The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils... See more...

Aliases for CXCL8 Gene

Aliases for CXCL8 Gene

  • C-X-C Motif Chemokine Ligand 8 2 3 5
  • Monocyte-Derived Neutrophil Chemotactic Factor 2 3 4
  • Monocyte-Derived Neutrophil-Activating Peptide 2 3 4
  • Granulocyte Chemotactic Protein 1 2 3 4
  • Chemokine (C-X-C Motif) Ligand 8 2 3 4
  • GCP-1 2 3 4
  • MDNCF 2 3 4
  • MONAP 2 3 4
  • NAP-1 2 3 4
  • Beta Endothelial Cell-Derived Neutrophil Activating Peptide 2 3
  • Lung Giant Cell Carcinoma-Derived Chemotactic Protein 2 3
  • Lymphocyte Derived Neutrophil Activating Peptide 2 3
  • Alveolar Macrophage Chemotactic Factor I 2 3
  • Tumor Necrosis Factor-Induced Gene 1 2 3
  • Neutrophil-Activating Peptide 1 2 3
  • T-Cell Chemotactic Factor 3 4
  • Interleukin 8 2 3
  • Interleukin-8 3 4
  • Emoctakin 3 4
  • LYNAP 2 3
  • SCYB8 2 3
  • GCP1 2 3
  • LECT 2 3
  • LUCT 2 3
  • NAP1 2 3
  • IL-8 2 4
  • IL8 3 4
  • NAF 2 3
  • Small Inducible Cytokine Subfamily B, Member 8 3
  • Beta-Thromboglobulin-Like Protein 3
  • Neutrophil-Activating Protein 1 4
  • C-X-C Motif Chemokine 8 4
  • Protein 3-10C 4
  • AMCF-I 2
  • B-ENAP 2
  • CXCL8 5
  • TSG-1 2
  • 3-10C 2
  • K60 2

External Ids for CXCL8 Gene

Previous HGNC Symbols for CXCL8 Gene

  • IL8

Summaries for CXCL8 Gene

Entrez Gene Summary for CXCL8 Gene

  • The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]

GeneCards Summary for CXCL8 Gene

CXCL8 (C-X-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CXCL8 include Melanoma and Adult Respiratory Distress Syndrome. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include chemokine activity and interleukin-8 receptor binding. An important paralog of this gene is PPBP.

UniProtKB/Swiss-Prot Summary for CXCL8 Gene

  • IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Gene Wiki entry for CXCL8 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL8 Gene

Genomics for CXCL8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXCL8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J073739 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.0 30 2.5 PRDM10 ZNF629 LEF1 IKZF1 JUND FOXA1 MTA1 HDAC1 GABPA SOX6 CXCL8 PF4V1 lnc-CXCL6-3 CXCL6
GH04J073702 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 66.4 -35.8 -35843 3.8 CEBPG LEF1 IKZF1 JUND DDX20 MTA2 PKNOX1 ZNF24 MTA1 REST CXCL8 CXCL2 CXCL3 ANKRD17 HMGA1P2 PF4V1 UMLILO CXCL5 MTHFD2L CXCL1
GH04J073716 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 55.2 -14.0 -14041 21.4 CEBPG SP1 CTCF ATF7 LEF1 IKZF1 BACH1 ETV6 JUND PKNOX1 CXCL2 CXCL8 CXCL3 MTHFD2L PF4V1 UMLILO CXCL6 CXCL5 ANKRD17 CXCL1
GH04J074107 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 35.7 +372.9 372930 11.5 TEAD4 PRDM10 RFX1 LEF1 IKZF1 JUND REST SP1 SOX6 FOXJ2 MTHFD2L CXCL2 EREG CXCL8 CXCL3 CXCL1 AREG HSALNG0035194 lnc-MTHFD2L-3 LOC105377277
GH04J073660 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 43.3 -77.6 -77640 4.6 CTCF REST RAD21 TRIM22 TOE1 CEBPB RAD51 FOS SMC3 FOSL1 CXCL3 CXCL2 CXCL8 RASSF6 MTHFD2L PF4V1 PPBP HSALNG0035158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL8

