Aliases for CXCL6 Gene

Aliases for CXCL6 Gene

  • C-X-C Motif Chemokine Ligand 6 2 3 5
  • Granulocyte Chemotactic Protein 2 2 3 4
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte Chemotactic Protein 2) 2 3
  • Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2) 2 3
  • Small-Inducible Cytokine B6 3 4
  • C-X-C Motif Chemokine 6 3 4
  • Chemokine Alpha 3 3 4
  • SCYB6 3 4
  • CKA-3 3 4
  • GCP-2 3 4
  • GCP2 3 4
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B 3
  • Chemokine (C-X-C Motif) Ligand 6 2

External Ids for CXCL6 Gene

Previous HGNC Symbols for CXCL6 Gene

  • SCYB6

Previous GeneCards Identifiers for CXCL6 Gene

  • GC04P074691
  • GC04P074942
  • GC04P075102
  • GC04P075168
  • GC04P075067
  • GC04P074921
  • GC04P070513

Summaries for CXCL6 Gene

GeneCards Summary for CXCL6 Gene

CXCL6 (C-X-C Motif Chemokine Ligand 6) is a Protein Coding gene. Diseases associated with CXCL6 include Tonsillitis and Mastitis. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is CXCL5.

UniProtKB/Swiss-Prot Summary for CXCL6 Gene

  • Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

Additional gene information for CXCL6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL6 Gene

Genomics for CXCL6 Gene

GeneHancer (GH) Regulatory Elements for CXCL6 Gene

Promoters and enhancers for CXCL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J073836 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 245 1.2 ZIC2 ZBTB26 HDAC2 ZBTB17 PHF8 SPI1 ZNF335 ZBTB48 ZNF398 ZBTB33 CXCL6 NONHSAG038186.2 lnc-PF4V1-1 PPBPP1
GH04J073716 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -110.1 -110056 21.4 CTCF TCF12 SP1 JUND FOS EP300 REST KLF4 MEF2C RAD21 CXCL2 CXCL8 CXCL3 MTHFD2L PF4V1 UMLILO CXCL6 CXCL5 ANKRD17 CXCL1
GH04J073674 Enhancer 1 Ensembl ENCODE dbSUPER 4.7 -160.3 -160337 3.7 TCF12 ZIC2 EP300 NCOR1 POLR2A FOS NR3C1 FOSL2 CEBPB RCOR1 PF4V1 CXCL8 CXCL6 RASSF6 HSALNG0035158 lnc-RASSF6-1
GH04J073762 Enhancer 0.9 FANTOM5 Ensembl 5.4 -74.9 -74856 5 NFIC PBX2 SPI1 FOSL1 GATA2 DPF2 MEIS2 POLR2A SMARCE1 JUN CXCL8 PF4V1 MTHFD2L CXCL6 PPBP PF4 piR-39416-034 lnc-CXCL6-3
GH04J073822 Enhancer 0.7 FANTOM5 Ensembl 5.4 -14.8 -14755 4.8 ZNF316 MAFF FOS MAFK CEBPG ATF4 TRIM24 EMSY STAT3 CXCL8 CXCL3 MTHFD2L PF4V1 CXCL2 CXCL6 RF00994-739 lnc-RASSF6-3 ENSG00000249051
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL6

Top Transcription factor binding sites by QIAGEN in the CXCL6 gene promoter:
  • aMEF-2
  • AP-4
  • Hlf
  • Lmo2
  • MEF-2
  • MEF-2A
  • Pbx1a
  • RFX1
  • SRF
  • SRF (504 AA)

Genomic Locations for CXCL6 Gene

Genomic Locations for CXCL6 Gene
chr4:73,836,556-73,849,064
(GRCh38/hg38)
Size:
12,509 bases
Orientation:
Plus strand
chr4:74,702,214-74,714,781
(GRCh37/hg19)
Size:
12,568 bases
Orientation:
Plus strand

Genomic View for CXCL6 Gene

Genes around CXCL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL6 Gene

Proteins for CXCL6 Gene

  • Protein details for CXCL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80162-CXCL6_HUMAN
    Recommended name:
    C-X-C motif chemokine 6
    Protein Accession:
    P80162
    Secondary Accessions:
    • B2R4X3
    • Q4W5D4

    Protein attributes for CXCL6 Gene

    Size:
    114 amino acids
    Molecular mass:
    11897 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CXCL6 Gene

Post-translational modifications for CXCL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CXCL6 Gene

Domains & Families for CXCL6 Gene

Gene Families for CXCL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CXCL6 Gene

Suggested Antigen Peptide Sequences for CXCL6 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine B6 (CXCL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P80162

UniProtKB/Swiss-Prot:

CXCL6_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL6: view

Function for CXCL6 Gene

Molecular function for CXCL6 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).

