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Aliases for CXCL8 Gene

Aliases for CXCL8 Gene

  • C-X-C Motif Chemokine Ligand 8 2 3 5
  • Monocyte-Derived Neutrophil Chemotactic Factor 2 3 4
  • Monocyte-Derived Neutrophil-Activating Peptide 2 3 4
  • Granulocyte Chemotactic Protein 1 2 3 4
  • Chemokine (C-X-C Motif) Ligand 8 2 3 4
  • Beta Endothelial Cell-Derived Neutrophil Activating Peptide 2 3
  • Lung Giant Cell Carcinoma-Derived Chemotactic Protein 2 3
  • Lymphocyte Derived Neutrophil Activating Peptide 2 3
  • Alveolar Macrophage Chemotactic Factor I 2 3
  • Tumor Necrosis Factor-Induced Gene 1 2 3
  • Neutrophil-Activating Peptide 1 2 3
  • T-Cell Chemotactic Factor 3 4
  • Interleukin 8 2 3
  • Emoctakin 3 4
  • GCP-1 3 4
  • MDNCF 3 4
  • MONAP 3 4
  • NAP-1 3 4
  • IL8 3 4
  • Small Inducible Cytokine Subfamily B, Member 8 3
  • Beta-Thromboglobulin-Like Protein 3
  • Neutrophil-Activating Protein 1 4
  • C-X-C Motif Chemokine 8 4
  • Interleukin-8 3
  • Protein 3-10C 4
  • LYNAP 3
  • NAP1 3
  • GCP1 3
  • LECT 3
  • LUCT 3
  • IL-8 4
  • NAF 3

External Ids for CXCL8 Gene

Previous HGNC Symbols for CXCL8 Gene

  • IL8

Summaries for CXCL8 Gene

Entrez Gene Summary for CXCL8 Gene

  • The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017]

GeneCards Summary for CXCL8 Gene

CXCL8 (C-X-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CXCL8 include Bronchiolitis and Extrinsic Allergic Alveolitis. Among its related pathways are PEDF Induced Signaling and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include chemokine activity and interleukin-8 receptor binding. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot for CXCL8 Gene

  • IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Gene Wiki entry for CXCL8 Gene

Additional gene information for CXCL8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL8 Gene

Genomics for CXCL8 Gene

GeneHancer (GH) Regulatory Elements for CXCL8 Gene

Promoters and enhancers for CXCL8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I073739 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.2 154 2.7 HDAC1 SMAD1 ATF1 FOXA2 SIN3A FEZF1 ZBTB40 POLR2B ZNF766 ZNF366 CXCL8 PF4V1 GC04P073743
GH04I073742 Enhancer 0.4 Ensembl dbSUPER 550.8 +1.8 1795 0.2 CXCL8 GC04P073743 PF4V1
GH04I073702 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 66.4 -35.8 -35808 3.8 PKNOX1 ATF1 ARNT FEZF1 YY1 TCF12 POLR2B ZNF766 E2F8 FOS CXCL8 CXCL2 CXCL3 ANKRD17 HMGA1P2 PF4V1 LOC105377272 CXCL5 MTHFD2L CXCL1
GH04I073730 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 55.2 -7.1 -7096 5.2 HDAC1 ATF1 PKNOX1 SMAD1 BMI1 BATF KLF5 IRF4 ZBTB40 ZNF766 CXCL8 CXCL2 CXCL3 PF4V1 MTHFD2L ANKRD17 CXCL1 LOC105377272
GH04I073725 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 46.6 -14.2 -14207 2 JUN TEAD4 CEBPB EP300 FOSL1 JUND ZNF366 POLR2A IKZF1 NFE2 CXCL2 CXCL8 CXCL3 MTHFD2L PF4V1 LOC105377272
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CXCL8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CXCL8 Gene

Genomic Locations for CXCL8 Gene
chr4:73,740,506-73,743,716
(GRCh38/hg38)
Size:
3,211 bases
Orientation:
Plus strand
chr4:74,606,223-74,609,433
(GRCh37/hg19)

Genomic View for CXCL8 Gene

Genes around CXCL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL8 Gene

Proteins for CXCL8 Gene

  • Protein details for CXCL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10145-IL8_HUMAN
    Recommended name:
    Interleukin-8
    Protein Accession:
    P10145
    Secondary Accessions:
    • B2R4L8
    • Q6FGF6
    • Q6LAE6
    • Q96RG6
    • Q9C077
    • Q9UCE1
    • Q9UCR8
    • Q9UCR9
    • Q9UCS0

    Protein attributes for CXCL8 Gene

    Size:
    99 amino acids
    Molecular mass:
    11098 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAK00048.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL8 Gene

neXtProt entry for CXCL8 Gene

Post-translational modifications for CXCL8 Gene

  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.
  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.

Other Protein References for CXCL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL8 Gene

Domains & Families for CXCL8 Gene

Gene Families for CXCL8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CXCL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10145

UniProtKB/Swiss-Prot:

IL8_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL8: view

Function for CXCL8 Gene

Molecular function for CXCL8 Gene

UniProtKB/Swiss-Prot Function:
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
UniProtKB/Swiss-Prot Induction:
By ER stress in a DDIT3/CHOP-dependent manner.