Genomic Locations for CXCL8 Gene

Genomic Locations for CXCL8 Gene
chr4:73,740,541-73,743,716
(GRCh38/hg38)
Size:
3,176 bases
Orientation:
Plus strand
chr4:74,606,223-74,609,433
(GRCh37/hg19)
Size:
3,211 bases
Orientation:
Plus strand

Genomic View for CXCL8 Gene

Genes around CXCL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL8 Gene

Proteins for CXCL8 Gene

  • Protein details for CXCL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10145-IL8_HUMAN
    Recommended name:
    Interleukin-8
    Protein Accession:
    P10145
    Secondary Accessions:
    • B2R4L8
    • Q6FGF6
    • Q6LAE6
    • Q96RG6
    • Q9C077
    • Q9UCE1
    • Q9UCR8
    • Q9UCR9
    • Q9UCS0

    Protein attributes for CXCL8 Gene

    Size:
    99 amino acids
    Molecular mass:
    11098 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAK00048.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCL8 Gene

neXtProt entry for CXCL8 Gene

Post-translational modifications for CXCL8 Gene

  • Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.
  • Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.

Other Protein References for CXCL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CXCL8

Protein Products

  • Abcam proteins for CXCL8

Assay Products

  • Abcam assays for CXCL8

No data available for DME Specific Peptides for CXCL8 Gene

Domains & Families for CXCL8 Gene

Gene Families for CXCL8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CXCL8 Gene

Suggested Antigen Peptide Sequences for CXCL8 Gene

GenScript: Design optimal peptide antigens:
  • T-cell chemotactic factor (IL8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10145

UniProtKB/Swiss-Prot:

IL8_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL8: view

Function for CXCL8 Gene

Molecular function for CXCL8 Gene

UniProtKB/Swiss-Prot Function:
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
UniProtKB/Swiss-Prot Induction:
By ER stress in a DDIT3/CHOP-dependent manner.

Phenotypes From GWAS Catalog for CXCL8 Gene

Gene Ontology (GO) - Molecular Function for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005153 interleukin-8 receptor binding IEA,IPI 1840701
GO:0005515 protein binding IPI 10880251
GO:0008009 chemokine activity IEA,TAS 12782716
GO:0045236 CXCR chemokine receptor binding IBA 21873635
genes like me logo Genes that share ontologies with CXCL8: view
genes like me logo Genes that share phenotypes with CXCL8: view

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL8 Gene

Localization for CXCL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL8 gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 3
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 3
endosome 3
cytosol 3
lysosome 3
peroxisome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
genes like me logo Genes that share ontologies with CXCL8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL8 Gene

Pathways & Interactions for CXCL8 Gene

PathCards logo

SuperPathways for CXCL8 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 Toll-like Receptor Signaling Pathway
3 TGF-Beta Pathway
.60
.60
.57
.43
.41
4 Peptide ligand-binding receptors
5 Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
genes like me logo Genes that share pathways with CXCL8: view

Pathways by source for CXCL8 Gene

14 GeneGo (Thomson Reuters) pathways for CXCL8 Gene
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Bacterial infections in CF airways
  • Cell adhesion_ECM remodeling
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
27 Qiagen pathways for CXCL8 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Cytokine Network
1 GeneTex pathway for CXCL8 Gene

SIGNOR curated interactions for CXCL8 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CXCL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 11483765
GO:0002237 response to molecule of bacterial origin IDA 19912257
GO:0006935 chemotaxis IEA,TAS 12782716
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IEA,TAS 11483765
genes like me logo Genes that share ontologies with CXCL8: view

