This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded is thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Aug 2020] See more...

Aliases for CXCL9 Gene

Aliases for CXCL9 Gene

  • C-X-C Motif Chemokine Ligand 9 2 3 5
  • SCYB9 2 3 4
  • Monokine Induced By Gamma Interferon 2 3
  • Monokine Induced By Interferon-Gamma 3 4
  • Gamma-Interferon-Induced Monokine 3 4
  • Chemokine (C-X-C Motif) Ligand 9 2 3
  • Small-Inducible Cytokine B9 3 4
  • C-X-C Motif Chemokine 9 3 4
  • Crg-10 2 3
  • Humig 2 3
  • CMK 3 4
  • MIG 3 4
  • CXCL9 5
  • HuMIG 4

External Ids for CXCL9 Gene

Previous HGNC Symbols for CXCL9 Gene

  • CMK
  • MIG

Previous GeneCards Identifiers for CXCL9 Gene

  • GC04M076818
  • GC04M077112
  • GC04M077315
  • GC04M077380
  • GC04M077279
  • GC04M076922
  • GC04M072674

Summaries for CXCL9 Gene

Entrez Gene Summary for CXCL9 Gene

  • This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded is thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Aug 2020]

GeneCards Summary for CXCL9 Gene

CXCL9 (C-X-C Motif Chemokine Ligand 9) is a Protein Coding gene. Diseases associated with CXCL9 include Proliferative Glomerulonephritis and Paracoccidioidomycosis. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and CXCR3 chemokine receptor binding. An important paralog of this gene is CXCL2.

UniProtKB/Swiss-Prot Summary for CXCL9 Gene

  • Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.

Gene Wiki entry for CXCL9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL9 Gene

Genomics for CXCL9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXCL9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J076007 Promoter 0.5 EPDnew 250.7 0.0 -20 0.1 JUND SP1 CXCL9 ART3
GH04J076042 Enhancer 0.6 FANTOM5 Ensembl 72.9 -34.8 -34750 0.5 ZBTB33 ATF2 JUNB FOS CXCL11 lnc-FAM47E-1 piR-39099-185 piR-33422-320 piR-58297-349 CXCL9 ART3 CXCL10 NAAA HSALNG0035292
GH04J076059 Enhancer 1.3 FANTOM5 Ensembl ENCODE 29.6 -53.2 -53191 4.6 BCLAF1 NCOR1 CEBPA NFIC YY1 BCL11A FOXA1 TRIM22 HES1 HOMEZ ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 SDAD1-AS1 KR153194-146 piR-58297-350
GH04J075843 Enhancer 1 FANTOM5 Ensembl ENCODE 27.3 +162.6 162631 2.6 CEBPA CEBPB FOXA2 SMAD4 RXRA RARA BCL6 HMG20A NR2F6 CEBPG CXCL10 CXCL9 CXCL11 NAAA piR-37097-076 RF00004-078 RNU2-16P PPEF2 G3BP2
GH04J076027 Enhancer 0.7 FANTOM5 ENCODE 27.4 -20.8 -20819 0.9 NFIC YY1 NFIB MEIS2 NFIA SOX6 ART3 CXCL9 CXCL10 CXCL11 SDAD1 NAAA lnc-CXCL10-1 RPL36P8 HSALNG0035292
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL9

Top Transcription factor binding sites by QIAGEN in the CXCL9 gene promoter:
  • AML1a
  • IRF-1
  • IRF-2
  • p53
  • STAT3

Genomic Locations for CXCL9 Gene

Latest Assembly
chr4:76,001,275-76,007,509
(GRCh38/hg38)
Size:
6,235 bases
Orientation:
Minus strand

Previous Assembly
chr4:76,922,428-76,928,662
(GRCh37/hg19 by Entrez Gene)
Size:
6,235 bases
Orientation:
Minus strand

chr4:76,922,428-76,928,641
(GRCh37/hg19 by Ensembl)
Size:
6,214 bases
Orientation:
Minus strand

Genomic View for CXCL9 Gene

Genes around CXCL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL9 Gene

Proteins for CXCL9 Gene

  • Protein details for CXCL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07325-CXCL9_HUMAN
    Recommended name:
    C-X-C motif chemokine 9
    Protein Accession:
    Q07325
    Secondary Accessions:
    • Q503B4

    Protein attributes for CXCL9 Gene

    Size:
    125 amino acids
    Molecular mass:
    14019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL9 Gene

Post-translational modifications for CXCL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for CXCL9 Gene

Domains & Families for CXCL9 Gene

Gene Families for CXCL9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CXCL9 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine B9 (CXCL9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q07325

UniProtKB/Swiss-Prot:

CXCL9_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL9: view

Function for CXCL9 Gene

Molecular function for CXCL9 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma. The induction is enhanced by TNF in dermal fibroblasts and vein endothelial cells.

