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Aliases for CXCL5 Gene

Aliases for CXCL5 Gene

  • C-X-C Motif Chemokine Ligand 5 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 5 (Epithelial-Derived Neutrophil-Activating Peptide 78) 2 3
  • Epithelial-Derived Neutrophil-Activating Protein 78 3 4
  • Neutrophil-Activating Peptide ENA-78 3 4
  • Chemokine (C-X-C Motif) Ligand 5 2 3
  • SCYB5 3 4
  • Neutrophil-Activating Protein 78 3
  • Small-Inducible Cytokine B5 4
  • C-X-C Motif Chemokine 5 3
  • ENA-78(1-78) 4
  • ENA-78 3
  • ENA78 4

External Ids for CXCL5 Gene

Previous HGNC Symbols for CXCL5 Gene

  • SCYB5

Previous GeneCards Identifiers for CXCL5 Gene

  • GC04M074851
  • GC04M075100
  • GC04M075263
  • GC04M075328
  • GC04M075327
  • GC04M075226
  • GC04M070672

Summaries for CXCL5 Gene

Entrez Gene Summary for CXCL5 Gene

  • This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

GeneCards Summary for CXCL5 Gene

CXCL5 (C-X-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CXCL5 include Pediatric Ulcerative Colitis and Acute Cervicitis. Among its related pathways are Akt Signaling and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL6.

UniProtKB/Swiss-Prot for CXCL5 Gene

  • Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Gene Wiki entry for CXCL5 Gene

Additional gene information for CXCL5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCL5 Gene

Genomics for CXCL5 Gene

GeneHancer (GH) Regulatory Elements for CXCL5 Gene

Promoters and enhancers for CXCL5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J073998 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 662.9 +0.2 205 1.1 SP1 POLR2A MAX ZNF143 SIN3A ZBTB33 CXCL5 GC04M073996 MTHFD2L
GH04J073702 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.3 +294.1 294081 3.8 PKNOX1 ATF1 ARNT FEZF1 YY1 TCF12 POLR2B ZNF766 E2F8 FOS CXCL8 CXCL2 CXCL3 ANKRD17 HMGA1P2 PF4V1 LOC105377272 CXCL5 MTHFD2L CXCL1
GH04J073984 Enhancer 0.6 ENCODE 11.1 +13.4 13383 1.9 PKNOX1 NANOG ARNT ZBTB8A ZNF501 ZIC2 FOXA1 ETS1 OSR2 CTBP1 CXCL5 MTHFD2L PF4V1 PF4 PPBP
GH04J073720 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +276.8 276831 2 ATF4 JUND JUN CEBPB ATF7 CEBPG TRIM24 EP300 CXCL8 CXCL2 CXCL3 MTHFD2L PF4V1 LOC105377272 CXCL5
GH04J073682 Enhancer 1 FANTOM5 ENCODE dbSUPER 4.2 +315.4 315437 2.2 FOSL1 SP1 CEBPB EHMT2 FOSL2 CXCL8 CXCL3 CXCL2 MTHFD2L PF4V1 LOC105377272 CXCL5 RASSF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CXCL5 gene promoter:
  • AML1a
  • GATA-1
  • HEN1
  • HNF-3beta
  • Meis-1b

Genomic Locations for CXCL5 Gene

Genomic Locations for CXCL5 Gene
3,138 bases
Minus strand
3,138 bases
Minus strand

Genomic View for CXCL5 Gene

Genes around CXCL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL5 Gene

Proteins for CXCL5 Gene

  • Protein details for CXCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-X-C motif chemokine 5
    Protein Accession:
    Secondary Accessions:
    • Q96QE1

    Protein attributes for CXCL5 Gene

    114 amino acids
    Molecular mass:
    11972 Da
    Quaternary structure:
    • Monomer (PubMed:24695525). Homodimer (PubMed:24695525).

    Three dimensional structures from OCA and Proteopedia for CXCL5 Gene

neXtProt entry for CXCL5 Gene

Post-translational modifications for CXCL5 Gene

  • N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CXCL5

No data available for DME Specific Peptides for CXCL5 Gene

Domains & Families for CXCL5 Gene

Gene Families for CXCL5 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CXCL5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intercrine alpha (chemokine CxC) family.
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL5: view

Function for CXCL5 Gene

Molecular function for CXCL5 Gene

UniProtKB/Swiss-Prot Function:
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Phenotypes From GWAS Catalog for CXCL5 Gene

Gene Ontology (GO) - Molecular Function for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI --
GO:0008009 chemokine activity IBA,TAS --
GO:0042802 identical protein binding IDA 24695525
GO:0045236 CXCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CXCL5: view
genes like me logo Genes that share phenotypes with CXCL5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CXCL5

miRNA for CXCL5 Gene

miRTarBase miRNAs that target CXCL5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL5 Gene