Drugs & Compounds for CXCL8 Gene

(80) Drugs for CXCL8 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Inhibitor, Competitive HMG-CoA reductase inhibitor 582
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2368
Sunitinib Approved, Investigational Pharma VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 552
Salbutamol Approved, Vet_approved Pharma Agonist, Partial agonist 0
ABT-510 Investigational Pharma Target 0

(65) Additional Compounds for CXCL8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL8: view

Transcripts for CXCL8 Gene

mRNA/cDNA for CXCL8 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL8

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for CXCL8 Gene

GeneLoc Exon Structure for
CXCL8

Expression for CXCL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CXCL8 Gene

This gene is overexpressed in Amniocyte (56.1) and Islet of Langerhans (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL8 Gene



Protein tissue co-expression partners for CXCL8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL8

Evidence on tissue expression from TISSUES for CXCL8 Gene

  • Blood(5)
  • Lung(4.9)
  • Skin(4.7)
  • Kidney(4.7)
  • Pancreas(4.5)
  • Nervous system(4.3)
  • Bone marrow(4.2)
  • Intestine(4.1)
  • Liver(3.8)
  • Heart(3.7)
  • Spleen(3.6)
  • Lymph node(3.6)
  • Stomach(3.3)
  • Muscle(3.3)
  • Gall bladder(3)
  • Bone(2.9)
  • Adrenal gland(2.8)
  • Eye(2.8)
  • Urine(2.7)
  • Saliva(2.7)
  • Thyroid gland(2.4)
genes like me logo Genes that share expression patterns with CXCL8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL8 Gene

Orthologs for CXCL8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL8 30 31
  • 99.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL8 30
  • 83.51 (n)
IL-8 31
  • 76 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia IL8 30 31
  • 81.44 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IL8 31
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL8 31
  • 41 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cxcl3 31
  • 37 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves IL8 31
  • 48 (a)
OneToMany
K60 31
  • 46 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia IL8 31
  • 40 (a)
OneToOne
Species where no ortholog for CXCL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CXCL8 Gene

ENSEMBL:
Gene Tree for CXCL8 (if available)
TreeFam:
Gene Tree for CXCL8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL8: view image

Paralogs for CXCL8 Gene

Paralogs for CXCL8 Gene

genes like me logo Genes that share paralogs with CXCL8: view

Variants for CXCL8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCL8 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
708667 Likely Benign: not provided 73,740,676(+) C/T SYNONYMOUS_VARIANT
726129 Likely Benign: not provided 73,740,727(+) G/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CXCL8 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXCL8 Gene

Variant ID Type Subtype PubMed ID
nsv1001725 CNV gain 25217958

Variation tolerance for CXCL8 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL8 Gene

Human Gene Mutation Database (HGMD)
CXCL8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL8 Gene

Disorders for CXCL8 Gene

MalaCards: The human disease database

(404) MalaCards diseases for CXCL8 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
adult respiratory distress syndrome
  • acute respiratory distress syndrome
bronchiolitis
extrinsic allergic alveolitis
  • hp
bronchiolitis obliterans
  • bronchiolitis exudativa
- elite association - COSMIC cancer census association via MalaCards
Search CXCL8 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CXCL8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL8 Gene

Publications for CXCL8 Gene

  1. Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact. (PMID: 11023497) Van den Steen PE … Opdenakker G (Blood 2000) 3 4 23
  2. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. (PMID: 2007144) Clark-Lewis I … Aebersold R (Biochemistry 1991) 3 4 23
  3. The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PMID: 2145175) Van Damme J … Billiau A (European journal of immunology 1990) 3 4 23
  4. Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. (PMID: 20829347) Park SH … Moon Y (The Journal of biological chemistry 2010) 3 4
  5. Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. (PMID: 20162422) Doll D … Janssen KP (International journal of colorectal disease 2010) 3 23

Products for CXCL8 Gene

  • Addgene plasmids for CXCL8

Sources for CXCL8 Gene