Phenotypes From GWAS Catalog for CXCL8 Gene

Gene Ontology (GO) - Molecular Function for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005153 interleukin-8 receptor binding IEA,IPI 1840701
GO:0005515 protein binding IPI 10880251
GO:0008009 chemokine activity TAS,IEA 12782716
genes like me logo Genes that share ontologies with CXCL8: view
genes like me logo Genes that share phenotypes with CXCL8: view

Clone Products

  • Addgene plasmids for CXCL8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL8 Gene

Localization for CXCL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL8 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 2

Gene Ontology (GO) - Cellular Components for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with CXCL8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL8 Gene

Pathways & Interactions for CXCL8 Gene

genes like me logo Genes that share pathways with CXCL8: view

SIGNOR curated interactions for CXCL8 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 11483765
GO:0002237 response to molecule of bacterial origin IDA 19912257
GO:0006928 movement of cell or subcellular component TAS 10820279
GO:0006935 chemotaxis TAS,IEA 12782716
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with CXCL8: view

Drugs & Compounds for CXCL8 Gene

(77) Drugs for CXCL8 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 537
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2087
Sunitinib Approved, Investigational Pharma VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 518
Salbutamol Approved, Vet_approved Pharma Partial agonist, Agonist 0
ABT-510 Investigational Pharma Target 0

(67) Additional Compounds for CXCL8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL8: view

Transcripts for CXCL8 Gene

Clone Products

  • Addgene plasmids for CXCL8

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for CXCL8 Gene

GeneLoc Exon Structure for
CXCL8
ECgene alternative splicing isoforms for
CXCL8

Expression for CXCL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CXCL8 Gene

This gene is overexpressed in Amniocyte (56.1) and Islet of Langerhans (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CXCL8 Gene



Protein tissue co-expression partners for CXCL8 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL8 Gene:

CXCL8

Evidence on tissue expression from TISSUES for CXCL8 Gene

  • Blood(5)
  • Lung(4.9)
  • Skin(4.6)
  • Kidney(4.5)
  • Pancreas(4.2)
  • Nervous system(4)
  • Bone marrow(3.8)
  • Intestine(3.8)
  • Heart(3.2)
  • Liver(3.2)
  • Stomach(3)
  • Spleen(2.9)
  • Lymph node(2.8)
  • Muscle(2.4)
  • Eye(2.2)
  • Gall bladder(2.1)
  • Bone(2)
  • Urine(2)
genes like me logo Genes that share expression patterns with CXCL8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL8 Gene

Orthologs for CXCL8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL8 34 33
  • 99.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL8 33
  • 83.51 (n)
IL-8 34
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL8 34 33
  • 81.44 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL8 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL8 34
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcl3 34
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IL8 34
  • 48 (a)
OneToMany
K60 34
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia IL8 34
  • 40 (a)
OneToOne
Species where no ortholog for CXCL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL8 Gene

ENSEMBL:
Gene Tree for CXCL8 (if available)
TreeFam:
Gene Tree for CXCL8 (if available)

Paralogs for CXCL8 Gene

Paralogs for CXCL8 Gene

genes like me logo Genes that share paralogs with CXCL8: view

Variants for CXCL8 Gene

Sequence variations from dbSNP and Humsavar for CXCL8 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000003014 -- 73,739,370(+) A/T upstream_transcript_variant
rs1000022557 -- 73,743,126(+) T/A 3_prime_UTR_variant
rs1000275946 -- 73,739,885(+) A/G upstream_transcript_variant
rs1000557302 -- 73,740,928(+) A/T intron_variant
rs1000965738 -- 73,740,637(+) A/G 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL8 Gene

Variant ID Type Subtype PubMed ID
nsv1001725 CNV gain 25217958

Variation tolerance for CXCL8 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL8 Gene

Human Gene Mutation Database (HGMD)
CXCL8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL8 Gene

Disorders for CXCL8 Gene

MalaCards: The human disease database

(220) MalaCards diseases for CXCL8 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bronchiolitis
extrinsic allergic alveolitis
  • hp
lung giant cell carcinoma
  • giant cell carcinoma
bronchiolitis obliterans
  • bronchiolitis exudativa
aseptic meningitis
  • acute aseptic meningitis
- elite association - COSMIC cancer census association via MalaCards
Search CXCL8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCL8

genes like me logo Genes that share disorders with CXCL8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL8 Gene

Publications for CXCL8 Gene

  1. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. (PMID: 19597126) Al Alam D … Gangloff SC (American journal of respiratory cell and molecular biology 2010) 3 22 58
  2. Cellular factors involved in CXCL8 expression induced by glycated serum albumin in vascular smooth muscle cells. (PMID: 19733855) Choi KH … Kim K (Atherosclerosis 2010) 3 22 58
  3. IL-8 production by macrophages is synergistically enhanced when cigarette smoke is combined with TNF-alpha. (PMID: 19874800) Sarir H … Folkerts G (Biochemical pharmacology 2010) 3 22 58
  4. Signal mechanisms of vascular endothelial growth factor and interleukin-8 in ovarian hyperstimulation syndrome: dopamine targets their common pathways. (PMID: 20008399) Chen SU … Yang YS (Human reproduction (Oxford, England) 2010) 3 22 58
  5. Cytokines in bronchoalveolar lavage fluid and serum of lung cancer patients during radiotherapy - Association of interleukin-8 and VEGF with survival. (PMID: 20044268) Crohns M … Kellokumpu-Lehtinen P (Cytokine 2010) 3 22 58

Products for CXCL8 Gene

  • Addgene plasmids for CXCL8

Sources for CXCL8 Gene

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