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Aliases for CXCR1 Gene

Aliases for CXCR1 Gene

  • C-X-C Motif Chemokine Receptor 1 2 3 5
  • High Affinity Interleukin-8 Receptor A 3 4
  • Chemokine (C-X-C Motif) Receptor 1 2 3
  • Interleukin 8 Receptor, Alpha 2 3
  • IL-8 Receptor Type 1 3 4
  • CDw128a 3 4
  • IL-8R A 3 4
  • CMKAR1 3 4
  • CXC-R1 3 4
  • CXCR-1 3 4
  • IL8RA 3 4
  • C-X-C Chemokine Receptor Type 1 3
  • Interleukin-8 Receptor Type 1 3
  • Interleukin-8 Receptor Type A 3
  • CD181 Antigen 4
  • C-C-CKR-1 3
  • IL8RBA 3
  • CD128 3
  • CD181 3
  • CKR-1 3
  • IL8R1 3
  • C-C 3

External Ids for CXCR1 Gene

Previous HGNC Symbols for CXCR1 Gene

  • CMKAR1
  • IL8RA

Previous GeneCards Identifiers for CXCR1 Gene

  • GC02M218736
  • GC02M219028
  • GC02M210880

Summaries for CXCR1 Gene

Entrez Gene Summary for CXCR1 Gene

  • The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

GeneCards Summary for CXCR1 Gene

CXCR1 (C-X-C Motif Chemokine Receptor 1) is a Protein Coding gene. Diseases associated with CXCR1 include Human Immunodeficiency Virus Type 1 and Acute Pyelonephritis. Among its related pathways are GPCRs, Other and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and interleukin-8 binding. An important paralog of this gene is CXCR2.

UniProtKB/Swiss-Prot for CXCR1 Gene

  • Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Gene Wiki entry for CXCR1 Gene

Additional gene information for CXCR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR1 Gene

Genomics for CXCR1 Gene

GeneHancer (GH) Regulatory Elements for CXCR1 Gene

Promoters and enhancers for CXCR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J218166 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 655 -0.1 -139 1.5 CTCF CXCR1 ARPC2 GPBAR1 HMGB1P9
GH02J218145 Enhancer 0.8 FANTOM5 50.4 +21.7 21669 0.3 NFIB CEBPG RBPJ LCORL GATAD1 THAP11 GATAD2A NFIA FOXA3 HMG20A CXCR2 CXCR1 ENSG00000261338 TNS1 SLC11A1 CTDSP1 ARPC2 GC02P218136
GH02J218156 Enhancer 0.4 FANTOM5 53.9 +10.7 10713 0.3 CTCF NFIL3 CXCR1 CXCR2 ENSG00000261338 CTDSP1 SLC11A1 ARPC2 GC02P218136
GH02J218228 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 -63.2 -63228 3.7 HDGF BATF IRF4 YY1 EGR1 ATF7 ETV6 IKZF2 BCLAF1 RUNX3 ENSG00000261338 GPBAR1 AAMP CXCR1 CATIP-AS1 ARPC2 GC02M218215 TRY-ATA1-1
GH02J218124 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 10.3 +40.7 40743 3.5 CTCF POLR2A ADNP ZNF341 ZMYM3 REST MNT CXCR2 ENSG00000261338 CXCR1 GC02P218135 GC02P218134
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCR1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CXCR1 Gene

Genomic Locations for CXCR1 Gene
4,151 bases
Minus strand
4,151 bases
Minus strand

Genomic View for CXCR1 Gene

Genes around CXCR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR1 Gene

Proteins for CXCR1 Gene

  • Protein details for CXCR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C chemokine receptor type 1
    Protein Accession:
    Secondary Accessions:
    • B2R6Q3
    • Q2YEF8
    • Q2YEG4
    • Q2YEG5
    • Q2YEG7
    • Q2YEG8
    • Q53R18
    • Q6IN95
    • Q8N6T6
    • Q9P2T8
    • Q9P2T9
    • Q9P2U0
    • Q9P2U1
    • Q9P2U2

    Protein attributes for CXCR1 Gene

    350 amino acids
    Molecular mass:
    39791 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CXCR1 Gene

neXtProt entry for CXCR1 Gene

Post-translational modifications for CXCR1 Gene

  • Glycosylation at Asn16 and posLast=33
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCR1 Gene

Domains & Families for CXCR1 Gene

Gene Families for CXCR1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • G-protein coupled receptors
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR1: view

Function for CXCR1 Gene

Molecular function for CXCR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Phenotypes From GWAS Catalog for CXCR1 Gene

Gene Ontology (GO) - Molecular Function for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004918 interleukin-8 receptor activity IDA 10734056
GO:0004930 G-protein coupled receptor activity TAS 8381837
GO:0004950 chemokine receptor activity TAS 1840701
GO:0016494 C-X-C chemokine receptor activity IEA --
genes like me logo Genes that share ontologies with CXCR1: view
genes like me logo Genes that share phenotypes with CXCR1: view