Phenotypes From GWAS Catalog for CXCL9 Gene

Gene Ontology (GO) - Molecular Function for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 2115167
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity TAS,IDA 12782716
GO:0045236 CXCR chemokine receptor binding IBA 21873635
GO:0048248 CXCR3 chemokine receptor binding IDA 12782716
genes like me logo Genes that share ontologies with CXCL9: view
genes like me logo Genes that share phenotypes with CXCL9: view

Animal Models for research

  • Taconic Biosciences Mouse Models for CXCL9

miRNA for CXCL9 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL9 Gene

Localization for CXCL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL9 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IBA 21873635
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CXCL9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL9 Gene

Pathways & Interactions for CXCL9 Gene

PathCards logo

SuperPathways for CXCL9 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 Peptide ligand-binding receptors
3 Toll-like Receptor Signaling Pathway
4 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
5 ERK Signaling
.61
.61
.51
genes like me logo Genes that share pathways with CXCL9: view

Pathways by source for CXCL9 Gene

SIGNOR curated interactions for CXCL9 Gene

Activates:

Gene Ontology (GO) - Biological Process for CXCL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS,IDA 12782716
GO:0006952 defense response TAS 2115167
GO:0006954 inflammatory response TAS,IBA 21873635
GO:0006955 immune response IEA --
GO:0006968 cellular defense response TAS 10570316
genes like me logo Genes that share ontologies with CXCL9: view

Drugs & Compounds for CXCL9 Gene

(30) Drugs for CXCL9 Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2',3'-Dideoxycytidine-5'-Monophosphate Experimental Pharma Target 0
Aracytidine 5'-monophosphate Experimental Pharma Target 0
CDP Experimental Pharma Target 0
Cytidine monophosphate Experimental Pharma Target 0
Adrenocorticotropic Hormone Pharma 206

(11) Additional Compounds for CXCL9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL9: view

Transcripts for CXCL9 Gene

mRNA/cDNA for CXCL9 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL9

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL9 Gene

No ASD Table

Relevant External Links for CXCL9 Gene

GeneLoc Exon Structure for
CXCL9

Expression for CXCL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL9 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL9 Gene

This gene is overexpressed in Lung (x6.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL9

SOURCE GeneReport for Unigene cluster for CXCL9 Gene:

Hs.77367

Evidence on tissue expression from TISSUES for CXCL9 Gene

  • Blood(4.6)
  • Skin(4.5)
  • Lymph node(3.7)
  • Spleen(3.3)
  • Intestine(3.1)
  • Lung(2.8)
  • Liver(2.7)
  • Heart(2.6)
  • Kidney(2.4)
  • Nervous system(2.4)
  • Bone marrow(2.4)
  • Muscle(2.3)
  • Stomach(2.2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with CXCL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL9 Gene

Orthologs for CXCL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CXCL9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CXCL9 29 30
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CXCL9 29 30
  • 78.76 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Cxcl9 30
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CXCL9 30
  • 41 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 34 (a)
OneToMany
Species where no ortholog for CXCL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CXCL9 Gene

ENSEMBL:
Gene Tree for CXCL9 (if available)
TreeFam:
Gene Tree for CXCL9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL9: view image
Alliance of Genome Resources:
Additional Orthologs for CXCL9

Paralogs for CXCL9 Gene

Paralogs for CXCL9 Gene

(8) SIMAP similar genes for CXCL9 Gene using alignment to 2 proteins:

  • CXCL9_HUMAN
  • L8E8X0_HUMAN
genes like me logo Genes that share paralogs with CXCL9: view

Variants for CXCL9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCL9 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs138184008 Benign: not provided 76,003,601(-) T/C
NM_002416.3(CXCL9):c.375A>G (p.Thr125=)
SYNONYMOUS
rs145442311 Likely Benign: not provided 76,006,220(-) G/C
NM_002416.3(CXCL9):c.119C>G (p.Thr40Ser)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CXCL9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CXCL9 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER inversion 18451855

Variation tolerance for CXCL9 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL9
Leiden Open Variation Database (LOVD)
CXCL9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL9 Gene

Disorders for CXCL9 Gene

MalaCards: The human disease database

(46) MalaCards diseases for CXCL9 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
proliferative glomerulonephritis
paracoccidioidomycosis
  • mucocutaneous-lymphangitic paracoccidioidomycosis
melioidosis
  • melioidosis, susceptibility to
pulmonary sarcoidosis
  • lung sarcoidosis
lichen planus
  • lichen ruber planus
- elite association - COSMIC cancer census association via MalaCards
Search CXCL9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCL9

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CXCL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL9 Gene

Publications for CXCL9 Gene

  1. Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome. (PMID: 19258635) Lau YL … Peiris JS (Hong Kong medical journal = Xianggang yi xue za zhi 2009) 3 22 40
  2. Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). (PMID: 10233762) Tensen CP … Willemze R (The Journal of investigative dermatology 1999) 3 4 22
  3. HuMig: a new human member of the chemokine family of cytokines. (PMID: 8476424) Farber JM (Biochemical and biophysical research communications 1993) 2 3 4
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 40
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 40

Products for CXCL9 Gene

Sources for CXCL9 Gene