCards Summary for CXCR1 Gene
CXCR1 (C-X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include Human Immunodeficiency Virus Type 1 and Acute Pyelonephritis. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and interleukin-8 binding. An important paralog of this gene is CXCR2.
UniProtKB/Swiss-Prot Summary for CXCR1 Gene
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.