Animal Models for CXCR1 Gene

MGI Knock Outs for CXCR1:
  • Cxcr1 Cxcr1<tm1Dgen>
  • Cxcr1 Cxcr1<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for CXCR1 Gene

miRTarBase miRNAs that target CXCR1

Clone Products

  • Addgene plasmids for CXCR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCR1 Gene

Localization for CXCR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCR1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with CXCR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCR1 Gene

Pathways & Interactions for CXCR1 Gene

genes like me logo Genes that share pathways with CXCR1: view

SIGNOR curated interactions for CXCR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CXCR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006935 chemotaxis IEA --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IDA 10734056
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CXCR1: view

Drugs & Compounds for CXCR1 Gene

(35) Drugs for CXCR1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ketoprofen Approved, Vet_approved Pharma Inhibition, Inhibitor, Target, other 92
calcium Approved Nutra 0
Reparixin Investigational Pharma Inhibitor of CXCL8 receptor and CXCR1/CXCR2 activation 0
[<sup>125</sup>I]CXCL8 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]mini-TyrRS Pharma Full agonist, Agonist 0

(23) Additional Compounds for CXCR1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lyn peptide inhibitor
R 7050

(5) Tocris Compounds for CXCR1 Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8
genes like me logo Genes that share compounds with CXCR1: view

Transcripts for CXCR1 Gene

mRNA/cDNA for CXCR1 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCR1 Gene

Chemokine (C-X-C motif) receptor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for CXCR1

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR1 Gene

No ASD Table

Relevant External Links for CXCR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCR1 Gene

mRNA differential expression in normal tissues according to GTEx for CXCR1 Gene

This gene is overexpressed in Whole Blood (x50.8).

NURSA nuclear receptor signaling pathways regulating expression of CXCR1 Gene:


SOURCE GeneReport for Unigene cluster for CXCR1 Gene:


Evidence on tissue expression from TISSUES for CXCR1 Gene

  • Blood(5)
  • Spleen(2.7)
  • Intestine(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with CXCR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCR1 Gene

Orthologs for CXCR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXCR1 34 33
  • 99.52 (n)
(Mus musculus)
Mammalia Cxcr1 16 34 33
  • 75.75 (n)
(Rattus norvegicus)
Mammalia Cxcr1 33
  • 75.64 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
-- 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
-- 34
  • 59 (a)
(Gallus gallus)
Aves CXCR2 33
  • 62.12 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 57 (a)
-- 34
  • 56 (a)
African clawed frog
(Xenopus laevis)
Amphibia CXCR2 33
(Danio rerio)
Actinopterygii CXCR1 34
  • 43 (a)
Species where no ortholog for CXCR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR1 Gene

Gene Tree for CXCR1 (if available)
Gene Tree for CXCR1 (if available)
Evolutionary constrained regions (ECRs) for CXCR1: view image

Paralogs for CXCR1 Gene

Variants for CXCR1 Gene

Sequence variations from dbSNP and Humsavar for CXCR1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000800851 -- 218,163,151(-) T/C/G 3_prime_UTR_variant
rs1000827249 -- 218,162,806(-) G/C downstream_transcript_variant
rs1000982366 -- 218,167,682(-) C/T upstream_transcript_variant
rs1001165300 -- 218,164,192(-) A/C coding_sequence_variant, synonymous_variant
rs1001459719 -- 218,168,821(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCR1 Gene

Variant ID Type Subtype PubMed ID
esv3594329 CNV gain 21293372
esv3594330 CNV gain 21293372
nsv3164 CNV insertion 18451855

Variation tolerance for CXCR1 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCR1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR1 Gene

Disorders for CXCR1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CXCR1 Gene - From: HGMD, OMIM, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
acute pyelonephritis
urinary tract infections, recurrent
  • urinary tract infections, recurrent, susceptibility to
idiopathic anterior uveitis
  • anterior uveitis idiopathic
- elite association - COSMIC cancer census association via MalaCards
Search CXCR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCR1 Gene

Publications for CXCR1 Gene

  1. Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils. (PMID: 16205979) Liu Y … Su B (Journal of molecular evolution 2005) 3 4 22 58
  2. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35. (PMID: 1427896) Morris SW … Cerretti DP (Genomics 1992) 2 3 22 58
  3. Characterization of two high affinity human interleukin-8 receptors. (PMID: 1379593) Lee J … Wood WI (The Journal of biological chemistry 1992) 3 4 22 58
  4. The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist. (PMID: 20044480) Lüttichau HR (The Journal of biological chemistry 2010) 3 22 58
  5. Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion. (PMID: 19585580) Singh S … Singh RK (International journal of cancer 2010) 3 22 58

Products for CXCR1 Gene

  • Addgene plasmids for CXCR1

Sources for CXCR1 Gene

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