Localization for CXCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL5 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CXCL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL5 Gene

Pathways & Interactions for CXCL5 Gene

genes like me logo Genes that share pathways with CXCL5: view

Gene Ontology (GO) - Biological Process for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002446 neutrophil mediated immunity IBA --
GO:0002690 positive regulation of leukocyte chemotaxis IBA --
GO:0006935 chemotaxis TAS 10820279
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA --
genes like me logo Genes that share ontologies with CXCL5: view

No data available for SIGNOR curated interactions for CXCL5 Gene

Drugs & Compounds for CXCL5 Gene

(11) Drugs for CXCL5 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
hmg coa reductase inhibitors Pharma 0

(13) Additional Compounds for CXCL5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL5: view

Transcripts for CXCL5 Gene

mRNA/cDNA for CXCL5 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CXCL5 Gene

Chemokine (C-X-C motif) ligand 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL5 Gene

No ASD Table

Relevant External Links for CXCL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CXCL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CXCL5 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL5 Gene

This gene is overexpressed in Minor Salivary Gland (x5.1).

Protein differential expression in normal tissues from HIPED for CXCL5 Gene

This gene is overexpressed in Stomach (58.2) and Platelet (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXCL5 Gene

Protein tissue co-expression partners for CXCL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of CXCL5 Gene:


SOURCE GeneReport for Unigene cluster for CXCL5 Gene:


Evidence on tissue expression from TISSUES for CXCL5 Gene

  • Blood(4.5)
  • Lung(4.5)
  • Kidney(4.1)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with CXCL5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL5 Gene

Orthologs for CXCL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXCL5 34 33
  • 98.54 (n)
(Bos Taurus)
Mammalia CXCL6 34 33
  • 79.2 (n)
(Canis familiaris)
Mammalia -- 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
-- 34
  • 45 (a)
-- 34
  • 38 (a)
(Mus musculus)
Mammalia Cxcl5 34
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
(Gallus gallus)
Aves -- 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 38 (a)
Species where no ortholog for CXCL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CXCL5 Gene

Gene Tree for CXCL5 (if available)
Gene Tree for CXCL5 (if available)
Evolutionary constrained regions (ECRs) for CXCL5: view image

Paralogs for CXCL5 Gene

Paralogs for CXCL5 Gene

(11) SIMAP similar genes for CXCL5 Gene using alignment to 2 proteins:

  • Q6I9S7_HUMAN
genes like me logo Genes that share paralogs with CXCL5: view

Variants for CXCL5 Gene

Sequence variations from dbSNP and Humsavar for CXCL5 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1001818154 -- 73,995,484(-) G/C downstream_transcript_variant
rs1001986761 -- 73,998,665(-) T/A/G 5_prime_UTR_variant
rs1002036535 -- 73,998,461(-) A/C/T intron_variant
rs1002602681 -- 74,000,133(-) A/G/T upstream_transcript_variant
rs1003458284 -- 73,999,879(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CXCL5 Gene

Variant ID Type Subtype PubMed ID
esv3575747 CNV gain 25503493
nsv1004768 CNV gain 25217958
nsv1006029 CNV gain 25217958
nsv525980 CNV gain 19592680

Variation tolerance for CXCL5 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCL5 Gene

Disorders for CXCL5 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CXCL5 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pediatric ulcerative colitis
  • ulcerative colitis, pediatric
acute cervicitis
pulmonary sarcoidosis
  • lung sarcoidosis
nonspecific interstitial pneumonia
  • nsip
- elite association - COSMIC cancer census association via MalaCards
Search CXCL5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCL5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CXCL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL5 Gene

Publications for CXCL5 Gene

  1. Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene. (PMID: 7929219) Chang MS … Simonet S (The Journal of biological chemistry 1994) 2 3 4 22 58
  2. [Association of ENA-78, IP-10 and VEGF gene polymorphism with idiopathic pulmonary fibrosis]. (PMID: 20137269) Liu L … Xin P (Zhonghua yi xue za zhi 2009) 3 22 44 58
  3. Regulated upon activation normal T-cell expressed and secreted (RANTES) and epithelial cell-derived neutrophil-activating peptide (ENA-78) gene polymorphisms in patients with biopsy-proven erythema nodosum. (PMID: 19646363) Amoli MM … Gonzalez-Gay MA (Clinical and experimental rheumatology 2009) 3 22 44 58
  4. CXCL5 gene polymorphism association with diabetes mellitus. (PMID: 19035625) Hasani Ranjbar S … Amoli MM (Molecular diagnosis & therapy 2008) 3 22 44 58
  5. Epithelial neutrophil-activating peptide (ENA-78), acute coronary syndrome prognosis, and modulatory effect of statins. (PMID: 18769620) Zineh I … Spertus JA (PloS one 2008) 3 22 44 58

Products for CXCL5 Gene

Sources for CXCL5 Gene

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