This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective t... See more...

Aliases for CXCL5 Gene

Aliases for CXCL5 Gene

  • C-X-C Motif Chemokine Ligand 5 2 3 5
  • Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 5 (Epithelial-Derived Neutrophil-Activating Peptide 78) 2 3
  • Epithelial-Derived Neutrophil-Activating Protein 78 3 4
  • Neutrophil-Activating Peptide ENA-78 3 4
  • Chemokine (C-X-C Motif) Ligand 5 2 3
  • C-X-C Motif Chemokine 5 3 4
  • ENA-78 2 3
  • SCYB5 3 4
  • Neutrophil-Activating Protein 78 3
  • Small-Inducible Cytokine B5 4
  • ENA-78(1-78) 4
  • CXCL5 5
  • ENA78 4

External Ids for CXCL5 Gene

Previous HGNC Symbols for CXCL5 Gene

  • SCYB5

Previous GeneCards Identifiers for CXCL5 Gene

  • GC04M074851
  • GC04M075100
  • GC04M075263
  • GC04M075328
  • GC04M075327
  • GC04M075226
  • GC04M070672

Summaries for CXCL5 Gene

Entrez Gene Summary for CXCL5 Gene

  • This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

GeneCards Summary for CXCL5 Gene

CXCL5 (C-X-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CXCL5 include Nonspecific Interstitial Pneumonia and Pediatric Ulcerative Colitis. Among its related pathways are Rheumatoid arthritis and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL6.

UniProtKB/Swiss-Prot Summary for CXCL5 Gene

  • Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Gene Wiki entry for CXCL5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CXCL5 Gene

Genomics for CXCL5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CXCL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J073998 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 263 +1.2 1176 3 POLR2A CTCF TAF1 ZBTB33 RAD21 ZNF143 KDM1A SIN3A CXCL5 lnc-CXCL5-1 NONHSAG038190.2 CXCL3 MTHFD2L PPBP ENSG00000287037
GH04J073984 Enhancer 0.8 Ensembl ENCODE 11.1 +13.3 13258 2 ZIC2 ETS1 ZNF24 SP7 POU5F1 ZBTB8A PKNOX1 CTBP1 NANOG FOXA1 CXCL5 MTHFD2L PF4V1 PF4 PPBP ENSG00000287037
GH04J073716 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +272.2 272177 21.4 BCLAF1 SP1 ZNF654 IKZF1 JUND ZNF592 BCL11A CTCF CEBPB REST CXCL2 CXCL8 CXCL3 MTHFD2L PF4V1 UMLILO CXCL6 CXCL5 ANKRD17 CXCL1
GH04J073702 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 4.3 +294.0 293979 3.8 NCOR1 IKZF1 MYC JUND ZNF592 CEBPA YY1 REST CEBPB HES1 CXCL8 CXCL2 CXCL3 ANKRD17 HMGA1P2 PF4V1 UMLILO CXCL5 MTHFD2L CXCL1
GH04J073978 Enhancer 0.8 Ensembl ENCODE 6.6 +19.3 19325 1.7 IKZF1 ZNF316 NFE2 PRDM10 MAFK MAFG MAFF ZBTB40 ARID1B NFE2L2 PF4 CXCL5 PF4V1 piR-50968-094 ENSG00000287037 CXCL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CXCL5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CXCL5

Top Transcription factor binding sites by QIAGEN in the CXCL5 gene promoter:
  • AML1a
  • GATA-1
  • HEN1
  • HNF-3beta
  • Meis-1b

Genomic Locations for CXCL5 Gene

Latest Assembly
chr4:73,995,642-73,998,677
(GRCh38/hg38)
Size:
3,036 bases
Orientation:
Minus strand

Previous Assembly
chr4:74,861,359-74,864,394
(GRCh37/hg19 by Entrez Gene)
Size:
3,036 bases
Orientation:
Minus strand

chr4:74,861,359-74,864,496
(GRCh37/hg19 by Ensembl)
Size:
3,138 bases
Orientation:
Minus strand

Genomic View for CXCL5 Gene

Genes around CXCL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXCL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXCL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCL5 Gene

Proteins for CXCL5 Gene

  • Protein details for CXCL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42830-CXCL5_HUMAN
    Recommended name:
    C-X-C motif chemokine 5
    Protein Accession:
    P42830
    Secondary Accessions:
    • Q96QE1

    Protein attributes for CXCL5 Gene

    Size:
    114 amino acids
    Molecular mass:
    11972 Da
    Quaternary structure:
    • Monomer (PubMed:24695525). Homodimer (PubMed:24695525).

    Three dimensional structures from OCA and Proteopedia for CXCL5 Gene

neXtProt entry for CXCL5 Gene

Post-translational modifications for CXCL5 Gene

  • N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CXCL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for CXCL5

No data available for DME Specific Peptides for CXCL5 Gene

Domains & Families for CXCL5 Gene

Gene Families for CXCL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CXCL5 Gene

Suggested Antigen Peptide Sequences for CXCL5 Gene

GenScript: Design optimal peptide antigens:
  • Small-inducible cytokine B5 (CXCL5_HUMAN)
  • cDNA, FLJ92410, Homo sapiens chemokine (C-X-C motif) ligand 5 (CXCL5), mRNA (Q6I9S7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42830

UniProtKB/Swiss-Prot:

CXCL5_HUMAN :
  • Belongs to the intercrine alpha (chemokine CxC) family.
Family:
  • Belongs to the intercrine alpha (chemokine CxC) family.
genes like me logo Genes that share domains with CXCL5: view

Function for CXCL5 Gene

Molecular function for CXCL5 Gene

UniProtKB/Swiss-Prot Function:
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Phenotypes From GWAS Catalog for CXCL5 Gene