Phenotypes From GWAS Catalog for CXCL6 Gene

Gene Ontology (GO) - Molecular Function for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 28381538
GO:0008009 chemokine activity IEA,IDA 8399143
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with CXCL6: view
genes like me logo Genes that share phenotypes with CXCL6: view

Animal Models for CXCL6 Gene

MGI Knock Outs for CXCL6:

Animal Model Products

CRISPR Products

miRNA for CXCL6 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CXCL6 Gene

Localization for CXCL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL6 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
genes like me logo Genes that share ontologies with CXCL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL6 Gene

Pathways & Interactions for CXCL6 Gene

PathCards logo

SuperPathways for CXCL6 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 Peptide ligand-binding receptors
3 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
4 ERK Signaling
.61
.61
.51
5 Signaling by GPCR
genes like me logo Genes that share pathways with CXCL6: view

Pathways by source for CXCL6 Gene

2 GeneGo (Thomson Reuters) pathways for CXCL6 Gene
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
17 Qiagen pathways for CXCL6 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CXCL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001776 leukocyte homeostasis IEA --
GO:0006935 chemotaxis TAS,IEA 9164944
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IEA,IBA 21873635
genes like me logo Genes that share ontologies with CXCL6: view

No data available for SIGNOR curated interactions for CXCL6 Gene

Drugs & Compounds for CXCL6 Gene

(3) Drugs for CXCL6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CXCL6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL6: view

Transcripts for CXCL6 Gene

mRNA/cDNA for CXCL6 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL6

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL6 Gene

No ASD Table

Relevant External Links for CXCL6 Gene

GeneLoc Exon Structure for
CXCL6

Expression for CXCL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCL6 Gene

This gene is overexpressed in Spleen (x21.1).

Protein differential expression in normal tissues from HIPED for CXCL6 Gene

This gene is overexpressed in Islet of Langerhans (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXCL6 Gene



Protein tissue co-expression partners for CXCL6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL6

SOURCE GeneReport for Unigene cluster for CXCL6 Gene:

Hs.164021

Evidence on tissue expression from TISSUES for CXCL6 Gene

  • Spleen(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CXCL6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL6 Gene

Orthologs for CXCL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CXCL6 31 30
  • 98.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CXCL6 31
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cxcl5 17 31 30
  • 71.43 (n)
rat
(Rattus norvegicus)
Mammalia Cxcl5 30
  • 69.3 (n)
dog
(Canis familiaris)
Mammalia -- 31
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 48 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 37 (a)
OneToMany
Species where no ortholog for CXCL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL6 Gene

ENSEMBL:
Gene Tree for CXCL6 (if available)
TreeFam:
Gene Tree for CXCL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL6: view image

Paralogs for CXCL6 Gene

Paralogs for CXCL6 Gene

(12) SIMAP similar genes for CXCL6 Gene using alignment to 2 proteins:

  • CXCL6_HUMAN
  • D6RF92_HUMAN
genes like me logo Genes that share paralogs with CXCL6: view

Variants for CXCL6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCL6 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
710320 Benign: not provided 73,837,092(+) G/GT FRAMESHIFT_VARIANT

Additional dbSNP identifiers (rs#s) for CXCL6 Gene

Structural Variations from Database of Genomic Variants (DGV) for CXCL6 Gene

Variant ID Type Subtype PubMed ID
nsv1001725 CNV gain 25217958
nsv1143412 CNV deletion 24896259
nsv1148833 CNV deletion 26484159
nsv4389 CNV insertion 18451855

Variation tolerance for CXCL6 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL6 Gene

Disorders for CXCL6 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CXCL6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tonsillitis
  • chronic tonsillitis
mastitis
  • breast inflammation
auricular cancer
  • malignant tumor of ear
acute endometritis
gastroduodenitis
- elite association - COSMIC cancer census association via MalaCards
Search CXCL6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCL6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL6 Gene

Publications for CXCL6 Gene

  1. The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial. (PMID: 18443119) Linge HM … Egesten A (Antimicrobial agents and chemotherapy 2008) 3 4 23 54
  2. Cloning and characterization of the human granulocyte chemotactic protein-2 gene. (PMID: 9164944) Rovai LE … Smith JB (Journal of immunology (Baltimore, Md. : 1950) 1997) 3 4 23 54
  3. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs. (PMID: 9057843) Froyen G … Billiau A (European journal of biochemistry 1997) 3 4 23 54
  4. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. (PMID: 8423327) Proost P … Van Damme J (Journal of immunology (Baltimore, Md. : 1950) 1993) 3 4 23 54
  5. Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines. (PMID: 8399143) Proost P … Van Damme J (Biochemistry 1993) 3 4 23 54

Products for CXCL6 Gene

Sources for CXCL6 Gene