Gene Ontology (GO) - Molecular Function for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 32296183
GO:0008009 chemokine activity TAS,IBA 21873635
GO:0042802 identical protein binding IDA 24695525
GO:0045236 CXCR chemokine receptor binding IBA 21873635
genes like me logo Genes that share ontologies with CXCL5: view
genes like me logo Genes that share phenotypes with CXCL5: view

miRNA for CXCL5 Gene

miRTarBase miRNAs that target CXCL5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CXCL5 Gene

Localization for CXCL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CXCL5 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with CXCL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CXCL5 Gene

Pathways & Interactions for CXCL5 Gene

PathCards logo

SuperPathways for CXCL5 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 Peptide ligand-binding receptors
3 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions
4 ERK Signaling
.61
.61
.51
5 Signaling by GPCR
genes like me logo Genes that share pathways with CXCL5: view

Pathways by source for CXCL5 Gene

17 Qiagen pathways for CXCL5 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • Endothelin-1 Signaling Pathway

Gene Ontology (GO) - Biological Process for CXCL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006935 chemotaxis TAS 10820279
GO:0006952 defense response IEA --
GO:0006954 inflammatory response IBA 21873635
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 10820279
genes like me logo Genes that share ontologies with CXCL5: view

No data available for SIGNOR curated interactions for CXCL5 Gene

Drugs & Compounds for CXCL5 Gene

(11) Drugs for CXCL5 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
hmg coa reductase inhibitors Pharma 0

(13) Additional Compounds for CXCL5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CXCL5: view

Transcripts for CXCL5 Gene

mRNA/cDNA for CXCL5 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CXCL5

Alternative Splicing Database (ASD) splice patterns (SP) for CXCL5 Gene

No ASD Table

Relevant External Links for CXCL5 Gene

GeneLoc Exon Structure for
CXCL5

Expression for CXCL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CXCL5 Gene

mRNA differential expression in normal tissues according to GTEx for CXCL5 Gene

This gene is overexpressed in Minor Salivary Gland (x5.1).

Protein differential expression in normal tissues from HIPED for CXCL5 Gene

This gene is overexpressed in Stomach (58.2) and Platelet (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CXCL5 Gene



Protein tissue co-expression partners for CXCL5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CXCL5

SOURCE GeneReport for Unigene cluster for CXCL5 Gene:

Hs.89714

Evidence on tissue expression from TISSUES for CXCL5 Gene

  • Blood(4.6)
  • Lung(4.5)
  • Kidney(4.3)
  • Intestine(2.9)
  • Lymph node(2.5)
  • Heart(2.5)
  • Spleen(2.5)
  • Nervous system(2.2)
  • Bone marrow(2.1)
  • Skin(2.1)
  • Stomach(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CXCL5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CXCL5 Gene

Orthologs for CXCL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCL5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CXCL5 29 30
  • 98.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CXCL6 29 30
  • 79.2 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 61 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 47 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 38 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Cxcl5 30
  • 45 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 44 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 29 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 38 (a)
OneToMany
Species where no ortholog for CXCL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CXCL5 Gene

ENSEMBL:
Gene Tree for CXCL5 (if available)
TreeFam:
Gene Tree for CXCL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CXCL5: view image
Alliance of Genome Resources:
Additional Orthologs for CXCL5

Paralogs for CXCL5 Gene

Paralogs for CXCL5 Gene

(11) SIMAP similar genes for CXCL5 Gene using alignment to 2 proteins:

  • CXCL5_HUMAN
  • Q6I9S7_HUMAN
genes like me logo Genes that share paralogs with CXCL5: view

Variants for CXCL5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CXCL5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CXCL5 Gene

Variant ID Type Subtype PubMed ID
esv3575747 CNV gain 25503493
nsv1004768 CNV gain 25217958
nsv1006029 CNV gain 25217958
nsv525980 CNV gain 19592680

Variation tolerance for CXCL5 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CXCL5 Gene

Human Gene Mutation Database (HGMD)
CXCL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CXCL5
Leiden Open Variation Database (LOVD)
CXCL5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CXCL5 Gene

Disorders for CXCL5 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CXCL5 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
nonspecific interstitial pneumonia
  • nsip
pediatric ulcerative colitis
  • ulcerative colitis, pediatric
pulmonary sarcoidosis
  • lung sarcoidosis
rheumatoid arthritis
  • ra
gastritis
  • acute gastric mucosal erosion
- elite association - COSMIC cancer census association via MalaCards
Search CXCL5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CXCL5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CXCL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CXCL5 Gene

Publications for CXCL5 Gene

  1. Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene. (PMID: 7929219) Chang MS … Simonet S (The Journal of biological chemistry 1994) 2 3 4 22
  2. [Association of ENA-78, IP-10 and VEGF gene polymorphism with idiopathic pulmonary fibrosis]. (PMID: 20137269) Liu L … Xin P (Zhonghua yi xue za zhi 2009) 3 22 40
  3. Regulated upon activation normal T-cell expressed and secreted (RANTES) and epithelial cell-derived neutrophil-activating peptide (ENA-78) gene polymorphisms in patients with biopsy-proven erythema nodosum. (PMID: 19646363) Amoli MM … Gonzalez-Gay MA (Clinical and experimental rheumatology 2009) 3 22 40
  4. Epithelial neutrophil-activating peptide (ENA-78), acute coronary syndrome prognosis, and modulatory effect of statins. (PMID: 18769620) Zineh I … Spertus JA (PloS one 2008) 3 22 40
  5. CXCL5 gene polymorphism association with diabetes mellitus. (PMID: 19035625) Hasani Ranjbar S … Amoli MM (Molecular diagnosis & therapy 2008) 3 22 40

Products for CXCL5 Gene

Sources for CXCL5 Gene